Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone
Identifieur interne : 000148 ( Istex/Corpus ); précédent : 000147; suivant : 000149Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone
Auteurs : G. Gherardi ; V. Lo Cascio ; E. BonucciSource :
- Histopathology [ 0309-0167 ] ; 1980-01.
English descriptors
- Teeft :
- Active bone resorption, Argyrophilic, Argyrophilic filaments, Average diameter, Biopsy, Bone biopsies, Cascio, Central core, Chronic polymyositis, Corona virus, Cytoplasm, Cytoplasmic, Cytoplasmic inclusion, Degenerative changes, Dense chromatin, Endoplasmic reticulum, External membrane, Favourable sections, Filament, Filamentous, Filamentous inclusions, Fine structure, Form bundles, Granular material, Grimley friedman, Grimley schaff, Heine dalton, Inclusion, Intermediate forms, Longitudinal striation, Measles virus, Membranous, Membranous strands, Microfilaments, Mills singer, Neural cells, Nuclear changes, Nuclear fragmentation, Nuclear matrix, Osmium tetroxide, Osteoclast, Paracrystalline, Paracrystalline pattern, Pathological anatomy, Pathological changes, Periodic acid, Phosphatase values, Respiratory syncitial virus, Simultaneous presence, Singer mills, Systemic lupus erythematosus, Tubular structures, Tubule, Ultrathin sections, Unusual cytoplasmic inclusions, Uranyl acetate, Viral, Viral nucleocapsids, Welsh meyer.
Abstract
To investigate the fine structural features of nuclei and cytoplasm in osteoclasts from patients with Paget's disease of bone, eight bone biopsies were examined. Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of bone.
Url:
DOI: 10.1111/j.1365-2559.1980.tb02898.x
Links to Exploration step
ISTEX:D8E53523C3B78C81BA0CA84285191CB415FF52A5Le document en format XML
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Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. 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Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. 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(1971)</json:string><json:string>Nakai, Shand & Howatson 1969</json:string><json:string>Raine et al. 1974a</json:string><json:string>Oshiro, Schieble & Lennette 1971</json:string><json:string>Singer & Mills 1977</json:string><json:string>Rebel et al., 1974, 1975</json:string><json:string>Raine, Byington & Johnson 1974a</json:string><json:string>Nakai et al. 1969</json:string><json:string>Daniels et al. 1974</json:string><json:string>Kallman et al. 1959</json:string><json:string>Grimley & Friedman 1970</json:string><json:string>Rebel et al. (1975)</json:string><json:string>Bariety et al. 1974</json:string><json:string>Chou Shi-Ming 1967,1968</json:string><json:string>Marinozzi 1961</json:string><json:string>Grimley et al. 1973</json:string><json:string>Bariety et al. 1973</json:string><json:string>Davis et al. 1973</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-VDX30P98-C</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pathology</json:string><json:string>2 - cell biology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pathology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Histology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - 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The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of bone.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Paget's disease of bone</term><term xml:id="k2">osteoclast</term><term xml:id="k3">nuclear and cytoplasmic inclusions</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-VDX30P98-C/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2559</doi><issn type="print">0309-0167</issn><issn type="electronic">1365-2559</issn><idGroup><id type="product" value="HIS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="HISTOPATHOLOGY">Histopathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/his.1980.4.issue-1</doi><numberingGroup><numbering type="journalVolume" number="4">4</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="1980-01">January 1980</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0006300" status="forIssue"><doi origin="wiley">10.1111/j.1365-2559.1980.tb02898.x</doi><idGroup><id type="unit" value="HIS63"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><eventGroup><event type="firstOnline" date="2007-04-03"></event><event type="publishedOnlineFinalForm" date="2007-04-03"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="63">63</numbering><numbering type="pageLast" number="74">74</numbering></numberingGroup><correspondenceTo>*Dr G. Gherardi, 1st Institute of Pathological Anatomy, Policlinico Umberto 1, Viale Regina Elene 324, Roma, Italy 00163.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:HIS.HIS63.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 17 July 1979</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="29"></count><count type="linksCrossRef" number="4"></count></countGroup><titleGroup><title type="main">Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>G.</givenNames><familyName>GHERARDI</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>V.LO</givenNames><familyName>CASCIO</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>E.</givenNames><familyName>BONUCCI</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation><i>Laboratory of Histochemistry, 1st Institute of Pathological Anatomy, University of Rome, and Metabolic Unit, 3rd Medical Clinic, University of Padua at Verona</i></unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Paget's disease of bone</keyword><keyword xml:id="k2">osteoclast</keyword><keyword xml:id="k3">nuclear and cytoplasmic inclusions</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>To investigate the fine structural features of nuclei and cytoplasm in osteoclasts from patients with Paget's disease of bone, eight bone biopsies were examined. Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of bone.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">GHERARDI</namePart><affiliation>Laboratory of Histochemistry, 1st Institute of Pathological Anatomy, University of Rome, and Metabolic Unit, 3rd Medical Clinic, University of Padua at Verona</affiliation><affiliation>Correspondence address: *Dr G. Gherardi, 1st Institute of Pathological Anatomy, Policlinico Umberto 1, Viale Regina Elene 324, Roma, Italy 00163.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.LO</namePart><namePart type="family">CASCIO</namePart><affiliation>Laboratory of Histochemistry, 1st Institute of Pathological Anatomy, University of Rome, and Metabolic Unit, 3rd Medical Clinic, University of Padua at Verona</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">BONUCCI</namePart><affiliation>Laboratory of Histochemistry, 1st Institute of Pathological Anatomy, University of Rome, and Metabolic Unit, 3rd Medical Clinic, University of Padua at Verona</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1980-01</dateIssued><edition>Accepted for publication 17 July 1979</edition><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">29</extent><extent unit="linksCrossRef">4</extent></physicalDescription><abstract lang="en">To investigate the fine structural features of nuclei and cytoplasm in osteoclasts from patients with Paget's disease of bone, eight bone biopsies were examined. Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of bone.</abstract><subject lang="en"><genre>keywords</genre><topic>Paget's disease of bone</topic><topic>osteoclast</topic><topic>nuclear and cytoplasmic inclusions</topic></subject><relatedItem type="host"><titleInfo><title>Histopathology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0309-0167</identifier><identifier type="eISSN">1365-2559</identifier><identifier type="DOI">10.1111/(ISSN)1365-2559</identifier><identifier type="PublisherID">HIS</identifier><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>63</start><end>74</end><total>12</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Frequency of renal ultraendothelial microtubular inclusions in kidney transplants</title></titleInfo><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Bariety</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.M.</namePart><namePart type="family">Idatte</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Bedrossion</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Collard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.D.</namePart><namePart type="family">Appay</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bariety J., Idatte J.M., Bedrossion J., Collard P. & Appay M.D. (1974) Frequency of renal ultraendothelial microtubular inclusions in kidney transplants. Transplantation 17, 140–142.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>140</start><end>142</end></extent></part><relatedItem type="host"><titleInfo><title>Transplantation</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>140</start><end>142</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Frequency of intraendothelial “virus‐like” particles: an electron microscopy study of 376 human renal biopsies</title></titleInfo><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Bariety</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Richer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.D.</namePart><namePart type="family">Appay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Grossetale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Collard</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bariety J., Richer D., Appay M.D., Grossetale J. & Collard P. (1973) Frequency of intraendothelial “virus‐like” particles: an electron microscopy study of 376 human renal biopsies. Journal of Clinical Pathology 26, 21–24.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>21</start><end>24</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Clinical Pathology</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>21</start><end>24</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Ultrastructure and cytochemistry of lymphocytes in the genetic mucopolysaccharidoses</title></titleInfo><name type="personal"><namePart type="given">R.W.</namePart><namePart type="family">Belcher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Belcher R.W. (1972) Ultrastructure and cytochemistry of lymphocytes in the genetic mucopolysaccharidoses. Archives of Pathology 93, 1–7.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>1</start><end>7</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Pathology</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>1</start><end>7</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Ultrastructure of inclusions in peripheral blood mononuclear cells in sarcoidosis</title></titleInfo><name type="personal"><namePart type="given">R.W.</namePart><namePart type="family">Belcher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.M.</namePart><namePart type="family">Czarnetzki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.B.</namePart><namePart type="family">Campbell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Belcher R.W., Czarnetzki B.M. & Campbell P.B. (1975) Ultrastructure of inclusions in peripheral blood mononuclear cells in sarcoidosis. American Journal of Pathology 78, 461–468.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>461</start><end>468</end></extent></part><relatedItem type="host"><titleInfo><title>American Journal of Pathology</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>461</start><end>468</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Studies of two kinds of virus particles which comprise influenza A2 virus strain. III. Morphological characteristics: independence of morphological and functional traits</title></titleInfo><name type="personal"><namePart type="given">P.W.</namePart><namePart type="family">Choppin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.S.</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Tamm</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Choppin P.W., Murphy J.S. & Tamm I. (1969) Studies of two kinds of virus particles which comprise influenza A2 virus strain. III. Morphological characteristics: independence of morphological and functional traits. Journal of Experimental Medicine 112, 945–952.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>945</start><end>952</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Experimental Medicine</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>112</number></detail><extent unit="pages"><start>945</start><end>952</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Myxovirus‐like structures in a case of human chronic polymyositis</title></titleInfo><name type="personal"><namePart type="given">Chou</namePart><namePart type="family">Shi‐ming</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chou Shi‐ming (1967) Myxovirus‐like structures in a case of human chronic polymyositis. Science 158, 1453–1455.</note><part><date>1967</date><detail type="volume"><caption>vol.</caption><number>158</number></detail><extent unit="pages"><start>1453</start><end>1455</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1967</date><detail type="volume"><caption>vol.