The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model
Identifieur interne : 000269 ( Istex/Corpus ); précédent : 000268; suivant : 000270The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model
Auteurs : P. Wen ; J. S. Loeffler ; J. H. Morris ; L. A. LampsonSource :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1990.
English descriptors
- Teeft :
- Additional controls, Brain tumors, Class cells, Future studies, Gliosarcoma, Gliosarcoma brain tumor model, High doses, Immune parameters, Lampson, Leucocytic infiltration, Lymphocyte subsets, Lymphocytic, Lymphocytic infiltration, Major histocompatibility, Malignant glioma, Malignant gliomas, Negative control, Neural cells, Normal goat serum, Parietal lobes, Positive cells, Positive controls, Radiation therapy, Significant change, Single dose, Unirradiated rats.
Abstract
Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.
Url:
DOI: 10.1016/0165-5728(90)90074-W
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ISTEX:B5EBE4113D374B4DE770BAB3F24F4077143793B5Le document en format XML
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Morris</name><affiliation><mods:affiliation>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Lampson, L A" sort="Lampson, L A" uniqKey="Lampson L" first="L. A." last="Lampson">L. A. Lampson</name><affiliation><mods:affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B5EBE4113D374B4DE770BAB3F24F4077143793B5</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1016/0165-5728(90)90074-W</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-FPLW00GX-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000269</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000269</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model</title><author><name sortKey="Wen, P" sort="Wen, P" uniqKey="Wen P" first="P." last="Wen">P. Wen</name><affiliation><mods:affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Loeffler, J S" sort="Loeffler, J S" uniqKey="Loeffler J" first="J. S." last="Loeffler">J. S. Loeffler</name><affiliation><mods:affiliation>The Joint Center for Radiation Therapy Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Morris, J H" sort="Morris, J H" uniqKey="Morris J" first="J. H." last="Morris">J. H. Morris</name><affiliation><mods:affiliation>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Lampson, L A" sort="Lampson, L A" uniqKey="Lampson L" first="L. A." last="Lampson">L. A. Lampson</name><affiliation><mods:affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="239">239</biblScope><biblScope unit="page" to="244">244</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Additional controls</term><term>Brain tumors</term><term>Class cells</term><term>Future studies</term><term>Gliosarcoma</term><term>Gliosarcoma brain tumor model</term><term>High doses</term><term>Immune parameters</term><term>Lampson</term><term>Leucocytic infiltration</term><term>Lymphocyte subsets</term><term>Lymphocytic</term><term>Lymphocytic infiltration</term><term>Major histocompatibility</term><term>Malignant glioma</term><term>Malignant gliomas</term><term>Negative control</term><term>Neural cells</term><term>Normal goat serum</term><term>Parietal lobes</term><term>Positive cells</term><term>Positive controls</term><term>Radiation therapy</term><term>Significant change</term><term>Single dose</term><term>Unirradiated rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>gliosarcoma</json:string><json:string>lymphocytic infiltration</json:string><json:string>lampson</json:string><json:string>lymphocytic</json:string><json:string>class cells</json:string><json:string>gliosarcoma brain tumor model</json:string><json:string>radiation therapy</json:string><json:string>parietal lobes</json:string><json:string>major histocompatibility</json:string><json:string>leucocytic infiltration</json:string><json:string>malignant gliomas</json:string><json:string>brain tumors</json:string><json:string>normal goat serum</json:string><json:string>significant change</json:string><json:string>single dose</json:string><json:string>high doses</json:string><json:string>unirradiated rats</json:string><json:string>additional controls</json:string><json:string>immune parameters</json:string><json:string>positive controls</json:string><json:string>future studies</json:string><json:string>positive cells</json:string><json:string>malignant glioma</json:string><json:string>lymphocyte subsets</json:string><json:string>neural cells</json:string><json:string>negative control</json:string></teeft></keywords><author><json:item><name>P. Wen</name><affiliations><json:string>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</json:string></affiliations></json:item><json:item><name>J.S. Loeffler</name><affiliations><json:string>The Joint Center for Radiation Therapy Harvard Medical School, Boston, MA 02115, U.S.A.</json:string></affiliations></json:item><json:item><name>J.H. Morris</name><affiliations><json:string>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</json:string></affiliations></json:item><json:item><name>L.A. Lampson</name><affiliations><json:string>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Irradiation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Major histocompatibility complex antigen</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lymphocytic infiltration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Brain tumor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>9L gliosarcoma</value></json:item></subject><arkIstex>ark:/67375/6H6-FPLW00GX-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.</abstract><qualityIndicators><score>6.076</score><pdfWordCount>2840</pdfWordCount><pdfCharCount>15020</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>533 x 742 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>103</abstractWordCount><abstractCharCount>744</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model</title><pmid><json:string>2332484</json:string></pmid><pii><json:string>0165-5728(90)90074-W</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Proc. Natl. Acad. Sci. 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The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">J.S.</forename><surname>Loeffler</surname></persName><affiliation>The Joint Center for Radiation Therapy Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J.H.</forename><surname>Morris</surname></persName><affiliation>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">L.A.</forename><surname>Lampson</surname></persName><affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation></author><idno type="istex">B5EBE4113D374B4DE770BAB3F24F4077143793B5</idno><idno type="ark">ark:/67375/6H6-FPLW00GX-8</idno><idno type="DOI">10.1016/0165-5728(90)90074-W</idno><idno type="PII">0165-5728(90)90074-W</idno></analytic><monogr><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="pISSN">0165-5728</idno><idno type="PII">S0165-5728(00)X0160-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990"></date><biblScope unit="volume">27</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="239">239</biblScope><biblScope unit="page" to="244">244</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Irradiation</term></item><item><term>Major histocompatibility complex antigen</term></item><item><term>Lymphocytic infiltration</term></item><item><term>Brain tumor</term></item><item><term>9L gliosarcoma</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-01-16">Modified</change><change when="1990">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FPLW00GX-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNI</jid><aid>9090074W</aid><ce:pii>0165-5728(90)90074-W</ce:pii><ce:doi>10.1016/0165-5728(90)90074-W</ce:doi><ce:copyright type="unknown" year="1990"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model</ce:title><ce:author-group><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Wen</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.S.</ce:given-name><ce:surname>Loeffler</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.H.</ce:given-name><ce:surname>Morris</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>L.A.</ce:given-name><ce:surname>Lampson</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>The Joint Center for Radiation Therapy Harvard Medical School, Boston, MA 02115, U.S.A.</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for correspondence: Patrick Wen, M.D. Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115, U.S.A.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="4" month="10" year="1989"></ce:date-received><ce:date-revised day="16" month="1" year="1990"></ce:date-revised><ce:date-accepted day="16" month="1" year="1991"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Irradiation</ce:text></ce:keyword><ce:keyword><ce:text>Major histocompatibility complex antigen</ce:text></ce:keyword><ce:keyword><ce:text>Lymphocytic infiltration</ce:text></ce:keyword><ce:keyword><ce:text>Brain tumor</ce:text></ce:keyword><ce:keyword><ce:text>9L gliosarcoma</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Wen</namePart><affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation><description>Address for correspondence: Patrick Wen, M.D. Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115, U.S.A.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.S.</namePart><namePart type="family">Loeffler</namePart><affiliation>The Joint Center for Radiation Therapy Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.H.</namePart><namePart type="family">Morris</namePart><affiliation>Department of Pathology; Brigham and Women's Hospital; and the Department of Neurology, Radiation Therapy and Pathology, Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.A.</namePart><namePart type="family">Lampson</namePart><affiliation>The Brain Tumor Group; The Center for Neurologic Diseases, Division of Neurology, Department of Medecine Harvard Medical School, Boston, MA 02115, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1990</dateIssued><dateModified encoding="w3cdtf">1990-01-16</dateModified><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.</abstract><note type="content">Section title: Short communication</note><subject><genre>Keywords</genre><topic>Irradiation</topic><topic>Major histocompatibility complex antigen</topic><topic>Lymphocytic infiltration</topic><topic>Brain tumor</topic><topic>9L gliosarcoma</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroimmunology</title></titleInfo><titleInfo type="abbreviated"><title>JNI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1990</dateIssued></originInfo><identifier type="ISSN">0165-5728</identifier><identifier type="PII">S0165-5728(00)X0160-9</identifier><part><date>1990</date><detail type="volume"><number>27</number><caption>vol.</caption></detail><detail type="issue"><number>2–3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>89</start><end>254</end></extent><extent unit="pages"><start>239</start><end>244</end></extent></part></relatedItem><identifier type="istex">B5EBE4113D374B4DE770BAB3F24F4077143793B5</identifier><identifier type="ark">ark:/67375/6H6-FPLW00GX-8</identifier><identifier type="DOI">10.1016/0165-5728(90)90074-W</identifier><identifier type="PII">0165-5728(90)90074-W</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FPLW00GX-8/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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