Interferon‐gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients
Identifieur interne : 000602 ( Istex/Curation ); précédent : 000601; suivant : 000603Interferon‐gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients
Auteurs : D. Vu [États-Unis] ; T. Shah [États-Unis] ; J. Ansari [États-Unis] ; P. Sakharkar [États-Unis] ; Q. Yasir [États-Unis] ; R. Naraghi [États-Unis] ; I. Hutchinson [États-Unis] ; D. Min [États-Unis]Source :
- Transplant Infectious Disease [ 1398-2273 ] ; 2014-10.
Abstract
Background: Cytomegalovirus (CMV) is the most common cause of viral infection, causing morbidity and mortality among renal transplant recipients (RTRs). Cytokines such as tumor necrosis factor‐alpha (TNF‐α), interleukin‐10 (IL‐10), and interferon‐gamma (IFN‐γ) have been shown to possess antiviral properties, and their polymorphisms are associated with disease outcome. The aim was to investigate the association of gene polymorphisms in IL‐10, IFN‐γ, and TNF‐α with CMV infection in RTRs. Methods: IL‐10 −1082 A>G, −592 A>C; TNF‐α −308 A>G; and IFN‐γ +874 A>T gene polymorphisms were studied in 247 Hispanic RTRs (52 RTRs with CMV infection and 195 without CMV infection), using DNA‐based polymerase chain reaction with sequence‐specific primers and restriction. Results: Median time to CMV infection was 8 months, with a mean peak CMV viral load of 25,314 copies/mL. Patients with donor‐positive/recipient‐negative (D+/R−) serostatus were found to be associated with a high risk of CMV infection (P = 0.001). A statistically significant correlation was found between IFN‐γ +874 A>T polymorphism and the risk of CMV infection. The IFN‐γ +874 AA genotype was associated with a 3.4‐fold increased risk for the CMV‐infected group compared to the non‐CMV group (odds ratio = 3.4, 95% confidence interval = 1.24–9.34, P = 0.01). The association was independently significant in multiple logistic regression (P = 0.01), along with serologic status D+/R−, acute rejection, and anti‐thymocyte globulin induction. The allelic as well as genotypic frequencies of TNF‐α and IL‐10 did not significantly differ between the CMV‐infection group and the control group. Individuals with IFN‐γ +874 AT and AA genotypes exhibited higher risk of allograft loss. Conclusion: This study suggested that RTRs with variant homozygous IFN‐γ AA genotype were at risk of CMV infection, whereas the high producer IFN‐γ +874 TT genotype appears to be associated with lower risk of CMV infection.
Url:
DOI: 10.1111/tid.12285
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000622
Links to Exploration step
ISTEX:CE601EA00FEC6453E4ADFC7EAD20DCDF930FDBC5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interferon‐gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients</title><author><name sortKey="Vu, D" sort="Vu, D" uniqKey="Vu D" first="D." last="Vu">D. Vu</name><affiliation wicri:level="1"><mods:affiliation>Mendez National Institute of Transplantation, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mendez National Institute of Transplantation, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, Pomona, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, Pomona, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Transplant Research Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Transplant Research Institute, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, California, Los Angeles</wicri:regionArea></affiliation><affiliation><mods:affiliation>Correspondence to:David Min, Western University of Health Sciences, 309 E. 2nd Street, Pomona, CA 91766, USATel: 1 (909) 469‐5602Fax: 1 (909) 469‐5539E‐mail: (or)Don Vu, Transplant Research Institute, 2200 West Third Street, Suite 500, Los Angeles, CA 90057, USATel: 1 (714) 548‐4372Fax: 1 (213) 384‐4872E‐mail:</mods:affiliation><wicri:noCountry code="subField">384‐4872E‐mail:</wicri:noCountry></affiliation><affiliation><mods:affiliation>E-mail: dmin@westernu.edudonduyvu@yahoo.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: dmin@westernu.edudonduyvu@yahoo.com</wicri:noCountry></affiliation></author><author><name sortKey="Shah, T" sort="Shah, T" uniqKey="Shah T" first="T." last="Shah">T. Shah</name><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, Pomona, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, Pomona, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Transplant Research Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Transplant Research Institute, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Southern California, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, California, Los Angeles</wicri:regionArea></affiliation></author><author><name sortKey="Ansari, J" sort="Ansari, J" uniqKey="Ansari J" first="J." last="Ansari">J. Ansari</name><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, California, Pomona, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, California, Pomona</wicri:regionArea></affiliation></author><author><name sortKey="Sakharkar, P" sort="Sakharkar, P" uniqKey="Sakharkar P" first="P." last="Sakharkar">P. Sakharkar</name><affiliation wicri:level="1"><mods:affiliation>Roosevelt University College of Pharmacy, Illinois, Schaumburg, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roosevelt University College of Pharmacy, Illinois, Schaumburg</wicri:regionArea></affiliation></author><author><name sortKey="Yasir, Q" sort="Yasir, Q" uniqKey="Yasir Q" first="Q." last="Yasir">Q. Yasir</name><affiliation wicri:level="1"><mods:affiliation>Roosevelt University College of Pharmacy, Illinois, Schaumburg, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roosevelt University College of Pharmacy, Illinois, Schaumburg</wicri:regionArea></affiliation></author><author><name sortKey="Naraghi, R" sort="Naraghi, R" uniqKey="Naraghi R" first="R." last="Naraghi">R. Naraghi</name><affiliation wicri:level="1"><mods:affiliation>Transplant Research Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Transplant Research Institute, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, California, Los Angeles</wicri:regionArea></affiliation></author><author><name sortKey="Hutchinson, I" sort="Hutchinson, I" uniqKey="Hutchinson I" first="I." last="Hutchinson">I. Hutchinson</name><affiliation wicri:level="1"><mods:affiliation>Mendez National Institute of Transplantation, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mendez National Institute of Transplantation, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Southern California, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, California, Los Angeles</wicri:regionArea></affiliation></author><author><name sortKey="Min, D" sort="Min, D" uniqKey="Min D" first="D." last="Min">D. Min</name><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, Pomona, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, Pomona, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, California, Los Angeles</wicri:regionArea></affiliation><affiliation><mods:affiliation>Correspondence to:David Min, Western University of Health Sciences, 309 E. 2nd Street, Pomona, CA 91766, USATel: 1 (909) 469‐5602Fax: 1 (909) 469‐5539E‐mail: (or)Don Vu, Transplant Research Institute, 2200 West Third Street, Suite 500, Los Angeles, CA 90057, USATel: 1 (714) 548‐4372Fax: 1 (213) 384‐4872E‐mail:</mods:affiliation><wicri:noCountry code="subField">384‐4872E‐mail:</wicri:noCountry></affiliation><affiliation><mods:affiliation>E-mail: dmin@westernu.edudonduyvu@yahoo.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: dmin@westernu.edudonduyvu@yahoo.com</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CE601EA00FEC6453E4ADFC7EAD20DCDF930FDBC5</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1111/tid.12285</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-M68BN5H9-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000622</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000622</idno><idno type="wicri:Area/Istex/Curation">000602</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Interferon‐gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients</title><author><name sortKey="Vu, D" sort="Vu, D" uniqKey="Vu D" first="D." last="Vu">D. Vu</name><affiliation wicri:level="1"><mods:affiliation>Mendez National Institute of Transplantation, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mendez National Institute of Transplantation, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, Pomona, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, Pomona, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Transplant Research Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Transplant Research Institute, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, California, Los Angeles</wicri:regionArea></affiliation><affiliation><mods:affiliation>Correspondence to:David Min, Western University of Health Sciences, 309 E. 2nd Street, Pomona, CA 91766, USATel: 1 (909) 469‐5602Fax: 1 (909) 469‐5539E‐mail: (or)Don Vu, Transplant Research Institute, 2200 West Third Street, Suite 500, Los Angeles, CA 90057, USATel: 1 (714) 548‐4372Fax: 1 (213) 384‐4872E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: dmin@westernu.edudonduyvu@yahoo.com</mods:affiliation></affiliation></author><author><name sortKey="Shah, T" sort="Shah, T" uniqKey="Shah T" first="T." last="Shah">T. Shah</name><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, Pomona, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, Pomona, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Transplant Research Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Transplant Research Institute, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Southern California, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, California, Los Angeles</wicri:regionArea></affiliation></author><author><name sortKey="Ansari, J" sort="Ansari, J" uniqKey="Ansari J" first="J." last="Ansari">J. Ansari</name><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, California, Pomona, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, California, Pomona</wicri:regionArea></affiliation></author><author><name sortKey="Sakharkar, P" sort="Sakharkar, P" uniqKey="Sakharkar P" first="P." last="Sakharkar">P. Sakharkar</name><affiliation wicri:level="1"><mods:affiliation>Roosevelt University College of Pharmacy, Illinois, Schaumburg, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roosevelt University College of Pharmacy, Illinois, Schaumburg</wicri:regionArea></affiliation></author><author><name sortKey="Yasir, Q" sort="Yasir, Q" uniqKey="Yasir Q" first="Q." last="Yasir">Q. Yasir</name><affiliation wicri:level="1"><mods:affiliation>Roosevelt University College of Pharmacy, Illinois, Schaumburg, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roosevelt University College of Pharmacy, Illinois, Schaumburg</wicri:regionArea></affiliation></author><author><name sortKey="Naraghi, R" sort="Naraghi, R" uniqKey="Naraghi R" first="R." last="Naraghi">R. Naraghi</name><affiliation wicri:level="1"><mods:affiliation>Transplant Research Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Transplant Research Institute, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, California, Los Angeles</wicri:regionArea></affiliation></author><author><name sortKey="Hutchinson, I" sort="Hutchinson, I" uniqKey="Hutchinson I" first="I." last="Hutchinson">I. Hutchinson</name><affiliation wicri:level="1"><mods:affiliation>Mendez National Institute of Transplantation, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mendez National Institute of Transplantation, Los Angeles, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Southern California, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, California, Los Angeles</wicri:regionArea></affiliation></author><author><name sortKey="Min, D" sort="Min, D" uniqKey="Min D" first="D." last="Min">D. Min</name><affiliation wicri:level="1"><mods:affiliation>Western University of Health Sciences, Pomona, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Western University of Health Sciences, Pomona, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>St. Vincent Medical Center, California, Los Angeles, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Vincent Medical Center, California, Los Angeles</wicri:regionArea></affiliation><affiliation><mods:affiliation>Correspondence to:David Min, Western University of Health Sciences, 309 E. 2nd Street, Pomona, CA 91766, USATel: 1 (909) 469‐5602Fax: 1 (909) 469‐5539E‐mail: (or)Don Vu, Transplant Research Institute, 2200 West Third Street, Suite 500, Los Angeles, CA 90057, USATel: 1 (714) 548‐4372Fax: 1 (213) 384‐4872E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: dmin@westernu.edudonduyvu@yahoo.com</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Transplant Infectious Disease</title><title level="j" type="alt">TRANSPLANT INFECTIOUS DISEASE</title><idno type="ISSN">1398-2273</idno><idno type="eISSN">1399-3062</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="724">724</biblScope><biblScope unit="page" to="732">732</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2014-10">2014-10</date></imprint><idno type="ISSN">1398-2273</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1398-2273</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Cytomegalovirus (CMV) is the most common cause of viral infection, causing morbidity and mortality among renal transplant recipients (RTRs). Cytokines such as tumor necrosis factor‐alpha (TNF‐α), interleukin‐10 (IL‐10), and interferon‐gamma (IFN‐γ) have been shown to possess antiviral properties, and their polymorphisms are associated with disease outcome. The aim was to investigate the association of gene polymorphisms in IL‐10, IFN‐γ, and TNF‐α with CMV infection in RTRs. Methods: IL‐10 −1082 A>G, −592 A>C; TNF‐α −308 A>G; and IFN‐γ +874 A>T gene polymorphisms were studied in 247 Hispanic RTRs (52 RTRs with CMV infection and 195 without CMV infection), using DNA‐based polymerase chain reaction with sequence‐specific primers and restriction. Results: Median time to CMV infection was 8 months, with a mean peak CMV viral load of 25,314 copies/mL. Patients with donor‐positive/recipient‐negative (D+/R−) serostatus were found to be associated with a high risk of CMV infection (P = 0.001). A statistically significant correlation was found between IFN‐γ +874 A>T polymorphism and the risk of CMV infection. The IFN‐γ +874 AA genotype was associated with a 3.4‐fold increased risk for the CMV‐infected group compared to the non‐CMV group (odds ratio = 3.4, 95% confidence interval = 1.24–9.34, P = 0.01). The association was independently significant in multiple logistic regression (P = 0.01), along with serologic status D+/R−, acute rejection, and anti‐thymocyte globulin induction. The allelic as well as genotypic frequencies of TNF‐α and IL‐10 did not significantly differ between the CMV‐infection group and the control group. Individuals with IFN‐γ +874 AT and AA genotypes exhibited higher risk of allograft loss. Conclusion: This study suggested that RTRs with variant homozygous IFN‐γ AA genotype were at risk of CMV infection, whereas the high producer IFN‐γ +874 TT genotype appears to be associated with lower risk of CMV infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000602 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000602 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:CE601EA00FEC6453E4ADFC7EAD20DCDF930FDBC5
|texte= Interferon‐gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients
}}
| This area was generated with Dilib version V0.6.33. |  |