CovidV1, PubMed, Checkpoint, bibRecord, 000610

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.

Identifieur interne : 000610 ( PubMed/Checkpoint ); précédent : 000609; suivant : 000611

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.

Auteurs : Ahmed A. Al-Qahtani [Arabie saoudite] ; Konstantina Lyroni [Grèce] ; Marina Aznaourova [Grèce] ; Melpomeni Tseliou [Grèce] ; Mashael R. Al-Anazi [Arabie saoudite] ; Mohammed N. Al-Ahdal [Arabie saoudite] ; Saad Alkahtani [Arabie saoudite] ; George Sourvinos [Grèce] ; Christos Tsatsanis [Grèce]

Source :

Oncotarget [ 1949-2553 ] ; 2017.

RBID : pubmed:28118607

Descripteurs français

English descriptors

KwdEn :
- Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Dipeptidyl-Peptidase IV Inhibitors (pharmacology), Host-Pathogen Interactions, Humans, Interleukin-1 Receptor-Associated Kinases (genetics), Interleukin-1 Receptor-Associated Kinases (metabolism), Interleukin-10 (metabolism), Interleukin-6 (metabolism), Macrophage Activation (drug effects), Macrophages (drug effects), Macrophages (enzymology), Macrophages (immunology), Macrophages (virology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (metabolism), Middle East Respiratory Syndrome Coronavirus (pathogenicity), PPAR gamma (genetics), PPAR gamma (metabolism), RNA Interference, Signal Transduction, Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), THP-1 Cells, Transfection, Tumor Necrosis Factor-alpha (metabolism).
MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, Interleukin-1 Receptor-Associated Kinases, PPAR gamma, Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Interleukin-1 Receptor-Associated Kinases, Interleukin-10, Interleukin-6, PPAR gamma, Spike Glycoprotein, Coronavirus, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Dipeptidyl-Peptidase IV Inhibitors.
- drug effects : Macrophage Activation, Macrophages.
- enzymology : Macrophages.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Macrophages, Middle East Respiratory Syndrome Coronavirus.
- metabolism : Middle East Respiratory Syndrome Coronavirus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- virology : Macrophages.
- Host-Pathogen Interactions, Humans, RNA Interference, Signal Transduction, THP-1 Cells, Transfection.

Abstract

Middle East Respiratory Syndrome Corona Virus (MERS-CoV) is transmitted via the respiratory tract and causes severe Acute Respiratory Distress Syndrome by infecting lung epithelial cells and macrophages. Macrophages can readily recognize the virus and eliminate it. MERS-CoV infects cells via its Spike (S) glycoprotein that binds on Dipeptidyl-Peptidase 4 (DPP4) receptor present on macrophages. Whether this Spike/DPP4 association affects macrophage responses remains unknown. Herein we demonstrated that infection of macrophages with lentiviral particles pseudotyped with MERS-CoV S glycoprotein results in suppression of macrophage responses since it reduced the capacity of macrophages to produce TNFα and IL-6 in naive and LPS-activated THP-1 macrophages and augmented LPS-induced production of the immunosuppressive cytokine IL-10. MERS-CoV S glycoprotein induced the expression of the negative regulator of TLR signaling IRAK-M as well as of the transcriptional repressor PPARγ. Inhibition of DPP4 by its inhibitor sitagliptin or siRNA abrogated the effects of MERS-CoV S glycoprotein on IRAK-M, PPARγ and IL-10, confirming that its immunosuppressive effects were mediated by DPP4 receptor. The effect was observed both in THP-1 macrophages and human primary peripheral blood monocytes. These findings support a DPP4-mediated suppressive action of MERS-CoV in macrophages and suggest a potential target for effective elimination of its pathogenicity.

