Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.
Identifieur interne : 000189 ( Pmc/Corpus ); précédent : 000188; suivant : 000190Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.
Auteurs : R. L. Knobler ; L. A. Tunison ; P. W. Lampert ; M. B. OldstoneSource :
- The American Journal of Pathology [ 0002-9440 ] ; 1982.
Abstract
The model system of central nervous system (CNS) disease induced by mouse hepatitis virus type 4 (MHV-4) is explored by comparison of wild type (wt) MHV-4 and two temperature-sensitive (ts) mutants, designated ts8 and ts15, in BALB/c and SJL/J mice. In BALB/c mice, 3 plaque-forming units (PFU) of wt MHV-4 given intracerebrally caused fatal encephalomyelitis in all mice by 7 days after infection, with spread of virus outside the CNS, especially to liver. In SJL/J mice, 3 PFU of wt virus was cleared within 2-3 days, with little spread, and up tp 100 PFU failed to cause fatal encephalomyelitis. However, larger amounts of virus, like 1000 PFU, caused fatal encephalomyelitis in SJL/J mice. In contrast, 10(4) PFU of MHV-4 ts8 did not cause death in either BALB/c or SJL/J mice, and persisted in the CNS of both strains while retaining its ts phenotype. There was significatnly less spread of virus outside the CNS. BALB/c mice usually showed demyelination, remyelination, and recurrent demyelination with ts8, while SJL/J mice only rarely had lesions. Intracerebral inoculation with 10(4) PFU of MHV-4 ts15 was associated with a persistent infection in CNS and liver of BALB/c mice; however, only occasional demyelination and hepatic lesions occurred. TS15 did not cause death in either BALB/c or SJL/J mice and did not cause histopathologic injury in SJL/J mice.
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PubMed: 6291396
PubMed Central: 1916093
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.</title><author><name sortKey="Knobler, R L" sort="Knobler, R L" uniqKey="Knobler R" first="R. L." last="Knobler">R. L. Knobler</name></author><author><name sortKey="Tunison, L A" sort="Tunison, L A" uniqKey="Tunison L" first="L. A." last="Tunison">L. A. Tunison</name></author><author><name sortKey="Lampert, P W" sort="Lampert, P W" uniqKey="Lampert P" first="P. W." last="Lampert">P. W. Lampert</name></author><author><name sortKey="Oldstone, M B" sort="Oldstone, M B" uniqKey="Oldstone M" first="M. B." last="Oldstone">M. B. Oldstone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6291396</idno><idno type="pmc">1916093</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916093</idno><idno type="RBID">PMC:1916093</idno><date when="1982">1982</date><idno type="wicri:Area/Pmc/Corpus">000189</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000189</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.</title><author><name sortKey="Knobler, R L" sort="Knobler, R L" uniqKey="Knobler R" first="R. L." last="Knobler">R. L. Knobler</name></author><author><name sortKey="Tunison, L A" sort="Tunison, L A" uniqKey="Tunison L" first="L. A." last="Tunison">L. A. Tunison</name></author><author><name sortKey="Lampert, P W" sort="Lampert, P W" uniqKey="Lampert P" first="P. W." last="Lampert">P. W. Lampert</name></author><author><name sortKey="Oldstone, M B" sort="Oldstone, M B" uniqKey="Oldstone M" first="M. B." last="Oldstone">M. B. Oldstone</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="1982">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The model system of central nervous system (CNS) disease induced by mouse hepatitis virus type 4 (MHV-4) is explored by comparison of wild type (wt) MHV-4 and two temperature-sensitive (ts) mutants, designated ts8 and ts15, in BALB/c and SJL/J mice. In BALB/c mice, 3 plaque-forming units (PFU) of wt MHV-4 given intracerebrally caused fatal encephalomyelitis in all mice by 7 days after infection, with spread of virus outside the CNS, especially to liver. In SJL/J mice, 3 PFU of wt virus was cleared within 2-3 days, with little spread, and up tp 100 PFU failed to cause fatal encephalomyelitis. However, larger amounts of virus, like 1000 PFU, caused fatal encephalomyelitis in SJL/J mice. In contrast, 10(4) PFU of MHV-4 ts8 did not cause death in either BALB/c or SJL/J mice, and persisted in the CNS of both strains while retaining its ts phenotype. There was significatnly less spread of virus outside the CNS. BALB/c mice usually showed demyelination, remyelination, and recurrent demyelination with ts8, while SJL/J mice only rarely had lesions. Intracerebral inoculation with 10(4) PFU of MHV-4 ts15 was associated with a persistent infection in CNS and liver of BALB/c mice; however, only occasional demyelination and hepatic lesions occurred. TS15 did not cause death in either BALB/c or SJL/J mice and did not cause histopathologic injury in SJL/J mice.