Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Identifieur interne : 001E96 ( Main/Curation ); précédent : 001E95; suivant : 001E97Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Auteurs : K. Nagashima [Allemagne] ; H. Wege [Allemagne] ; R. Meyermann [Allemagne] ; V. Ter Meulen [Allemagne]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1979-01-01.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes viraux.
- étiologie : Encéphalomyélite, Maladies démyélinisantes.
- Animaux, Facteurs temps, Infections à Coronaviridae, Maladie chronique, Rats, Récidive.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, Viral.
- complications : Coronaviridae Infections.
- etiology : Demyelinating Diseases, Encephalomyelitis.
- Teeft :
- Acta, Acta neuropathol, Allergic encephalomyelitis, Animal model, Animals, Astrocytic processes, Axon, Basement membrane, Brain suspension, Chronic Disease, Chronic relapsing, Clinical signs, Control animals, Corona, Corona virus, Demyelinated areas, Demyelinating, Demyelinating encephalomyelitis, Demyelinating lesions, Demyelinating plaques, Demyelination, Disease process, Electron microscopy, Encephalomyelitis, Federal republic, Glial, Glial cells, Incubation period, Inoculation, Intracerebral inoculation, Late onset, Lesion, Light microscopy, Long incubation period, Lower part, Mononuclear cells, Mouse hepatitis virus, Multiple sclerosis, Murine corona virus, Myelin, Myelin sheaths, Nagashima, Naked axon, Naked axons, Neurological signs, Neuropathol, Optic nerve, Optic tract, Peripheral myelin, Peripheral nerves, Plaque, Present study, Rats, Recurrence, Remyelinated areas, Remyelination, Schwann, Schwann cell, Schwann cells, Sclerosis, Sheath, Small cells, Spinal, Spinal cord, Spinal tract, Subacute demyelinating encephalomyelitis, Time Factors, Trigeminal, Trigeminal nerve, Trigeminal nerves, Ultrastructural study, Upper corner, Vesicular disruption, Viral antigen, Virus inoculation, Weanling rats, White matter.
Abstract
Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.
Url:
- https://api.istex.fr/ark:/67375/1BB-1Q58M6WQ-V/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086537
DOI: 10.1007/BF00702672
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000053
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000029
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000834
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000163
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000163
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000B18
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000E14
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000E14
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000D93
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000291
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000291
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000291
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001F25
Links to Exploration step
ISTEX:893A3708A5B07785EA0E3694B68A9E8274262348Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</title>
<author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K." last="Nagashima">K. Nagashima</name>
</author>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name>
</author>
<author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R." last="Meyermann">R. Meyermann</name>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:893A3708A5B07785EA0E3694B68A9E8274262348</idno>
<date when="1979" year="1979">1979</date>
<idno type="doi">10.1007/BF00702672</idno>
<idno type="url">https://api.istex.fr/ark:/67375/1BB-1Q58M6WQ-V/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000053</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000053</idno>
<idno type="wicri:Area/Istex/Curation">000029</idno>
<idno type="wicri:Area/Istex/Checkpoint">000834</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000834</idno>
<idno type="wicri:doubleKey">0001-6322:1979:Nagashima K:demyelinating:encephalomyelitis:induced</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086537</idno>
<idno type="RBID">PMC:7086537</idno>
<idno type="wicri:Area/Pmc/Corpus">000163</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000163</idno>
<idno type="wicri:Area/Pmc/Curation">000163</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000163</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B18</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B18</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:220834</idno>
<idno type="wicri:Area/PubMed/Corpus">000E14</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E14</idno>
<idno type="wicri:Area/PubMed/Curation">000E14</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E14</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D93</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D93</idno>
<idno type="wicri:Area/Ncbi/Merge">000291</idno>
<idno type="wicri:Area/Ncbi/Curation">000291</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000291</idno>
<idno type="wicri:doubleKey">0001-6322:1979:Nagashima K:demyelinating:encephalomyelitis:induced</idno>
