Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.
Identifieur interne : 001160 ( Ncbi/Merge ); précédent : 001159; suivant : 001161Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.
Auteurs : Giuseppe Lippi [Italie] ; Mario Plebani [Italie] ; Brandon Michael Henry [États-Unis]Source :
- Clinica chimica acta; international journal of clinical chemistry [ 1873-3492 ] ; 2020.
Abstract
Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19.
DOI: 10.1016/j.cca.2020.03.022
PubMed: 32178975
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Electronic address: Brandon.henry@cchmc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32178975</idno><idno type="pmid">32178975</idno><idno type="doi">10.1016/j.cca.2020.03.022</idno><idno type="wicri:Area/PubMed/Corpus">000435</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000435</idno><idno type="wicri:Area/PubMed/Curation">000435</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000435</idno><idno type="wicri:Area/PubMed/Checkpoint">000205</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000205</idno><idno type="wicri:Area/Ncbi/Merge">001160</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.</title><author><name sortKey="Lippi, Giuseppe" sort="Lippi, Giuseppe" uniqKey="Lippi G" first="Giuseppe" last="Lippi">Giuseppe Lippi</name><affiliation wicri:level="1"><nlm:affiliation>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Plebani, Mario" sort="Plebani, Mario" uniqKey="Plebani M" first="Mario" last="Plebani">Mario Plebani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Michael Henry, Brandon" sort="Michael Henry, Brandon" uniqKey="Michael Henry B" first="Brandon" last="Michael Henry">Brandon Michael Henry</name><affiliation wicri:level="2"><nlm:affiliation>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio, USA. Electronic address: Brandon.henry@cchmc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Clinica chimica acta; international journal of clinical chemistry</title><idno type="eISSN">1873-3492</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32178975</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3492</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>13</Day></PubDate></JournalIssue><Title>Clinica chimica acta; international journal of clinical chemistry</Title><ISOAbbreviation>Clin. Chim. Acta</ISOAbbreviation></Journal><ArticleTitle>Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0009-8981(20)30124-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cca.2020.03.022</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An electronic search in Medline, Scopus and Web of Science was performed to identify studies reporting data on platelet count in COVID-19 patients. A meta-analysis was performed, with calculation of weighted mean difference (WMD) of platelet number in COVID-19 patients with or without severe disease and odds ratio (OR) of thrombocytopenia for severe form of COVID-19.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Nine studies with 1779 COVID-19 patients, 399 (22.4%) with severe disease, were included in the meta-analysis. The pooled analysis revealed that platelet count was significantly lower in patients with more severe COVID-19 (WMD -31×10<sup>9</sup>/L; 95% CI, from -35 to -29×10<sup>9</sup>/L). A subgroup analysis comparing patients by survival, found an even lower platelet count was observed with mortality (WMD, -48×10<sup>9</sup>/L; 95% CI, -57 to -39×10<sup>9</sup>/L. In the four studies (n=1427) which reported data on rate of thrombocytopenia, a low platelet count was associated with over fivefold enhanced risk of severe COVID-19 (OR, 5.1; 95% CI, 1.8-14.6).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lippi</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plebani</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michael Henry</LastName><ForeName>Brandon</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio, USA. Electronic address: Brandon.henry@cchmc.org.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Clin Chim Acta</MedlineTA><NlmUniqueID>1302422</NlmUniqueID><ISSNLinking>0009-8981</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">coronavirus, COVID-19</Keyword><Keyword MajorTopicYN="N">platelets</Keyword><Keyword MajorTopicYN="N">thrombocytopenia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32178975</ArticleId><ArticleId IdType="pii">S0009-8981(20)30124-8</ArticleId><ArticleId IdType="doi">10.1016/j.cca.2020.03.022</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="Italie"><noRegion><name sortKey="Lippi, Giuseppe" sort="Lippi, Giuseppe" uniqKey="Lippi G" first="Giuseppe" last="Lippi">Giuseppe Lippi</name></noRegion><name sortKey="Plebani, Mario" sort="Plebani, Mario" uniqKey="Plebani M" first="Mario" last="Plebani">Mario Plebani</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Michael Henry, Brandon" sort="Michael Henry, Brandon" uniqKey="Michael Henry B" first="Brandon" last="Michael Henry">Brandon Michael Henry</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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