Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies
Identifieur interne : 000909 ( Istex/Corpus ); précédent : 000908; suivant : 000910Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies
Auteurs : Patricia A. Broderick ; Frank T. Phelan ; Frank Eng ; Robert T. WechslerSource :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1994.
English descriptors
- Teeft :
- Accumbens, Alkaloid, Ambulation, Ambulation frequency, Ambulatory, Ambulatory behavior, Analyses show, Animals habituated, Anova, Anova statistics, Basal, Baseline, Behav, Behavioral, Behavioral chamber, Biochem, Broderick, Central ambulation frequency, Central ambulations, Cocaine, Cocaine injection, Cocaine injection plsd, Cocaineinduced, Confidence limits, Consecutive days, Dopamine, Downmodulated, Electrochemical, Environmental habituation, Environmental stimulation, Exploratory behavior, Extracellular concentrations, Fine movement behavior, Fine movement frequency, Fine movements, First hour, Fourth hour, Fourth hours, Glick, Group figure, Habituated, Habituation, Habituation response, Hourly data, Iboga, Ibogaine, Ibogaine groups, Ibogaine injection, Ibogaine pretreatment, Ibogaine study, Ibogalne, Individual interval time course data points, Indole, Locomotor, Locomotor activity, Maisonneuve, Male rats, Maximally, Microelectrode, Microelectrodes, Nacc, Neurotransmitter, Novel environment, Pharmacol, Pharmacology, Plsd, Pretreatment, Psychostimulant, Psychostimulant behaviors, Receptor, Saline pretreatment, Saline study, Second hour, Second hours, Serotonin, Serotonin release, Significant differences, Significant increase, Statistical comparison, Stearate, Synaptic, Synaptic concentrations, Tabernanthine, Third hour, Time course study, Time period, Vlnacc, Voltammogram.
Abstract
Abstract: Ibogaine, a serotonergic (5-HTergic) indole alkaloid, was studied for cocaine modulatory effects on four parameters of behavior by computerized infrared photocell beam detection. The behavioral parameters were: a) locomotor activity (ambulations), b) rearing, c) stereotypy (fine movements, primarily grooming), and d) agoraphobia [(thigmotaxis) a natural tendency to avoid the center of the behavioral chamber]. With each behavioral data point, dopamine (DA) release, and serotonin (5-HT) release were detected within seconds in nucleus accumbens (NAcc) of the same behaving male Sprague-Dawley rats, using in vivo electrochemistry (voltammetry). Ibogaine was administered (40 mg/kg IP) for 4 consecutive days. Importantly, the DAergic and the 5-HTergic responses to (SC) cocaine and two behavioral responses, ambulations and central ambulations, were reduced in intensity due to extended time spent in the novel behavioral chamber (habituated). Rearing and fine movement patterns were not habituated. The results show that ibogaine downmodulated the (SC) cocaine-induced increase in NAcc DA release (p < 0.0001) and potentiated the (SC) cocaine-induced decrease in NAcc 5-HT release (p < 0.0001). Concurrently, ibogaine downmodulated cocaine-induced ambulation (p < 0.0001) and central ambulation behavior (p < 0.0001). On the other hand, the behavioral parameters that did not exhibit habituation, i.e., rearing behavior and fine movement behavior, were not downmodulated by ibogaine (p < 0.1558) (p < 0.3763), respectively. Furthermore, ibogaine itself did not significantly alter NAcc DA release over the 2-h period studied (p < 0.9113) although individual time points were significantly affected bidirectionally. Concurrently ibogaine significantly increased 5-HT release (p < 0.0155). Behaviorally, ibogaine appears to be a weak psychostimulant. The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions. Also elucidated as critical is the efficacy of ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment.