DOI: 10.18632/oncotarget.14754
PubMed: 28118607

Affiliations:

Arabie saoudite, Grèce

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000615
to stream PubMed, to step Curation: 000615

Links to Exploration step

pubmed:28118607

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.</title>
<author><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A" last="Al-Qahtani">Ahmed A. Al-Qahtani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea>
<wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lyroni, Konstantina" sort="Lyroni, Konstantina" uniqKey="Lyroni K" first="Konstantina" last="Lyroni">Konstantina Lyroni</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aznaourova, Marina" sort="Aznaourova, Marina" uniqKey="Aznaourova M" first="Marina" last="Aznaourova">Marina Aznaourova</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tseliou, Melpomeni" sort="Tseliou, Melpomeni" uniqKey="Tseliou M" first="Melpomeni" last="Tseliou">Melpomeni Tseliou</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Anazi, Mashael R" sort="Al Anazi, Mashael R" uniqKey="Al Anazi M" first="Mashael R" last="Al-Anazi">Mashael R. Al-Anazi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea>
<wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N" last="Al-Ahdal">Mohammed N. Al-Ahdal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea>
<wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alkahtani, Saad" sort="Alkahtani, Saad" uniqKey="Alkahtani S" first="Saad" last="Alkahtani">Saad Alkahtani</name>
<affiliation wicri:level="1"><nlm:affiliation>Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Zoology Department, College of Science, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sourvinos, George" sort="Sourvinos, George" uniqKey="Sourvinos G" first="George" last="Sourvinos">George Sourvinos</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsatsanis, Christos" sort="Tsatsanis, Christos" uniqKey="Tsatsanis C" first="Christos" last="Tsatsanis">Christos Tsatsanis</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28118607</idno>
<idno type="pmid">28118607</idno>
<idno type="doi">10.18632/oncotarget.14754</idno>
<idno type="wicri:Area/PubMed/Corpus">000615</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000615</idno>
<idno type="wicri:Area/PubMed/Curation">000615</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000615</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000610</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000610</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.</title>
<author><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A" last="Al-Qahtani">Ahmed A. Al-Qahtani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea>
<wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lyroni, Konstantina" sort="Lyroni, Konstantina" uniqKey="Lyroni K" first="Konstantina" last="Lyroni">Konstantina Lyroni</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aznaourova, Marina" sort="Aznaourova, Marina" uniqKey="Aznaourova M" first="Marina" last="Aznaourova">Marina Aznaourova</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tseliou, Melpomeni" sort="Tseliou, Melpomeni" uniqKey="Tseliou M" first="Melpomeni" last="Tseliou">Melpomeni Tseliou</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Anazi, Mashael R" sort="Al Anazi, Mashael R" uniqKey="Al Anazi M" first="Mashael R" last="Al-Anazi">Mashael R. Al-Anazi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea>
<wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N" last="Al-Ahdal">Mohammed N. Al-Ahdal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center</wicri:regionArea>
<wicri:noRegion>King Faisal Specialist Hospital and Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alkahtani, Saad" sort="Alkahtani, Saad" uniqKey="Alkahtani S" first="Saad" last="Alkahtani">Saad Alkahtani</name>
<affiliation wicri:level="1"><nlm:affiliation>Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Zoology Department, College of Science, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sourvinos, George" sort="Sourvinos, George" uniqKey="Sourvinos G" first="George" last="Sourvinos">George Sourvinos</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Virology, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsatsanis, Christos" sort="Tsatsanis, Christos" uniqKey="Tsatsanis C" first="Christos" last="Tsatsanis">Christos Tsatsanis</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion</wicri:regionArea>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Oncotarget</title>
<idno type="eISSN">1949-2553</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dipeptidyl Peptidase 4 (genetics)</term>
<term>Dipeptidyl Peptidase 4 (metabolism)</term>
<term>Dipeptidyl-Peptidase IV Inhibitors (pharmacology)</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Interleukin-1 Receptor-Associated Kinases (genetics)</term>
<term>Interleukin-1 Receptor-Associated Kinases (metabolism)</term>
<term>Interleukin-10 (metabolism)</term>
<term>Interleukin-6 (metabolism)</term>
<term>Macrophage Activation (drug effects)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (enzymology)</term>
<term>Macrophages (immunology)</term>
<term>Macrophages (virology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (metabolism)</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>PPAR gamma (genetics)</term>
<term>PPAR gamma (metabolism)</term>
<term>RNA Interference</term>
<term>Signal Transduction</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (metabolism)</term>
