Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients
Identifieur interne : 000056 ( Istex/Corpus ); précédent : 000055; suivant : 000057Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients
Auteurs : Ji Hyun Lee ; Ja-Hyun Jang ; Soo Hyun Lee ; Yae-Jean Kim ; Keon Hee Yoo ; Ki-Woong Sung ; Nam Yong Lee ; Chang-Seok Ki ; Hong Heo KooSource :
- Clinical Transplantation [ 0902-0063 ] ; 2012-09.
Abstract
Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.
Url:
DOI: 10.1111/j.1399-0012.2012.01607.x
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fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: changski@skku.eduhhkoo@skku.edu</mods:affiliation></affiliation></author><author><name sortKey="Koo, Hong Heo" sort="Koo, Hong Heo" uniqKey="Koo H" first="Hong Heo" last="Koo">Hong Heo Koo</name><affiliation><mods:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: changski@skku.eduhhkoo@skku.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="ISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><imprint><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="736">736</biblScope><biblScope unit="page" to="740">740</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2012-09">2012-09</date></imprint><idno type="ISSN">0902-0063</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0902-0063</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>hsct</json:string><json:string>viral</json:string><json:string>multiplex</json:string><json:string>pediatric</json:string><json:string>hematopoietic</json:string><json:string>transplantation</json:string><json:string>viral culture</json:string><json:string>pediatric hsct recipient</json:string><json:string>adenovirus</json:string><json:string>respiratory virus</json:string><json:string>cell transplant recipient</json:string><json:string>pediatric hematopoietic</json:string><json:string>cell transplantation</json:string><json:string>samsung medical center</json:string><json:string>respiratory syncytial virus</json:string><json:string>hsct recipient</json:string><json:string>transplant</json:string><json:string>pulmonary hemorrhage</json:string><json:string>mortality rate</json:string><json:string>corona virus</json:string><json:string>positive detection rate</json:string><json:string>respiratory viral infection</json:string><json:string>sungkyunkwan university school</json:string><json:string>immunocompromised patient</json:string><json:string>assay</json:string><json:string>infection</json:string><json:string>respiratory symptom</json:string><json:string>mortality case</json:string><json:string>respiratory virus infection</json:string></teeft></keywords><author><json:item><name>Ji Hyun Lee</name><affiliations><json:string>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Ja‐Hyun Jang</name><affiliations><json:string>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Soo Hyun Lee</name><affiliations><json:string>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Yae‐Jean Kim</name><affiliations><json:string>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Keon Hee Yoo</name><affiliations><json:string>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Ki‐Woong Sung</name><affiliations><json:string>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Nam Yong Lee</name><affiliations><json:string>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Chang‐Seok Ki</name><affiliations><json:string>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string><json:string>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</json:string><json:string>E-mail: changski@skku.eduhhkoo@skku.edu</json:string></affiliations></json:item><json:item><name>Hong Heo Koo</name><affiliations><json:string>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string><json:string>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</json:string><json:string>E-mail: changski@skku.eduhhkoo@skku.edu</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>hematopoietic stem cell transplant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Korea</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiplex PCR</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pediatric</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>respiratory viral infection</value></json:item></subject><articleId><json:string>CTR1607</json:string></articleId><arkIstex>ark:/67375/WNG-X8ZJDNZ2-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</abstract><qualityIndicators><score>6.709</score><pdfWordCount>2369</pdfWordCount><pdfCharCount>15482</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>474</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>195</abstractWordCount><abstractCharCount>1302</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients</title><pmid><json:string>22385011</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Transplantation</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1399-0012</json:string></doi><issn><json:string>0902-0063</json:string></issn><eissn><json:string>1399-0012</json:string></eissn><publisherId><json:string>CTR</json:string></publisherId><volume>26</volume><issue>5</issue><pages><first>736</first><last>740</last><total>5</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item><json:item><value>Original Articles</value></json:item></subject></host><namedEntities><unitex><date><json:string>2009</json:string><json:string>2012-02-12</json:string><json:string>from January 2007 to August 2009</json:string><json:string>2007</json:string><json:string>From