New Pre-pandemic Influenza Vaccines: An Egg-and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice
Identifieur interne : 000669 ( Pmc/Checkpoint ); précédent : 000668; suivant : 000670New Pre-pandemic Influenza Vaccines: An Egg-and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice
Auteurs : Ma Hoelscher [Géorgie (pays)] ; L. Jayashankar [États-Unis] ; S. Garg [Géorgie (pays)] ; V. Veguilla [Géorgie (pays)] ; N. Singh [États-Unis] ; Jm Katz [Géorgie (pays)] ; Sk Mittal [États-Unis] ; S. Sambhara [Géorgie (pays)]Source :
- Clinical pharmacology and therapeutics [ 0009-9236 ] ; 2007.
Abstract
Highly pathogenic avian H5N1 influenza viruses that are currently circulating in southeast Asia may acquire the potential to cause the next influenza pandemic. A number of alternate approaches are being pursued to generate cross-protective, dose-sparing, safe, and effective vaccines, as traditional vaccine approaches, i.e., embryonated egg-grown, are not immunogenic. We developed a replication-incompetent adenoviral vector-based, adjuvant-and egg-independent pandemic influenza vaccine strategy as a potential alternative to conventional egg-derived vaccines. In this paper, we address suboptimal dose and longevity of vaccine-induced protective immunity and demonstrate that a vaccine dose as little as 1 × 106 plaque-forming unit (PFU) is sufficient to induce protective immune responses against a highly pathogenic H5N1 virus. Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year.
Url:
DOI: 10.1038/sj.clpt.6100418
PubMed: 17957181
PubMed Central: 2793094
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New Pre-pandemic Influenza Vaccines: An Egg-and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice</title><author><name sortKey="Hoelscher, Ma" sort="Hoelscher, Ma" uniqKey="Hoelscher M" first="Ma" last="Hoelscher">Ma Hoelscher</name><affiliation wicri:level="1"><nlm:aff id="A1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Jayashankar, L" sort="Jayashankar, L" uniqKey="Jayashankar L" first="L" last="Jayashankar">L. Jayashankar</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Garg, S" sort="Garg, S" uniqKey="Garg S" first="S" last="Garg">S. 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Jayashankar</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Garg, S" sort="Garg, S" uniqKey="Garg S" first="S" last="Garg">S. Garg</name><affiliation wicri:level="1"><nlm:aff id="A1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Veguilla, V" sort="Veguilla, V" uniqKey="Veguilla V" first="V" last="Veguilla">V. Veguilla</name><affiliation wicri:level="1"><nlm:aff id="A1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Singh, N" sort="Singh, N" uniqKey="Singh N" first="N" last="Singh">N. Singh</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Katz, Jm" sort="Katz, Jm" uniqKey="Katz J" first="Jm" last="Katz">Jm Katz</name><affiliation wicri:level="1"><nlm:aff id="A1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Mittal, Sk" sort="Mittal, Sk" uniqKey="Mittal S" first="Sk" last="Mittal">Sk Mittal</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette</wicri:cityArea></affiliation></author><author><name sortKey="Sambhara, S" sort="Sambhara, S" uniqKey="Sambhara S" first="S" last="Sambhara">S. Sambhara</name><affiliation wicri:level="1"><nlm:aff id="A1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical pharmacology and therapeutics</title><idno type="ISSN">0009-9236</idno><idno type="eISSN">1532-6535</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Highly pathogenic avian H5N1 influenza viruses that are currently circulating in southeast Asia may acquire the potential to cause the next influenza pandemic. A number of alternate approaches are being pursued to generate cross-protective, dose-sparing, safe, and effective vaccines, as traditional vaccine approaches, i.e., embryonated egg-grown, are not immunogenic. We developed a replication-incompetent adenoviral vector-based, adjuvant-and egg-independent pandemic influenza vaccine strategy as a potential alternative to conventional egg-derived vaccines. In this paper, we address suboptimal dose and longevity of vaccine-induced protective immunity and demonstrate that a vaccine dose as little as 1 × 10<sup>6</sup> plaque-forming unit (PFU) is sufficient to induce protective immune responses against a highly pathogenic H5N1 virus. Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372741</journal-id><journal-id journal-id-type="pubmed-jr-id">3058</journal-id><journal-id journal-id-type="nlm-ta">Clin Pharmacol Ther</journal-id><journal-title>Clinical pharmacology and therapeutics</journal-title><issn pub-type="ppub">0009-9236</issn><issn pub-type="epub">1532-6535</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17957181</article-id><article-id pub-id-type="pmc">2793094</article-id><article-id pub-id-type="doi">10.1038/sj.clpt.6100418</article-id><article-id pub-id-type="manuscript">NIHMS116548</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>New Pre-pandemic Influenza Vaccines: An Egg-and Adjuvant-independent Human Adenoviral Vector Strategy Induces Long-lasting Protective Immune Responses in Mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hoelscher</surname><given-names>MA</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">3</xref></contrib><contrib contrib-type="author"><name><surname>Jayashankar</surname><given-names>L</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">3</xref></contrib><contrib contrib-type="author"><name><surname>Garg</surname><given-names>S</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Veguilla</surname><given-names>V</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>XLu</surname></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Singh</surname><given-names>N</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Katz</surname><given-names>JM</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mittal</surname><given-names>SK</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sambhara</surname><given-names>S</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</aff><aff id="A2"><label>2</label>Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana</aff><author-notes><corresp id="cor1">Correspondence: S Sambhara (<email>ssambhara@cdc.gov</email>) or SK Mittal (<email>mittal@purdue.edu</email>)</corresp><fn id="FN1" fn-type="equal"><label>3</label><p id="P1">These authors contributed equally to this work.</p></fn><fn id="FN3" fn-type="conflict"><p id="P21"><bold>CONFLICT OF INTEREST</bold></p><p id="P22">The authors declared no conflict of interest.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>24</day><month>10</month><year>2007</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>12</month><year>2009</year></pub-date><volume>82</volume><issue>6</issue><fpage>665</fpage><lpage>671</lpage><abstract><p id="P2">Highly pathogenic avian H5N1 influenza viruses that are currently circulating in southeast Asia may acquire the potential to cause the next influenza pandemic. A number of alternate approaches are being pursued to generate cross-protective, dose-sparing, safe, and effective vaccines, as traditional vaccine approaches, i.e., embryonated egg-grown, are not immunogenic. We developed a replication-incompetent adenoviral vector-based, adjuvant-and egg-independent pandemic influenza vaccine strategy as a potential alternative to conventional egg-derived vaccines. In this paper, we address suboptimal dose and longevity of vaccine-induced protective immunity and demonstrate that a vaccine dose as little as 1 × 10<sup>6</sup> plaque-forming unit (PFU) is sufficient to induce protective immune responses against a highly pathogenic H5N1 virus. Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year.</p></abstract><contract-num rid="AI1">R01 AI059374-04
||AI</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Hoelscher, Ma" sort="Hoelscher, Ma" uniqKey="Hoelscher M" first="Ma" last="Hoelscher">Ma Hoelscher</name></noRegion><name sortKey="Garg, S" sort="Garg, S" uniqKey="Garg S" first="S" last="Garg">S. Garg</name><name sortKey="Katz, Jm" sort="Katz, Jm" uniqKey="Katz J" first="Jm" last="Katz">Jm Katz</name><name sortKey="Sambhara, S" sort="Sambhara, S" uniqKey="Sambhara S" first="S" last="Sambhara">S. Sambhara</name><name sortKey="Veguilla, V" sort="Veguilla, V" uniqKey="Veguilla V" first="V" last="Veguilla">V. Veguilla</name></country><country name="États-Unis"><region name="Indiana"><name sortKey="Jayashankar, L" sort="Jayashankar, L" uniqKey="Jayashankar L" first="L" last="Jayashankar">L. Jayashankar</name></region><name sortKey="Mittal, Sk" sort="Mittal, Sk" uniqKey="Mittal S" first="Sk" last="Mittal">Sk Mittal</name><name sortKey="Singh, N" sort="Singh, N" uniqKey="Singh N" first="N" last="Singh">N. Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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