Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity.
Identifieur interne : 000922 ( Ncbi/Merge ); précédent : 000921; suivant : 000923Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity.
Auteurs : Gerard Kian-Meng Goh [Singapour] ; A Keith Dunker [États-Unis] ; James A. Foster [États-Unis] ; Vladimir N. Uversky [États-Unis]Source :
- Biomolecules [ 2218-273X ] ; 2020.
Abstract
The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002-2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins.
DOI: 10.3390/biom10020331
PubMed: 32092911
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Foster</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, University of Idaho, Moscow, ID 83844</wicri:regionArea><wicri:noRegion>ID 83844</wicri:noRegion></affiliation></author><author><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N" last="Uversky">Vladimir N. Uversky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612</wicri:regionArea><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j">Biomolecules</title><idno type="eISSN">2218-273X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002-2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32092911</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>16</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2218-273X</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>02</Month><Day>19</Day></PubDate></JournalIssue><Title>Biomolecules</Title><ISOAbbreviation>Biomolecules</ISOAbbreviation></Journal><ArticleTitle>Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E331</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/biom10020331</ELocationID><Abstract><AbstractText>The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002-2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goh</LastName><ForeName>Gerard Kian-Meng</ForeName><Initials>GK</Initials><Identifier Source="ORCID">0000-0003-3635-0806</Identifier><AffiliationInfo><Affiliation>Goh's BioComputing, Singapore 548957, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dunker</LastName><ForeName>A Keith</ForeName><Initials>AK</Initials><Identifier Source="ORCID">0000-0002-0744-5243</Identifier><AffiliationInfo><Affiliation>Center for Computational Biology, Indiana and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foster</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uversky</LastName><ForeName>Vladimir N</ForeName><Initials>VN</Initials><Identifier Source="ORCID">0000-0002-4037-5857</Identifier><AffiliationInfo><Affiliation>Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Moscow region, 142290 Pushchino, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016421">Editorial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Biomolecules</MedlineTA><NlmUniqueID>101596414</NlmUniqueID><ISSNLinking>2218-273X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Wuhan-2019-nCoV</Keyword><Keyword MajorTopicYN="Y">membrane protein</Keyword><Keyword MajorTopicYN="Y">nucleocapsid protein</Keyword><Keyword MajorTopicYN="Y">protein intrinsic disorder</Keyword><Keyword MajorTopicYN="Y">shell disorder</Keyword><Keyword MajorTopicYN="Y">transmission</Keyword><Keyword MajorTopicYN="Y">virulence</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32092911</ArticleId><ArticleId IdType="pii">biom10020331</ArticleId><ArticleId IdType="doi">10.3390/biom10020331</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Singapour</li><li>États-Unis</li></country><region><li>Floride</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Goh, Gerard Kian Meng" sort="Goh, Gerard Kian Meng" uniqKey="Goh G" first="Gerard Kian-Meng" last="Goh">Gerard Kian-Meng Goh</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Dunker, A Keith" sort="Dunker, A Keith" uniqKey="Dunker A" first="A Keith" last="Dunker">A Keith Dunker</name></noRegion><name sortKey="Foster, James A" sort="Foster, James A" uniqKey="Foster J" first="James A" last="Foster">James A. Foster</name><name sortKey="Uversky, Vladimir N" sort="Uversky, Vladimir N" uniqKey="Uversky V" first="Vladimir N" last="Uversky">Vladimir N. Uversky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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