</caption><number>158</number></detail><extent unit="pages"><start>1453</start><end>1455</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Myxovirus‐like structures and accompanying nuclear changes in chronic polymyositis</title></titleInfo><name type="personal"><namePart type="given">Shi‐ming</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chou Shi‐ming (1968) Myxovirus‐like structures and accompanying nuclear changes in chronic polymyositis. Archives of Pathology 86, 649–658.</note><part><date>1968</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>649</start><end>658</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Pathology</title></titleInfo><part><date>1968</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>649</start><end>658</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Tubuloreticular structures within labial salivary glands in Sjögren's syndrome</title></titleInfo><name type="personal"><namePart type="given">T.E.</namePart><namePart type="family">Daniels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.A.</namePart><namePart type="family">Sylvester</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Silverman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Polando</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Talal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Daniels T.E., Sylvester R.A., Silverman S., Polando V. & Talal N. (1974) Tubuloreticular structures within labial salivary glands in Sjögren's syndrome. Arthritis and Rheumatism 17, 593–597.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>593</start><end>597</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis and Rheumatism</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>593</start><end>597</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Davis D.B., Dulbecco R., Eisen H.N., Ginsberg H.S. & Wood B.W. Jr (1973) Microbiology, 2nd edn. Harper & Row, New York & London .</title></titleInfo><note type="citation/reference">Davis D.B., Dulbecco R., Eisen H.N., Ginsberg H.S. & Wood B.W. Jr (1973) Microbiology, 2nd edn. Harper & Row, New York & London .</note><name type="personal"><namePart type="given">D.B.</namePart><namePart type="family">Davis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Dulbecco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.N.</namePart><namePart type="family">Eisen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.S.</namePart><namePart type="family">Ginsberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.W.</namePart><namePart type="family">Wood Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Harper & Row</publisher></originInfo><part><date>1973</date></part></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Abnormal structures in circulating lymphocytes from patients with systemic lupus erythematosis and related diseases</title></titleInfo><name type="personal"><namePart type="given">P.M.</namePart><namePart type="family">Grimley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.L.</namePart><namePart type="family">Decker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.J.</namePart><namePart type="family">Michelitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.M.</namePart><namePart type="family">Frantz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grimley P.M., Decker J.L., Michelitch H.J. & Frantz M.M. (1973) Abnormal structures in circulating lymphocytes from patients with systemic lupus erythematosis and related diseases. Arthritis and Rheumatism 16, 313–323.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>313</start><end>323</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis and Rheumatism</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>313</start><end>323</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Development of Semliki Forest virus in mouse brain: an electron microscopic study</title></titleInfo><name type="personal"><namePart type="given">P.M.</namePart><namePart type="family">Grimley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.M.</namePart><namePart type="family">Friedman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grimley P.M. & Friedman R.M. (1970) Development of Semliki Forest virus in mouse brain: an electron microscopic study. Experimental and Molecular Pathology 12, 1–13.</note><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1</start><end>13</end></extent></part><relatedItem type="host"><titleInfo><title>Experimental and Molecular Pathology</title></titleInfo><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1</start><end>13</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Significance of tubuloreticular inclusions in the pathobiology of human diseases</title></titleInfo><name type="personal"><namePart type="given">P.M.</namePart><namePart type="family">Grimley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Schaff</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Pathobiology Annual</title></titleInfo><originInfo><publisher>Appleton‐Century‐Crofts</publisher></originInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>221</start><end>257</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>The structure and composition of the myxoviruses. II. Components released from the influenza virus</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Hoyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.W.</namePart><namePart type="family">Horne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.P.</namePart><namePart type="family">Waterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hoyle L., Horne R.W. & Waterson A.P. (1961) The structure and composition of the myxoviruses. II. Components released from the influenza virus. Virology 13, 448–459.</note><part><date>1961</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>448</start><end>459</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>1961</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>448</start><end>459</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Intracellular branched tubular structures in osteosarcoma. An ultrastroctural and serological study</title></titleInfo><name type="personal"><namePart type="given">A.B.</namePart><namePart type="family">Jenson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.J.</namePart><namePart type="family">Spyut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.N.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Rapp</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jenson A.B., Spyut H.J., Smith M.N. & Rapp F. (1971) Intracellular branched tubular structures in osteosarcoma. An ultrastroctural and serological study. Cancer 27, 1440–1448.