Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone
Identifieur interne : 001755 ( Main/Merge ); précédent : 001754; suivant : 001756Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone
Auteurs : G. Gherardi ; V. Lo Cascio ; E. BonucciSource :
- Histopathology [ 0309-0167 ] ; 1980-01.
English descriptors
- Teeft :
- Active bone resorption, Argyrophilic, Argyrophilic filaments, Average diameter, Biopsy, Bone biopsies, Cascio, Central core, Chronic polymyositis, Corona virus, Cytoplasm, Cytoplasmic, Cytoplasmic inclusion, Degenerative changes, Dense chromatin, Endoplasmic reticulum, External membrane, Favourable sections, Filament, Filamentous, Filamentous inclusions, Fine structure, Form bundles, Granular material, Grimley friedman, Grimley schaff, Heine dalton, Inclusion, Intermediate forms, Longitudinal striation, Measles virus, Membranous, Membranous strands, Microfilaments, Mills singer, Neural cells, Nuclear changes, Nuclear fragmentation, Nuclear matrix, Osmium tetroxide, Osteoclast, Paracrystalline, Paracrystalline pattern, Pathological anatomy, Pathological changes, Periodic acid, Phosphatase values, Respiratory syncitial virus, Simultaneous presence, Singer mills, Systemic lupus erythematosus, Tubular structures, Tubule, Ultrathin sections, Unusual cytoplasmic inclusions, Uranyl acetate, Viral, Viral nucleocapsids, Welsh meyer.
Abstract
To investigate the fine structural features of nuclei and cytoplasm in osteoclasts from patients with Paget's disease of bone, eight bone biopsies were examined. Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of bone.
Url:
DOI: 10.1111/j.1365-2559.1980.tb02898.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone</title><author><name sortKey="Gherardi, G" sort="Gherardi, G" uniqKey="Gherardi G" first="G." last="Gherardi">G. Gherardi</name></author><author><name sortKey="Cascio, V Lo" sort="Cascio, V Lo" uniqKey="Cascio V" first="V. Lo" last="Cascio">V. Lo Cascio</name></author><author><name sortKey="Bonucci, E" sort="Bonucci, E" uniqKey="Bonucci E" first="E." last="Bonucci">E. 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Gherardi</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">00163.</wicri:noCountry></affiliation></author><author><name sortKey="Cascio, V Lo" sort="Cascio, V Lo" uniqKey="Cascio V" first="V. Lo" last="Cascio">V. Lo Cascio</name><affiliation><wicri:noCountry code="subField">Verona</wicri:noCountry></affiliation></author><author><name sortKey="Bonucci, E" sort="Bonucci, E" uniqKey="Bonucci E" first="E." last="Bonucci">E. Bonucci</name><affiliation><wicri:noCountry code="subField">Verona</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Histopathology</title><title level="j" type="alt">HISTOPATHOLOGY</title><idno type="ISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><imprint><biblScope unit="vol">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="63">63</biblScope><biblScope unit="page" to="74">74</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1980-01">1980-01</date></imprint><idno type="ISSN">0309-0167</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0309-0167</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active bone resorption</term><term>Argyrophilic</term><term>Argyrophilic filaments</term><term>Average diameter</term><term>Biopsy</term><term>Bone biopsies</term><term>Cascio</term><term>Central core</term><term>Chronic polymyositis</term><term>Corona virus</term><term>Cytoplasm</term><term>Cytoplasmic</term><term>Cytoplasmic inclusion</term><term>Degenerative changes</term><term>Dense chromatin</term><term>Endoplasmic reticulum</term><term>External membrane</term><term>Favourable sections</term><term>Filament</term><term>Filamentous</term><term>Filamentous inclusions</term><term>Fine structure</term><term>Form bundles</term><term>Granular material</term><term>Grimley friedman</term><term>Grimley schaff</term><term>Heine dalton</term><term>Inclusion</term><term>Intermediate forms</term><term>Longitudinal striation</term><term>Measles virus</term><term>Membranous</term><term>Membranous strands</term><term>Microfilaments</term><term>Mills singer</term><term>Neural cells</term><term>Nuclear changes</term><term>Nuclear fragmentation</term><term>Nuclear matrix</term><term>Osmium tetroxide</term><term>Osteoclast</term><term>Paracrystalline</term><term>Paracrystalline pattern</term><term>Pathological anatomy</term><term>Pathological changes</term><term>Periodic acid</term><term>Phosphatase values</term><term>Respiratory syncitial virus</term><term>Simultaneous presence</term><term>Singer mills</term><term>Systemic lupus erythematosus</term><term>Tubular structures</term><term>Tubule</term><term>Ultrathin sections</term><term>Unusual cytoplasmic inclusions</term><term>Uranyl acetate</term><term>Viral</term><term>Viral nucleocapsids</term><term>Welsh meyer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the fine structural features of nuclei and cytoplasm in osteoclasts from patients with Paget's disease of bone, eight bone biopsies were examined. Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of bone.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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