<term>THP-1 Cells</term>
<term>Transfection</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des macrophages ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Dipeptidyl peptidase 4 (génétique)</term>
<term>Dipeptidyl peptidase 4 (métabolisme)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (métabolisme)</term>
<term>Humains</term>
<term>Inhibiteurs de la dipeptidyl-peptidase IV (pharmacologie)</term>
<term>Interactions hôte-pathogène</term>
<term>Interférence par ARN</term>
<term>Interleukin-1 Receptor-Associated Kinases (génétique)</term>
<term>Interleukin-1 Receptor-Associated Kinases (métabolisme)</term>
<term>Interleukine-10 (métabolisme)</term>
<term>Interleukine-6 (métabolisme)</term>
<term>Macrophages ()</term>
<term>Macrophages (enzymologie)</term>
<term>Macrophages (immunologie)</term>
<term>Macrophages (virologie)</term>
<term>Récepteur PPAR gamma (génétique)</term>
<term>Récepteur PPAR gamma (métabolisme)</term>
<term>Transduction du signal</term>
<term>Transfection</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term>
<term>Interleukin-1 Receptor-Associated Kinases</term>
<term>PPAR gamma</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term>
<term>Interleukin-1 Receptor-Associated Kinases</term>
<term>Interleukin-10</term>
<term>Interleukin-6</term>
<term>PPAR gamma</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dipeptidyl-Peptidase IV Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophage Activation</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Dipeptidyl peptidase 4</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Interleukin-1 Receptor-Associated Kinases</term>
<term>Récepteur PPAR gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Macrophages</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Dipeptidyl peptidase 4</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Interleukin-1 Receptor-Associated Kinases</term>
<term>Interleukine-10</term>
<term>Interleukine-6</term>
<term>Récepteur PPAR gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de la dipeptidyl-peptidase IV</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>RNA Interference</term>
<term>Signal Transduction</term>
<term>THP-1 Cells</term>
<term>Transfection</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des macrophages</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Interférence par ARN</term>
<term>Macrophages</term>
<term>Transduction du signal</term>
<term>Transfection</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Middle East Respiratory Syndrome Corona Virus (MERS-CoV) is transmitted via the respiratory tract and causes severe Acute Respiratory Distress Syndrome by infecting lung epithelial cells and macrophages. Macrophages can readily recognize the virus and eliminate it. MERS-CoV infects cells via its Spike (S) glycoprotein that binds on Dipeptidyl-Peptidase 4 (DPP4) receptor present on macrophages. Whether this Spike/DPP4 association affects macrophage responses remains unknown. Herein we demonstrated that infection of macrophages with lentiviral particles pseudotyped with MERS-CoV S glycoprotein results in suppression of macrophage responses since it reduced the capacity of macrophages to produce TNFα and IL-6 in naive and LPS-activated THP-1 macrophages and augmented LPS-induced production of the immunosuppressive cytokine IL-10. MERS-CoV S glycoprotein induced the expression of the negative regulator of TLR signaling IRAK-M as well as of the transcriptional repressor PPARγ. Inhibition of DPP4 by its inhibitor sitagliptin or siRNA abrogated the effects of MERS-CoV S glycoprotein on IRAK-M, PPARγ and IL-10, confirming that its immunosuppressive effects were mediated by DPP4 receptor. The effect was observed both in THP-1 macrophages and human primary peripheral blood monocytes. These findings support a DPP4-mediated suppressive action of MERS-CoV in macrophages and suggest a potential target for effective elimination of its pathogenicity.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28118607</PMID>
<DateCompleted><Year>2018</Year>
<Month>02</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>6</Issue>
<PubDate><Year>2017</Year>
<Month>Feb</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>Oncotarget</Title>
<ISOAbbreviation>Oncotarget</ISOAbbreviation>
</Journal>
<ArticleTitle>Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.</ArticleTitle>
<Pagination><MedlinePgn>9053-9066</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.14754</ELocationID>
<Abstract><AbstractText>Middle East Respiratory Syndrome Corona Virus (MERS-CoV) is transmitted via the respiratory tract and causes severe Acute Respiratory Distress Syndrome by infecting lung epithelial cells and macrophages. Macrophages can readily recognize the virus and eliminate it. MERS-CoV infects cells via its Spike (S) glycoprotein that binds on Dipeptidyl-Peptidase 4 (DPP4) receptor present on macrophages. Whether this Spike/DPP4 association affects macrophage responses remains unknown. Herein we demonstrated that infection of macrophages with lentiviral particles pseudotyped with MERS-CoV S glycoprotein results in suppression of macrophage responses since it reduced the capacity of macrophages to produce TNFα and IL-6 in naive and LPS-activated THP-1 macrophages and augmented LPS-induced production of the immunosuppressive cytokine IL-10. MERS-CoV S glycoprotein induced the expression of the negative regulator of TLR signaling IRAK-M as well as of the transcriptional repressor PPARγ. Inhibition of DPP4 by its inhibitor sitagliptin or siRNA abrogated the effects of MERS-CoV S glycoprotein on IRAK-M, PPARγ and IL-10, confirming that its immunosuppressive effects were mediated by DPP4 receptor. The effect was observed both in THP-1 macrophages and human primary peripheral blood monocytes. These findings support a DPP4-mediated suppressive action of MERS-CoV in macrophages and suggest a potential target for effective elimination of its pathogenicity.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Al-Qahtani</LastName>
<ForeName>Ahmed A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lyroni</LastName>
<ForeName>Konstantina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aznaourova</LastName>
<ForeName>Marina</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tseliou</LastName>
<ForeName>Melpomeni</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Anazi</LastName>
<ForeName>Mashael R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Ahdal</LastName>
<ForeName>Mohammed N</ForeName>
<Initials>MN</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medicine, Alfaisal University, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alkahtani</LastName>
<ForeName>Saad</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sourvinos</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsatsanis</LastName>
<ForeName>Christos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Chemistry, Medical School, University of Crete, Heraklion, Greece.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Oncotarget</MedlineTA>
<NlmUniqueID>101532965</NlmUniqueID>
<ISSNLinking>1949-2553</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054873">Dipeptidyl-Peptidase IV Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508609">IL10 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047495">PPAR gamma</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>130068-27-8</RegistryNumber>
<NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C507771">IRAK3 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D053592">Interleukin-1 Receptor-Associated Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber>
<NameOfSubstance UI="C042807">DPP4 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber>
<NameOfSubstance UI="D018819">Dipeptidyl Peptidase 4</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D018819" MajorTopicYN="N">Dipeptidyl Peptidase 4</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054873" MajorTopicYN="N">Dipeptidyl-Peptidase IV Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053592" MajorTopicYN="N">Interleukin-1 Receptor-Associated Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016753" MajorTopicYN="N">Interleukin-10</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008262" MajorTopicYN="Y">Macrophage Activation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047495" MajorTopicYN="N">PPAR gamma</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000074084" MajorTopicYN="N">THP-1 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014162" MajorTopicYN="N">Transfection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DPP4</Keyword>
<Keyword MajorTopicYN="N">IRAK-M</Keyword>
<Keyword MajorTopicYN="N">Immune response</Keyword>
<Keyword MajorTopicYN="N">Immunity</Keyword>
<Keyword MajorTopicYN="N">Immunology and Microbiology Section</Keyword>
<Keyword MajorTopicYN="N">MERS CoV</Keyword>
<Keyword MajorTopicYN="N">cytokines</Keyword>
<Keyword MajorTopicYN="N">macrophages</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>07</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>01</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>1</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>2</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>1</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28118607</ArticleId>
<ArticleId IdType="pii">14754</ArticleId>
<ArticleId IdType="doi">10.18632/oncotarget.14754</ArticleId>
<ArticleId IdType="pmc">PMC5354714</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 2013 Nov;87(21):11950-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23986586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Aug;84(15):7703-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20484496</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Immunol. 2008 May;45(10):2970-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18336909</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2017 Feb 1;198(3):1297-1307</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28011933</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2013 Aug;23(8):986-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23835475</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367 (19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes. 2013 Jan;62(1):149-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22936179</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2014 Feb 18;5(1):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24549846</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 Feb;88(3):1834-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24257613</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2013 Jun 1;207(11):1743-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23532101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2014 Jan 1;192(1):394-406</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24277697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Aug 8;500(7461):227-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23831647</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2014 