Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles
Identifieur interne : 000884 ( Istex/Corpus ); précédent : 000883; suivant : 000885Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles
Auteurs : S. Rittinghausen ; U. Mohr ; D. L. DungworthSource :
- Experimental and Toxicologic Pathology [ 0940-2993 ] ; 1997.
English descriptors
- KwdEn :
- Aerosol, inhalation, B(a)P, Carbon black, Carcinoma, squamous cell, keratinizing, lung, Coal oven exhaust, Crocidolite instillation, DB (ah) A, Diesel exhaust particles, Epithelioma, cystic, keratinizing, lung, Gas, irritant, Inhalation, different particles, Instillation, different particles, Irritant gas, Keratinizing cysts, lung, Keratinizing squamous cell lesion, pulmonary, Lung, inhalation, different particles, Lung, keratinizing squamous cell lesion, Particles, inhalation, Particles, instillation, Proliferative cell nuclear antigen (PCNA), Pulmonary keratinizing squamous cell lesion, Squamous metaplasia, lun, Tar/pitch condensation aerosol, Titanium dioxide, benzo(a)pyrene, dibenz(ah)antracene.
- Teeft :
- Adjacent alveolar spaces, Appl, Arch environ health, Benign, Cancer risk, Carcinogenic, Carcinogenic effects, Carcinoma, Cell carcinoma, Cell carcinomas, Cell layers, Central keratin, Chronic exposure, Chronic inhalation, Coal oven exhaust, Condensation aerosol, Connective tissue, Crocidolite, Cyst, Cystic, Cystic keratinizing, Cystic keratinizing epithelioma, Cystic keratinizing epitheliomas, Cystic keratinizing lesions, Diesel, Diesel exhaust, Diesel exhaust particles, Different concentrations, Different particles, Dioxide, Dungworth, Environ, Epithelial, Epithelial cells, Epithelial wall, Epithelioma, Epithelium, Exhaust, Fibril, Fund appl, Fund appl toxicol, Great majority, Hannover, Heinrich, High dose, Histologically, Ilsi press washington, Inhalation, Inhalation studies, Inhaled, Inhaled particles, Instillation, Instillation studies, Intratracheal, Intratracheal instillation, Intratracheal instillation study, Invasive growth, Irritant, Keratin, Keratinization, Keratinized, Keratinizing, Keratinizing cyst, Keratinizing cysts, Keratinizing epitheliomas, Lesion, Lesions exposure atmosphere, Leucocyte, Lung cancer, Lung tissue, Macrophage, Mast cells, Mauderly, Mayers haemalaun, Metaplasia, Mitotic figures, Mohr, Muhle, Native diesel exhaust particles, Neoplasm, Neoplastic, Other species, Pathol, Pcna, Peripheral cell layers, Polymorphonuclear, Polymorphonuclear leucocytes, Pott, Printex, Proliferative, Proliferative activity, Proliferative keratin cyst, Pulmonary response, Railroad workers, Rat, Recovery period, Respiratory tract, Solid particles, Squamous, Squamous cell carcinoma, Squamous cell carcinomas, Squamous epithelium, Squamous metaplasia, Titanium, Titanium dioxide, Total dose, Total number, Toxic, Toxic pathol, Toxicol, Toxicology, Transitional stages, Tumour, Tumour cells, Tumour wall, Unfiltered diesel exhaust.
Abstract
Summary: Cystic keratinizing squamous cell lesions from three inhalation studies (Study A, B, C) and one intratracheal instillation study (Study D) in rats were reclassified and a certain number of lesions examined immunohistochemically for PCNA (proliferating cell nuclear antigen) as a marker of cellular proliferation. The following classification was used: squamous cell metaplasia with marked keratinization, keratinizing cyst, cystic keratinizing epithelioma, cystic keratinizing squamous cell carcinoma, keratinizing squamous cell carcinoma and non-keratinizing squamous cell carcinoma. In study A (inhalation of coal oven exhaust and subcutaneous injection of a high dose of DB (ah)A) 49.3 % of rats developed cystic keratinizing squamous cell carcinomas. Inhalation of coal oven exhaust gas together with intratracheal instillation of crocidolite or subcutaneous injection of a low dose DB(ah)A (dibenz(ah)anthracene) resulted in cystic keratinizing squamous cell carcinomas in 23 % to 24 % of the rats. High incidences of cystic squamous cell carcinomas in the range of 31.9 % to 76.4 % were observed in rats of Study B1 after a 10-months exposure to tar/pitch condensation aerosol (different B(a)P (benzo(a)pyrene) concentrations) with added carbon black in some groups. After a 20-months exposure period to the same inhalation atmospheres (Study B2) the incidence of squamous cell carcinomas was increased up to 95.8 %. Exposure of rats to various concentrations of unfiltered diesel exhaust (Study C) resulted in incidences of cystic keratinizing epitheliomas ranging from 2.5 % (2.5 mg/m3) to 10.7 % (7.5 mg/m3). Epitheliomas were also observed in 16.2 % of carbon black and 16.0 % of titanium dioxide exposed rats. Only a few cystic keratinizing squamous cell carcinomas occurred. In the intratrachel instillation study (Study D) increased incidences of cystic keratinizing epitheliomas occurred in rats exposed to native diesel exhaust particles (16.7 %), high dose of extracted diesel exhaust particles (14.6 %), extracted printex 90-carbon black particles (18.8 %), and extracted printex 90-carbon black particles + B(a)P (18.8 %). High indicences of cystic keratinizing squamous cell carcinomas were noted in rats that received 15 mg B(a)P (14.6 %) or 30 mg B(a)P (72.7 %) intratracheally. Immunohistochemical labeling of nuclei with PCNA demonstrated proliferative activity in one or two (and focally more than two) peripheral cell layers of cystic keratinizing epitheliomas and in more than three peripheral cell layers of cystic keratinizing squamous cell carcinomas and keratinizing squamous cell carcinomas. The wall of keratinizing cysts showed no or a weak reaction.
Url:
DOI: 10.1016/S0940-2993(97)80131-5
Links to Exploration step
ISTEX:56FDF44DC07B137BD5A47E528E8B1FDDD16873F3Le document en format XML
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Mohr</name><affiliation><mods:affiliation>Hannover Medical School, Department of Experimental Pathology, Hannover, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dungworth, D L" sort="Dungworth, D L" uniqKey="Dungworth D" first="D. L." last="Dungworth">D. L. Dungworth</name><affiliation><mods:affiliation>University of California at Davis, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>4Professor Emeritus</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:56FDF44DC07B137BD5A47E528E8B1FDDD16873F3</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0940-2993(97)80131-5</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-FM7MVC2V-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000884</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000884</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles</title><author><name sortKey="Rittinghausen, S" sort="Rittinghausen, S" uniqKey="Rittinghausen S" first="S." last="Rittinghausen">S. Rittinghausen</name><affiliation><mods:affiliation>Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Address for correspondence: Dr. S. Rittinghausen, Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Str. 1, D - 30625 Hannover, Germany.</mods:affiliation></affiliation></author><author><name sortKey="Mohr, U" sort="Mohr, U" uniqKey="Mohr U" first="U." last="Mohr">U. Mohr</name><affiliation><mods:affiliation>Hannover Medical School, Department of Experimental Pathology, Hannover, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dungworth, D L" sort="Dungworth, D L" uniqKey="Dungworth D" first="D. L." last="Dungworth">D. L. Dungworth</name><affiliation><mods:affiliation>University of California at Davis, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>4Professor Emeritus</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental and Toxicologic Pathology</title><title level="j" type="abbrev">ETP</title><idno type="ISSN">0940-2993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">49</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="433">433</biblScope><biblScope unit="page" to="446">446</biblScope></imprint><idno type="ISSN">0940-2993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0940-2993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aerosol, inhalation</term><term>B(a)P</term><term>Carbon black</term><term>Carcinoma, squamous cell, keratinizing, lung</term><term>Coal oven exhaust</term><term>Crocidolite instillation</term><term>DB (ah) A</term><term>Diesel exhaust particles</term><term>Epithelioma, cystic, keratinizing, lung</term><term>Gas, irritant</term><term>Inhalation, different particles</term><term>Instillation, different particles</term><term>Irritant gas</term><term>Keratinizing cysts, lung</term><term>Keratinizing squamous cell lesion, pulmonary</term><term>Lung, inhalation, different particles</term><term>Lung, keratinizing squamous cell lesion</term><term>Particles, inhalation</term><term>Particles, instillation</term><term>Proliferative cell nuclear antigen (PCNA)</term><term>Pulmonary keratinizing squamous cell lesion</term><term>Squamous metaplasia, lun</term><term>Tar/pitch condensation aerosol</term><term>Titanium dioxide</term><term>benzo(a)pyrene</term><term>dibenz(ah)antracene</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adjacent alveolar spaces</term><term>Appl</term><term>Arch environ health</term><term>Benign</term><term>Cancer risk</term><term>Carcinogenic</term><term>Carcinogenic effects</term><term>Carcinoma</term><term>Cell carcinoma</term><term>Cell carcinomas</term><term>Cell layers</term><term>Central keratin</term><term>Chronic exposure</term><term>Chronic inhalation</term><term>Coal oven exhaust</term><term>Condensation aerosol</term><term>Connective tissue</term><term>Crocidolite</term><term>Cyst</term><term>Cystic</term><term>Cystic keratinizing</term><term>Cystic keratinizing epithelioma</term><term>Cystic keratinizing epitheliomas</term><term>Cystic keratinizing lesions</term><term>Diesel</term><term>Diesel exhaust</term><term>Diesel exhaust particles</term><term>Different concentrations</term><term>Different particles</term><term>Dioxide</term><term>Dungworth</term><term>Environ</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelial wall</term><term>Epithelioma</term><term>Epithelium</term><term>Exhaust</term><term>Fibril</term><term>Fund appl</term><term>Fund appl toxicol</term><term>Great majority</term><term>Hannover</term><term>Heinrich</term><term>High dose</term><term>Histologically</term><term>Ilsi press washington</term><term>Inhalation</term><term>Inhalation studies</term><term>Inhaled</term><term>Inhaled particles</term><term>Instillation</term><term>Instillation studies</term><term>Intratracheal</term><term>Intratracheal instillation</term><term>Intratracheal instillation study</term><term>Invasive growth</term><term>Irritant</term><term>Keratin</term><term>Keratinization</term><term>Keratinized</term><term>Keratinizing</term><term>Keratinizing cyst</term><term>Keratinizing cysts</term><term>Keratinizing epitheliomas</term><term>Lesion</term><term>Lesions exposure atmosphere</term><term>Leucocyte</term><term>Lung cancer</term><term>Lung tissue</term><term>Macrophage</term><term>Mast cells</term><term>Mauderly</term><term>Mayers haemalaun</term><term>Metaplasia</term><term>Mitotic figures</term><term>Mohr</term><term>Muhle</term><term>Native diesel exhaust particles</term><term>Neoplasm</term><term>Neoplastic</term><term>Other species</term><term>Pathol</term><term>Pcna</term><term>Peripheral cell layers</term><term>Polymorphonuclear</term><term>Polymorphonuclear leucocytes</term><term>Pott</term><term>Printex</term><term>Proliferative</term><term>Proliferative activity</term><term>Proliferative keratin cyst</term><term>Pulmonary response</term><term>Railroad workers</term><term>Rat</term><term>Recovery period</term><term>Respiratory tract</term><term>Solid particles</term><term>Squamous</term><term>Squamous cell carcinoma</term><term>Squamous cell carcinomas</term><term>Squamous epithelium</term><term>Squamous metaplasia</term><term>Titanium</term><term>Titanium dioxide</term><term>Total dose</term><term>Total number</term><term>Toxic</term><term>Toxic pathol</term><term>Toxicol</term><term>Toxicology</term><term>Transitional stages</term><term>Tumour</term><term>Tumour cells</term><term>Tumour wall</term><term>Unfiltered diesel exhaust</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary: Cystic keratinizing squamous cell lesions from three inhalation studies (Study A, B, C) and one intratracheal instillation study (Study D) in rats were reclassified and a certain number of lesions examined immunohistochemically for PCNA (proliferating cell nuclear antigen) as a marker of cellular proliferation. The following classification was used: squamous cell metaplasia with marked keratinization, keratinizing cyst, cystic keratinizing epithelioma, cystic keratinizing squamous cell carcinoma, keratinizing squamous cell carcinoma and non-keratinizing squamous cell carcinoma. In study A (inhalation of coal oven exhaust and subcutaneous injection of a high dose of DB (ah)A) 49.3 % of rats developed cystic keratinizing squamous cell carcinomas. Inhalation of coal oven exhaust gas together with intratracheal instillation of crocidolite or subcutaneous injection of a low dose DB(ah)A (dibenz(ah)anthracene) resulted in cystic keratinizing squamous cell carcinomas in 23 % to 24 % of the rats. High incidences of cystic squamous cell carcinomas in the range of 31.9 % to 76.4 % were observed in rats of Study B1 after a 10-months exposure to tar/pitch condensation aerosol (different B(a)P (benzo(a)pyrene) concentrations) with added carbon black in some groups. After a 20-months exposure period to the same inhalation atmospheres (Study B2) the incidence of squamous cell carcinomas was increased up to 95.8 %. Exposure of rats to various concentrations of unfiltered diesel exhaust (Study C) resulted in incidences of cystic keratinizing epitheliomas ranging from 2.5 % (2.5 mg/m3) to 10.7 % (7.5 mg/m3). Epitheliomas were also observed in 16.2 % of carbon black and 16.0 % of titanium dioxide exposed rats. Only a few cystic keratinizing squamous cell carcinomas occurred. In the intratrachel instillation study (Study D) increased incidences of cystic keratinizing epitheliomas occurred in rats exposed to native diesel exhaust particles (16.7 %), high dose of extracted diesel exhaust particles (14.6 %), extracted printex 90-carbon black particles (18.8 %), and extracted printex 90-carbon black particles + B(a)P (18.8 %). High indicences of cystic keratinizing squamous cell carcinomas were noted in rats that received 15 mg B(a)P (14.6 %) or 30 mg B(a)P (72.7 %) intratracheally. Immunohistochemical labeling of nuclei with PCNA demonstrated proliferative activity in one or two (and focally more than two) peripheral cell layers of cystic keratinizing epitheliomas and in more than three peripheral cell layers of cystic keratinizing squamous cell carcinomas and keratinizing squamous cell carcinomas. The wall of keratinizing cysts showed no or a weak reaction.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>keratinizing</json:string><json:string>cystic</json:string><json:string>tumour</json:string><json:string>epithelioma</json:string><json:string>squamous</json:string><json:string>carcinoma</json:string><json:string>cystic keratinizing</json:string><json:string>cyst</json:string><json:string>cell carcinomas</json:string><json:string>inhalation</json:string><json:string>keratin</json:string><json:string>diesel</json:string><json:string>epithelial</json:string><json:string>neoplasm</json:string><json:string>cystic keratinizing epitheliomas</json:string><json:string>cell carcinoma</json:string><json:string>cystic keratinizing lesions</json:string><json:string>inhaled</json:string><json:string>pcna</json:string><json:string>intratracheal</json:string><json:string>titanium dioxide</json:string><json:string>cystic keratinizing epithelioma</json:string><json:string>diesel exhaust particles</json:string><json:string>mauderly</json:string><json:string>proliferative</json:string><json:string>lesion</json:string><json:string>dungworth</json:string><json:string>toxicol</json:string><json:string>mohr</json:string><json:string>inhalation