Url:
DOI: 10.1016/0091-3057(94)90092-2
Links to Exploration step
ISTEX:AAE4DCE1868D69345B75D997B1A97862292EE583Le document en format XML
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Broderick</name><affiliation><mods:affiliation>Department of Pharmacology, The City University of New York Medical School, USA</mods:affiliation></affiliation></author><author><name sortKey="Phelan, Frank T" sort="Phelan, Frank T" uniqKey="Phelan F" first="Frank T." last="Phelan">Frank T. Phelan</name><affiliation><mods:affiliation>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</mods:affiliation></affiliation></author><author><name sortKey="Eng, Frank" sort="Eng, Frank" uniqKey="Eng F" first="Frank" last="Eng">Frank Eng</name><affiliation><mods:affiliation>Department of Pharmacology, The City University of New York Medical School, USA</mods:affiliation></affiliation></author><author><name sortKey="Wechsler, Robert T" sort="Wechsler, Robert T" uniqKey="Wechsler R" first="Robert T." last="Wechsler">Robert T. Wechsler</name><affiliation><mods:affiliation>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">49</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="711">711</biblScope><biblScope unit="page" to="728">728</biblScope></imprint><idno type="ISSN">0091-3057</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Accumbens</term><term>Alkaloid</term><term>Ambulation</term><term>Ambulation frequency</term><term>Ambulatory</term><term>Ambulatory behavior</term><term>Analyses show</term><term>Animals habituated</term><term>Anova</term><term>Anova statistics</term><term>Basal</term><term>Baseline</term><term>Behav</term><term>Behavioral</term><term>Behavioral chamber</term><term>Biochem</term><term>Broderick</term><term>Central ambulation frequency</term><term>Central ambulations</term><term>Cocaine</term><term>Cocaine injection</term><term>Cocaine injection plsd</term><term>Cocaineinduced</term><term>Confidence limits</term><term>Consecutive days</term><term>Dopamine</term><term>Downmodulated</term><term>Electrochemical</term><term>Environmental habituation</term><term>Environmental stimulation</term><term>Exploratory behavior</term><term>Extracellular concentrations</term><term>Fine movement behavior</term><term>Fine movement frequency</term><term>Fine movements</term><term>First hour</term><term>Fourth hour</term><term>Fourth hours</term><term>Glick</term><term>Group figure</term><term>Habituated</term><term>Habituation</term><term>Habituation response</term><term>Hourly data</term><term>Iboga</term><term>Ibogaine</term><term>Ibogaine groups</term><term>Ibogaine injection</term><term>Ibogaine pretreatment</term><term>Ibogaine study</term><term>Ibogalne</term><term>Individual interval time course data points</term><term>Indole</term><term>Locomotor</term><term>Locomotor activity</term><term>Maisonneuve</term><term>Male rats</term><term>Maximally</term><term>Microelectrode</term><term>Microelectrodes</term><term>Nacc</term><term>Neurotransmitter</term><term>Novel environment</term><term>Pharmacol</term><term>Pharmacology</term><term>Plsd</term><term>Pretreatment</term><term>Psychostimulant</term><term>Psychostimulant behaviors</term><term>Receptor</term><term>Saline pretreatment</term><term>Saline study</term><term>Second hour</term><term>Second hours</term><term>Serotonin</term><term>Serotonin release</term><term>Significant differences</term><term>Significant increase</term><term>Statistical comparison</term><term>Stearate</term><term>Synaptic</term><term>Synaptic concentrations</term><term>Tabernanthine</term><term>Third hour</term><term>Time course study</term><term>Time period</term><term>Vlnacc</term><term>Voltammogram</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Ibogaine, a serotonergic (5-HTergic) indole alkaloid, was studied for cocaine modulatory effects on four parameters of behavior by computerized infrared photocell beam detection. The behavioral parameters were: a) locomotor activity (ambulations), b) rearing, c) stereotypy (fine movements, primarily grooming), and d) agoraphobia [(thigmotaxis) a natural tendency to avoid the center of the behavioral chamber]. With each behavioral data point, dopamine (DA) release, and serotonin (5-HT) release were detected within seconds in nucleus accumbens (NAcc) of the same behaving male Sprague-Dawley rats, using in vivo electrochemistry (voltammetry). Ibogaine was administered (40 mg/kg IP) for 4 consecutive days. Importantly, the DAergic and the 5-HTergic responses to (SC) cocaine and two behavioral responses, ambulations and central ambulations, were reduced in intensity due to extended time spent in the novel behavioral chamber (habituated). Rearing and fine movement patterns were not habituated. The results show that ibogaine downmodulated the (SC) cocaine-induced increase in NAcc DA release (p < 0.0001) and potentiated the (SC) cocaine-induced decrease in NAcc 5-HT release (p < 0.0001). Concurrently, ibogaine downmodulated cocaine-induced ambulation (p < 0.0001) and central ambulation behavior (p < 0.0001). On the other hand, the behavioral parameters that did not exhibit habituation, i.e., rearing behavior and fine movement behavior, were not downmodulated by ibogaine (p < 0.1558) (p < 0.3763), respectively. Furthermore, ibogaine itself did not significantly alter NAcc DA release over the 2-h period studied (p < 0.9113) although individual time points were significantly affected bidirectionally. Concurrently ibogaine significantly increased 5-HT release (p < 0.0155). Behaviorally, ibogaine appears to be a weak psychostimulant. The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions. Also elucidated as critical is the efficacy of ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>ibogaine</json:string><json:string>cocaine</json:string><json:string>anova</json:string><json:string>ambulation</json:string><json:string>vlnacc</json:string><json:string>habituated</json:string><json:string>pretreatment</json:string><json:string>habituation</json:string><json:string>time period</json:string><json:string>novel environment</json:string><json:string>baseline</json:string><json:string>male rats</json:string><json:string>dopamine</json:string><json:string>broderick</json:string><json:string>ibogaine pretreatment</json:string><json:string>ambulation frequency</json:string><json:string>pharmacol</json:string><json:string>ibogaine study</json:string><json:string>synaptic</json:string><json:string>receptor</json:string><json:string>significant differences</json:string><json:string>maximally</json:string><json:string>alkaloid</json:string><json:string>nacc</json:string><json:string>fourth hours</json:string><json:string>fine movements</json:string><json:string>central ambulation frequency</json:string><json:string>locomotor</json:string><json:string>microelectrode</json:string><json:string>serotonin</json:string><json:string>tabernanthine</json:string><json:string>electrochemical</json:string><json:string>synaptic concentrations</json:string><json:string>saline study</json:string><json:string>basal</json:string><json:string>fine movement behavior</json:string><json:string>psychostimulant</json:string><json:string>fine movement frequency</json:string><json:string>central ambulations</json:string><json:string>ambulatory behavior</json:string><json:string>time course study</json:string><json:string>saline pretreatment</json:string><json:string>animals habituated</json:string><json:string>anova statistics</json:string><json:string>plsd</json:string><json:string>group figure</json:string><json:string>analyses show</json:string><json:string>glick</json:string><json:string>hourly data</json:string><json:string>ambulatory</json:string><json:string>confidence limits</json:string><json:string>stearate</json:string><json:string>first hour</json:string><json:string>second hour</json:string><json:string>behav</json:string><json:string>individual interval time course data points</json:string><json:string>exploratory behavior</json:string><json:string>cocaineinduced</json:string><json:string>biochem</json:string><json:string>pharmacology</json:string><json:string>maisonneuve</json:string><json:string>iboga</json:string><json:string>indole</json:string><json:string>cocaine injection</json:string><json:string>neurotransmitter</json:string><json:string>voltammogram</json:string><json:string>ibogalne</json:string><json:string>locomotor activity</json:string><json:string>microelectrodes</json:string><json:string>environmental stimulation</json:string><json:string>accumbens</json:string><json:string>cocaine injection plsd</json:string><json:string>downmodulated</json:string><json:string>behavioral chamber</json:string><json:string>habituation response</json:string><json:string>significant increase</json:string><json:string>consecutive days</json:string><json:string>statistical comparison</json:string><json:string>extracellular concentrations</json:string><json:string>second hours</json:string><json:string>psychostimulant behaviors</json:string><json:string>environmental habituation</json:string><json:string>ibogaine injection</json:string><json:string>serotonin release</json:string><json:string>fourth hour</json:string><json:string>third hour</json:string><json:string>ibogaine groups</json:string><json:string>behavioral</json:string><json:string>vivo</json:string><json:string>rat</json:string><json:string>behavioral studies</json:string><json:string>significant difference</json:string><json:string>male spraguedawley rats</json:string><json:string>locomotor behavior</json:string><json:string>cocaine responses</json:string><json:string>vivo electrochemical signals</json:string><json:string>injection</json:string><json:string>morphine</json:string></teeft></keywords><author><json:item><name>Patricia A. Broderick</name><affiliations><json:string>Department of Pharmacology, The City University of New York Medical School, USA</json:string></affiliations></json:item><json:item><name>Frank T. Phelan</name><affiliations><json:string>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</json:string></affiliations></json:item><json:item><name>Frank Eng</name><affiliations><json:string>Department of Pharmacology, The City University of New York Medical School, USA</json:string></affiliations></json:item><json:item><name>Robert T. Wechsler</name><affiliations><json:string>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Ibogaine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cocaine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Psychostimulant behavior</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Nucleus accumbens (NAcc)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dopamine (DA)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Serotonin (5-HT)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>In vivo electrochemistry (Voltammetry)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Stearate microelectrode</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Freely moving rat paradigm</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Locomotor activity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Central locomotor activity (agoraphobic inhibition)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rearing behavior</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Stereotypy</value></json:item></subject><arkIstex>ark:/67375/6H6-SV21WTBK-G</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Ibogaine, a serotonergic (5-HTergic) indole alkaloid, was studied for cocaine modulatory effects on four parameters of behavior by computerized infrared photocell beam detection. The behavioral parameters were: a) locomotor activity (ambulations), b) rearing, c) stereotypy (fine movements, primarily grooming), and d) agoraphobia [(thigmotaxis) a natural tendency to avoid the center of the behavioral chamber]. With each behavioral data point, dopamine (DA) release, and serotonin (5-HT) release were detected within seconds in nucleus accumbens (NAcc) of the same behaving male Sprague-Dawley rats, using in vivo electrochemistry (voltammetry). Ibogaine was administered (40 mg/kg IP) for 4 consecutive days. Importantly, the DAergic and the 5-HTergic responses to (SC) cocaine and two behavioral responses, ambulations and central ambulations, were reduced in intensity due to extended time spent in the novel behavioral chamber (habituated). Rearing and fine movement patterns were not habituated. The results show that ibogaine downmodulated the (SC) cocaine-induced increase in NAcc DA release (p > 0.0001) and potentiated the (SC) cocaine-induced decrease in NAcc 5-HT release (p > 0.0001). Concurrently, ibogaine downmodulated cocaine-induced ambulation (p > 0.0001) and central ambulation behavior (p > 0.0001). On the other hand, the behavioral parameters that did not exhibit habituation, i.e., rearing behavior and fine movement behavior, were not downmodulated by ibogaine (p > 0.1558) (p > 0.3763), respectively. Furthermore, ibogaine itself did not significantly alter NAcc DA release over the 2-h period studied (p > 0.9113) although individual time points were significantly affected bidirectionally. Concurrently ibogaine significantly increased 5-HT release (p > 0.0155). Behaviorally, ibogaine appears to be a weak psychostimulant. The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions. Also elucidated as critical is the efficacy of ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment.</abstract><qualityIndicators><score>10</score><pdfWordCount>14475</pdfWordCount><pdfCharCount>86825</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>18</pdfPageCount><pdfPageSize>627 x 800 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>296</abstractWordCount><abstractCharCount>2109</abstractCharCount><keywordCount>13</keywordCount></qualityIndicators><title>Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies</title><pmid><json:string>7862728</json:string></pmid><pii><json:string>0091-3057(94)90092-2</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Ph.D. Thesis</title><language><json:string>unknown</json:string></language></serie><host><title>Pharmacology, Biochemistry and Behavior</title><language><json:string>unknown</json:string></language><publicationDate>1994</publicationDate><issn><json:string>0091-3057</json:string></issn><pii><json:string>S0091-3057(00)X0150-5</json:string></pii><volume>49</volume><issue>3</issue><pages><first>711</first><last>728</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1992</json:string><json:string>1901</json:string><json:string>1957</json:string><json:string>1971</json:string><json:string>1994</json:string></date><geogName><json:string>Staten Island</json:string><json:string>Ill</json:string></geogName><orgName><json:string>NIDA</json:string><json:string>Environmental Habituation</json:string><json:string>Department of Environmental Protection, Department of Limnology, Ben Nesin Lab</json:string><json:string>Department of Pharmacology, Rm</json:string><json:string>Elsevier Science, Ltd.</json:string><json:string>National Institute on Drug Abuse</json:string><json:string>The City University</json:string><json:string>Brain Power Inc.</json:string><json:string>Becker Parkin Dental Supply Co.</json:string><json:string>Gabon, Africa</json:string><json:string>Annual International</json:string><json:string>Medwire Corp.</json:string><json:string>Ultra-Carbon Corp.</json:string><json:string>San Diego Instruments, San Diego</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>O'Hearn</json:string><json:string>Initial</json:string><json:string>Results</json:string><json:string>Sigg</json:string><json:string>Bay Road</json:string><json:string>Charles River</json:string><json:string>P. A. 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Broderick, Department of Pharmacology, Rm. J-910, The City University of NY Medical School, Convent Ave. & W. 138th St., New York, NY 10031</note><affiliation>Requests for reprints should be addressed to Dr. P.A. Broderick, Department of Pharmacology, Rm. J-910, The City University of NY Medical School, Convent Ave. & W. 138th St., New York, NY 10031</affiliation><affiliation>Department of Pharmacology, The City University of New York Medical School, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Frank T.</forename><surname>Phelan</surname></persName><note type="biography">Present address: NYC, Department of Environmental Protection, Department of Limnology, Ben Nesin Lab., 28A, Shokan, NY.</note><affiliation>Present address: NYC, Department of Environmental Protection, Department of Limnology, Ben Nesin Lab., 28A, Shokan, NY.</affiliation><affiliation>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Frank</forename><surname>Eng</surname></persName><affiliation>Department of Pharmacology, The City University of New York Medical School, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Robert T.</forename><surname>Wechsler</surname></persName><note type="biography">Present address: Chicago Medical School, 333 Green Bay Road, N. Chicago, IL 60064-3095.</note><affiliation>Present address: Chicago Medical School, 333 Green Bay Road, N. Chicago, IL 60064-3095.</affiliation><affiliation>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</affiliation></author><idno type="istex">AAE4DCE1868D69345B75D997B1A97862292EE583</idno><idno type="ark">ark:/67375/6H6-SV21WTBK-G</idno><idno type="DOI">10.1016/0091-3057(94)90092-2</idno><idno type="PII">0091-3057(94)90092-2</idno></analytic><monogr><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="pISSN">0091-3057</idno><idno type="PII">S0091-3057(00)X0150-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">49</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="711">711</biblScope><biblScope unit="page" to="728">728</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Ibogaine, a serotonergic (5-HTergic) indole alkaloid, was studied for cocaine modulatory effects on four parameters of behavior by computerized infrared photocell beam detection. The behavioral parameters were: a) locomotor activity (ambulations), b) rearing, c) stereotypy (fine movements, primarily grooming), and d) agoraphobia [(thigmotaxis) a natural tendency to avoid the center of the behavioral chamber]. With each behavioral data point, dopamine (DA) release, and serotonin (5-HT) release were detected within seconds in nucleus accumbens (NAcc) of the same behaving male Sprague-Dawley rats, using in vivo electrochemistry (voltammetry). Ibogaine was administered (40 mg/kg IP) for 4 consecutive days. Importantly, the DAergic and the 5-HTergic responses to (SC) cocaine and two behavioral responses, ambulations and central ambulations, were reduced in intensity due to extended time spent in the novel behavioral chamber (habituated). Rearing and fine movement patterns were not habituated. The results show that ibogaine downmodulated the (SC) cocaine-induced increase in NAcc DA release (p < 0.0001) and potentiated the (SC) cocaine-induced decrease in NAcc 5-HT release (p < 0.0001). Concurrently, ibogaine downmodulated cocaine-induced ambulation (p < 0.0001) and central ambulation behavior (p < 0.0001). On the other hand, the behavioral parameters that did not exhibit habituation, i.e., rearing behavior and fine movement behavior, were not downmodulated by ibogaine (p < 0.1558) (p < 0.3763), respectively. Furthermore, ibogaine itself did not significantly alter NAcc DA release over the 2-h period studied (p < 0.9113) although individual time points were significantly affected bidirectionally. Concurrently ibogaine significantly increased 5-HT release (p < 0.0155). Behaviorally, ibogaine appears to be a weak psychostimulant. The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions. Also elucidated as critical is the efficacy of ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Ibogaine</term></item><item><term>Cocaine</term></item><item><term>Psychostimulant behavior</term></item><item><term>Nucleus accumbens (NAcc)</term></item><item><term>Dopamine (DA)</term></item><item><term>Serotonin (5-HT)</term></item><item><term>In vivo electrochemistry (Voltammetry)</term></item><item><term>Stearate microelectrode</term></item><item><term>Freely moving rat paradigm</term></item><item><term>Locomotor activity</term></item><item><term>Central locomotor activity (agoraphobic inhibition)</term></item><item><term>Rearing behavior</term></item><item><term>Stereotypy</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-SV21WTBK-G/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PBB</jid><aid>94900922</aid><ce:pii>0091-3057(94)90092-2</ce:pii><ce:doi>10.1016/0091-3057(94)90092-2</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>These results were originally presented at the Second Annual International Behavioral Neuroscience Society Conference held in Clearwater Beach, FL, April 22–25, 1993.</ce:note-para></ce:article-footnote><ce:title>Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies</ce:title><ce:author-group><ce:author><ce:given-name>Patricia A.</ce:given-name><ce:surname>Broderick</ce:surname><ce:cross-ref refid="COR1"><ce:sup>2</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Frank T.</ce:given-name><ce:surname>Phelan</ce:surname><ce:cross-ref refid="COR2"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Frank</ce:given-name><ce:surname>Eng</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Robert T.</ce:given-name><ce:surname>Wechsler</ce:surname><ce:cross-ref refid="COR3"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>∗</ce:label><ce:textfn>Department of Pharmacology, The City University of New York Medical School, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>†</ce:label><ce:textfn>Departments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>2</ce:label><ce:text>Requests for reprints should be addressed to Dr. P.A. Broderick, Department of Pharmacology, Rm. J-910, The City University of NY Medical School, Convent Ave. & W. 138th St., New York, NY 10031</ce:text></ce:correspondence><ce:correspondence id="COR2"><ce:label>3</ce:label><ce:text>Present address: NYC, Department of Environmental Protection, Department of Limnology, Ben Nesin Lab., 28A, Shokan, NY.