Drug targets for corona virus: A systematic review
Identifieur interne : 001480 ( Ncbi/Curation ); précédent : 001479; suivant : 001481Drug targets for corona virus: A systematic review
Auteurs : Manisha Prajapat ; Phulen Sarma ; Nishant Shekhar ; Pramod Avti ; Shweta Sinha ; Hardeep Kaur ; Subodh Kumar ; Anusuya Bhattacharyya ; Harish Kumar ; Seema Bansal ; Bikash MedhiSource :
- Indian Journal of Pharmacology [ 0253-7613 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Viral Proteins.
- chemistry : Betacoronavirus.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Drug Design, Humans, Middle East Respiratory Syndrome Coronavirus, Molecular Targeted Therapy, SARS Virus.
Abstract
The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.
Url:
DOI: 10.4103/ijp.IJP_115_20
PubMed: 32201449
PubMed Central: 7074424
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PMC:7074424Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21<sup>th</sup>
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.</p>
</div>
</front>
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