Apr 03;10(4):e1004053</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24699679</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2009 May 15;182(10):6444-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19414798</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Mar 14;495(7440):176-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23486053</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2014;5:3067</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24473083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2015 Dec 15;195(12):5750-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26538391</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2015 Jun 25;20(25):14-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26132768</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2012 Oct 1;303(7):L608-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22886503</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2015 Apr;89(7):3859-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25609809</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2016 Mar 15;213(6):904-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26203058</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2010 May;10 (5):365-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20414208</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):745-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23782859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2014 Dec 19;194:200-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25451066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Retrovirology. 2014 Oct 17;11:88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25323821</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2009 Oct;5(10):e1000633</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19851458</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2016 Feb;97(2):344-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26602089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):466-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23902487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):407-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23782161</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26124093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L64-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23624787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2012 Nov 20;3(6):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23170002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15214-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25288733</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lupus. 2012 Oct;21(11):1166-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22634523</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):752-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23891402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Acquir Immune Defic Syndr. 2014 Oct 1;67(2):113-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25072612</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Aug;87(16):9379-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23785207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 May;87(10):5502-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23468491</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunology. 2015 Aug;145(4):476-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25762305</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Grèce</li>
</country>
</list>
<tree><country name="Arabie saoudite"><noRegion><name sortKey="Al Qahtani, Ahmed A" sort="Al Qahtani, Ahmed A" uniqKey="Al Qahtani A" first="Ahmed A" last="Al-Qahtani">Ahmed A. Al-Qahtani</name>
</noRegion>
<name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N" last="Al-Ahdal">Mohammed N. Al-Ahdal</name>
<name sortKey="Al Anazi, Mashael R" sort="Al Anazi, Mashael R" uniqKey="Al Anazi M" first="Mashael R" last="Al-Anazi">Mashael R. Al-Anazi</name>
<name sortKey="Alkahtani, Saad" sort="Alkahtani, Saad" uniqKey="Alkahtani S" first="Saad" last="Alkahtani">Saad Alkahtani</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Lyroni, Konstantina" sort="Lyroni, Konstantina" uniqKey="Lyroni K" first="Konstantina" last="Lyroni">Konstantina Lyroni</name>
</noRegion>
<name sortKey="Aznaourova, Marina" sort="Aznaourova, Marina" uniqKey="Aznaourova M" first="Marina" last="Aznaourova">Marina Aznaourova</name>
<name sortKey="Sourvinos, George" sort="Sourvinos, George" uniqKey="Sourvinos G" first="George" last="Sourvinos">George Sourvinos</name>
<name sortKey="Tsatsanis, Christos" sort="Tsatsanis, Christos" uniqKey="Tsatsanis C" first="Christos" last="Tsatsanis">Christos Tsatsanis</name>
<name sortKey="Tseliou, Melpomeni" sort="Tseliou, Melpomeni" uniqKey="Tseliou M" first="Melpomeni" last="Tseliou">Melpomeni Tseliou</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000610 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000610 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:28118607
   |texte=   Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:28118607" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidV1

This area was generated with Dilib version V0.6.33.
Data generation: Fri Mar 27 18:14:15 2020. Site generation: Sun Jan 31 15:15:08 2021

	Serveur d'exploration Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Covid

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki