In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Identifieur interne : 000E45 ( Main/Exploration ); précédent : 000E44; suivant : 000E46In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Auteurs : P. Selvam [Inde] ; N. Murgesh [Inde] ; M. Chandramohan [Belgique] ; E. De Clercq [Belgique] ; E. Keyaerts [Belgique] ; L. Vijgen [Belgique] ; P. Maes [Belgique] ; J. Neyts [Belgique] ; M. V. Ranst [Belgique]Source :
- Indian Journal of Pharmaceutical Sciences [ 0250-474X ] ; 2008.
Abstract
4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
Url:
DOI: 10.4103/0250-474X.40339
PubMed: 20390088
PubMed Central: 2852069
Affiliations:
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Ranst</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author></analytic><series><title level="j">Indian Journal of Pharmaceutical Sciences</title><idno type="ISSN">0250-474X</idno><idno type="eISSN">1998-3743</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Popp, Fd" uniqKey="Popp F">FD Popp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varma, Rs" uniqKey="Varma R">RS Varma</name></author><author><name sortKey="Nobles, Wl" uniqKey="Nobles W">WL Nobles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandeya, Sn" uniqKey="Pandeya S">SN Pandeya</name></author><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Pannecouque, C" uniqKey="Pannecouque C">C Pannecouque</name></author><author><name sortKey="Witvrouw, M" uniqKey="Witvrouw M">M Witvrouw</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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