studies</json:string><json:string>pott</json:string><json:string>histologically</json:string><json:string>metaplasia</json:string><json:string>macrophage</json:string><json:string>polymorphonuclear</json:string><json:string>printex</json:string><json:string>heinrich</json:string><json:string>instillation</json:string><json:string>fibril</json:string><json:string>diesel exhaust</json:string><json:string>neoplastic</json:string><json:string>environ</json:string><json:string>coal oven exhaust</json:string><json:string>crocidolite</json:string><json:string>epithelium</json:string><json:string>appl</json:string><json:string>keratinizing cysts</json:string><json:string>total number</json:string><json:string>squamous cell carcinomas</json:string><json:string>different concentrations</json:string><json:string>condensation aerosol</json:string><json:string>squamous cell carcinoma</json:string><json:string>polymorphonuclear leucocytes</json:string><json:string>pathol</json:string><json:string>leucocyte</json:string><json:string>epithelial cells</json:string><json:string>rat</json:string><json:string>keratinization</json:string><json:string>carcinogenic</json:string><json:string>toxicology</json:string><json:string>hannover</json:string><json:string>lung cancer</json:string><json:string>total dose</json:string><json:string>keratinized</json:string><json:string>muhle</json:string><json:string>central keratin</json:string><json:string>peripheral cell layers</json:string><json:string>squamous metaplasia</json:string><json:string>tumour wall</json:string><json:string>dioxide</json:string><json:string>carcinogenic effects</json:string><json:string>chronic inhalation</json:string><json:string>pulmonary response</json:string><json:string>intratracheal instillation</json:string><json:string>different particles</json:string><json:string>respiratory tract</json:string><json:string>cell layers</json:string><json:string>great majority</json:string><json:string>irritant</json:string><json:string>connective tissue</json:string><json:string>squamous epithelium</json:string><json:string>ilsi press washington</json:string><json:string>recovery period</json:string><json:string>toxic pathol</json:string><json:string>keratinizing cyst</json:string><json:string>keratinizing epitheliomas</json:string><json:string>intratracheal instillation study</json:string><json:string>unfiltered diesel exhaust</json:string><json:string>fund appl</json:string><json:string>proliferative activity</json:string><json:string>native diesel exhaust particles</json:string><json:string>solid particles</json:string><json:string>titanium</json:string><json:string>exhaust</json:string><json:string>benign</json:string><json:string>invasive growth</json:string><json:string>arch environ health</json:string><json:string>railroad workers</json:string><json:string>high dose</json:string><json:string>inhaled particles</json:string><json:string>adjacent alveolar spaces</json:string><json:string>lung tissue</json:string><json:string>instillation studies</json:string><json:string>chronic exposure</json:string><json:string>other species</json:string><json:string>mayers haemalaun</json:string><json:string>proliferative keratin cyst</json:string><json:string>mitotic figures</json:string><json:string>lesions exposure atmosphere</json:string><json:string>transitional stages</json:string><json:string>cancer risk</json:string><json:string>epithelial wall</json:string><json:string>mast cells</json:string><json:string>fund appl toxicol</json:string><json:string>tumour cells</json:string><json:string>toxic</json:string></teeft></keywords><author><json:item><name>S. Rittinghausen</name><affiliations><json:string>Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany</json:string><json:string>Address for correspondence: Dr. S. Rittinghausen, Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Str. 1, D - 30625 Hannover, Germany.</json:string></affiliations></json:item><json:item><name>U. Mohr</name><affiliations><json:string>Hannover Medical School, Department of Experimental Pathology, Hannover, Germany</json:string></affiliations></json:item><json:item><name>D.L. Dungworth</name><affiliations><json:string>University of California at Davis, USA</json:string><json:string>4Professor Emeritus</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Keratinizing squamous cell lesion, pulmonary</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pulmonary keratinizing squamous cell lesion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Inhalation, different particles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Particles, inhalation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Particles, instillation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Instillation, different particles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Diesel exhaust particles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Coal oven exhaust</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Crocidolite instillation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DB (ah) A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dibenz(ah)antracene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>B(a)P</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>benzo(a)pyrene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Carbon