</ce:text></ce:correspondence><ce:correspondence id="COR3"><ce:label>4</ce:label><ce:text>Present address: Chicago Medical School, 333 Green Bay Road, N. Chicago, IL 60064-3095.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="23" month="12" year="1993"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Ibogaine, a serotonergic (5-HTergic) indole alkaloid, was studied for cocaine modulatory effects on four parameters of behavior by computerized infrared photocell beam detection. The behavioral parameters were: a) locomotor activity (ambulations), b) rearing, c) stereotypy (fine movements, primarily grooming), and d) agoraphobia [(thigmotaxis) a natural tendency to avoid the center of the behavioral chamber]. With each behavioral data point, dopamine (DA) release, and serotonin (5-HT) release were detected within seconds in nucleus accumbens (NAcc) of the same behaving male Sprague-Dawley rats, using in vivo electrochemistry (voltammetry). Ibogaine was administered (40 mg/kg IP) for 4 consecutive days. Importantly, the DAergic and the 5-HTergic responses to (SC) cocaine and two behavioral responses, ambulations and central ambulations, were reduced in intensity due to extended time spent in the novel behavioral chamber (habituated). Rearing and fine movement patterns were not habituated. The results show that ibogaine downmodulated the (SC) cocaine-induced increase in NAcc DA release (<ce:italic>p</ce:italic> < 0.0001) and potentiated the (SC) cocaine-induced decrease in NAcc 5-HT release (<ce:italic>p</ce:italic> < 0.0001). Concurrently, ibogaine downmodulated cocaine-induced ambulation (<ce:italic>p</ce:italic> < 0.0001) and central ambulation behavior (<ce:italic>p</ce:italic> < 0.0001). On the other hand, the behavioral parameters that did not exhibit habituation, i.e., rearing behavior and fine movement behavior, were not downmodulated by ibogaine (<ce:italic>p</ce:italic> < 0.1558) (<ce:italic>p</ce:italic> < 0.3763), respectively. Furthermore, ibogaine itself did not significantly alter NAcc DA release over the 2-h period studied (<ce:italic>p</ce:italic> < 0.9113) although individual time points were significantly affected bidirectionally. Concurrently ibogaine significantly increased 5-HT release (<ce:italic>p</ce:italic> < 0.0155). Behaviorally, ibogaine appears to be a weak psychostimulant. The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions. Also elucidated as critical is the efficacy of ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Ibogaine</ce:text></ce:keyword><ce:keyword><ce:text>Cocaine</ce:text></ce:keyword><ce:keyword><ce:text>Psychostimulant behavior</ce:text></ce:keyword><ce:keyword><ce:text>Nucleus accumbens (NAcc)</ce:text></ce:keyword><ce:keyword><ce:text>Dopamine (DA)</ce:text></ce:keyword><ce:keyword><ce:text>Serotonin (5-HT)</ce:text></ce:keyword><ce:keyword><ce:text>In vivo electrochemistry (Voltammetry)</ce:text></ce:keyword><ce:keyword><ce:text>Stearate microelectrode</ce:text></ce:keyword><ce:keyword><ce:text>Freely moving rat paradigm</ce:text></ce:keyword><ce:keyword><ce:text>Locomotor activity</ce:text></ce:keyword><ce:keyword><ce:text>Central locomotor activity (agoraphobic inhibition)</ce:text></ce:keyword><ce:keyword><ce:text>Rearing behavior</ce:text></ce:keyword><ce:keyword><ce:text>Stereotypy</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies</title></titleInfo><name type="personal"><namePart type="given">Patricia A.</namePart><namePart type="family">Broderick</namePart><affiliation>Department of Pharmacology, The City University of New York Medical School, USA</affiliation><description>Requests for reprints should be addressed to Dr. P.A. Broderick, Department of Pharmacology, Rm. J-910, The City University of NY Medical School, Convent Ave. & W. 138th St., New York, NY 10031</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank T.</namePart><namePart type="family">Phelan</namePart><affiliation>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</affiliation><description>Present address: NYC, Department of Environmental Protection, Department of Limnology, Ben Nesin Lab., 28A, Shokan, NY.