Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
Identifieur interne : 001693 ( Main/Merge ); précédent : 001692; suivant : 001694Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
Auteurs : Masaji Okada [Japon] ; Yoshinobu Okuno [Japon] ; Satomi Hashimoto [Japon] ; Yoko Kita [Japon] ; Noriko Kanamaru [Japon] ; Yasuko Nishida [Japon] ; Yoshie Tsunai [Japon] ; Ruriko Inoue [Japon] ; Hitoshi Nakatani [Japon] ; Reiko Fukamizu [Japon] ; Yumi Namie [Japon] ; Junko Yamada [Japon] ; Kyoko Takao [Japon] ; Ritsuko Asai [Japon] ; Ryoko Asaki [Japon] ; Tetsuo Kase [Japon] ; Yuji Takemoto [Japon] ; Shigeto Yoshida [Japon] ; J. S. M. Peiris [Hong Kong] ; Pei-Jer Chen [Taïwan] ; Naoki Yamamoto [Japon] ; Tatsuji Nomura [Japon] ; Isao Ishida [Japon] ; Shigeru Morikawa [Japon] ; Masato Tashiro [Japon] ; Mitsunori Sakatani [Japon]Source :
- Vaccine [ 0264-410X ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.
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<author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
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<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
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<author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name>
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<author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
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<author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
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<author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
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<author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name>
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<author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name>
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<author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name>
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<author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name>
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<author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
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<author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1>
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<wicri:noRegion>Minamikawachi-machi, Tochigi 329-0498</wicri:noRegion>
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<author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1>
<s3>HKG</s3>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology, The University of Hong Kong, Prokfulam Road</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1>
<s2>Jhongjheng District 100, Taipei</s2>
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<country>Taïwan</country>
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<author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjyuku, Tokyo 162-8640</s2>
<s3>JPN</s3>
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<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
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<author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1>
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<author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1>
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<s3>JPN</s3>
<sZ>23 aut.</sZ>
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<country>Japon</country>
<wicri:noRegion>Takasaki, Gunma 370-1295</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
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<s3>JPN</s3>
<sZ>24 aut.</sZ>
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<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0226642</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0226642 INIST</idno>
<idno type="RBID">Pascal:07-0226642</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000036</idno>
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<idno type="wicri:Area/PascalFrancis/Checkpoint">000035</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</title>
<author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
<s2>Higashinari-ku, Osaka 537-0025</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>15 aut.</sZ>
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<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>15 aut.</sZ>
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<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>4 aut.</sZ>
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<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>4 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>4 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>1 aut.</sZ>
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<sZ>15 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>1 aut.</sZ>
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<sZ>15 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
<s2>Higashinari-ku, Osaka 537-0025</s2>
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<sZ>2 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>1 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1>
<s2>Minamikawachi-machi, Tochigi 329-0498</s2>
<s3>JPN</s3>
<sZ>18 aut.</sZ>
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<country>Japon</country>
<wicri:noRegion>Minamikawachi-machi, Tochigi 329-0498</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1>
<s3>HKG</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology, The University of Hong Kong, Prokfulam Road</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1>
<s2>Jhongjheng District 100, Taipei</s2>
<s3>TWN</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Jhongjheng District 100, Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjyuku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1>
<s2>Kawasaki, Kanagawa 216-0001</s2>
<s3>JPN</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Kawasaki, Kanagawa 216-0001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1>
<s2>Takasaki, Gunma 370-1295</s2>
<s3>JPN</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Takasaki, Gunma 370-1295</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term>
<term>Combined immune deficiency</term>
<term>Genetic vaccine</term>
<term>Human</term>
<term>Immunotherapy</term>
<term>Neutralizing antibody</term>
<term>Severe</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term>
<term>Homme</term>
<term>Vaccin génétique</term>
<term>Immunothérapie</term>
<term>Grave</term>
<term>Modèle animal</term>
<term>Anticorps neutralisant</term>
<term>Immunodéficit mixte</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Mutation severe combined immunodeficiency (scid)</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
<li>Japon</li>
<li>Taïwan</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
</noRegion>
<name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name>
<name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name>
<name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name>
<name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name>
<name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name>
<name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name>
<name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
<name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name>
<name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
<name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name>
<name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name>
<name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
<name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name>
<name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name>
<name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name>
<name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name>
<name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
<name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name>
<name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name>
<name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name>
<name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name>
</country>
<country name="Hong Kong"><noRegion><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
</noRegion>
</country>
<country name="Taïwan"><noRegion><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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