black</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Gas, irritant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Irritant gas</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Tar/pitch condensation aerosol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Titanium dioxide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Aerosol, inhalation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lung, inhalation, different particles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lung, keratinizing squamous cell lesion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Proliferative cell nuclear antigen (PCNA)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Squamous metaplasia, lun</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Keratinizing cysts, lung</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Epithelioma, cystic, keratinizing, lung</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Carcinoma, squamous cell, keratinizing, lung</value></json:item></subject><articleId><json:string>80131</json:string></articleId><arkIstex>ark:/67375/6H6-FM7MVC2V-P</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Summary: Cystic keratinizing squamous cell lesions from three inhalation studies (Study A, B, C) and one intratracheal instillation study (Study D) in rats were reclassified and a certain number of lesions examined immunohistochemically for PCNA (proliferating cell nuclear antigen) as a marker of cellular proliferation. The following classification was used: squamous cell metaplasia with marked keratinization, keratinizing cyst, cystic keratinizing epithelioma, cystic keratinizing squamous cell carcinoma, keratinizing squamous cell carcinoma and non-keratinizing squamous cell carcinoma. In study A (inhalation of coal oven exhaust and subcutaneous injection of a high dose of DB (ah)A) 49.3 % of rats developed cystic keratinizing squamous cell carcinomas. Inhalation of coal oven exhaust gas together with intratracheal instillation of crocidolite or subcutaneous injection of a low dose DB(ah)A (dibenz(ah)anthracene) resulted in cystic keratinizing squamous cell carcinomas in 23 % to 24 % of the rats. High incidences of cystic squamous cell carcinomas in the range of 31.9 % to 76.4 % were observed in rats of Study B1 after a 10-months exposure to tar/pitch condensation aerosol (different B(a)P (benzo(a)pyrene) concentrations) with added carbon black in some groups. After a 20-months exposure period to the same inhalation atmospheres (Study B2) the incidence of squamous cell carcinomas was increased up to 95.8 %. Exposure of rats to various concentrations of unfiltered diesel exhaust (Study C) resulted in incidences of cystic keratinizing epitheliomas ranging from 2.5 % (2.5 mg/m3) to 10.7 % (7.5 mg/m3). Epitheliomas were also observed in 16.2 % of carbon black and 16.0 % of titanium dioxide exposed rats. Only a few cystic keratinizing squamous cell carcinomas occurred. In the intratrachel instillation study (Study D) increased incidences of cystic keratinizing epitheliomas occurred in rats exposed to native diesel exhaust particles (16.7 %), high dose of extracted diesel exhaust particles (14.6 %), extracted printex 90-carbon black particles (18.8 %), and extracted printex 90-carbon black particles + B(a)P (18.8 %). High indicences of cystic keratinizing squamous cell carcinomas were noted in rats that received 15 mg B(a)P (14.6 %) or 30 mg B(a)P (72.7 %) intratracheally. Immunohistochemical labeling of nuclei with PCNA demonstrated proliferative activity in one or two (and focally more than two) peripheral cell layers of cystic keratinizing epitheliomas and in more than three peripheral cell layers of cystic keratinizing squamous cell carcinomas and keratinizing squamous cell carcinomas. The wall of keratinizing cysts showed no or a weak reaction.</abstract><qualityIndicators><score>10</score><pdfWordCount>8782</pdfWordCount><pdfCharCount>56403</pdfCharCount><pdfVersion>1.7</pdfVersion><pdfPageCount>14</pdfPageCount><pdfPageSize>581.16 x 822 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>394</abstractWordCount><abstractCharCount>2692</abstractCharCount><keywordCount>26</keywordCount></qualityIndicators><title>Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles</title><pii><json:string>S0940-2993(97)80131-5</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Experimental and Toxicologic Pathology</title><language><json:string>unknown</json:string></language><publicationDate>1997</publicationDate><issn><json:string>0940-2993</json:string></issn><pii><json:string>S0940-2993(97)X8129-1</json:string></pii><volume>49</volume><issue>6</issue><pages><first>433</first><last>446</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1997</json:string></date><geogName></geogName><orgName><json:string>Department of Experimental Pathology, Hannover, Germany</json:string><json:string>NATIONAL TOXICOLOGY PROGRAM</json:string><json:string>Fraunhofer Institute of Toxicology and Aerosol</json:string><json:string>University of California</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>C. Cystic</json:string><json:string>Hope Farms</json:string></persName><placeName><json:string>Germany</json:string><json:string>Newark</json:string><json:string>U.S.