New Pre-pandemic Influenza Vaccines: An Egg-and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice
Identifieur interne : 000E82 ( Main/Exploration ); précédent : 000E81; suivant : 000E83New Pre-pandemic Influenza Vaccines: An Egg-and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice
Auteurs : Ma Hoelscher [Géorgie (pays)] ; L. Jayashankar [États-Unis] ; S. Garg [Géorgie (pays)] ; V. Veguilla [Géorgie (pays)] ; N. Singh [États-Unis] ; Jm Katz [Géorgie (pays)] ; Sk Mittal [États-Unis] ; S. Sambhara [Géorgie (pays)]Source :
- Clinical pharmacology and therapeutics [ 0009-9236 ] ; 2007.
Abstract
Highly pathogenic avian H5N1 influenza viruses that are currently circulating in southeast Asia may acquire the potential to cause the next influenza pandemic. A number of alternate approaches are being pursued to generate cross-protective, dose-sparing, safe, and effective vaccines, as traditional vaccine approaches, i.e., embryonated egg-grown, are not immunogenic. We developed a replication-incompetent adenoviral vector-based, adjuvant-and egg-independent pandemic influenza vaccine strategy as a potential alternative to conventional egg-derived vaccines. In this paper, we address suboptimal dose and longevity of vaccine-induced protective immunity and demonstrate that a vaccine dose as little as 1 × 106 plaque-forming unit (PFU) is sufficient to induce protective immune responses against a highly pathogenic H5N1 virus. Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year.
Url:
DOI: 10.1038/sj.clpt.6100418
PubMed: 17957181
PubMed Central: 2793094
Affiliations:
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Sambhara</name><affiliation wicri:level="1"><nlm:aff id="A1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical pharmacology and therapeutics</title><idno type="ISSN">0009-9236</idno><idno type="eISSN">1532-6535</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Highly pathogenic avian H5N1 influenza viruses that are currently circulating in southeast Asia may acquire the potential to cause the next influenza pandemic. A number of alternate approaches are being pursued to generate cross-protective, dose-sparing, safe, and effective vaccines, as traditional vaccine approaches, i.e., embryonated egg-grown, are not immunogenic. We developed a replication-incompetent adenoviral vector-based, adjuvant-and egg-independent pandemic influenza vaccine strategy as a potential alternative to conventional egg-derived vaccines. In this paper, we address suboptimal dose and longevity of vaccine-induced protective immunity and demonstrate that a vaccine dose as little as 1 × 10<sup>6</sup> plaque-forming unit (PFU) is sufficient to induce protective immune responses against a highly pathogenic H5N1 virus. Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year.</p></div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Hoelscher, Ma" sort="Hoelscher, Ma" uniqKey="Hoelscher M" first="Ma" last="Hoelscher">Ma Hoelscher</name></noRegion><name sortKey="Garg, S" sort="Garg, S" uniqKey="Garg S" first="S" last="Garg">S. Garg</name><name sortKey="Katz, Jm" sort="Katz, Jm" uniqKey="Katz J" first="Jm" last="Katz">Jm Katz</name><name sortKey="Sambhara, S" sort="Sambhara, S" uniqKey="Sambhara S" first="S" last="Sambhara">S. Sambhara</name><name sortKey="Veguilla, V" sort="Veguilla, V" uniqKey="Veguilla V" first="V" last="Veguilla">V. Veguilla</name></country><country name="États-Unis"><region name="Indiana"><name sortKey="Jayashankar, L" sort="Jayashankar, L" uniqKey="Jayashankar L" first="L" last="Jayashankar">L. Jayashankar</name></region><name sortKey="Mittal, Sk" sort="Mittal, Sk" uniqKey="Mittal S" first="Sk" last="Mittal">Sk Mittal</name><name sortKey="Singh, N" sort="Singh, N" uniqKey="Singh N" first="N" last="Singh">N. Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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