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank</namePart><namePart type="family">Eng</namePart><affiliation>Department of Pharmacology, The City University of New York Medical School, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert T.</namePart><namePart type="family">Wechsler</namePart><affiliation>Department of Pharmacology, The City University of New York Medical School, USADepartments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</affiliation><description>Present address: Chicago Medical School, 333 Green Bay Road, N. Chicago, IL 60064-3095.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Ibogaine, a serotonergic (5-HTergic) indole alkaloid, was studied for cocaine modulatory effects on four parameters of behavior by computerized infrared photocell beam detection. The behavioral parameters were: a) locomotor activity (ambulations), b) rearing, c) stereotypy (fine movements, primarily grooming), and d) agoraphobia [(thigmotaxis) a natural tendency to avoid the center of the behavioral chamber]. With each behavioral data point, dopamine (DA) release, and serotonin (5-HT) release were detected within seconds in nucleus accumbens (NAcc) of the same behaving male Sprague-Dawley rats, using in vivo electrochemistry (voltammetry). Ibogaine was administered (40 mg/kg IP) for 4 consecutive days. Importantly, the DAergic and the 5-HTergic responses to (SC) cocaine and two behavioral responses, ambulations and central ambulations, were reduced in intensity due to extended time spent in the novel behavioral chamber (habituated). Rearing and fine movement patterns were not habituated. The results show that ibogaine downmodulated the (SC) cocaine-induced increase in NAcc DA release (p < 0.0001) and potentiated the (SC) cocaine-induced decrease in NAcc 5-HT release (p < 0.0001). Concurrently, ibogaine downmodulated cocaine-induced ambulation (p < 0.0001) and central ambulation behavior (p < 0.0001). On the other hand, the behavioral parameters that did not exhibit habituation, i.e., rearing behavior and fine movement behavior, were not downmodulated by ibogaine (p < 0.1558) (p < 0.3763), respectively. Furthermore, ibogaine itself did not significantly alter NAcc DA release over the 2-h period studied (p < 0.9113) although individual time points were significantly affected bidirectionally. Concurrently ibogaine significantly increased 5-HT release (p < 0.0155). Behaviorally, ibogaine appears to be a weak psychostimulant. The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions. Also elucidated as critical is the efficacy of ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment.</abstract><note>These results were originally presented at the Second Annual International Behavioral Neuroscience Society Conference held in Clearwater Beach, FL, April 22–25, 1993.</note><subject><genre>Keywords</genre><topic>Ibogaine</topic><topic>Cocaine</topic><topic>Psychostimulant behavior</topic><topic>Nucleus accumbens (NAcc)</topic><topic>Dopamine (DA)</topic><topic>Serotonin (5-HT)</topic><topic>In vivo electrochemistry (Voltammetry)</topic><topic>Stearate microelectrode</topic><topic>Freely moving rat paradigm</topic><topic>Locomotor activity</topic><topic>Central locomotor activity (agoraphobic inhibition)</topic><topic>Rearing behavior</topic><topic>Stereotypy</topic></subject><relatedItem type="host"><titleInfo><title>Pharmacology, Biochemistry and Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PBB</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0091-3057</identifier><identifier type="PII">S0091-3057(00)X0150-5</identifier><part><date>1994</date><detail type="volume"><number>49</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>443</start><end>776</end></extent><extent unit="pages"><start>711</start><end>728</end></extent></part></relatedItem><identifier type="istex">AAE4DCE1868D69345B75D997B1A97862292EE583</identifier><identifier type="ark">ark:/67375/6H6-SV21WTBK-G</identifier><identifier type="DOI">10.1016/0091-3057(94)90092-2</identifier><identifier type="PII">0091-3057(94)90092-2</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-SV21WTBK-G/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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