Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
Identifieur interne : 000040 ( Pmc/Curation ); précédent : 000039; suivant : 000041Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital
Auteurs : Basem Alraddadi ; Noha Bawareth ; Haneen Omar ; Hanadi Alsalmi ; Abeer Alshukairi ; Ismael Qushmaq ; Maun Feteih ; Mohammed Qutob ; Ghassan Wali ; Imran KhalidSource :
- Annals of Thoracic Medicine [ 1817-1737 ] ; 2016.
Abstract
In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital.
All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes.
A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality.
MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. Future studies to identify the risk factors for worse outcome are needed.
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DOI: 10.4103/1817-1737.180027
PubMed: 27168861
PubMed Central: 4854059
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sortKey="Alshukairi, Abeer" sort="Alshukairi, Abeer" uniqKey="Alshukairi A" first="Abeer" last="Alshukairi">Abeer Alshukairi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Feteih, Maun" sort="Feteih, Maun" uniqKey="Feteih M" first="Maun" last="Feteih">Maun Feteih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qutob, Mohammed" sort="Qutob, Mohammed" uniqKey="Qutob M" first="Mohammed" last="Qutob">Mohammed Qutob</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wali, Ghassan" sort="Wali, Ghassan" uniqKey="Wali G" first="Ghassan" last="Wali">Ghassan Wali</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Khalid, 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sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bawareth, Noha" sort="Bawareth, Noha" uniqKey="Bawareth N" first="Noha" last="Bawareth">Noha Bawareth</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Omar, Haneen" sort="Omar, Haneen" uniqKey="Omar H" first="Haneen" last="Omar">Haneen Omar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Alsalmi, Hanadi" sort="Alsalmi, Hanadi" uniqKey="Alsalmi H" first="Hanadi" last="Alsalmi">Hanadi Alsalmi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Alshukairi, Abeer" sort="Alshukairi, Abeer" uniqKey="Alshukairi A" first="Abeer" last="Alshukairi">Abeer Alshukairi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Feteih, Maun" sort="Feteih, Maun" uniqKey="Feteih M" first="Maun" last="Feteih">Maun Feteih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qutob, Mohammed" sort="Qutob, Mohammed" uniqKey="Qutob M" first="Mohammed" last="Qutob">Mohammed Qutob</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wali, Ghassan" sort="Wali, Ghassan" uniqKey="Wali G" first="Ghassan" last="Wali">Ghassan Wali</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Khalid, Imran" sort="Khalid, Imran" uniqKey="Khalid I" first="Imran" last="Khalid">Imran Khalid</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Thoracic Medicine</title><idno type="ISSN">1817-1737</idno><idno type="eISSN">1998-3557</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>BACKGROUND:</title><p>In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital.</p></sec><sec id="st2"><title>METHODS:</title><p>All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes.</p></sec><sec id="st3"><title>RESULTS:</title><p>A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality.</p></sec><sec id="st4"><title>CONCLUSIONS:</title><p>MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. Future studies to identify the risk factors for worse outcome are needed.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Hinedi, K" uniqKey="Hinedi K">K Hinedi</name></author><author><name sortKey="Ghandour, J" uniqKey="Ghandour J">J Ghandour</name></author><author><name sortKey="Khairalla, H" uniqKey="Khairalla H">H Khairalla</name></author><author><name sortKey="Musleh, S" uniqKey="Musleh S">S Musleh</name></author><author><name sortKey="Ujayli, A" uniqKey="Ujayli A">A Ujayli</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author><author><name sortKey="Price, Cs" uniqKey="Price C">CS Price</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al Rabeeah</name></author><author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name></author><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name></author><author><name sortKey="Rha, B" uniqKey="Rha B">B Rha</name></author><author><name sortKey="Tohme, Ra" uniqKey="Tohme R">RA Tohme</name></author><author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, Fa" uniqKey="Al Rabiah F">FA Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A Al-Barrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A Bahloul</name></author><author><name sortKey="Elzein, F" uniqKey="Elzein F">F Elzein</name></author><author><name sortKey="Matin, Ma" uniqKey="Matin M">MA Matin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gulland, A" uniqKey="Gulland A">A Gulland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name></author><author><name sortKey="Tomczyk, Sm" uniqKey="Tomczyk S">SM Tomczyk</name></author><author><name sortKey="Al Asmari, Am" uniqKey="Al Asmari A">AM Al-Asmari</name></author><author><name