CovidV2, PascalFrancis, Curation, bibRecord, 000023

Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models

Identifieur interne : 000023 ( PascalFrancis/Curation ); précédent : 000022; suivant : 000024

Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models

Auteurs : Masaji Okada [Japon] ; Yoshinobu Okuno [Japon] ; Satomi Hashimoto [Japon] ; Yoko Kita [Japon] ; Noriko Kanamaru [Japon] ; Yasuko Nishida [Japon] ; Yoshie Tsunai [Japon] ; Ruriko Inoue [Japon] ; Hitoshi Nakatani [Japon] ; Reiko Fukamizu [Japon] ; Yumi Namie [Japon] ; Junko Yamada [Japon] ; Kyoko Takao [Japon] ; Ritsuko Asai [Japon] ; Ryoko Asaki [Japon] ; Tetsuo Kase [Japon] ; Yuji Takemoto [Japon] ; Shigeto Yoshida [Japon] ; J. S. M. Peiris [Hong Kong] ; Pei-Jer Chen [Taïwan] ; Naoki Yamamoto [Japon] ; Tatsuji Nomura [Japon] ; Isao Ishida [Japon] ; Shigeru Morikawa [Japon] ; Masato Tashiro [Japon] ; Mitsunori Sakatani [Japon]

Source :

Vaccine [ 0264-410X ] ; 2007.

RBID : Pascal:07-0226642

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Homme, Vaccin génétique, Immunothérapie, Grave, Modèle animal, Anticorps neutralisant, Immunodéficit mixte, Syndrome respiratoire aigu sévère, Mutation severe combined immunodeficiency (scid).
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animal model, Combined immune deficiency, Genetic vaccine, Human, Immunotherapy, Neutralizing antibody, Severe, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus.

Abstract

We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.

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A02	`01`			`@0 VACCDE`
A03		`1`		`@0 Vaccine`
A05				`@2 25`
A06				`@2 16`
A08	`01`	`1`	`ENG`	`@1 Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models`
A09	`01`	`1`	`ENG`	`@1 Vaccines, immunisation and immunotherapy. Based on the Fifth World Congress on Vaccines, Immunisation and Immunotherapy, Montreal, 6-9 November 2006`
A11	`01`	`1`		`@1 OKADA (Masaji)`
A11	`02`	`1`		`@1 OKUNO (Yoshinobu)`
A11	`03`	`1`		`@1 HASHIMOTO (Satomi)`
A11	`04`	`1`		`@1 KITA (Yoko)`
A11	`05`	`1`		`@1 KANAMARU (Noriko)`
A11	`06`	`1`		`@1 NISHIDA (Yasuko)`
A11	`07`	`1`		`@1 TSUNAI (Yoshie)`
A11	`08`	`1`		`@1 INOUE (Ruriko)`
A11	`09`	`1`		`@1 NAKATANI (Hitoshi)`
A11	`10`	`1`		`@1 FUKAMIZU (Reiko)`
A11	`11`	`1`		`@1 NAMIE (Yumi)`
A11	`12`	`1`		`@1 YAMADA (Junko)`
A11	`13`	`1`		`@1 TAKAO (Kyoko)`
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A11	`16`	`1`		`@1 KASE (Tetsuo)`
A11	`17`	`1`		`@1 TAKEMOTO (Yuji)`
A11	`18`	`1`		`@1 YOSHIDA (Shigeto)`
A11	`19`	`1`		`@1 PEIRIS (J. S. M.)`
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A11	`26`	`1`		`@1 SAKATANI (Mitsunori)`
A12	`01`	`1`		`@1 KURSTAK (Edouard) @9 ed.`
A14	`01`			`@1 Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku @2 Sakai, Osaka 591-8555 @3 JPN @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 11 aut. @Z 12 aut. @Z 13 aut. @Z 14 aut. @Z 15 aut. @Z 17 aut. @Z 26 aut.`
A14	`02`			`@1 Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome @2 Higashinari-ku, Osaka 537-0025 @3 JPN @Z 2 aut. @Z 16 aut.`
A14	`03`			`@1 Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji @2 Minamikawachi-machi, Tochigi 329-0498 @3 JPN @Z 18 aut.`
A14	`04`			`@1 Department of Microbiology, The University of Hong Kong, Prokfulam Road @3 HKG @Z 19 aut.`
A14	`05`			`@1 Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd @2 Jhongjheng District 100, Taipei @3 TWN @Z 20 aut.`
A14	`06`			`@1 AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama @2 Shinjyuku, Tokyo 162-8640 @3 JPN @Z 21 aut.`
A14	`07`			`@1 Central Institute for Experimental Animals, 1430 Nogawa, Miyamae @2 Kawasaki, Kanagawa 216-0001 @3 JPN @Z 22 aut.`
A14	`08`			`@1 Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara @2 Takasaki, Gunma 370-1295 @3 JPN @Z 23 aut.`
A14	`09`			`@1 National Institute of Infectious Diseases, 1-23-1 Toyama @2 Shinjuku-ku, Tokyo 162-8640 @3 JPN @Z 24 aut. @Z 25 aut.`
A15	`01`			`@1 Infections Control World Organization (ICWO), Faculty of Medicine, University of Montreal @2 Montreal, Que. H3C 3J7 @3 CAN @Z 1 aut.`
A18	`01`	`1`		`@1 Infections Control World Organization @2 Montreal, PQ @3 CAN @9 org-cong.`
A20				`@1 3038-3040`
A21				`@1 2007`
A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.
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C03	`08`	`X`	`SPA`	`@0 Inmunodeficiencia mixta @2 NM @5 14`
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C07	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW`
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N21				`@1 155`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

A30	`01`	`1`	`ENG`	`@1 World Congress on Vaccines, Immunisation and Immunotherapy @2 5 @3 Montreal, PQ CAN @4 2006-11-06`

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Pascal:07-0226642

Le document en format XML

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<author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
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<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
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<author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
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<author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<country>Japon</country>
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<author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<country>Japon</country>
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</author>
<author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
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<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
<s2>Higashinari-ku, Osaka 537-0025</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1>
<s2>Minamikawachi-machi, Tochigi 329-0498</s2>
<s3>JPN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1>
<s3>HKG</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1>
<s2>Jhongjheng District 100, Taipei</s2>
<s3>TWN</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjyuku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1>
<s2>Kawasaki, Kanagawa 216-0001</s2>
<s3>JPN</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1>
<s2>Takasaki, Gunma 370-1295</s2>
<s3>JPN</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0226642</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0226642 INIST</idno>
<idno type="RBID">Pascal:07-0226642</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000036</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000023</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</title>
<author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
<s2>Higashinari-ku, Osaka 537-0025</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
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<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
<s2>Higashinari-ku, Osaka 537-0025</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
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<author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1>
<s2>Minamikawachi-machi, Tochigi 329-0498</s2>
<s3>JPN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1>
<s3>HKG</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1>
<s2>Jhongjheng District 100, Taipei</s2>
<s3>TWN</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjyuku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1>
<s2>Kawasaki, Kanagawa 216-0001</s2>
<s3>JPN</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1>
<s2>Takasaki, Gunma 370-1295</s2>
<s3>JPN</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
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<country>Japon</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term>
<term>Combined immune deficiency</term>
<term>Genetic vaccine</term>
<term>Human</term>
<term>Immunotherapy</term>
<term>Neutralizing antibody</term>
<term>Severe</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term>
<term>Homme</term>
<term>Vaccin génétique</term>
<term>Immunothérapie</term>
<term>Grave</term>
<term>Modèle animal</term>
<term>Anticorps neutralisant</term>
<term>Immunodéficit mixte</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Mutation severe combined immunodeficiency (scid)</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</div>
</front>
</TEI>
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</fA02>
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</fA03>
<fA05><s2>25</s2>
</fA05>
<fA06><s2>16</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</s1>
</fA08>
<fA09 i1="01" i2="1" l="ENG"><s1>Vaccines, immunisation and immunotherapy. Based on the Fifth World Congress on Vaccines, Immunisation and Immunotherapy, Montreal, 6-9 November 2006</s1>
</fA09>
<fA11 i1="01" i2="1"><s1>OKADA (Masaji)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>OKUNO (Yoshinobu)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>HASHIMOTO (Satomi)</s1>
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<fA11 i1="11" i2="1"><s1>NAMIE (Yumi)</s1>
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<fA11 i1="12" i2="1"><s1>YAMADA (Junko)</s1>
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<fA11 i1="13" i2="1"><s1>TAKAO (Kyoko)</s1>
