Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea
Identifieur interne : 000185 ( Istex/Curation ); précédent : 000184; suivant : 000186Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea
Auteurs : Keren Yeshuroon-Koffler [Israël] ; Yonat Shemer-Avni [Israël] ; Ayelet Keren-Naus [Israël] ; Aviv D. Goldbart [Israël]Source :
- Pediatric Pulmonology [ 8755-6863 ] ; 2015-02.
Abstract
Background: Early life viral infection is associated with neurogenic inflammation that is present in lymphoid tissues of the upper airway in children with obstructive sleep apnea (OSA). We hypothesized that viral genomic material is present in tonsils of children with OSA. Therefore, we examined tonsils for the presence of respiratory viruses' nucleic acids in children with OSA, and in children without OSA (undergoing surgery for recurrent throat infections (RI)). Methods: Tonsillar tissue from patients with OSA and RI was subjected to multiplex quantitative real time reverse transcription PCR (mqRTPCR), analyzed for the presence of common respiratory viruses' genetic material. Results: Fifty‐six patients were included, of whom 34 had OSA (age (years ± S.D), 4.22 ± 1.14) and 22 with RI (4.35 ± 1.36). Respiratory viruses nucleic acids (24 detections) were observed in 17 (50%) OSA samples. In contrast, no virus was detected in RI samples (relative frequency P < 0.0001). Viruses detected, based on frequency were Rhinovirus, Adenovirus, human metapneumovirus (hMPV), respiratory syncytial virus (RSV), and corona virus. Conclusions: Respiratory viruses are detected in OSA hypertrophic tonsils, suggestive of their role in the evolution of tonsillar inflammation and hypertrophy. Early life viral infections may contribute to the pathogenesis of pediatric OSA. Pediatr Pulmonol. 2015; 50:187–195. © 2014 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/ppul.23005
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000205
Links to Exploration step
ISTEX:5A13E24E828C57CC47F8A01C795173EFB31AB2FCLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea</title>
<author><name sortKey="Yeshuroon Offler, Keren" sort="Yeshuroon Offler, Keren" uniqKey="Yeshuroon Offler K" first="Keren" last="Yeshuroon-Koffler">Keren Yeshuroon-Koffler</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shemer Vni, Yonat" sort="Shemer Vni, Yonat" uniqKey="Shemer Vni Y" first="Yonat" last="Shemer-Avni">Yonat Shemer-Avni</name>
<affiliation wicri:level="1"><mods:affiliation>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Keren Aus, Ayelet" sort="Keren Aus, Ayelet" uniqKey="Keren Aus A" first="Ayelet" last="Keren-Naus">Ayelet Keren-Naus</name>
<affiliation wicri:level="1"><mods:affiliation>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldbart, Aviv D" sort="Goldbart, Aviv D" uniqKey="Goldbart A" first="Aviv D." last="Goldbart">Aviv D. Goldbart</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Sleep wake disorders unit, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sleep wake disorders unit, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: avivgold@bgu.ac.il</mods:affiliation>
<country wicri:rule="url">Israël</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5A13E24E828C57CC47F8A01C795173EFB31AB2FC</idno>
<date when="2015" year="2015">2015</date>
<idno type="doi">10.1002/ppul.23005</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-ZNF9K59S-8/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000205</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000205</idno>
<idno type="wicri:Area/Istex/Curation">000185</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea</title>
<author><name sortKey="Yeshuroon Offler, Keren" sort="Yeshuroon Offler, Keren" uniqKey="Yeshuroon Offler K" first="Keren" last="Yeshuroon-Koffler">Keren Yeshuroon-Koffler</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shemer Vni, Yonat" sort="Shemer Vni, Yonat" uniqKey="Shemer Vni Y" first="Yonat" last="Shemer-Avni">Yonat Shemer-Avni</name>
<affiliation wicri:level="1"><mods:affiliation>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Keren Aus, Ayelet" sort="Keren Aus, Ayelet" uniqKey="Keren Aus A" first="Ayelet" last="Keren-Naus">Ayelet Keren-Naus</name>
<affiliation wicri:level="1"><mods:affiliation>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Clinical Virology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Microbiology, Immunology and Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, Beer Sheva</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldbart, Aviv D" sort="Goldbart, Aviv D" uniqKey="Goldbart A" first="Aviv D." last="Goldbart">Aviv D. Goldbart</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Sleep wake disorders unit, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sleep wake disorders unit, Soroka University Medical Center, Faculty of Health Sciences, Ben‐Gurion University of the Negev, 84101, Beer Sheva</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: avivgold@bgu.ac.il</mods:affiliation>
<country wicri:rule="url">Israël</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Pediatric Pulmonology</title>
<title level="j" type="alt">PEDIATRIC PULMONOLOGY</title>
<idno type="ISSN">8755-6863</idno>
<idno type="eISSN">1099-0496</idno>
<imprint><biblScope unit="vol">50</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="187">187</biblScope>
<biblScope unit="page" to="195">195</biblScope>
<biblScope unit="page-count">9</biblScope>
<date type="published" when="2015-02">2015-02</date>
</imprint>
<idno type="ISSN">8755-6863</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">8755-6863</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Early life viral infection is associated with neurogenic inflammation that is present in lymphoid tissues of the upper airway in children with obstructive sleep apnea (OSA). We hypothesized that viral genomic material is present in tonsils of children with OSA. Therefore, we examined tonsils for the presence of respiratory viruses' nucleic acids in children with OSA, and in children without OSA (undergoing surgery for recurrent throat infections (RI)). Methods: Tonsillar tissue from patients with OSA and RI was subjected to multiplex quantitative real time reverse transcription PCR (mqRTPCR), analyzed for the presence of common respiratory viruses' genetic material. Results: Fifty‐six patients were included, of whom 34 had OSA (age (years ± S.D), 4.22 ± 1.14) and 22 with RI (4.35 ± 1.36). Respiratory viruses nucleic acids (24 detections) were observed in 17 (50%) OSA samples. In contrast, no virus was detected in RI samples (relative frequency P < 0.0001). Viruses detected, based on frequency were Rhinovirus, Adenovirus, human metapneumovirus (hMPV), respiratory syncytial virus (RSV), and corona virus. Conclusions: Respiratory viruses are detected in OSA hypertrophic tonsils, suggestive of their role in the evolution of tonsillar inflammation and hypertrophy. Early life viral infections may contribute to the pathogenesis of pediatric OSA. Pediatr Pulmonol. 2015; 50:187–195. © 2014 Wiley Periodicals, Inc.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000185 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000185 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:5A13E24E828C57CC47F8A01C795173EFB31AB2FC |texte= Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea }}
This area was generated with Dilib version V0.6.33. |