sortKey="Banjar, Aa" uniqKey="Banjar A">AA Banjar</name></author><author><name sortKey="Al Mugti, H" uniqKey="Al Mugti H">H Al-Mugti</name></author><author><name sortKey="Aloraini, Ms" uniqKey="Aloraini M">MS Aloraini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Costabel, U" uniqKey="Costabel U">U Costabel</name></author><author><name sortKey="Timm, J" uniqKey="Timm J">J Timm</name></author><author><name sortKey="Binger, T" uniqKey="Binger T">T Binger</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalhoub, S" uniqKey="Shalhoub S">S Shalhoub</name></author><author><name sortKey="Farahat, F" uniqKey="Farahat F">F Farahat</name></author><author><name sortKey="Al Jiffri, A" uniqKey="Al Jiffri A">A Al-Jiffri</name></author><author><name sortKey="Simhairi, R" uniqKey="Simhairi R">R Simhairi</name></author><author><name sortKey="Shamma, O" uniqKey="Shamma O">O Shamma</name></author><author><name sortKey="Siddiqi, N" uniqKey="Siddiqi N">N Siddiqi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Thorac Med</journal-id><journal-id journal-id-type="iso-abbrev">Ann Thorac Med</journal-id><journal-id journal-id-type="publisher-id">ATM</journal-id><journal-title-group><journal-title>Annals of Thoracic Medicine</journal-title></journal-title-group><issn pub-type="ppub">1817-1737</issn><issn pub-type="epub">1998-3557</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27168861</article-id><article-id pub-id-type="pmc">4854059</article-id><article-id pub-id-type="publisher-id">ATM-11-128</article-id><article-id pub-id-type="doi">10.4103/1817-1737.180027</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Alraddadi</surname><given-names>Basem</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bawareth</surname><given-names>Noha</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Omar</surname><given-names>Haneen</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Alsalmi</surname><given-names>Hanadi</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Alshukairi</surname><given-names>Abeer</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Qushmaq</surname><given-names>Ismael</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Feteih</surname><given-names>Maun</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Qutob</surname><given-names>Mohammed</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Wali</surname><given-names>Ghassan</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Khalid</surname><given-names>Imran</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><italic>King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Imran Khalid, King Faisal Specialist Hospital and Research Centre, P. O. Box 40047, MBC J102, Jeddah 21499, Saudi Arabia. E-mail: <email xlink:href="ikhalid97@kfshrc.edu.sa">ikhalid97@kfshrc.edu.sa</email></corresp></author-notes><pub-date pub-type="ppub"><season>Apr-Jun</season><year>2016</year></pub-date><volume>11</volume><issue>2</issue><fpage>128</fpage><lpage>131</lpage><history><date date-type="received"><day>23</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>30</day><month>1</month><year>2016</year></date></history><permissions><copyright-statement>Copyright: © 2016 Annals of Thoracic Medicine</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>BACKGROUND:</title><p>In April 2014, a surge in cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was seen in Jeddah, Saudi Arabia. The aim of this study is to describe the demographic and clinical features, laboratory and radiological findings of MERS-CoV patients identified during this outbreak in a single tertiary hospital.</p></sec><sec id="st2"><title>METHODS:</title><p>All laboratory-confirmed MERS-CoV cases who presented to King Faisal Specialist Hospital from March 1, 2014, to May 30, 2014, were identified. Patients' charts were reviewed for demographic information, comorbidities, clinical presentations, and outcomes.</p></sec><sec id="st3"><title>RESULTS:</title><p>A total of 39 patients with confirmed MERS-CoV infection were identified. Twenty-one were male (54%), aged 40 ± 19 years and included 3 (8%) pediatric patients (<18-year-old). 16 (41%) patients were health care workers. Twenty-one (53%) patients were previously healthy whereas eighteen (47%) had at least one comorbidity. The predominant comorbidities included hypertension (31%), diabetes (26%), respiratory (23%), and renal disease (18%). Thirty patients (81%) were symptomatic at presentation, fever (69%) being the most common complaint. The overall mortality rate was 28%. In univariate analysis, older age, hypertension, and chronic kidney disease were associated with mortality.</p></sec><sec id="st4"><title>CONCLUSIONS:</title><p>MERS-CoV presentation varies from asymptomatic infection to severe respiratory disease causing death. Future studies to identify the risk factors for worse outcome are needed.</p></sec></abstract><kwd-group><kwd>Characteristics</kwd><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>patient</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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