Drug targets for corona virus: A systematic review
Identifieur interne : 000153 ( Pmc/Checkpoint ); précédent : 000152; suivant : 000154Drug targets for corona virus: A systematic review
Auteurs : Manisha Prajapat ; Phulen Sarma ; Nishant Shekhar ; Pramod Avti ; Shweta Sinha ; Hardeep Kaur ; Subodh Kumar ; Anusuya Bhattacharyya ; Harish Kumar ; Seema Bansal ; Bikash MedhiSource :
- Indian Journal of Pharmacology [ 0253-7613 ] ; 2020.
Abstract
The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.
Url:
DOI: 10.4103/ijp.IJP_115_20
PubMed: 32201449
PubMed Central: 7074424
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21<sup>th</sup>
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Pharmacol</journal-id>
<journal-id journal-id-type="iso-abbrev">Indian J Pharmacol</journal-id>
<journal-id journal-id-type="publisher-id">IJPharm</journal-id>
<journal-title-group><journal-title>Indian Journal of Pharmacology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0253-7613</issn>
<issn pub-type="epub">1998-3751</issn>
<publisher><publisher-name>Wolters Kluwer - Medknow</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32201449</article-id>
<article-id pub-id-type="pmc">7074424</article-id>
<article-id pub-id-type="publisher-id">IJPharm-52-56</article-id>
<article-id pub-id-type="doi">10.4103/ijp.IJP_115_20</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Systematic Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Drug targets for corona virus: A systematic review</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Prajapat</surname>
<given-names>Manisha</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="author-notes" rid="fn1">#</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sarma</surname>
<given-names>Phulen</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="author-notes" rid="fn1">#</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shekhar</surname>
<given-names>Nishant</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="author-notes" rid="fn1">#</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Avti</surname>
<given-names>Pramod</given-names>
</name>
<xref ref-type="aff" rid="aff2">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sinha</surname>
<given-names>Shweta</given-names>
</name>
<xref ref-type="aff" rid="aff3">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaur</surname>
<given-names>Hardeep</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Subodh</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bhattacharyya</surname>
<given-names>Anusuya</given-names>
</name>
<xref ref-type="aff" rid="aff4">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Harish</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bansal</surname>
<given-names>Seema</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Medhi</surname>
<given-names>Bikash</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
</contrib-group>
<aff id="aff1"><italic>Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India</italic>
</aff>
<aff id="aff2"><label>1</label>
<italic>Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India</italic>
</aff>
<aff id="aff3"><label>2</label>
<italic>Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India</italic>
</aff>
<aff id="aff4"><label>3</label>
<italic>Departments of Ophthalmology, Government Medical College and Hospital, Chandigarh, India</italic>
</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence:</bold>
Dr. Bikash Medhi, Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. E-mail: <email xlink:href="drbikashus@yahoo.com">drbikashus@yahoo.com</email>
</corresp>
<fn id="fn1"><label>#</label>
<p><italic>Equal contribution</italic>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><season>Jan-Feb</season>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>3</month>
<year>2020</year>
</pub-date>
<volume>52</volume>
<issue>1</issue>
<fpage>56</fpage>
<lpage>65</lpage>
<history><date date-type="received"><day>13</day>
<month>2</month>
<year>2020</year>
</date>
<date date-type="rev-recd"><day>23</day>
<month>2</month>
<year>2020</year>
</date>
<date date-type="accepted"><day>25</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2020 Indian Journal of Pharmacology</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0"><license-p>This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.</license-p>
</license>
</permissions>
<abstract><p>The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21<sup>th</sup>
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.</p>
</abstract>
<kwd-group><kwd>Coronavirus</kwd>
<kwd>drug targets</kwd>
<kwd>Middle East respiratory syndrome</kwd>
<kwd>severe acute respiratory syndrome</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Avti, Pramod" sort="Avti, Pramod" uniqKey="Avti P" first="Pramod" last="Avti">Pramod Avti</name>
<name sortKey="Bansal, Seema" sort="Bansal, Seema" uniqKey="Bansal S" first="Seema" last="Bansal">Seema Bansal</name>
<name sortKey="Bhattacharyya, Anusuya" sort="Bhattacharyya, Anusuya" uniqKey="Bhattacharyya A" first="Anusuya" last="Bhattacharyya">Anusuya Bhattacharyya</name>
<name sortKey="Kaur, Hardeep" sort="Kaur, Hardeep" uniqKey="Kaur H" first="Hardeep" last="Kaur">Hardeep Kaur</name>
<name sortKey="Kumar, Harish" sort="Kumar, Harish" uniqKey="Kumar H" first="Harish" last="Kumar">Harish Kumar</name>
<name sortKey="Kumar, Subodh" sort="Kumar, Subodh" uniqKey="Kumar S" first="Subodh" last="Kumar">Subodh Kumar</name>
<name sortKey="Medhi, Bikash" sort="Medhi, Bikash" uniqKey="Medhi B" first="Bikash" last="Medhi">Bikash Medhi</name>
<name sortKey="Prajapat, Manisha" sort="Prajapat, Manisha" uniqKey="Prajapat M" first="Manisha" last="Prajapat">Manisha Prajapat</name>
<name sortKey="Sarma, Phulen" sort="Sarma, Phulen" uniqKey="Sarma P" first="Phulen" last="Sarma">Phulen Sarma</name>
<name sortKey="Shekhar, Nishant" sort="Shekhar, Nishant" uniqKey="Shekhar N" first="Nishant" last="Shekhar">Nishant Shekhar</name>
<name sortKey="Sinha, Shweta" sort="Sinha, Shweta" uniqKey="Sinha S" first="Shweta" last="Sinha">Shweta Sinha</name>
</noCountry>
</tree>
</affiliations>
</record>
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