Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
Identifieur interne : 000838 ( Main/Exploration ); précédent : 000837; suivant : 000839Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
Auteurs : Basem Alraddadi ; Noha Bawareth ; Haneen Omar ; Hanadi Alsalmi ; Abeer Alshukairi ; Ismael Qushmaq ; Maun Feteih ; Mohammed Qutob ; Ghassan Wali ; Imran KhalidSource :
- Annals of Thoracic Medicine [ 1817-1737 ] ; 2016.
Abstract
In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital.
All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes.
A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality.
MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. Future studies to identify the risk factors for worse outcome are needed.
Url:
DOI: 10.4103/1817-1737.180027
PubMed: 27168861
PubMed Central: 4854059
Affiliations:
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sortKey="Alshukairi, Abeer" sort="Alshukairi, Abeer" uniqKey="Alshukairi A" first="Abeer" last="Alshukairi">Abeer Alshukairi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Feteih, Maun" sort="Feteih, Maun" uniqKey="Feteih M" first="Maun" last="Feteih">Maun Feteih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qutob, Mohammed" sort="Qutob, Mohammed" uniqKey="Qutob M" first="Mohammed" last="Qutob">Mohammed Qutob</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wali, Ghassan" sort="Wali, Ghassan" uniqKey="Wali G" first="Ghassan" last="Wali">Ghassan Wali</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Khalid, 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first="Haneen" last="Omar">Haneen Omar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Alsalmi, Hanadi" sort="Alsalmi, Hanadi" uniqKey="Alsalmi H" first="Hanadi" last="Alsalmi">Hanadi Alsalmi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Alshukairi, Abeer" sort="Alshukairi, Abeer" uniqKey="Alshukairi A" first="Abeer" last="Alshukairi">Abeer Alshukairi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Feteih, Maun" sort="Feteih, Maun" uniqKey="Feteih M" first="Maun" last="Feteih">Maun Feteih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qutob, Mohammed" sort="Qutob, Mohammed" uniqKey="Qutob M" first="Mohammed" last="Qutob">Mohammed Qutob</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wali, Ghassan" sort="Wali, Ghassan" uniqKey="Wali G" first="Ghassan" last="Wali">Ghassan Wali</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Khalid, Imran" sort="Khalid, Imran" uniqKey="Khalid I" first="Imran" last="Khalid">Imran Khalid</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Thoracic Medicine</title><idno type="ISSN">1817-1737</idno><idno type="eISSN">1998-3557</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>BACKGROUND:</title><p>In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital.</p></sec><sec id="st2"><title>METHODS:</title><p>All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes.</p></sec><sec id="st3"><title>RESULTS:</title><p>A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality.</p></sec><sec id="st4"><title>CONCLUSIONS:</title><p>MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. 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Alraddadi</name><name sortKey="Alsalmi, Hanadi" sort="Alsalmi, Hanadi" uniqKey="Alsalmi H" first="Hanadi" last="Alsalmi">Hanadi Alsalmi</name><name sortKey="Alshukairi, Abeer" sort="Alshukairi, Abeer" uniqKey="Alshukairi A" first="Abeer" last="Alshukairi">Abeer Alshukairi</name><name sortKey="Bawareth, Noha" sort="Bawareth, Noha" uniqKey="Bawareth N" first="Noha" last="Bawareth">Noha Bawareth</name><name sortKey="Feteih, Maun" sort="Feteih, Maun" uniqKey="Feteih M" first="Maun" last="Feteih">Maun Feteih</name><name sortKey="Khalid, Imran" sort="Khalid, Imran" uniqKey="Khalid I" first="Imran" last="Khalid">Imran Khalid</name><name sortKey="Omar, Haneen" sort="Omar, Haneen" uniqKey="Omar H" first="Haneen" last="Omar">Haneen Omar</name><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><name sortKey="Qutob, Mohammed" sort="Qutob, Mohammed" uniqKey="Qutob M" first="Mohammed" last="Qutob">Mohammed Qutob</name><name 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