Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.
Identifieur interne : 001119 ( Ncbi/Merge ); précédent : 001118; suivant : 001120Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.
Auteurs : Fang Liu [République populaire de Chine] ; Aifang Xu [République populaire de Chine] ; Yan Zhang [République populaire de Chine] ; Weiling Xuan [République populaire de Chine] ; Tingbo Yan [République populaire de Chine] ; Kenv Pan [République populaire de Chine] ; Wenyan Yu [République populaire de Chine] ; Jun Zhang [République populaire de Chine]Source :
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2020.
Abstract
To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.
DOI: 10.1016/j.ijid.2020.03.013
PubMed: 32173576
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Electronic address: jameszhang2000@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32173576</idno><idno type="pmid">32173576</idno><idno type="doi">10.1016/j.ijid.2020.03.013</idno><idno type="wicri:Area/PubMed/Corpus">000475</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000475</idno><idno type="wicri:Area/PubMed/Curation">000475</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000475</idno><idno type="wicri:Area/PubMed/Checkpoint">000476</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000476</idno><idno type="wicri:Area/Ncbi/Merge">001119</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.</title><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><affiliation wicri:level="3"><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Xu, Aifang" sort="Xu, Aifang" uniqKey="Xu A" first="Aifang" last="Xu">Aifang Xu</name><affiliation wicri:level="3"><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Xuan, Weiling" sort="Xuan, Weiling" uniqKey="Xuan W" first="Weiling" last="Xuan">Weiling Xuan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Yan, Tingbo" sort="Yan, Tingbo" uniqKey="Yan T" first="Tingbo" last="Yan">Tingbo Yan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Pan, Kenv" sort="Pan, Kenv" uniqKey="Pan K" first="Kenv" last="Pan">Kenv Pan</name><affiliation wicri:level="3"><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Yu, Wenyan" sort="Yu, Wenyan" uniqKey="Yu W" first="Wenyan" last="Yu">Wenyan Yu</name><affiliation wicri:level="3"><nlm:affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: jameszhang2000@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="eISSN">1878-3511</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32173576</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3511</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>12</Day></PubDate></JournalIssue><Title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</Title><ISOAbbreviation>Int. J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1201-9712(20)30132-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijid.2020.03.013</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We collected data from ten COVID-19 patients admitted between January 22, 2020 and February 11, 2020 at Xixi hospital in Hangzhou, China.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of ten patients, secondary, tertiary and quartus patients emerged, the incubation period was 3-7 days. Mainly initial symptoms were cough and low fever (37.3-38.0 ℃). An asymptomatic case presented normal radiography, the others existed ground glass opacities. All cases (three transferred, seven discharged) exposed to lopinavir on initial hospitalization. Three patients stopped lopinavir using because of adverse effect, two of them deteriorated, one hospitalized longer than others who with sustained lopinavir using. Levels of potassium, albumin, lymphocyte were low, but increased persistently after treatment. Eosinophil values were low on initial hospitalization, then all returned to normal before discharge. Viral load of SARS-CoV-2, radiography and eosinophil improved continuously in 3-14, 6-8 and 7-9 days, respectively.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Increasing eosinophils may be an indicator of COVID-19 improvement. The COVID-19 patients may benefit from sustained lopinavir using. More researches on a larger scale are needed to verify these points.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Fang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Aifang</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xuan</LastName><ForeName>Weiling</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Tingbo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Radiology, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>Kenv</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Wenyan</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: jameszhang2000@zju.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>Int J Infect Dis</MedlineTA><NlmUniqueID>9610933</NlmUniqueID><ISSNLinking>1201-9712</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2019-Coronavirus disease</Keyword><Keyword MajorTopicYN="N">Asymptomatic infection</Keyword><Keyword MajorTopicYN="N">Eosinophil</Keyword><Keyword MajorTopicYN="N">Lopinavir</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32173576</ArticleId><ArticleId IdType="pii">S1201-9712(20)30132-6</ArticleId><ArticleId IdType="doi">10.1016/j.ijid.2020.03.013</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name></region><name sortKey="Pan, Kenv" sort="Pan, Kenv" uniqKey="Pan K" first="Kenv" last="Pan">Kenv Pan</name><name sortKey="Xu, Aifang" sort="Xu, Aifang" uniqKey="Xu A" first="Aifang" last="Xu">Aifang Xu</name><name sortKey="Xuan, Weiling" sort="Xuan, Weiling" uniqKey="Xuan W" first="Weiling" last="Xuan">Weiling Xuan</name><name sortKey="Yan, Tingbo" sort="Yan, Tingbo" uniqKey="Yan T" first="Tingbo" last="Yan">Tingbo Yan</name><name sortKey="Yu, Wenyan" sort="Yu, Wenyan" uniqKey="Yu W" first="Wenyan" last="Yu">Wenyan Yu</name><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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