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 4</label><graphic xlink:href="amjpathol00200-0037-a" xlink:role="163"></graphic></fig><fig id="F2"><label>Figure 5</label><graphic xlink:href="amjpathol00200-0038-a" xlink:role="164"></graphic></fig><fig id="F3"><label>Figure 6</label><graphic xlink:href="amjpathol00200-0039-a" xlink:role="165"></graphic></fig><fig id="F4"><label>Figure 7</label><graphic xlink:href="amjpathol00200-0040-a" xlink:role="166"></graphic></fig><fig id="F5"><label>Figure 8</label><graphic xlink:href="amjpathol00200-0040-b" xlink:role="166"></graphic></fig><fig id="F6"><label>Figure 9</label><graphic xlink:href="amjpathol00200-0041-a" xlink:role="167"></graphic></fig><fig id="F7"><label>Figure 10</label><graphic xlink:href="amjpathol00200-0041-b" xlink:role="167"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-title>The American Journal of Pathology</journal-title><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn></journal-meta><article-meta><article-id pub-id-type="pmid">6291396</article-id><article-id pub-id-type="pmc">1916093</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Knobler</surname><given-names>R. L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tunison</surname><given-names>L. A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lampert</surname><given-names>P. W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Oldstone</surname><given-names>M. B.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>11</month><year>1982</year></pub-date><volume>109</volume><issue>2</issue><fpage>157</fpage><lpage>168</lpage><abstract><p>The model system of central nervous system (CNS) disease induced by mouse hepatitis virus type 4 (MHV-4) is explored by comparison of wild type (wt) MHV-4 and two temperature-sensitive (ts) mutants, designated ts8 and ts15, in BALB/c and SJL/J mice. In BALB/c mice, 3 plaque-forming units (PFU) of wt MHV-4 given intracerebrally caused fatal encephalomyelitis in all mice by 7 days after infection, with spread of virus outside the CNS, especially to liver. In SJL/J mice, 3 PFU of wt virus was cleared within 2-3 days, with little spread, and up tp 100 PFU failed to cause fatal encephalomyelitis. However, larger amounts of virus, like 1000 PFU, caused fatal encephalomyelitis in SJL/J mice. In contrast, 10(4) PFU of MHV-4 ts8 did not cause death in either BALB/c or SJL/J mice, and persisted in the CNS of both strains while retaining its ts phenotype. There was significatnly less spread of virus outside the CNS. BALB/c mice usually showed demyelination, remyelination, and recurrent demyelination with ts8, while SJL/J mice only rarely had lesions. Intracerebral inoculation with 10(4) PFU of MHV-4 ts15 was associated with a persistent infection in CNS and liver of BALB/c mice; however, only occasional demyelination and hepatic lesions occurred. TS15 did not cause death in either BALB/c or SJL/J mice and did not cause histopathologic injury in SJL/J mice.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 4</label><graphic xlink:href="amjpathol00200-0037-a" xlink:role="163"></graphic></fig><fig id="F2"><label>Figure 5</label><graphic xlink:href="amjpathol00200-0038-a" xlink:role="164"></graphic></fig><fig id="F3"><label>Figure 6</label><graphic xlink:href="amjpathol00200-0039-a" xlink:role="165"></graphic></fig><fig id="F4"><label>Figure 7</label><graphic xlink:href="amjpathol00200-0040-a" xlink:role="166"></graphic></fig><fig id="F5"><label>Figure 8</label><graphic xlink:href="amjpathol00200-0040-b" xlink:role="166"></graphic></fig><fig id="F6"><label>Figure 9</label><graphic xlink:href="amjpathol00200-0041-a" xlink:role="167"></graphic></fig><fig id="F7"><label>Figure 10</label><graphic xlink:href="amjpathol00200-0041-b" xlink:role="167"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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