Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.
Identifieur interne : 000435 ( PubMed/Curation ); précédent : 000434; suivant : 000436Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.
Auteurs : Giuseppe Lippi [Italie] ; Mario Plebani [Italie] ; Brandon Michael Henry [États-Unis]Source :
- Clinica chimica acta; international journal of clinical chemistry [ 1873-3492 ] ; 2020.
Abstract
Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19.
DOI: 10.1016/j.cca.2020.03.022
PubMed: 32178975
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000435
Links to Exploration step
pubmed:32178975Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.</title>
<author><name sortKey="Lippi, Giuseppe" sort="Lippi, Giuseppe" uniqKey="Lippi G" first="Giuseppe" last="Lippi">Giuseppe Lippi</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Plebani, Mario" sort="Plebani, Mario" uniqKey="Plebani M" first="Mario" last="Plebani">Mario Plebani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padova</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michael Henry, Brandon" sort="Michael Henry, Brandon" uniqKey="Michael Henry B" first="Brandon" last="Michael Henry">Brandon Michael Henry</name>
<affiliation wicri:level="1"><nlm:affiliation>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio, USA. Electronic address: Brandon.henry@cchmc.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32178975</idno>
<idno type="pmid">32178975</idno>
<idno type="doi">10.1016/j.cca.2020.03.022</idno>
<idno type="wicri:Area/PubMed/Corpus">000435</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000435</idno>
<idno type="wicri:Area/PubMed/Curation">000435</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000435</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.</title>
<author><name sortKey="Lippi, Giuseppe" sort="Lippi, Giuseppe" uniqKey="Lippi G" first="Giuseppe" last="Lippi">Giuseppe Lippi</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Plebani, Mario" sort="Plebani, Mario" uniqKey="Plebani M" first="Mario" last="Plebani">Mario Plebani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padova</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michael Henry, Brandon" sort="Michael Henry, Brandon" uniqKey="Michael Henry B" first="Brandon" last="Michael Henry">Brandon Michael Henry</name>
<affiliation wicri:level="1"><nlm:affiliation>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio, USA. Electronic address: Brandon.henry@cchmc.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinica chimica acta; international journal of clinical chemistry</title>
<idno type="eISSN">1873-3492</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32178975</PMID>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3492</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year>
<Month>Mar</Month>
<Day>13</Day>
</PubDate>
</JournalIssue>
<Title>Clinica chimica acta; international journal of clinical chemistry</Title>
<ISOAbbreviation>Clin. Chim. Acta</ISOAbbreviation>
</Journal>
<ArticleTitle>Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">S0009-8981(20)30124-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cca.2020.03.022</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">An electronic search in Medline, Scopus and Web of Science was performed to identify studies reporting data on platelet count in COVID-19 patients. A meta-analysis was performed, with calculation of weighted mean difference (WMD) of platelet number in COVID-19 patients with or without severe disease and odds ratio (OR) of thrombocytopenia for severe form of COVID-19.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Nine studies with 1779 COVID-19 patients, 399 (22.4%) with severe disease, were included in the meta-analysis. The pooled analysis revealed that platelet count was significantly lower in patients with more severe COVID-19 (WMD -31×10<sup>9</sup>
/L; 95% CI, from -35 to -29×10<sup>9</sup>
/L). A subgroup analysis comparing patients by survival, found an even lower platelet count was observed with mortality (WMD, -48×10<sup>9</sup>
/L; 95% CI, -57 to -39×10<sup>9</sup>
/L. In the four studies (n=1427) which reported data on rate of thrombocytopenia, a low platelet count was associated with over fivefold enhanced risk of severe COVID-19 (OR, 5.1; 95% CI, 1.8-14.6).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization.</AbstractText>
<CopyrightInformation>Copyright © 2020. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lippi</LastName>
<ForeName>Giuseppe</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Plebani</LastName>
<ForeName>Mario</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Michael Henry</LastName>
<ForeName>Brandon</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Ohio, USA. Electronic address: Brandon.henry@cchmc.org.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>03</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Clin Chim Acta</MedlineTA>
<NlmUniqueID>1302422</NlmUniqueID>
<ISSNLinking>0009-8981</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">coronavirus, COVID-19</Keyword>
<Keyword MajorTopicYN="N">platelets</Keyword>
<Keyword MajorTopicYN="N">thrombocytopenia</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>03</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>03</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>03</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>3</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>3</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>3</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32178975</ArticleId>
<ArticleId IdType="pii">S0009-8981(20)30124-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.cca.2020.03.022</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000435 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000435 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:32178975 |texte= Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:32178975" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a CovidV2
![]() | This area was generated with Dilib version V0.6.33. | ![]() |