<idno type="wicri:Area/Main/Merge">001F25</idno>
<idno type="wicri:Area/Main/Curation">001E96</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</title>
<author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K." last="Nagashima">K. Nagashima</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg</wicri:regionArea>
<wicri:noRegion>Würzburg</wicri:noRegion>
<wicri:noRegion>Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg</wicri:regionArea>
<wicri:noRegion>Würzburg</wicri:noRegion>
<wicri:noRegion>Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R." last="Meyermann">R. Meyermann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg</wicri:regionArea>
<wicri:noRegion>Würzburg</wicri:noRegion>
<wicri:noRegion>Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg</wicri:regionArea>
<wicri:noRegion>Würzburg</wicri:noRegion>
<wicri:noRegion>Würzburg</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Acta Neuropathologica</title>
<title level="j" type="abbrev">Acta Neuropathol</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1979-01-01">1979-01-01</date>
<biblScope unit="volume">45</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="205">205</biblScope>
<biblScope unit="page" to="213">213</biblScope>
</imprint>
<idno type="ISSN">0001-6322</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0001-6322</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antigens, Viral (analysis)</term>
<term>Chronic Disease</term>
<term>Corona virus rats</term>
<term>Coronaviridae Infections (complications)</term>
<term>Demyelinating Diseases (etiology)</term>
<term>Encephalomyelitis (etiology)</term>
<term>Late onset demyelination</term>
<term>Multiple sclerosis</term>
<term>Rats</term>
<term>Recurrence</term>
<term>Remyelination</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antigènes viraux (analyse)</term>
<term>Encéphalomyélite (étiologie)</term>
<term>Facteurs temps</term>
<term>Infections à Coronaviridae ()</term>
<term>Maladie chronique</term>
<term>Maladies démyélinisantes (étiologie)</term>
<term>Rats</term>
<term>Récidive</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronaviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Demyelinating Diseases</term>
<term>Encephalomyelitis</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Encéphalomyélite</term>
<term>Maladies démyélinisantes</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acta</term>
<term>Acta neuropathol</term>
<term>Allergic encephalomyelitis</term>
<term>Animal model</term>
<term>Animals</term>
<term>Astrocytic processes</term>
<term>Axon</term>
<term>Basement membrane</term>
<term>Brain suspension</term>
<term>Chronic Disease</term>
<term>Chronic relapsing</term>
<term>Clinical signs</term>
<term>Control animals</term>
<term>Corona</term>
<term>Corona virus</term>
<term>Demyelinated areas</term>
<term>Demyelinating</term>
<term>Demyelinating encephalomyelitis</term>
<term>Demyelinating lesions</term>
<term>Demyelinating plaques</term>
<term>Demyelination</term>
<term>Disease process</term>
<term>Electron microscopy</term>
<term>Encephalomyelitis</term>
<term>Federal republic</term>
<term>Glial</term>
<term>Glial cells</term>
<term>Incubation period</term>
<term>Inoculation</term>
<term>Intracerebral inoculation</term>
<term>Late onset</term>
<term>Lesion</term>
<term>Light microscopy</term>
<term>Long incubation period</term>
<term>Lower part</term>
<term>Mononuclear cells</term>
<term>Mouse hepatitis virus</term>
<term>Multiple sclerosis</term>
<term>Murine corona virus</term>
<term>Myelin</term>
<term>Myelin sheaths</term>
<term>Nagashima</term>
<term>Naked axon</term>
<term>Naked axons</term>
<term>Neurological signs</term>
<term>Neuropathol</term>
<term>Optic nerve</term>
<term>Optic tract</term>
<term>Peripheral myelin</term>
<term>Peripheral nerves</term>
<term>Plaque</term>
<term>Present study</term>
<term>Rats</term>
<term>Recurrence</term>
<term>Remyelinated areas</term>
<term>Remyelination</term>
<term>Schwann</term>
<term>Schwann cell</term>
<term>Schwann cells</term>
<term>Sclerosis</term>
<term>Sheath</term>
<term>Small cells</term>
<term>Spinal</term>
<term>Spinal cord</term>
<term>Spinal tract</term>
<term>Subacute demyelinating encephalomyelitis</term>
<term>Time Factors</term>
<term>Trigeminal</term>
<term>Trigeminal nerve</term>
<term>Trigeminal nerves</term>
<term>Ultrastructural study</term>
<term>Upper corner</term>
<term>Vesicular disruption</term>
<term>Viral antigen</term>
<term>Virus inoculation</term>
<term>Weanling rats</term>
<term>White matter</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Facteurs temps</term>
<term>Infections à Coronaviridae</term>
<term>Maladie chronique</term>
<term>Rats</term>
<term>Récidive</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E96 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001E96 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:893A3708A5B07785EA0E3694B68A9E8274262348 |texte= Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats }}
This area was generated with Dilib version V0.6.33. |