</json:string><json:string>China</json:string><json:string>Netherlands</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>OflSHINISHI et al. (1986)</json:string><json:string>Xu et al.</json:string><json:string>Slade et al. 1985</json:string><json:string>1985, 1986a</json:string><json:string>1962, 1976</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-FM7MVC2V-P</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - toxicology</json:string><json:string>2 - pathology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - toxicology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Cell Biology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Toxicology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pathology and Forensic Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - sarcoidoses. granulomatoses d'etiologie indeterminee. maladies du tissu conjonctif. maladies du tissu elastique. vascularites</json:string></inist></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1016/S0940-2993(97)80131-5</json:string></doi><id>56FDF44DC07B137BD5A47E528E8B1FDDD16873F3</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FM7MVC2V-P/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FM7MVC2V-P/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-FM7MVC2V-P/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1997 Gustav Fischer Verlag</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1997</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles</title><author xml:id="author-0000"><persName><forename type="first">S.</forename><surname>Rittinghausen</surname></persName><affiliation>Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany</affiliation><affiliation>Address for correspondence: Dr. S. Rittinghausen, Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Str. 1, D - 30625 Hannover, Germany.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">U.</forename><surname>Mohr</surname></persName><affiliation>Hannover Medical School, Department of Experimental Pathology, Hannover, Germany</affiliation></author><author xml:id="author-0002"><persName><forename type="first">D.L.</forename><surname>Dungworth</surname></persName><affiliation>University of California at Davis, USA</affiliation><affiliation>4Professor Emeritus</affiliation></author><idno type="istex">56FDF44DC07B137BD5A47E528E8B1FDDD16873F3</idno><idno type="ark">ark:/67375/6H6-FM7MVC2V-P</idno><idno type="DOI">10.1016/S0940-2993(97)80131-5</idno><idno type="PII">S0940-2993(97)80131-5</idno><idno type="article-id">80131</idno></analytic><monogr><title level="j">Experimental and Toxicologic Pathology</title><title level="j" type="abbrev">ETP</title><idno type="pISSN">0940-2993</idno><idno type="PII">S0940-2993(97)X8129-1</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">49</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="433">433</biblScope><biblScope unit="page" to="446">446</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Summary: Cystic keratinizing squamous cell lesions from three inhalation studies (Study A, B, C) and one intratracheal instillation study (Study D) in rats were reclassified and a certain number of lesions examined immunohistochemically for PCNA (proliferating cell nuclear antigen) as a marker of cellular proliferation. The following classification was used: squamous cell metaplasia with marked keratinization, keratinizing cyst, cystic keratinizing epithelioma, cystic keratinizing squamous cell carcinoma, keratinizing squamous cell carcinoma and non-keratinizing squamous cell carcinoma. In study A (inhalation of coal oven exhaust and subcutaneous injection of a high dose of DB (ah)A) 49.3 % of rats developed cystic keratinizing squamous cell carcinomas. Inhalation of coal oven exhaust gas together with intratracheal instillation of crocidolite or subcutaneous injection of a low dose DB(ah)A (dibenz(ah)anthracene) resulted in cystic keratinizing squamous cell carcinomas in 23 % to 24 % of the rats. High incidences of cystic squamous cell carcinomas in the range of 31.9 % to 76.4 % were observed in rats of Study B1 after a 10-months exposure to tar/pitch condensation aerosol (different B(a)P (benzo(a)pyrene) concentrations) with added carbon black in some groups. After a 20-months exposure period to the same inhalation atmospheres (Study B2) the incidence of squamous cell carcinomas was increased up to 95.8 %. Exposure of rats to various concentrations of unfiltered diesel exhaust (Study C) resulted in incidences of cystic keratinizing epitheliomas ranging from 2.5 % (2.5 mg/m3) to 10.7 % (7.5 mg/m3). Epitheliomas were also observed in 16.2 % of carbon black and 16.0 % of titanium dioxide exposed rats. Only a few cystic keratinizing squamous cell carcinomas occurred. In the intratrachel instillation study (Study D) increased incidences of cystic keratinizing epitheliomas occurred in rats exposed to native diesel exhaust particles (16.7 %), high dose of extracted diesel exhaust particles (14.6 %), extracted printex 90-carbon black particles (18.8 %), and extracted printex 90-carbon black particles + B(a)P (18.8 %). High indicences of cystic keratinizing squamous cell carcinomas were noted in rats that received 15 mg B(a)P (14.6 %) or 30 mg B(a)P (72.7 %) intratracheally. Immunohistochemical labeling of nuclei with PCNA demonstrated proliferative activity in one or two (and focally more than two) peripheral cell layers of cystic keratinizing epitheliomas and in more than three peripheral cell layers of cystic keratinizing squamous cell carcinomas and keratinizing squamous cell carcinomas. The wall of keratinizing cysts showed no or a weak reaction.