Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.
Identifieur interne : 001675 ( Main/Exploration ); précédent : 001674; suivant : 001676Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.
Auteurs : R. L. Knobler ; L. A. Tunison ; P. W. Lampert ; M. B. OldstoneSource :
- The American Journal of Pathology [ 0002-9440 ] ; 1982.
Abstract
The model system of central nervous system (CNS) disease induced by mouse hepatitis virus type 4 (MHV-4) is explored by comparison of wild type (wt) MHV-4 and two temperature-sensitive (ts) mutants, designated ts8 and ts15, in BALB/c and SJL/J mice. In BALB/c mice, 3 plaque-forming units (PFU) of wt MHV-4 given intracerebrally caused fatal encephalomyelitis in all mice by 7 days after infection, with spread of virus outside the CNS, especially to liver. In SJL/J mice, 3 PFU of wt virus was cleared within 2-3 days, with little spread, and up tp 100 PFU failed to cause fatal encephalomyelitis. However, larger amounts of virus, like 1000 PFU, caused fatal encephalomyelitis in SJL/J mice. In contrast, 10(4) PFU of MHV-4 ts8 did not cause death in either BALB/c or SJL/J mice, and persisted in the CNS of both strains while retaining its ts phenotype. There was significatnly less spread of virus outside the CNS. BALB/c mice usually showed demyelination, remyelination, and recurrent demyelination with ts8, while SJL/J mice only rarely had lesions. Intracerebral inoculation with 10(4) PFU of MHV-4 ts15 was associated with a persistent infection in CNS and liver of BALB/c mice; however, only occasional demyelination and hepatic lesions occurred. TS15 did not cause death in either BALB/c or SJL/J mice and did not cause histopathologic injury in SJL/J mice.
Url:
PubMed: 6291396
PubMed Central: 1916093
Affiliations:
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Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.</title><author><name sortKey="Knobler, R L" sort="Knobler, R L" uniqKey="Knobler R" first="R. L." last="Knobler">R. L. Knobler</name></author><author><name sortKey="Tunison, L A" sort="Tunison, L A" uniqKey="Tunison L" first="L. A." last="Tunison">L. A. Tunison</name></author><author><name sortKey="Lampert, P W" sort="Lampert, P W" uniqKey="Lampert P" first="P. W." last="Lampert">P. W. Lampert</name></author><author><name sortKey="Oldstone, M B" sort="Oldstone, M B" uniqKey="Oldstone M" first="M. B." last="Oldstone">M. B. Oldstone</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="1982">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The model system of central nervous system (CNS) disease induced by mouse hepatitis virus type 4 (MHV-4) is explored by comparison of wild type (wt) MHV-4 and two temperature-sensitive (ts) mutants, designated ts8 and ts15, in BALB/c and SJL/J mice. In BALB/c mice, 3 plaque-forming units (PFU) of wt MHV-4 given intracerebrally caused fatal encephalomyelitis in all mice by 7 days after infection, with spread of virus outside the CNS, especially to liver. In SJL/J mice, 3 PFU of wt virus was cleared within 2-3 days, with little spread, and up tp 100 PFU failed to cause fatal encephalomyelitis. However, larger amounts of virus, like 1000 PFU, caused fatal encephalomyelitis in SJL/J mice. In contrast, 10(4) PFU of MHV-4 ts8 did not cause death in either BALB/c or SJL/J mice, and persisted in the CNS of both strains while retaining its ts phenotype. There was significatnly less spread of virus outside the CNS. BALB/c mice usually showed demyelination, remyelination, and recurrent demyelination with ts8, while SJL/J mice only rarely had lesions. Intracerebral inoculation with 10(4) PFU of MHV-4 ts15 was associated with a persistent infection in CNS and liver of BALB/c mice; however, only occasional demyelination and hepatic lesions occurred. TS15 did not cause death in either BALB/c or SJL/J mice and did not cause histopathologic injury in SJL/J mice.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 4</label><graphic xlink:href="amjpathol00200-0037-a" xlink:role="163"></graphic></fig><fig id="F2"><label>Figure 5</label><graphic xlink:href="amjpathol00200-0038-a" xlink:role="164"></graphic></fig><fig id="F3"><label>Figure 6</label><graphic xlink:href="amjpathol00200-0039-a" xlink:role="165"></graphic></fig><fig id="F4"><label>Figure 7</label><graphic xlink:href="amjpathol00200-0040-a" xlink:role="166"></graphic></fig><fig id="F5"><label>Figure 8</label><graphic xlink:href="amjpathol00200-0040-b" xlink:role="166"></graphic></fig><fig id="F6"><label>Figure 9</label><graphic xlink:href="amjpathol00200-0041-a" xlink:role="167"></graphic></fig><fig id="F7"><label>Figure 10</label><graphic xlink:href="amjpathol00200-0041-b" xlink:role="167"></graphic></fig></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Knobler, R L" sort="Knobler, R L" uniqKey="Knobler R" first="R. L." last="Knobler">R. L. Knobler</name><name sortKey="Lampert, P W" sort="Lampert, P W" uniqKey="Lampert P" first="P. W." last="Lampert">P. W. Lampert</name><name sortKey="Oldstone, M B" sort="Oldstone, M B" uniqKey="Oldstone M" first="M. B." last="Oldstone">M. B. Oldstone</name><name sortKey="Tunison, L A" sort="Tunison, L A" uniqKey="Tunison L" first="L. A." last="Tunison">L. A. Tunison</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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