The murine coronavirus as a model of trafficking and assembly of viral proteins in neural tissue
Identifieur interne : 000138 ( Istex/Curation ); précédent : 000137; suivant : 000139The murine coronavirus as a model of trafficking and assembly of viral proteins in neural tissue
Auteurs : Kishna Kalicharran [Canada] ; Samuel Dales [Canada]Source :
- Trends in Microbiology [ 0966-842X ] ; 1996.
English descriptors
- Teeft :
- Axonal, Bioi, Cell bioi, Disease process, Dissemination, Ecretory pathway, Ependymal cells, Hippocampal, Hippocampal neurons, Inoculation, Intracranial inoculation, Intranasal inoculation, Jhmv, Microtubule, Murine coronavirus, Natl acad, Neuron, Neuronal, Neuronal cells, Neuronal surface, Progeny virions, Same neurons, Scale bars, Secondary antibodies, Sequence identities, Sequence similarities, Trafficking, Viral, Viral components, Virion, Virol, Virology.
Abstract
Abstract: The replication of JHM, a murine coronavirus, provides a useful model of the assembly and dissemination of viral components in neuronal cells. Involvement of microtubules in virus trafficking is an important feature which may explain dissemination of the infection from primary cell targets at olfactory, hippocampal and cerebellar sites within the central nervous system, resulting in severe neuropathies.
Url:
DOI: 10.1016/0966-842X(96)10045-7
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<front><div type="abstract" xml:lang="en">Abstract: The replication of JHM, a murine coronavirus, provides a useful model of the assembly and dissemination of viral components in neuronal cells. Involvement of microtubules in virus trafficking is an important feature which may explain dissemination of the infection from primary cell targets at olfactory, hippocampal and cerebellar sites within the central nervous system, resulting in severe neuropathies.</div>
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