In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Identifieur interne : 000170 ( Ncbi/Merge ); précédent : 000169; suivant : 000171In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Auteurs : P. Selvam [Inde] ; N. Murgesh [Inde] ; M. Chandramohan [Belgique] ; E. De Clercq [Belgique] ; E. Keyaerts [Belgique] ; L. Vijgen [Belgique] ; P. Maes [Belgique] ; J. Neyts [Belgique] ; M. V. Ranst [Belgique]Source :
- Indian Journal of Pharmaceutical Sciences [ 0250-474X ] ; 2008.
Abstract
4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
Url:
DOI: 10.4103/0250-474X.40339
PubMed: 20390088
PubMed Central: 2852069
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Neyts</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Ranst, M V" sort="Ranst, M V" uniqKey="Ranst M" first="M. V." last="Ranst">M. V. 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Selvam</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190</wicri:regionArea><wicri:noRegion>Krishnankoil - 626 190</wicri:noRegion></affiliation></author><author><name sortKey="Murgesh, N" sort="Murgesh, N" uniqKey="Murgesh N" first="N." last="Murgesh">N. Murgesh</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Institute of Pharmacology, Madurai Medical College, Madurai - 625 020, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Institute of Pharmacology, Madurai Medical College, Madurai - 625 020</wicri:regionArea><wicri:noRegion>Madurai - 625 020</wicri:noRegion></affiliation></author><author><name sortKey="Chandramohan, M" sort="Chandramohan, M" uniqKey="Chandramohan M" first="M." last="Chandramohan">M. Chandramohan</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Bharat Ratna Kamarajar Liver Hospital and Research Center, Madurai - 625 001, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Bharat Ratna Kamarajar Liver Hospital and Research Center, Madurai - 625 001</wicri:regionArea><wicri:noRegion>Madurai - 625 001</wicri:noRegion></affiliation></author><author><name sortKey="De Clercq, E" sort="De Clercq, E" uniqKey="De Clercq E" first="E." last="De Clercq">E. De Clercq</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Keyaerts, E" sort="Keyaerts, E" uniqKey="Keyaerts E" first="E." last="Keyaerts">E. Keyaerts</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Vijgen, L" sort="Vijgen, L" uniqKey="Vijgen L" first="L." last="Vijgen">L. Vijgen</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Maes, P" sort="Maes, P" uniqKey="Maes P" first="P." last="Maes">P. Maes</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Neyts, J" sort="Neyts, J" uniqKey="Neyts J" first="J." last="Neyts">J. Neyts</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Ranst, M V" sort="Ranst, M V" uniqKey="Ranst M" first="M. V." last="Ranst">M. V. Ranst</name><affiliation wicri:level="4"><nlm:aff id="AF0004">Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author></analytic><series><title level="j">Indian Journal of Pharmaceutical Sciences</title><idno type="ISSN">0250-474X</idno><idno type="eISSN">1998-3743</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Popp, Fd" uniqKey="Popp F">FD Popp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varma, Rs" uniqKey="Varma R">RS Varma</name></author><author><name sortKey="Nobles, Wl" uniqKey="Nobles W">WL Nobles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandeya, Sn" uniqKey="Pandeya S">SN Pandeya</name></author><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Pannecouque, C" uniqKey="Pannecouque C">C Pannecouque</name></author><author><name sortKey="Witvrouw, M" uniqKey="Witvrouw M">M Witvrouw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandeya, Sn" uniqKey="Pandeya S">SN Pandeya</name></author><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="Nath, G" uniqKey="Nath G">G Nath</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bauer, Dj" uniqKey="Bauer D">DJ Bauer</name></author><author><name sortKey="Sadler, Pw" uniqKey="Sadler P">PW Sadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolf, Me" uniqKey="Wolf M">ME Wolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teitz, Y" uniqKey="Teitz Y">Y Teitz</name></author><author><name sortKey="Ronen, D" uniqKey="Ronen D">D Ronen</name></author><author><name sortKey="Vansover, A" uniqKey="Vansover A">A Vansover</name></author><author><name sortKey="Stematsky, T" uniqKey="Stematsky T">T Stematsky</name></author><author><name sortKey="Rigg, Jl" uniqKey="Rigg J">JL Rigg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pauwels, R" uniqKey="Pauwels R">R Pauwels</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author><author><name sortKey="Baba, M" uniqKey="Baba M">M Baba</name></author><author><name sortKey="Snoeck, R" uniqKey="Snoeck R">R Snoeck</name></author><author><name sortKey="Schols, Dj" uniqKey="Schols D">DJ Schols</name></author><author><name sortKey="Herdewijin, P" uniqKey="Herdewijin P">P Herdewijin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selvam, P" uniqKey="Selvam P">P Selvam</name></author><author><name sortKey="Chandramohan, M" uniqKey="Chandramohan M">M Chandramohan</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Pannecouque, C" uniqKey="Pannecouque C">C Pannecouque</name></author><author><name sortKey="Witrouw, M" uniqKey="Witrouw M">M Witrouw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keyaerts, E" uniqKey="Keyaerts E">E Keyaerts</name></author><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L vijgen</name></author><author><name sortKey="Maes, P" uniqKey="Maes P">P Maes</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author><author><name