The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model
Identifieur interne : 000249 ( Istex/Curation ); précédent : 000248; suivant : 000250The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model
Auteurs : P. Wen [États-Unis] ; J. S. Loeffler [États-Unis] ; J. H. Morris [États-Unis] ; L. A. Lampson [États-Unis]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1990.
English descriptors
- Teeft :
- Additional controls, Brain tumors, Class cells, Future studies, Gliosarcoma, Gliosarcoma brain tumor model, High doses, Immune parameters, Lampson, Leucocytic infiltration, Lymphocyte subsets, Lymphocytic, Lymphocytic infiltration, Major histocompatibility, Malignant glioma, Malignant gliomas, Negative control, Neural cells, Normal goat serum, Parietal lobes, Positive cells, Positive controls, Radiation therapy, Significant change, Single dose, Unirradiated rats.
Abstract
Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.
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DOI: 10.1016/0165-5728(90)90074-W
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Morris</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115</wicri:regionArea></affiliation></author><author><name sortKey="Lampson, L A" sort="Lampson, L A" uniqKey="Lampson L" first="L. A." last="Lampson">L. A. Lampson</name><affiliation wicri:level="1"><mods:affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="239">239</biblScope><biblScope unit="page" to="244">244</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Additional controls</term><term>Brain tumors</term><term>Class cells</term><term>Future studies</term><term>Gliosarcoma</term><term>Gliosarcoma brain tumor model</term><term>High doses</term><term>Immune parameters</term><term>Lampson</term><term>Leucocytic infiltration</term><term>Lymphocyte subsets</term><term>Lymphocytic</term><term>Lymphocytic infiltration</term><term>Major histocompatibility</term><term>Malignant glioma</term><term>Malignant gliomas</term><term>Negative control</term><term>Neural cells</term><term>Normal goat serum</term><term>Parietal lobes</term><term>Positive cells</term><term>Positive controls</term><term>Radiation therapy</term><term>Significant change</term><term>Single dose</term><term>Unirradiated rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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