Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients
Identifieur interne : 000041 ( Istex/Curation ); précédent : 000040; suivant : 000042Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients
Auteurs : Ji Hyun Lee [Corée du Sud] ; Ja-Hyun Jang [Corée du Sud] ; Soo Hyun Lee [Corée du Sud] ; Yae-Jean Kim [Corée du Sud] ; Keon Hee Yoo [Corée du Sud] ; Ki-Woong Sung [Corée du Sud] ; Nam Yong Lee [Corée du Sud] ; Chang-Seok Ki [Corée du Sud, États-Unis] ; Hong Heo Koo [Corée du Sud, États-Unis]Source :
- Clinical Transplantation [ 0902-0063 ] ; 2012-09.
Abstract
Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.
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DOI: 10.1111/j.1399-0012.2012.01607.x
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in pediatric hematopoietic stem cell transplant recipients</title><author><name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Jang, Ja Yun" sort="Jang, Ja Yun" uniqKey="Jang J" first="Ja-Hyun" last="Jang">Ja-Hyun Jang</name><affiliation wicri:level="1"><mods:affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Soo Hyun" sort="Lee, Soo Hyun" uniqKey="Lee S" first="Soo Hyun" last="Lee">Soo Hyun Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yae Ean" sort="Kim, Yae Ean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Yoo, Keon Hee" sort="Yoo, Keon Hee" uniqKey="Yoo K" first="Keon Hee" last="Yoo">Keon Hee Yoo</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Sung, Ki Oong" sort="Sung, Ki Oong" uniqKey="Sung K" first="Ki-Woong" last="Sung">Ki-Woong Sung</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Nam Yong" sort="Lee, Nam Yong" uniqKey="Lee N" first="Nam Yong" last="Lee">Nam Yong Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Ki, Chang Eok" sort="Ki, Chang Eok" uniqKey="Ki C" first="Chang-Seok" last="Ki">Chang-Seok Ki</name><affiliation wicri:level="1"><mods:affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation><affiliation><mods:affiliation>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: changski@skku.eduhhkoo@skku.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Koo, Hong Heo" sort="Koo, Hong Heo" uniqKey="Koo H" first="Hong Heo" last="Koo">Hong Heo Koo</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea></affiliation><affiliation><mods:affiliation>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: changski@skku.eduhhkoo@skku.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="ISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><imprint><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="736">736</biblScope><biblScope unit="page" to="740">740</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2012-09">2012-09</date></imprint><idno type="ISSN">0902-0063</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0902-0063</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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