CovidV1, Main, Merge, bibRecord, 001224

A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design

Identifieur interne : 001224 ( Main/Merge ); précédent : 001223; suivant : 001225

A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design

Auteurs : D. L. Arnold ; R. Stapley ; F. Bryce ; D. Mahon

Source :

Regulatory Toxicology and Pharmacology [ 0273-2300 ] ; 1998.

RBID : ISTEX:3A0E26CA74346358DB5C68908AD638D523A08462

English descriptors

Teeft :
- Acclimation period, Alkaline phosphatase, Approximate time, Biphenyls, Birth size, Birth weight, Blood agar, Body weight, Breast milk, Chemical safety, Chinook salmon, Chronic ingestion, Clinical examination, Coho, Coho salmon, Contaminant, Control group, Coulter counter model, Creatinine phosphokinase, Dichlorodiphenyl dichloroethene, Environ, Epidemiological studies, Feed consumption, Fein, Gladen, Great lakes, Great lakes basin, Great lakes coho salmon, Great lakes salmon, Health consequences, Heavy metals, Immune system, Ingestion, Jacobson, Laboratory animals, Lake michigan, Lake ontario, Leatherland, Leucocyte count, Litter, Multigeneration study, Natural resources, Necropsy, Necropsy group, Negative association, Oncorhynchus tsawytscha, Ontario, Ontario ministry, Owen sound salmon, Partial thromboplastin time, Pcbs, Platelet count, Polybrominated biphenyls, Polychlorinated, Polychlorinated biphenyls, Poor health, Prenatal exposure, Prothrombin time, Public health, Pup, Ralston purina, Rat, Reproductive, Reproductive study, Reticulocyte count, Rogan, Rtpa, Salmon, Sani chip bedding, Separate rooms, Serum levels, Sonstegard, Test diets, Toxic effects, Toxicol, Toxicological, Toxicological effects, Toxicological response, Transplacental exposure, Weight range, Wire mesh cages.

Abstract

Abstract: Fish from the Great Lakes can be contaminated with a plethora of industrial, agricultural, and environmental chemicals. These chemicals have been associated with reproductive and other toxicological effects in fish and fish-eating birds found in the Great Lakes basin. To obtain more insight into this association, several laboratory studies have been undertaken wherein fish have been incorporated into the experimental diets to determine the effect of their ingestion upon the test animals. In addition, several human epidemiological studies have found correlations between Great Lakes fish consumption and effects in neonates which have been attributed to polychlorinated biphenyls without any appreciable consideration as to what synergistic or antagonistic effects other chemicals or heavy metals may or may not have contributed to the observed findings. Herein is presented the design of a two-generation feeding–reproduction study that incorporated lyophilized chinook salmon (Oncorhynchus tsawytscha) fillets into the diets of Sprague–Dawley rats. The findings of this study will be presented in the sections which follow.

Url:

https://api.istex.fr/ark:/67375/6H6-GPWRPKBH-C/fulltext.pdf

DOI: 10.1006/rtph.1997.1186

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000820
to stream Istex, to step Curation: 000800
to stream Istex, to step Checkpoint: 000399

Links to Exploration step

ISTEX:3A0E26CA74346358DB5C68908AD638D523A08462

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design</title>
<author><name sortKey="Arnold, D L" sort="Arnold, D L" uniqKey="Arnold D" first="D. L." last="Arnold">D. L. Arnold</name>
</author>
<author><name sortKey="Stapley, R" sort="Stapley, R" uniqKey="Stapley R" first="R." last="Stapley">R. Stapley</name>
</author>
<author><name sortKey="Bryce, F" sort="Bryce, F" uniqKey="Bryce F" first="F." last="Bryce">F. Bryce</name>
</author>
<author><name sortKey="Mahon, D" sort="Mahon, D" uniqKey="Mahon D" first="D." last="Mahon">D. Mahon</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3A0E26CA74346358DB5C68908AD638D523A08462</idno>
<date when="1998" year="1998">1998</date>
<idno type="doi">10.1006/rtph.1997.1186</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-GPWRPKBH-C/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000820</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000820</idno>
<idno type="wicri:Area/Istex/Curation">000800</idno>
<idno type="wicri:Area/Istex/Checkpoint">000399</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000399</idno>
<idno type="wicri:doubleKey">0273-2300:1998:Arnold D:a:multigeneration:study</idno>
<idno type="wicri:Area/Main/Merge">001224</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design</title>
<author><name sortKey="Arnold, D L" sort="Arnold, D L" uniqKey="Arnold D" first="D. L." last="Arnold">D. L. Arnold</name>
<affiliation><wicri:noCountry code="subField">0L2</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Stapley, R" sort="Stapley, R" uniqKey="Stapley R" first="R." last="Stapley">R. Stapley</name>
<affiliation><wicri:noCountry code="subField">0L2</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bryce, F" sort="Bryce, F" uniqKey="Bryce F" first="F." last="Bryce">F. Bryce</name>
<affiliation><wicri:noCountry code="subField">0L2</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mahon, D" sort="Mahon, D" uniqKey="Mahon D" first="D." last="Mahon">D. Mahon</name>
<affiliation><wicri:noCountry code="subField">0L2</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Regulatory Toxicology and Pharmacology</title>
<title level="j" type="abbrev">YRTPH</title>
<idno type="ISSN">0273-2300</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1998">1998</date>
<biblScope unit="volume">27</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="S1">S1</biblScope>
<biblScope unit="page" to="S7">S7</biblScope>
</imprint>
<idno type="ISSN">0273-2300</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0273-2300</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acclimation period</term>
<term>Alkaline phosphatase</term>
<term>Approximate time</term>
<term>Biphenyls</term>
<term>Birth size</term>
<term>Birth weight</term>
<term>Blood agar</term>
<term>Body weight</term>
<term>Breast milk</term>
<term>Chemical safety</term>
<term>Chinook salmon</term>
<term>Chronic ingestion</term>
<term>Clinical examination</term>
<term>Coho</term>
<term>Coho salmon</term>
<term>Contaminant</term>
<term>Control group</term>
<term>Coulter counter model</term>
<term>Creatinine phosphokinase</term>
<term>Dichlorodiphenyl dichloroethene</term>
<term>Environ</term>
<term>Epidemiological studies</term>
<term>Feed consumption</term>
<term>Fein</term>
<term>Gladen</term>
<term>Great lakes</term>
<term>Great lakes basin</term>
<term>Great lakes coho salmon</term>
<term>Great lakes salmon</term>
<term>Health consequences</term>
<term>Heavy metals</term>
<term>Immune system</term>
<term>Ingestion</term>
<term>Jacobson</term>
<term>Laboratory animals</term>
<term>Lake michigan</term>
<term>Lake ontario</term>
<term>Leatherland</term>
<term>Leucocyte count</term>
<term>Litter</term>
<term>Multigeneration study</term>
<term>Natural resources</term>
<term>Necropsy</term>
<term>Necropsy group</term>
<term>Negative association</term>
<term>Oncorhynchus tsawytscha</term>
<term>Ontario</term>
<term>Ontario ministry</term>
<term>Owen sound salmon</term>
<term>Partial thromboplastin time</term>
<term>Pcbs</term>
<term>Platelet count</term>
<term>Polybrominated biphenyls</term>
<term>Polychlorinated</term>
<term>Polychlorinated biphenyls</term>
<term>Poor health</term>
<term>Prenatal exposure</term>
<term>Prothrombin time</term>
<term>Public health</term>
<term>Pup</term>
<term>Ralston purina</term>
<term>Rat</term>
<term>Reproductive</term>
<term>Reproductive study</term>
<term>Reticulocyte count</term>
<term>Rogan</term>
<term>Rtpa</term>
<term>Salmon</term>
<term>Sani chip bedding</term>
<term>Separate rooms</term>
<term>Serum levels</term>
<term>Sonstegard</term>
<term>Test diets</term>
<term>Toxic effects</term>
<term>Toxicol</term>
<term>Toxicological</term>
<term>Toxicological effects</term>
<term>Toxicological response</term>
<term>Transplacental exposure</term>
<term>Weight range</term>
<term>Wire mesh cages</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Fish from the Great Lakes can be contaminated with a plethora of industrial, agricultural, and environmental chemicals. These chemicals have been associated with reproductive and other toxicological effects in fish and fish-eating birds found in the Great Lakes basin. To obtain more insight into this association, several laboratory studies have been undertaken wherein fish have been incorporated into the experimental diets to determine the effect of their ingestion upon the test animals. In addition, several human epidemiological studies have found correlations between Great Lakes fish consumption and effects in neonates which have been attributed to polychlorinated biphenyls without any appreciable consideration as to what synergistic or antagonistic effects other chemicals or heavy metals may or may not have contributed to the observed findings. Herein is presented the design of a two-generation feeding–reproduction study that incorporated lyophilized chinook salmon (Oncorhynchus tsawytscha) fillets into the diets of Sprague–Dawley rats. The findings of this study will be presented in the sections which follow.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001224 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001224 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:3A0E26CA74346358DB5C68908AD638D523A08462
   |texte=   A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design
}}

This area was generated with Dilib version V0.6.33.
Data generation: Fri Mar 27 18:14:15 2020. Site generation: Sun Jan 31 15:15:08 2021

	Serveur d'exploration Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Covid

A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design

A Multigeneration Study to Ascertain the Toxicological Effects of Great Lakes Salmon Fed to Rats: Study Overview and Design

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri