The revolution of the biology of the genome
Identifieur interne : 000039 ( Ncbi/Merge ); précédent : 000038; suivant : 000040The revolution of the biology of the genome
Auteurs : Wolfgang HennigSource :
- Cell Research [ 1001-0602 ] ; 2004.
Abstract
Sequence data of entire eukaryotic genomes and their detailed comparison have provided new evidence on genome evolution. The major mechanisms involved in the increase of genome sizes are polyploidization and gene duplication. Subsequent gene silencing or mutations, preferentially in regulatory sequences of genes, modify the genome and permit the development of genes with new properties. Mechanisms such as lateral gene transfer, exon shuffling or the creation of new genes by transposition contribute to the evolution of a genome, but remain of relatively restricted relevance. Mechanisms to decrease genome sizes and, in particular, to remove specific DNA sequences, such as blocks of satellite DNAs, appear to involve the action of RNA interference (RNAi). RNAi mechanisms have been proven to be involved in chromatin packaging related with gene inactivation as well as in DNA excision during the macronucleus development in ciliates.
Url:
DOI: 10.1038/sj.cr.7290196
PubMed: 15040884
PubMed Central: 7091781
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The major mechanisms involved in the increase of genome sizes are polyploidization and gene duplication. Subsequent gene silencing or mutations, preferentially in regulatory sequences of genes, modify the genome and permit the development of genes with new properties. Mechanisms such as lateral gene transfer, exon shuffling or the creation of new genes by transposition contribute to the evolution of a genome, but remain of relatively restricted relevance. Mechanisms to decrease genome sizes and, in particular, to remove specific DNA sequences, such as blocks of satellite DNAs, appear to involve the action of RNA interference (RNAi). 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uniqKey="Hermans M">M Hermans</name></author><author><name sortKey="Sinke, R" uniqKey="Sinke R">R Sinke</name></author><author><name sortKey="Hennig, W" uniqKey="Hennig W">W Hennig</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Res</journal-id><journal-id journal-id-type="iso-abbrev">Cell Res</journal-id><journal-title-group><journal-title>Cell Research</journal-title></journal-title-group><issn pub-type="ppub">1001-0602</issn><issn pub-type="epub">1748-7838</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15040884</article-id><article-id pub-id-type="pmc">7091781</article-id><article-id pub-id-type="publisher-id">BF7290196</article-id><article-id pub-id-type="doi">10.1038/sj.cr.7290196</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The revolution of the biology of the genome</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>HENNIG</surname><given-names>Wolfgang</given-names></name><address><email>whennig@sibs.ac.cn</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.419092.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 0467 2285</institution-id><institution>German Academic Exchange Service (DAAD) Laboratory, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,</institution></institution-wrap>320 Yue Yang Road, Shanghai, 200031 China</aff></contrib-group><pub-date pub-type="ppub"><month>2</month><year>2004</year></pub-date><volume>14</volume><issue>1</issue><fpage>1</fpage><lpage>7</lpage><permissions><copyright-statement>© Science Press 2004</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Sequence data of entire eukaryotic genomes and their detailed comparison have provided new evidence on genome evolution. The major mechanisms involved in the increase of genome sizes are polyploidization and gene duplication. Subsequent gene silencing or mutations, preferentially in regulatory sequences of genes, modify the genome and permit the development of genes with new properties. Mechanisms such as lateral gene transfer, exon shuffling or the creation of new genes by transposition contribute to the evolution of a genome, but remain of relatively restricted relevance. Mechanisms to decrease genome sizes and, in particular, to remove specific DNA sequences, such as blocks of satellite DNAs, appear to involve the action of RNA interference (RNAi). RNAi mechanisms have been proven to be involved in chromatin packaging related with gene inactivation as well as in DNA excision during the macronucleus development in ciliates.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>genome structure</kwd><kwd>gene duplication</kwd><kwd>RNAi</kwd><kwd>gene silencing</kwd><kwd>chromatin</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© IBCB, SIBS, CAS 2004</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Hennig, Wolfgang" sort="Hennig, Wolfgang" uniqKey="Hennig W" first="Wolfgang" last="Hennig">Wolfgang Hennig</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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