sortKey="Ranst, Mv" uniqKey="Ranst M">MV Ranst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartenschalager, R" uniqKey="Bartenschalager R">R Bartenschalager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pietschman, T" uniqKey="Pietschman T">T Pietschman</name></author><author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name></author><author><name sortKey="Rutter, G" uniqKey="Rutter G">G Rutter</name></author><author><name sortKey="Kurpanek, K" uniqKey="Kurpanek K">K Kurpanek</name></author><author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lohmann, V" uniqKey="Lohmann V">V Lohmann</name></author><author><name sortKey="Korner, F" uniqKey="Korner F">F Korner</name></author><author><name sortKey="Koch, J" uniqKey="Koch J">J Koch</name></author><author><name sortKey="Herian, V" uniqKey="Herian V">V Herian</name></author><author><name sortKey="Theilmann, L" uniqKey="Theilmann L">L Theilmann</name></author><author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="other"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Pharm Sci</journal-id><journal-id journal-id-type="publisher-id">IJPhS</journal-id><journal-title-group><journal-title>Indian Journal of Pharmaceutical Sciences</journal-title></journal-title-group><issn pub-type="ppub">0250-474X</issn><issn pub-type="epub">1998-3743</issn><publisher><publisher-name>Medknow Publications</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20390088</article-id><article-id pub-id-type="pmc">2852069</article-id><article-id pub-id-type="publisher-id">IJPhS-70-91</article-id><article-id pub-id-type="doi">10.4103/0250-474X.40339</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Communication</subject></subj-group></article-categories><title-group><article-title><italic>In Vitro</italic> Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Selvam</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="AF0001"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Murgesh</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="AF0002">1</xref></contrib><contrib contrib-type="author"><name><surname>Chandramohan</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="AF0003">2</xref></contrib><contrib contrib-type="author"><name><surname>De Clercq</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Keyaerts</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Vijgen</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Maes</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Neyts</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Ranst</surname><given-names>M. V.</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib></contrib-group><aff id="AF0001">Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India</aff><aff id="AF0002"><label>1</label>Institute of Pharmacology, Madurai Medical College, Madurai - 625 020, India</aff><aff id="AF0003"><label>2</label>Bharat Ratna Kamarajar Liver Hospital and Research Center, Madurai - 625 001, Belgium</aff><aff id="AF0004"><label>3</label>Raga Institute for Medical Research, Katholieke Universiteit-Leuven, Minder broederstraat 10, LeuvenB-3000, Belgium</aff><author-notes><corresp id="cor1"><label>*</label><bold>For correspondence</bold> E-mail: <email xlink:href="periyasamyselvam2001@yahoo.co.in">periyasamyselvam2001@yahoo.co.in</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Feb</season><year>2008</year></pub-date><volume>70</volume><issue>1</issue><fpage>91</fpage><lpage>94</lpage><history><date date-type="received"><day>06</day><month>7</month><year>2006</year></date><date date-type="rev-recd"><day>23</day><month>7</month><year>2007</year></date><date date-type="accepted"><day>29</day><month>1</month><year>2008</year></date></history><permissions><copyright-statement>© Indian Journal of Pharmaceutical Sciences</copyright-statement><copyright-year>2008</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 μg/ml, without toxicity at a concentration up to 42 μg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.</p></abstract><kwd-group><kwd>Isatin</kwd><kwd>HCV</kwd><kwd>SARS-CoV</kwd><kwd>vero cells</kwd><kwd>huh 5-2 cells</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Belgique</li><li>Inde</li></country><region><li>Province du Brabant flamand</li><li>Région flamande</li></region><settlement><li>Louvain</li></settlement><orgName><li>Katholieke Universiteit Leuven</li></orgName></list><tree><country name="Inde"><noRegion><name sortKey="Selvam, P" sort="Selvam, P" uniqKey="Selvam P" first="P." last="Selvam">P. Selvam</name></noRegion><name sortKey="Murgesh, N" sort="Murgesh, N" uniqKey="Murgesh N" first="N." last="Murgesh">N. Murgesh</name></country><country name="Belgique"><noRegion><name sortKey="Chandramohan, M" sort="Chandramohan, M" uniqKey="Chandramohan M" first="M." last="Chandramohan">M. Chandramohan</name></noRegion><name sortKey="De Clercq, E" sort="De Clercq, E" uniqKey="De Clercq E" first="E." last="De Clercq">E. De Clercq</name><name sortKey="Keyaerts, E" sort="Keyaerts, E" uniqKey="Keyaerts E" first="E." last="Keyaerts">E. Keyaerts</name><name sortKey="Maes, P" sort="Maes, P" uniqKey="Maes P" first="P." last="Maes">P. Maes</name><name sortKey="Neyts, J" sort="Neyts, J" uniqKey="Neyts J" first="J." last="Neyts">J. Neyts</name><name sortKey="Ranst, M V" sort="Ranst, M V" uniqKey="Ranst M" first="M. V." last="Ranst">M. V. Ranst</name><name sortKey="Vijgen, L" sort="Vijgen, L" uniqKey="Vijgen L" first="L." last="Vijgen">L. Vijgen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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