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Haemagglutinin-esterase protein (HE) of murine corona virus : DVIM (diarrhea virus of infant mice)

Identifieur interne : 001225 ( Main/Merge ); précédent : 001224; suivant : 001226

Haemagglutinin-esterase protein (HE) of murine corona virus : DVIM (diarrhea virus of infant mice)

Auteurs : K. Sugiyama [Japon] ; M. Kasai [Japon] ; S. Kato [Japon] ; H. Kasai [Japon] ; K. Hatakeyama [Japon]

Source :

Archives of virology [ 0304-8608 ] ; 1998.

RBID : Pascal:98-0511618

Descripteurs français

Pascal (Inist)
- Virus hépatite murine, Hémagglutinine, Esterases, Caractérisation, Activité enzymatique, Spécificité substrat.

English descriptors

KwdEn :
- Characterization, Enzymatic activity, Esterases, Hemagglutinin, Murine hepatitis virus, Substrate specificity.

Abstract

The acetylesterase (AE) activity of DVIM (diarrhea virus of infant mice) was assigned to the haemagglutinin-esterase (HE) protein. The substrate specificity was examined using the natural substrate bovine submaxillary mucin (BSM) and/or synthetic substrates p-nitrophenylacetate (p-NiA) and α-naphthylacetate (α-NA) and compared with several strains of MHV and influenza viruses. The AE of DVIM hydrolyzed the O-acetylester bond of BSM, and the two synthetic substrates p-NiA and α-NA in vitro. MHV-S reacted efficiently with both p-NiA and α-NA but less with BSM. Influenza virus (C/Miyagi/77) reacted with BSM efficiently, however reacted with p-NiA weakly, but not with α-NA at all. Thus, the AE-reactivity of DVIM was distinctly different from that of MHV-S and influenza C virus, suggesting that the AE of HE may have a modified function. Isolation of HE by the treatment with non ionic detergent NP40, resulted in globules approximately 5 nm in diameter. DVIM-binding proteins were demonstrated in the plasma membrane of mouse intestinal brush-border cells and hepatocytes. The same protein was recognized by MHV-S and MHV-4. The cell membranes obtained from these target tissues were substrates for the AE of DVIM. The biological importance of the HE protein for DVIM is discussed.

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Pascal:98-0511618

Le document en format XML

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<front><div type="abstract" xml:lang="en">The acetylesterase (AE) activity of DVIM (diarrhea virus of infant mice) was assigned to the haemagglutinin-esterase (HE) protein. The substrate specificity was examined using the natural substrate bovine submaxillary mucin (BSM) and/or synthetic substrates p-nitrophenylacetate (p-NiA) and α-naphthylacetate (α-NA) and compared with several strains of MHV and influenza viruses. The AE of DVIM hydrolyzed the O-acetylester bond of BSM, and the two synthetic substrates p-NiA and α-NA in vitro. MHV-S reacted efficiently with both p-NiA and α-NA but less with BSM. Influenza virus (C/Miyagi/77) reacted with BSM efficiently, however reacted with p-NiA weakly, but not with α-NA at all. Thus, the AE-reactivity of DVIM was distinctly different from that of MHV-S and influenza C virus, suggesting that the AE of HE may have a modified function. Isolation of HE by the treatment with non ionic detergent NP40, resulted in globules approximately 5 nm in diameter. DVIM-binding proteins were demonstrated in the plasma membrane of mouse intestinal brush-border cells and hepatocytes. The same protein was recognized by MHV-S and MHV-4. The cell membranes obtained from these target tissues were substrates for the AE of DVIM. The biological importance of the HE protein for DVIM is discussed.</div>
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Haemagglutinin-esterase protein (HE) of murine corona virus : DVIM (diarrhea virus of infant mice)

Haemagglutinin-esterase protein (HE) of murine corona virus : DVIM (diarrhea virus of infant mice)

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri