In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Identifieur interne : 000206 ( Ncbi/Checkpoint ); précédent : 000205; suivant : 000207In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Auteurs : P. Selvam [Inde] ; N. Murgesh [Inde] ; M. Chandramohan [Belgique] ; E. De Clercq [Belgique] ; E. Keyaerts [Belgique] ; L. Vijgen [Belgique] ; P. Maes [Belgique] ; J. Neyts [Belgique] ; M. V. Ranst [Belgique]Source :
- Indian Journal of Pharmaceutical Sciences [ 0250-474X ] ; 2008.
Abstract
4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
Url:
DOI: 10.4103/0250-474X.40339
PubMed: 20390088
PubMed Central: 2852069
Affiliations:
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<name sortKey="Keyaerts, E" sort="Keyaerts, E" uniqKey="Keyaerts E" first="E." last="Keyaerts">E. Keyaerts</name>
<name sortKey="Maes, P" sort="Maes, P" uniqKey="Maes P" first="P." last="Maes">P. Maes</name>
<name sortKey="Neyts, J" sort="Neyts, J" uniqKey="Neyts J" first="J." last="Neyts">J. Neyts</name>
<name sortKey="Ranst, M V" sort="Ranst, M V" uniqKey="Ranst M" first="M. V." last="Ranst">M. V. Ranst</name>
<name sortKey="Vijgen, L" sort="Vijgen, L" uniqKey="Vijgen L" first="L." last="Vijgen">L. Vijgen</name>
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