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Keratinizing squamous cell lesion, pulmonary</term></item><item><term>Pulmonary keratinizing squamous cell lesion</term></item><item><term>Inhalation, different particles</term></item><item><term>Particles, inhalation</term></item><item><term>Particles, instillation</term></item><item><term>Instillation, different particles</term></item><item><term>Diesel exhaust particles</term></item><item><term>Coal oven exhaust</term></item><item><term>Crocidolite instillation</term></item><item><term>DB (ah) A</term></item><item><term>dibenz(ah)antracene</term></item><item><term>B(a)P</term></item><item><term>benzo(a)pyrene</term></item><item><term>Carbon black</term></item><item><term>Gas, irritant</term></item><item><term>Irritant gas</term></item><item><term>Tar/pitch condensation aerosol</term></item><item><term>Titanium dioxide</term></item><item><term>Aerosol, inhalation</term></item><item><term>Lung, inhalation, different particles</term></item><item><term>Lung, keratinizing squamous cell lesion</term></item><item><term>Proliferative cell nuclear antigen (PCNA)</term></item><item><term>Squamous metaplasia, lun</term></item><item><term>Keratinizing cysts, lung</term></item><item><term>Epithelioma, cystic, keratinizing, lung</term></item><item><term>Carcinoma, squamous cell, keratinizing, lung</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FM7MVC2V-P/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" </istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.1.0//EN//XML" URI="art510.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.1" xml:lang="en" docsubtype="fla"><item-info><jid>ETP</jid><aid>80131</aid><ce:pii>S0940-2993(97)80131-5</ce:pii><ce:doi>10.1016/S0940-2993(97)80131-5</ce:doi><ce:copyright type="other" year="1997">Gustav Fischer Verlag</ce:copyright></item-info><head><ce:title>Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles</ce:title><ce:author-group><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Rittinghausen</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>U.</ce:given-name><ce:surname>Mohr</ce:surname><ce:cross-ref refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.L.</ce:given-name><ce:surname>Dungworth</ce:surname><ce:cross-ref refid="aff3"><ce:sup>3</ce:sup></ce:cross-ref><ce:cross-ref refid="fn1"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>1</ce:label><ce:textfn>Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>2</ce:label><ce:textfn>Hannover Medical School, Department of Experimental Pathology, Hannover, Germany</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>3</ce:label><ce:textfn>University of California at Davis, USA</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text><ce:bold>Address for correspondence:</ce:bold> Dr. S. <ce:small-caps>Rittinghausen</ce:small-caps>, Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Str. 1, D - 30625 Hannover, Germany.</ce:text></ce:correspondence><ce:footnote id="fn1"><ce:label>4</ce:label><ce:note-para>Professor Emeritus</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="15" month="6" year="1997"></ce:date-received><ce:date-accepted day="14" month="7" year="1997"></ce:date-accepted><ce:abstract id="ab1"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para id="SP0005">Cystic keratinizing squamous cell lesions from three inhalation studies (Study A, B, C) and one intratracheal instillation study (Study D) in rats were reclassified and a certain number of lesions examined immunohistochemically for PCNA (proliferating cell nuclear antigen) as a marker of cellular proliferation. The following classification was used: squamous cell metaplasia with marked keratinization, keratinizing cyst, cystic keratinizing epithelioma, cystic keratinizing squamous cell carcinoma, keratinizing squamous cell carcinoma and non-keratinizing squamous cell carcinoma. In study A (inhalation of coal oven exhaust and subcutaneous injection of a high dose of DB (<ce:italic>ah</ce:italic>)A) 49.3 % of rats developed cystic keratinizing squamous cell carcinomas. Inhalation of coal oven exhaust gas together with intratracheal instillation of crocidolite or subcutaneous injection of a low dose DB(<ce:italic>ah</ce:italic>)A (dibenz(<ce:italic>ah</ce:italic>)anthracene) resulted in cystic keratinizing squamous cell carcinomas in 23 % to 24 % of the rats. High incidences of cystic squamous cell carcinomas in the range of 31.9 % to 76.4 % were observed in rats of Study B1 after a 10-months exposure to tar/pitch condensation aerosol (different B(<ce:italic>a</ce:italic>)P (benzo(<ce:italic>a</ce:italic>)pyrene) concentrations) with added carbon black in some groups. After a 20-months exposure period to the same inhalation atmospheres (Study B2) the incidence of squamous cell carcinomas was increased up to 95.8 %. Exposure of rats to various concentrations of unfiltered diesel exhaust (Study C) resulted in incidences of cystic