In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Identifieur interne : 000206 ( Ncbi/Merge ); précédent : 000205; suivant : 000207In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Auteurs : P. Selvam [Inde] ; N. Murgesh [Inde] ; M. Chandramohan [Belgique] ; E. De Clercq [Belgique] ; E. Keyaerts [Belgique] ; L. Vijgen [Belgique] ; P. Maes [Belgique] ; J. Neyts [Belgique] ; M. V. Ranst [Belgique]Source :
- Indian Journal of Pharmaceutical Sciences [ 0250-474X ] ; 2008.
Abstract
4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
Url:
DOI: 10.4103/0250-474X.40339
PubMed: 20390088
PubMed Central: 2852069
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Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses</title>
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Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses</article-title>
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<given-names>P.</given-names>
</name>
<xref ref-type="aff" rid="AF0001"></xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Murgesh</surname>
<given-names>N.</given-names>
</name>
<xref ref-type="aff" rid="AF0002">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chandramohan</surname>
<given-names>M.</given-names>
</name>
<xref ref-type="aff" rid="AF0003">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>De Clercq</surname>
<given-names>E.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Keyaerts</surname>
<given-names>E.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vijgen</surname>
<given-names>L.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maes</surname>
<given-names>P.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neyts</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ranst</surname>
<given-names>M. V.</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
</contrib-group>
<aff id="AF0001">Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India</aff>
<aff id="AF0002"><label>1</label>
Institute of Pharmacology, Madurai Medical College, Madurai - 625 020, India</aff>
<aff id="AF0003"><label>2</label>
Bharat Ratna Kamarajar Liver Hospital and Research Center, Madurai - 625 001, Belgium</aff>
<aff id="AF0004"><label>3</label>
Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>For correspondence</bold>
E-mail: <email xlink:href="periyasamyselvam2001@yahoo.co.in">periyasamyselvam2001@yahoo.co.in</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Jan-Feb</season>
<year>2008</year>
</pub-date>
<volume>70</volume>
<issue>1</issue>
<fpage>91</fpage>
<lpage>94</lpage>
<history><date date-type="received"><day>06</day>
<month>7</month>
<year>2006</year>
</date>
<date date-type="rev-recd"><day>23</day>
<month>7</month>
<year>2007</year>
</date>
<date date-type="accepted"><day>29</day>
<month>1</month>
<year>2008</year>
</date>
</history>
<permissions><copyright-statement>© Indian Journal of Pharmaceutical Sciences</copyright-statement>
<copyright-year>2008</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.</p>
</abstract>
<kwd-group><kwd>Isatin</kwd>
<kwd>HCV</kwd>
<kwd>SARS-CoV</kwd>
<kwd>vero cells</kwd>
<kwd>huh 5-2 cells</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Belgique</li>
<li>Inde</li>
</country>
<region><li>Province du Brabant flamand</li>
<li>Région flamande</li>
</region>
<settlement><li>Louvain</li>
</settlement>
<orgName><li>Katholieke Universiteit Leuven</li>
</orgName>
</list>
<tree><country name="Inde"><noRegion><name sortKey="Selvam, P" sort="Selvam, P" uniqKey="Selvam P" first="P." last="Selvam">P. Selvam</name>
</noRegion>
<name sortKey="Murgesh, N" sort="Murgesh, N" uniqKey="Murgesh N" first="N." last="Murgesh">N. Murgesh</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Chandramohan, M" sort="Chandramohan, M" uniqKey="Chandramohan M" first="M." last="Chandramohan">M. Chandramohan</name>
</noRegion>
<name sortKey="De Clercq, E" sort="De Clercq, E" uniqKey="De Clercq E" first="E." last="De Clercq">E. De Clercq</name>
<name sortKey="Keyaerts, E" sort="Keyaerts, E" uniqKey="Keyaerts E" first="E." last="Keyaerts">E. Keyaerts</name>
<name sortKey="Maes, P" sort="Maes, P" uniqKey="Maes P" first="P." last="Maes">P. Maes</name>
<name sortKey="Neyts, J" sort="Neyts, J" uniqKey="Neyts J" first="J." last="Neyts">J. Neyts</name>
<name sortKey="Ranst, M V" sort="Ranst, M V" uniqKey="Ranst M" first="M. V." last="Ranst">M. V. Ranst</name>
<name sortKey="Vijgen, L" sort="Vijgen, L" uniqKey="Vijgen L" first="L." last="Vijgen">L. Vijgen</name>
</country>
</tree>
</affiliations>
</record>
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