Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Identifieur interne : 000163 ( Pmc/Corpus ); précédent : 000162; suivant : 000164Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Auteurs : K. Nagashima ; H. Wege ; R. Meyermann ; V. Ter MeulenSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1979.
Abstract
About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined.
Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.
Url:
DOI: 10.1007/BF00702672
PubMed: 220834
PubMed Central: 7086537
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PMC:7086537Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</title><author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K." last="Nagashima">K. Nagashima</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R." last="Meyermann">R. Meyermann</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">220834</idno><idno type="pmc">7086537</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086537</idno><idno type="RBID">PMC:7086537</idno><idno type="doi">10.1007/BF00702672</idno><date when="1979">1979</date><idno type="wicri:Area/Pmc/Corpus">000163</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000163</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</title><author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K." last="Nagashima">K. Nagashima</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R." last="Meyermann">R. Meyermann</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Acta Neuropathologica</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><date when="1979">1979</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined.</p><p>Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bailey, O T" uniqKey="Bailey O">O. T. Bailey</name></author><author><name sortKey="Pappenheimer, A M" uniqKey="Pappenheimer A">A. M. Pappenheimer</name></author><author><name sortKey="Cheever, F S" uniqKey="Cheever F">F. S. Cheever</name></author><author><name sortKey="Daniels, J B" uniqKey="Daniels J">J. B. Daniels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blakemore, W F" uniqKey="Blakemore W">W. F. Blakemore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blakemore, W F" uniqKey="Blakemore W">W. F. 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Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karnowsky, M J" uniqKey="Karnowsky M">M. J. Karnowsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lampert, P W" uniqKey="Lampert P">P. W. Lampert</name></author><author><name sortKey="Sims, J K" uniqKey="Sims J">J. K. Sims</name></author><author><name sortKey="Kniazeff, A J" uniqKey="Kniazeff A">A. J. Kniazeff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagashima, K" uniqKey="Nagashima K">K. Nagashima</name></author><author><name sortKey="Wege, H" uniqKey="Wege H">H. Wege</name></author><author><name sortKey="Mcyermann, R" uniqKey="Mcyermann R">R. Mcyermann</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V. ter Meulen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogata, J" uniqKey="Ogata J">J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Neuropathol</journal-id><journal-id journal-id-type="iso-abbrev">Acta Neuropathol</journal-id><journal-title-group><journal-title>Acta Neuropathologica</journal-title></journal-title-group><issn pub-type="ppub">0001-6322</issn><issn pub-type="epub">1432-0533</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">220834</article-id><article-id pub-id-type="pmc">7086537</article-id><article-id pub-id-type="publisher-id">BF00702672</article-id><article-id pub-id-type="doi">10.1007/BF00702672</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Works</subject></subj-group></article-categories><title-group><article-title>Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</article-title><subtitle>A preliminary report</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nagashima</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Wege</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Meyermann</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>ter Meulen</surname><given-names>V.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Institute for Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Straße 7, D-8700 Würzburg, Germany</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.26999.3d</institution-id><institution-id institution-id-type="ISNI">000000012151536X</institution-id><institution>Present Address: Department of Pathology, Faculty of Medicine,</institution><institution>University of Tokyo,</institution></institution-wrap>7-3-1 Hongo, Bunkyo-ku, 113 Tokyo, Japan</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.7450.6</institution-id><institution-id institution-id-type="ISNI">0000000123644210</institution-id><institution>Present Address: Department of Neuropathology,</institution><institution>University of Göttingen,</institution></institution-wrap>D-3400 Göttingen, Germany</aff></contrib-group><pub-date pub-type="ppub"><year>1979</year></pub-date><volume>45</volume><issue>3</issue><fpage>205</fpage><lpage>213</lpage><history><date date-type="received"><day>31</day><month>7</month><year>1978</year></date><date date-type="accepted"><day>30</day><month>10</month><year>1978</year></date></history><permissions><copyright-statement>© Springer-Verlag 1979</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><title>Summary</title><p>About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined.</p><p>Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</p></abstract><kwd-group xml:lang="en"><title>Key words</title><kwd>Corona virus rats</kwd><kwd>Late onset demyelination</kwd><kwd>Remyelination</kwd><kwd>Multiple sclerosis</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 1979</meta-value></custom-meta></custom-meta-group></article-meta></front><back><fn-group><fn><p>Supported by Deutsche Forschungsgemeinschaft, Schwerpunkt Multiple Sklerose und verwandte Erkrankungen</p></fn></fn-group><ref-list id="Bib1"><title>References</title><ref id="CR1"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bailey</surname><given-names>O. T.</given-names></name><name><surname>Pappenheimer</surname><given-names>A. 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