</note><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>1440</start><end>1448</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer</title></titleInfo><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>1440</start><end>1448</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Fine structure of cellular inclusions in measles virus infections</title></titleInfo><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Kallman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.M.</namePart><namePart type="family">Adams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.L.</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.T.</namePart><namePart type="family">Imagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kallman F., Adams J.M., Williams R.L. & Imagawa D.T. (1959) Fine structure of cellular inclusions in measles virus infections. Journal of Biophysical and Biochemical Cytology 6, 379–392.</note><part><date>1959</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>379</start><end>392</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Biophysical and Biochemical Cytology</title></titleInfo><part><date>1959</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>379</start><end>392</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Silver impregnation of ultrathin sections for electron microscopy</title></titleInfo><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Marinozzi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marinozzi V. (1961) Silver impregnation of ultrathin sections for electron microscopy. Journal of Biophysical and Biochemical Cytology 9, 121–133.</note><part><date>1961</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>121</start><end>133</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Biophysical and Biochemical Cytology</title></titleInfo><part><date>1961</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>121</start><end>133</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Nuclear inclusions in Paget's disease of bone</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Mills</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.R.</namePart><namePart type="family">Singer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mills B. & Singer F.R. (1976) Nuclear inclusions in Paget's disease of bone. Science 194, 201–202.</note><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>194</number></detail><extent unit="pages"><start>201</start><end>202</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>194</number></detail><extent unit="pages"><start>201</start><end>202</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Development of measles virus in vitro</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Nakai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.L.</namePart><namePart type="family">Shand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.F.</namePart><namePart type="family">Howatson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nakai T., Shand F.L. & Howatson A.F. (1969) Development of measles virus in vitro. Virology 38, 50–67.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>50</start><end>67</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>50</start><end>67</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Microtubular inclusions in normal skin of systemic lupus erythematosus</title></titleInfo><name type="personal"><namePart type="given">N.W.</namePart><namePart type="family">Nieland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Hashimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.T.</namePart><namePart type="family">Masi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nieland N.W., Hashimoto K. & Masi A.T. (1972) Microtubular inclusions in normal skin of systemic lupus erythematosus. Arthritis and Rheumatism 15, 193–200.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>193</start><end>200</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis and Rheumatism</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>193</start><end>200</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Morphogenesis of respiratory syncitial virus in a green monkey kidney cell line (Vero)</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Norrby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Marusyk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Orvell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Norrby E., Marusyk H. & Orvell C. (1970) Morphogenesis of respiratory syncitial virus in a green monkey kidney cell line (Vero). Journal of Virology 6, 237–242.</note><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>237</start><end>242</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Virology</title></titleInfo><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>237</start><end>242</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Electron microscopic study of corona virus</title></titleInfo><name type="personal"><namePart type="given">L.S.</namePart><namePart type="family">Oshiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.H.</namePart><namePart type="family">Schieble</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.H.</namePart><namePart type="family">Lennette</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oshiro L.S., Schieble J.H. & Lennette E.H. (1971) Electron microscopic study of corona virus. Journal of General Virology 12, 161–172.</note><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>161</start><end>172</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of General Virology</title></titleInfo><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>161</start><end>172</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Experimental subacute sclerosing panencephalitis in the hamster—Ultrastructure of the chronic disease</title></titleInfo><name type="personal"><namePart type="given">C.S.</namePart><namePart type="family">Raine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.P.</namePart><namePart type="family">Byixgton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.P.</namePart><namePart type="family">Johnston</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Raine C.S., Byixgton D.P. & Johnston K.P. (1974b) Experimental subacute sclerosing panencephalitis in the hamster—Ultrastructure of the chronic disease. Laboratory Investigation 31, 355–368.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>355</start><end>368</end></extent></part><relatedItem type="host"><titleInfo><title>Laboratory Investigation</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>355</start><end>368</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Subacute sclerosing panencephalitis virus. Observations on a Neuroadapted and Non‐Neuroadapted strain in organotypic central nervous system cultures</title></titleInfo><name type="personal"><namePart type="given">C.S.</namePart><namePart type="family">Raine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.A.</namePart><namePart type="family">Feldman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.D.</namePart><namePart type="family">Sheppard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.H.</namePart><namePart type="family">Barbosa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.B.</namePart><namePart type="family">Bornstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Raine C.S., Feldman L.A., Sheppard R.D., Barbosa L.H. & Bornstein M.B. (1974b) Subacute sclerosing panencephalitis virus. Observations on a Neuroadapted and Non‐Neuroadapted strain in organotypic central nervous system cultures. Laboratory Investigation 31, 42–53.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>42</start><end>53</end></extent></part><relatedItem type="host"><titleInfo><title>Laboratory Investigation</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>42</start><end>53</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Les inclusions des ostéoclastes dans la maladie osseuse de Paget</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rebel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Bregeon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Basle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Malkani</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rebel A., Bregeon C., Basle M. & Malkani K. (1975) Les inclusions des ostéoclastes dans la maladie osseuse de Paget. Revue du Rhumatisme 42, 637–641.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>637</start><end>641</end></extent></part><relatedItem type="host"><titleInfo><title>Revue du Rhumatisme</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>637</start><end>641</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Anomalies nucleaires des ostéoclastes de la maladie de Paget</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rebel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Malkani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Basle</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rebel A., Malkani K. & Basle M. (1974) Anomalies nucleaires des ostéoclastes de la maladie de Paget. Niuvelle Presse Medicale 18, 1299–1301.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1299</start><end>1301</end></extent></part><relatedItem type="host"><titleInfo><title>Niuvelle Presse Medicale</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1299</start><end>1301</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Is Paget's bone disease a viral infection</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rebel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Malkani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Basle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Bregeon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rebel A., Malkani K., Basle M. & Bregeon C. (1977) Is Paget's bone disease a viral infection Calcified Tissue Research 22, suppl., 283–286.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>suppl.</number></detail><extent unit="pages"><start>283</start><end>286</end></extent></part><relatedItem type="host"><titleInfo><title>Calcified Tissue Research</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>suppl.</number></detail><extent unit="pages"><start>283</start><end>286</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Ultramorphological and ultracytochemical studies on tubuloreticular structures in lymphoid cells</title></titleInfo><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Schaff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Heine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.A.</namePart><namePart type="family">Dalton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Schaff Z., Heine U. & Dalton J.A. (1972) Ultramorphological and ultracytochemical studies on tubuloreticular structures in lymphoid cells. Cancer Research 32, 2696–2706.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>2696</start><end>2706</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Research</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>2696</start><end>2706</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>The etiology of Paget's disease of bone</title></titleInfo><name type="personal"><namePart type="given">F.R.</namePart><namePart type="family">Singer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Mills</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Singer F.R. & Mills B. (1977) The etiology of Paget's disease of bone. Clinical Orthopaedics and Related Research 127, 37–42.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>127</number></detail><extent unit="pages"><start>37</start><end>42</end></extent></part><relatedItem type="host"><titleInfo><title>Clinical Orthopaedics and Related Research</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>127</number></detail><extent unit="pages"><start>37</start><end>42</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Nuclear fragmentation and associated fibrils in giant cell tumor of bone</title></titleInfo><name type="personal"><namePart type="given">R.A.</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.T.</namePart><namePart type="family">Meyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh R.A. & Meyer A.T. (1970) Nuclear fragmentation and associated fibrils in giant cell tumor of bone. Laboratory Investigation 22, 63–72.</note><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>63</start><end>72</end></extent></part><relatedItem type="host"><titleInfo><title>Laboratory Investigation</title></titleInfo><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>63</start><end>72</end></extent></part></relatedItem></relatedItem><identifier type="istex">D8E53523C3B78C81BA0CA84285191CB415FF52A5</identifier><identifier type="ark">ark:/67375/WNG-VDX30P98-C</identifier><identifier type="DOI">10.1111/j.1365-2559.1980.tb02898.x</identifier><identifier type="ArticleID">HIS63</identifier><accessCondition type="use and reproduction" contentType="copyright">© Wiley. 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