January 2007 through August 2009</json:string><json:string>2008</json:string></date><geogName></geogName><orgName><json:string>Light Diagnostics</json:string><json:string>Seegene Inc., Seoul, Korea</json:string><json:string>Sungkyunkwan University</json:string><json:string>Department of Laboratory Medicine and Genetics</json:string><json:string>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string><json:string>Department of Pediatrics and Microbiology</json:string><json:string>Samsung Medical Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Hong Heo</json:string><json:string>Chang-Seok Ki</json:string><json:string>Nam Yong</json:string><json:string>Keon Hee</json:string><json:string>Jean Kimb</json:string><json:string>Ji Hyun</json:string></persName><placeName><json:string>Korea</json:string><json:string>Seoul</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Michael et al.</json:string><json:string>November 2008</json:string><json:string>Lee et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-X8ZJDNZ2-Q</json:string></ark><categories><wos><json:string>1 - 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<country>Korea</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ja‐Hyun</forename><surname>Jang</surname></persName><affiliation><orgName type="division">Department of Laboratory Medicine and Genetics</orgName>
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OF</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Nam Yong</forename><surname>Lee</surname></persName><affiliation><orgName type="division">Department of Laboratory Medicine and Genetics</orgName>
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<country>Korea</country></address></affiliation></author><author xml:id="author-0008" role="corresp"><persName><forename type="first">Hong Heo</forename><surname>Koo</surname></persName><affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Samsung Medical Center</orgName>
<orgName type="institution">Sungkyunkwan University School of Medicine</orgName>
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<country key="KP" xml:lang="en">KOREA, DEMOCRATIC PEOPLE'S REPUBLIC
OF</country></address></affiliation></author><idno type="istex">606B6C4F2C4B29F2446BD544ADC1214C9CDCAF6A</idno><idno type="ark">ark:/67375/WNG-X8ZJDNZ2-Q</idno><idno type="DOI">10.1111/j.1399-0012.2012.01607.x</idno><idno type="unit">CTR1607</idno><idno type="toTypesetVersion">file:CTR.CTR1607.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="pISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><idno type="book-DOI">10.1111/(ISSN)1399-0012</idno><idno type="book-part-DOI">10.1111/ctr.2012.26.issue-5</idno><idno type="product">CTR</idno><imprint><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="736">736</biblScope><biblScope unit="page" to="740">740</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2012-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main" xml:id="ctr1607-abs-0001"><head>Abstract</head><p>Respiratory viruses (<hi rend="fc">RV</hi>s) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (<hi rend="fc">HSCT</hi>). In this retrospective study, we focused on the first 28 d after transplantation in pediatric <hi rend="fc">HSCT</hi> recipients and showed that a multiplex <hi rend="fc">PCR</hi> assay significantly increased <hi rend="fc">RV</hi> detection compared with a viral culture method. Among 176 pediatric <hi rend="fc">HSCT</hi> recipients, 84 with respiratory symptoms within one yr after <hi rend="fc">HSCT</hi> were tested by viral culture or multiplex <hi rend="fc">PCR</hi>. Within 28 d after <hi rend="fc">HSCT</hi>, nine patients were infected with <hi rend="fc">RV</hi>s; the incidence of a first episode of <hi rend="fc">RV</hi> infection within 28 d after <hi rend="fc">HSCT</hi> was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (<hi rend="fc">A</hi>d<hi rend="fc">V</hi>) pneumonia with pulmonary hemorrhage; the mortality rate of <hi rend="fc">RV</hi> infection within 28 d after <hi rend="fc">HSCT</hi> was 0.57%.</p><p>In the nine patients with <hi rend="fc">RV</hi> infection, five different types of <hi rend="fc">RV</hi> were identified, either alone or with another <hi rend="fc">RV</hi>. These were corona virus (<hi rend="fc">C</hi>o<hi rend="fc">V</hi>), rhinovirus (<hi rend="fc">R</hi>h<hi rend="fc">V</hi>) and respiratory syncytial virus combined with <hi rend="fc">C</hi>o<hi rend="fc">V</hi>;<hi rend="fc"> A</hi>d<hi rend="fc">V</hi> combined with <hi rend="fc">R</hi>h<hi rend="fc">V</hi>; and parainfluenza virus. Viral culture detected only one case of <hi rend="fc">RV</hi> infection, while multiplex <hi rend="fc">PCR</hi> detected eight, suggesting that screening of respiratory infections using multiplex <hi rend="fc">PCR</hi> is better than the conventional culture method.</p></abstract><textClass><keywords><term xml:id="ctr1607-kwd-0001">hematopoietic stem cell transplant</term><term xml:id="ctr1607-kwd-0002"><hi rend="fc">K</hi>orea</term><term xml:id="ctr1607-kwd-0003">multiplex <hi rend="fc">PCR</hi></term><term xml:id="ctr1607-kwd-0004">pediatric</term><term xml:id="ctr1607-kwd-0005">respiratory viral infection</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-X8ZJDNZ2-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="ctr1607" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1399-0012</doi><issn type="print">0902-0063</issn><issn type="electronic">1399-0012</issn><idGroup><id type="product" value="CTR"></id></idGroup><titleGroup><title sort="CLINICAL TRANSPLANTATION" type="main">Clinical Transplantation</title><title type="short">Clin Transplant</title></titleGroup></publicationMeta><publicationMeta level="part" position="09105"><doi origin="wiley">10.1111/ctr.2012.26.issue-5</doi><copyright ownership="publisher">© 2012 John Wiley & Sons A/S</copyright><numberingGroup><numbering number="26" type="journalVolume">26</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2012-09">September/October 2012</coverDate></publicationMeta><publicationMeta level="unit" position="12" status="forIssue" type="article"><doi>10.1111/j.1399-0012.2012.01607.x</doi><idGroup><id type="unit" value="CTR1607"></id></idGroup><countGroup><count number="5" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2012 John Wiley & Sons A/S.</copyright><eventGroup><event date="2011-12-29" type="manuscriptAccepted"></event><event agent="SPS" date="2012-02-12" type="xmlCreated"></event><event agent="SPS" date="2012-03-23" type="xmlCorrected"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-03-04"></event><event type="firstOnline" date="2012-03-04"></event><event type="publishedOnlineFinalForm" date="2012-10-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst">736</numbering><numbering type="pageLast">740</numbering></numberingGroup><correspondenceTo><lineatedText><line>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</line><line>Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;</line><line>e‐mail: <email>changski@skku.edu</email></line><line>Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</line><line>Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;</line><line>e‐mail: <email>hhkoo@skku.edu</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="ctr1607-cit-0015">Lee JH, Jang J-H, Lee SH, Kim Y-J, Yoo KH, Sung K-W, Lee NY, Ki C-S, Koo HH. Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients. Clin Transplant 2012 DOI: 10.1111/j.1399-0012.2012.01607.x. © 2012 John Wiley & Sons A/S.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CTR.CTR1607.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients</title><title type="shortAuthors">Lee et al.</title></titleGroup><creators><creator affiliationRef="#ctr1607-aff-0001" creatorRole="author" xml:id="ctr1607-cr-0001"><personName><givenNames>Ji Hyun</givenNames> <familyName>Lee</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0001" creatorRole="author" xml:id="ctr1607-cr-0002"><personName><givenNames>Ja‐Hyun</givenNames> <familyName>Jang</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0002" creatorRole="author" xml:id="ctr1607-cr-0003"><personName><givenNames>Soo Hyun</givenNames> <familyName>Lee</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0002" creatorRole="author" xml:id="ctr1607-cr-0004"><personName><givenNames>Yae‐Jean</givenNames> <familyName>Kim</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0002" creatorRole="author" xml:id="ctr1607-cr-0005"><personName><givenNames>Keon Hee</givenNames> <familyName>Yoo</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0002" creatorRole="author" xml:id="ctr1607-cr-0006"><personName><givenNames>Ki‐Woong</givenNames> <familyName>Sung</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0001" creatorRole="author" xml:id="ctr1607-cr-0007"><personName><givenNames>Nam Yong</givenNames> <familyName>Lee</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0001" corresponding="yes" creatorRole="author" noteRef="#ctr1607-note-0001" xml:id="ctr1607-cr-0008"><personName><givenNames>Chang‐Seok</givenNames> <familyName>Ki</familyName></personName></creator><creator affiliationRef="#ctr1607-aff-0002" corresponding="yes" creatorRole="author" noteRef="#ctr1607-note-0001" xml:id="ctr1607-cr-0009"><personName><givenNames>Hong Heo</givenNames> <familyName>Koo</familyName></personName></creator></creators><affiliationGroup><affiliation type="organization" xml:id="ctr1607-aff-0001"><orgDiv>Department of Laboratory Medicine and Genetics</orgDiv> <orgName>Samsung Medical Center</orgName> <orgName>Sungkyunkwan University School of Medicine</orgName> <address><city>Seoul</city> <country>Korea</country></address></affiliation><affiliation countryCode="KP" type="organization" xml:id="ctr1607-aff-0002"><orgDiv>Department of Pediatrics</orgDiv> <orgName>Samsung Medical Center</orgName> <orgName>Sungkyunkwan University School of Medicine</orgName> <address><city>Seoul</city> <country>Korea</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="ctr1607-kwd-0001">hematopoietic stem cell transplant</keyword><keyword xml:id="ctr1607-kwd-0002"><fc>K</fc>orea</keyword><keyword xml:id="ctr1607-kwd-0003">multiplex <fc>PCR</fc></keyword><keyword xml:id="ctr1607-kwd-0004">pediatric</keyword><keyword xml:id="ctr1607-kwd-0005">respiratory viral infection</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="ctr1607-abs-0001"><title type="main">Abstract</title><p>Respiratory viruses (<fc>RV</fc>s) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (<fc>HSCT</fc>). In this retrospective study, we focused on the first 28 d after transplantation in pediatric <fc>HSCT</fc> recipients and showed that a multiplex <fc>PCR</fc> assay significantly increased <fc>RV</fc> detection compared with a viral culture method. Among 176 pediatric <fc>HSCT</fc> recipients, 84 with respiratory symptoms within one yr after <fc>HSCT</fc> were tested by viral culture or multiplex <fc>PCR</fc>. Within 28 d after <fc>HSCT</fc>, nine patients were infected with <fc>RV</fc>s; the incidence of a first episode of <fc>RV</fc> infection within 28 d after <fc>HSCT</fc> was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (<fc>A</fc>d<fc>V</fc>) pneumonia with pulmonary hemorrhage; the mortality rate of <fc>RV</fc> infection within 28 d after <fc>HSCT</fc> was 0.57%.</p><p>In the nine patients with <fc>RV</fc> infection, five different types of <fc>RV</fc> were identified, either alone or with another <fc>RV</fc>. These were corona virus (<fc>C</fc>o<fc>V</fc>), rhinovirus (<fc>R</fc>h<fc>V</fc>) and respiratory syncytial virus combined with <fc>C</fc>o<fc>V</fc>;<fc> A</fc>d<fc>V</fc> combined with <fc>R</fc>h<fc>V</fc>; and parainfluenza virus. Viral culture detected only one case of <fc>RV</fc> infection, while multiplex <fc>PCR</fc> detected eight, suggesting that screening of respiratory infections using multiplex <fc>PCR</fc> is better than the conventional culture method.</p></abstract></abstractGroup></contentMeta><noteGroup xml:id="ctr1607-ntgp-0001"><note xml:id="ctr1607-note-0001">Drs. Chang‐Seok Ki and Hong Heo Koo contributed equally to this work. </note><note numbered="no" xml:id="ctr1607-note-0002">Conflict of Interest: None.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients</title></titleInfo><name type="personal"><namePart type="given">Ji Hyun</namePart><namePart type="family">Lee</namePart><affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ja‐Hyun</namePart><namePart type="family">Jang</namePart><affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Soo Hyun</namePart><namePart type="family">Lee</namePart><affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yae‐Jean</namePart><namePart type="family">Kim</namePart><affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Keon Hee</namePart><namePart type="family">Yoo</namePart><affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ki‐Woong</namePart><namePart type="family">Sung</namePart><affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nam Yong</namePart><namePart type="family">Lee</namePart><affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chang‐Seok</namePart><namePart type="family">Ki</namePart><affiliation>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><description>Drs. Chang‐Seok Ki and Hong Heo Koo contributed equally to this work.</description><affiliation>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</affiliation><affiliation>E-mail: changski@skku.eduhhkoo@skku.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hong Heo</namePart><namePart type="family">Koo</namePart><affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><description>Drs. Chang‐Seok Ki and Hong Heo Koo contributed equally to this work.</description><affiliation>Corresponding author: Dr. Chang‐Seok Ki, Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 2709; fax: +82 2 3410 2719;e‐mail: Dr. Hong Heo Koo, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Tel.: +82 2 3410 3524; fax: +82 2 3410 0043;e‐mail:</affiliation><affiliation>E-mail: changski@skku.eduhhkoo@skku.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2012-09</dateIssued><dateCreated encoding="w3cdtf">2012-02-12</dateCreated><dateValid encoding="w3cdtf">2011-12-29</dateValid><edition>Lee JH, Jang J-H, Lee SH, Kim Y-J, Yoo KH, Sung K-W, Lee NY, Ki C-S, Koo HH. Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients. Clin Transplant 2012 DOI: 10.1111/j.1399-0012.2012.01607.x. © 2012 John Wiley & Sons A/S.</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1%. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</abstract><subject><genre>keywords</genre><topic>hematopoietic stem cell transplant</topic><topic>Korea</topic><topic>multiplex PCR</topic><topic>pediatric</topic><topic>respiratory viral infection</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Transplantation</title></titleInfo><titleInfo type="abbreviated"><title>Clin Transplant</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic><topic>Original Articles</topic></subject><identifier type="ISSN">0902-0063</identifier><identifier type="eISSN">1399-0012</identifier><identifier type="DOI">10.1111/(ISSN)1399-0012</identifier><identifier type="PublisherID">CTR</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>736</start><end>740</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="ctr1607-cit-0001"><titleInfo><title>Viral infections in immunocompromised patients: what's new with respiratory viruses?</title></titleInfo><name type="personal"><namePart type="given">MG</namePart><namePart type="family">Ison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FG</namePart><namePart type="family">Hayden</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ison MG, Hayden FG. 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Curr Opin Infect Dis 2002: 15: 355.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>355</start></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Infect Dis</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>355</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="ctr1607-cit-0002"><titleInfo><title>Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection</title></titleInfo><name type="personal"><namePart type="given">YJ</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Boeckh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Englund</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kim YJ, Boeckh M, Englund JA. 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