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<fA11 i1="14" i2="1"><s1>ASAI (Ritsuko)</s1>
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<fA11 i1="15" i2="1"><s1>ASAKI (Ryoko)</s1>
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<fA11 i1="16" i2="1"><s1>KASE (Tetsuo)</s1>
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<fA11 i1="17" i2="1"><s1>TAKEMOTO (Yuji)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>YOSHIDA (Shigeto)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>PEIRIS (J. S. M.)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>CHEN (Pei-Jer)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>YAMAMOTO (Naoki)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>NOMURA (Tatsuji)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>ISHIDA (Isao)</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>MORIKAWA (Shigeru)</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>TASHIRO (Masato)</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>SAKATANI (Mitsunori)</s1>
</fA11>
<fA12 i1="01" i2="1"><s1>KURSTAK (Edouard)</s1>
<s9>ed.</s9>
</fA12>
<fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1>
<s2>Sakai, Osaka 591-8555</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>26 aut.</sZ>
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<fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1>
<s2>Higashinari-ku, Osaka 537-0025</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1>
<s2>Minamikawachi-machi, Tochigi 329-0498</s2>
<s3>JPN</s3>
<sZ>18 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1>
<s3>HKG</s3>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1>
<s2>Jhongjheng District 100, Taipei</s2>
<s3>TWN</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjyuku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1>
<s2>Kawasaki, Kanagawa 216-0001</s2>
<s3>JPN</s3>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1>
<s2>Takasaki, Gunma 370-1295</s2>
<s3>JPN</s3>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1>
<s2>Shinjuku-ku, Tokyo 162-8640</s2>
<s3>JPN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</fA14>
<fA15 i1="01"><s1>Infections Control World Organization (ICWO), Faculty of Medicine, University of Montreal</s1>
<s2>Montreal, Que. H3C 3J7</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
</fA15>
<fA18 i1="01" i2="1"><s1>Infections Control World Organization</s1>
<s2>Montreal, PQ</s2>
<s3>CAN</s3>
<s9>org-cong.</s9>
</fA18>
<fA20><s1>3038-3040</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
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<s5>354000149378260120</s5>
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<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
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<fA47 i1="01" i2="1"><s0>07-0226642</s0>
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<fA60><s1>P</s1>
<s2>C</s2>
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<fC01 i1="01" l="ENG"><s0>We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05F04</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0>
<s5>02</s5>
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<s5>05</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Vaccina genética</s0>
<s5>05</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s5>07</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Modèle animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Animal model</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Modelo animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Anticorps neutralisant</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Neutralizing antibody</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>anticuerpo neutralizante</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Immunodéficit mixte</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Combined immune deficiency</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Inmunodeficiencia mixta</s0>
<s2>NM</s2>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Mutation severe combined immunodeficiency (scid)</s0>
<s4>INC</s4>
<s5>79</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>13</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>16</s5>
</fC07>
<fN21><s1>155</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>World Congress on Vaccines, Immunisation and Immunotherapy</s1>
<s2>5</s2>
<s3>Montreal, PQ CAN</s3>
<s4>2006-11-06</s4>
</fA30>
</pR>
</standard>
</inist>
</record>

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Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models

Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models

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