Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects
Identifieur interne : 000908 ( Istex/Corpus ); précédent : 000907; suivant : 000909Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects
Auteurs : Z. Zidek ; K. MašekSource :
- International Journal of Immunopharmacology [ 0192-0561 ] ; 1998.
English descriptors
- Teeft :
- Acad, Albina, Antigen expression, Apoptosis, Arginase, Arginase activity, Arginine, Biochem, Biol, Biophys, Chem, Clin, Colitis, Commun, Cyclic, Cytokine, Cytolytic, Cytotoxic, Cytotoxicity, Czech republic, Encephalomyelitis, Endogenous, Endogenous nitric oxide, Endothelial, Endothelial cells, Endotoxemia, Hepatocytes, Hibbs, Human macrophages, Human monocytes, Immune, Immunol, Inducible, Inducible nitric oxide synthase, Inhibition, Inhibitor, Inos, Inos activity, Inos mrna, Interferon, Interleukin, Intracellular, Karupiah, Leishmania, Lett, Leukoc, Leukocyte, Liew, Lipopolysaccharide, Macrophage, Mediator, Metastasis, Mitochondrial respiration, Moncada, Monocyte, Mrna, Murine, Murine macrophages, Muscle cells, Natl, Nitric, Nitric oxide, Nitric oxide production, Nitric oxide synthase, Nitric oxide synthase activity, Nitric oxide synthase inhibition, Nitric oxide synthesis, Nitrite, Ornithine, Oxide, Pathway, Peritoneal, Peritoneal macrophages, Peroxynitrite, Pharmacol, Physiol, Proc, Prostaglandin, Reactive, Replication, Sato, Stuehr, Synthase, Thomsen, Tumor cells, Tumor growth, Tumor necrosis factor, Ulcerative colitis, Zidek.
Abstract
Abstract: The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.
Url:
DOI: 10.1016/S0192-0561(98)00036-8
Links to Exploration step
ISTEX:51E588D99438DDDF672E89729EEF91DA39AC36DDLe document en format XML
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Zidek</name><affiliation><mods:affiliation>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author: Z. Zidek, Institute of Pharmacology, Academy of Sciences, Vídenská 1083, 142 20 Prague 4, Czech Republic. Tel.: 420–02–4752720; fax: 420–02–4752109; e-mail: zidekz@biomed.cas.cz</mods:affiliation></affiliation></author><author><name sortKey="Masek, K" sort="Masek, K" uniqKey="Masek K" first="K." last="Mašek">K. 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A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. 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Zidek</name><affiliations><json:string>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</json:string><json:string>Corresponding author: Z. Zidek, Institute of Pharmacology, Academy of Sciences, Vídenská 1083, 142 20 Prague 4, Czech Republic. Tel.: 420–02–4752720; fax: 420–02–4752109; e-mail: zidekz@biomed.cas.cz</json:string></affiliations></json:item><json:item><name>K. Mašek</name><affiliations><json:string>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Nitric oxide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Review</value></json:item></subject><arkIstex>ark:/67375/6H6-FS0LBRNT-J</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Review article</json:string></originalGenre><abstract>Abstract: The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. 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and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - immunopathologie</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S0192-0561(98)00036-8</json:string></doi><id>51E588D99438DDDF672E89729EEF91DA39AC36DD</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FS0LBRNT-J/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FS0LBRNT-J/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-FS0LBRNT-J/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1998 International Society for Immunopharmacology.</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1998</date></publicationStmt><notesStmt><note type="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects</title><author xml:id="author-0000"><persName><forename type="first">Z.</forename><surname>Zidek</surname></persName><affiliation>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</affiliation><affiliation>Corresponding author: Z. Zidek, Institute of Pharmacology, Academy of Sciences, Vídenská 1083, 142 20 Prague 4, Czech Republic. Tel.: 420–02–4752720; fax: 420–02–4752109; e-mail: zidekz@biomed.cas.cz</affiliation></author><author xml:id="author-0001"><persName><forename type="first">K.</forename><surname>Mašek</surname></persName><affiliation>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</affiliation></author><idno type="istex">51E588D99438DDDF672E89729EEF91DA39AC36DD</idno><idno type="ark">ark:/67375/6H6-FS0LBRNT-J</idno><idno type="DOI">10.1016/S0192-0561(98)00036-8</idno><idno type="PII">S0192-0561(98)00036-8</idno></analytic><monogr><title level="j">International Journal of Immunopharmacology</title><title level="j" type="abbrev">IMMP</title><idno type="pISSN">0192-0561</idno><idno type="PII">S0192-0561(00)X0035-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">20</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="319">319</biblScope><biblScope unit="page" to="343">343</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Nitric oxide</term></item><item><term>Immunity</term></item><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FS0LBRNT-J/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>IMMP</jid><aid>532</aid><ce:pii>S0192-0561(98)00036-8</ce:pii><ce:doi>10.1016/S0192-0561(98)00036-8</ce:doi><ce:copyright year="1998" type="society">International Society for Immunopharmacology.</ce:copyright></item-info><head><ce:title>Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects</ce:title><ce:author-group><ce:author><ce:given-name>Z.</ce:given-name><ce:surname>Zidek</ce:surname><ce:cross-ref refid="AFF1">1</ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>K.</ce:given-name><ce:surname>Mašek</ce:surname><ce:cross-ref refid="AFF1">1</ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author: Z. Zidek, Institute of Pharmacology, Academy of Sciences, Vídenská 1083, 142 20 Prague 4, Czech Republic. Tel.: 420–02–4752720; fax: 420–02–4752109; e-mail: zidekz@biomed.cas.cz</ce:text></ce:correspondence></ce:author-group><ce:date-received day="20" month="2" year="1998"></ce:date-received><ce:date-accepted day="31" month="3" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Nitric oxide</ce:text></ce:keyword><ce:keyword><ce:text>Immunity</ce:text></ce:keyword><ce:keyword><ce:text>Review</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Review Article Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects</title></titleInfo><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Zidek</namePart><affiliation>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</affiliation><affiliation>Corresponding author: Z. Zidek, Institute of Pharmacology, Academy of Sciences, Vídenská 1083, 142 20 Prague 4, Czech Republic. Tel.: 420–02–4752720; fax: 420–02–4752109; e-mail: zidekz@biomed.cas.cz</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Mašek</namePart><affiliation>Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague,Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic\kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.</abstract><subject><genre>Keywords</genre><topic>Nitric oxide</topic><topic>Immunity</topic><topic>Review</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Immunopharmacology</title></titleInfo><titleInfo type="abbreviated"><title>IMMP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued></originInfo><identifier type="ISSN">0192-0561</identifier><identifier type="PII">S0192-0561(00)X0035-5</identifier><part><date>1998</date><detail type="volume"><number>20</number><caption>vol.</caption></detail><detail type="issue"><number>7</number><caption>no.</caption></detail><extent unit="issue-pages"><start>319</start><end>374</end></extent><extent unit="pages"><start>319</start><end>343</end></extent></part></relatedItem><identifier type="istex">51E588D99438DDDF672E89729EEF91DA39AC36DD</identifier><identifier type="ark">ark:/67375/6H6-FS0LBRNT-J</identifier><identifier type="DOI">10.1016/S0192-0561(98)00036-8</identifier><identifier type="PII">S0192-0561(98)00036-8</identifier><accessCondition type="use and reproduction" contentType="copyright">©1998 International Society for Immunopharmacology.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>International Society for Immunopharmacology., ©1998</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FS0LBRNT-J/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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