Antibody against viruses in maternal and cord sera: non-specific inhibitors are found to higher titre on the maternal side of the circulation
Identifieur interne : 000095 ( Istex/Curation ); précédent : 000094; suivant : 000096Antibody against viruses in maternal and cord sera: non-specific inhibitors are found to higher titre on the maternal side of the circulation
Auteurs : P. D. Griffiths ; D. Girdhar ; S. Fisher-Hoch ; M. W. Race ; R. B. HeathSource :
- Journal of Hygiene [ 0022-1724 ] ; 1984-06.
Abstract
Pregnancies were identified in which maternal IgG antibodies against rubella virus were not detectable by single radial haemolysis. Twenty paired maternal/cord sera were then tested for haemagglutination-inhibiting (HI) activity against rubella virus without kaolin pretreatment of the sera. In the absence of specific antibody, the HI activity observed could thus be ascribed to the effect of non-specific inhibitors. The HI activity in maternal sera was significantly (P < 0·001) higher than that in cord sera. The 20 pairs of sera were similarly tested against a bunyavirus, an alphavirus and a flavivirus, both with and without kaolin pretreatment. The results showed non-specific inhibitors were found to higher titre in maternal sera, with the difference being statistically significant (P < 0·001) for each of the three viruses.
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DOI: 10.1017/S0022172400064536
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P. D. Griffiths<affiliation><mods:affiliation>Present address: Virus Laboratory, Royal Free Hospital Medical School, London, NW3.</mods:affiliation><wicri:noCountry code="subField">NW3.</wicri:noCountry></affiliation><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation><affiliation><mods:affiliation>Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4 0JG</mods:affiliation><wicri:noCountry code="subField">0JG</wicri:noCountry></affiliation><affiliation><mods:affiliation>Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4 0JG</mods:affiliation><wicri:noCountry code="subField">0JG</wicri:noCountry></affiliation><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation>Le document en format XML
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Girdhar</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation></author><author><name sortKey="Fisher Hoch, S" sort="Fisher Hoch, S" uniqKey="Fisher Hoch S" first="S." last="Fisher-Hoch">S. Fisher-Hoch</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation><affiliation><mods:affiliation>Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4 0JG</mods:affiliation><wicri:noCountry code="subField">0JG</wicri:noCountry></affiliation></author><author><name sortKey="Race, M W" sort="Race, M W" uniqKey="Race M" first="M. W." last="Race">M. W. Race</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation><affiliation><mods:affiliation>Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4 0JG</mods:affiliation><wicri:noCountry code="subField">0JG</wicri:noCountry></affiliation></author><author><name sortKey="Heath, R B" sort="Heath, R B" uniqKey="Heath R" first="R. B." last="Heath">R. B. Heath</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6CE344E8CE5C819825AAC65744E6B55632F47E27</idno><date when="1984" year="1984">1984</date><idno type="doi">10.1017/S0022172400064536</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-6W6SFQ47-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000115</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000115</idno><idno type="wicri:Area/Istex/Curation">000095</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Antibody against viruses in maternal and cord sera: non-specific inhibitors are found to higher titre on the maternal side of the circulation</title><author><name sortKey="Griffiths, P D" sort="Griffiths, P D" uniqKey="Griffiths P" first="P. D." last="Griffiths">P. D. Griffiths</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation><affiliation><mods:affiliation>Present address: Virus Laboratory, Royal Free Hospital Medical School, London, NW3.</mods:affiliation><wicri:noCountry code="subField">NW3.</wicri:noCountry></affiliation></author><author><name sortKey="Girdhar, D" sort="Girdhar, D" uniqKey="Girdhar D" first="D." last="Girdhar">D. Girdhar</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation></author><author><name sortKey="Fisher Hoch, S" sort="Fisher Hoch, S" uniqKey="Fisher Hoch S" first="S." last="Fisher-Hoch">S. Fisher-Hoch</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation><affiliation><mods:affiliation>Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4 0JG</mods:affiliation><wicri:noCountry code="subField">0JG</wicri:noCountry></affiliation></author><author><name sortKey="Race, M W" sort="Race, M W" uniqKey="Race M" first="M. W." last="Race">M. W. Race</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation><affiliation><mods:affiliation>Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4 0JG</mods:affiliation><wicri:noCountry code="subField">0JG</wicri:noCountry></affiliation></author><author><name sortKey="Heath, R B" sort="Heath, R B" uniqKey="Heath R" first="R. B." last="Heath">R. B. Heath</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation><wicri:noCountry code="subField">7BE</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1984-06">1984-06</date><biblScope unit="volume">92</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="297">297</biblScope><biblScope unit="page" to="301">301</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Pregnancies were identified in which maternal IgG antibodies against rubella virus were not detectable by single radial haemolysis. Twenty paired maternal/cord sera were then tested for haemagglutination-inhibiting (HI) activity against rubella virus without kaolin pretreatment of the sera. In the absence of specific antibody, the HI activity observed could thus be ascribed to the effect of non-specific inhibitors. The HI activity in maternal sera was significantly (P < 0·001) higher than that in cord sera. The 20 pairs of sera were similarly tested against a bunyavirus, an alphavirus and a flavivirus, both with and without kaolin pretreatment. The results showed non-specific inhibitors were found to higher titre in maternal sera, with the difference being statistically significant (P < 0·001) for each of the three viruses.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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