keratinizing epitheliomas ranging from 2.5 % (2.5 mg/m<ce:sup>3</ce:sup>) to 10.7 % (7.5 mg/m<ce:sup>3</ce:sup>). Epitheliomas were also observed in 16.2 % of carbon black and 16.0 % of titanium dioxide exposed rats. Only a few cystic keratinizing squamous cell carcinomas occurred. In the intratrachel instillation study (Study D) increased incidences of cystic keratinizing epitheliomas occurred in rats exposed to native diesel exhaust particles (16.7 %), high dose of extracted diesel exhaust particles (14.6 %), extracted printex 90-carbon black particles (18.8 %), and extracted printex 90-carbon black particles + B(<ce:italic>a</ce:italic>)P (18.8 %). High indicences of cystic keratinizing squamous cell carcinomas were noted in rats that received 15 mg B(<ce:italic>a</ce:italic>)P (14.6 %) or 30 mg B(<ce:italic>a</ce:italic>)P (72.7 %) intratracheally. Immunohistochemical labeling of nuclei with PCNA demonstrated proliferative activity in one or two (and focally more than two) peripheral cell layers of cystic keratinizing epitheliomas and in more than three peripheral cell layers of cystic keratinizing squamous cell carcinomas and keratinizing squamous cell carcinomas. The wall of keratinizing cysts showed no or a weak reaction.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Key words</ce:section-title><ce:keyword><ce:text>Keratinizing squamous cell lesion, pulmonary</ce:text></ce:keyword><ce:keyword><ce:text>Pulmonary keratinizing squamous cell lesion</ce:text></ce:keyword><ce:keyword><ce:text>Inhalation, different particles</ce:text></ce:keyword><ce:keyword><ce:text>Particles, inhalation</ce:text></ce:keyword><ce:keyword><ce:text>Particles, instillation</ce:text></ce:keyword><ce:keyword><ce:text>Instillation, different particles</ce:text></ce:keyword><ce:keyword><ce:text>Diesel exhaust particles</ce:text></ce:keyword><ce:keyword><ce:text>Coal oven exhaust</ce:text></ce:keyword><ce:keyword><ce:text>Crocidolite instillation</ce:text></ce:keyword><ce:keyword><ce:text>DB (<ce:italic>ah</ce:italic>) A</ce:text></ce:keyword><ce:keyword><ce:text>dibenz(<ce:italic>ah</ce:italic>)antracene</ce:text></ce:keyword><ce:keyword><ce:text>B(<ce:italic>a</ce:italic>)P</ce:text></ce:keyword><ce:keyword><ce:text>benzo(<ce:italic>a</ce:italic>)pyrene</ce:text></ce:keyword><ce:keyword><ce:text>Carbon black</ce:text></ce:keyword><ce:keyword><ce:text>Gas, irritant</ce:text></ce:keyword><ce:keyword><ce:text>Irritant gas</ce:text></ce:keyword><ce:keyword><ce:text>Tar/pitch condensation aerosol</ce:text></ce:keyword><ce:keyword><ce:text>Titanium dioxide</ce:text></ce:keyword><ce:keyword><ce:text>Aerosol, inhalation</ce:text></ce:keyword><ce:keyword><ce:text>Lung, inhalation, different particles</ce:text></ce:keyword><ce:keyword><ce:text>Lung, keratinizing squamous cell lesion</ce:text></ce:keyword><ce:keyword><ce:text>Proliferative cell nuclear antigen (PCNA)</ce:text></ce:keyword><ce:keyword><ce:text>Squamous metaplasia, lun</ce:text></ce:keyword><ce:keyword><ce:text>Keratinizing cysts, lung</ce:text></ce:keyword><ce:keyword><ce:text>Epithelioma, cystic, keratinizing, lung</ce:text></ce:keyword><ce:keyword><ce:text>Carcinoma, squamous cell, keratinizing, lung</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography id="R0005"><ce:section-title>References</ce:section-title><ce:bibliography-sec id="RS0005"><ce:bib-reference id="bib1"><ce:label>Alison et al., 1994</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:given-name>RH</ce:given-name><ce:surname>Alison</ce:surname></sb:author><sb:author><ce:given-name>CC</ce:given-name><ce:surname>Capen</ce:surname></sb:author><sb:author><ce:given-name>DE</ce:given-name><ce:surname>Prentice</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Neoplastic lesions of questionable significance to humans</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Toxicol 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Rittinghausen, Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Str. 1, D - 30625 Hannover, Germany.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Mohr</namePart><affiliation>Hannover Medical School, Department of Experimental Pathology, Hannover, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.L.</namePart><namePart type="family">Dungworth</namePart><affiliation>University of California at Davis, USA</affiliation><affiliation>4Professor Emeritus</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>Summary: Cystic keratinizing squamous cell lesions from three inhalation studies (Study A, B, C) and one intratracheal instillation study (Study D) in rats were reclassified and a certain number of lesions examined immunohistochemically for PCNA (proliferating cell nuclear antigen) as a marker of cellular proliferation. The following classification was used: squamous cell metaplasia with marked keratinization, keratinizing cyst, cystic keratinizing epithelioma, cystic keratinizing squamous cell carcinoma, keratinizing squamous cell carcinoma and non-keratinizing squamous cell carcinoma. In study A (inhalation of coal oven exhaust and subcutaneous injection of a high dose of DB (ah)A) 49.3 % of rats developed cystic keratinizing squamous cell carcinomas. Inhalation of coal oven exhaust gas together with intratracheal instillation of crocidolite or subcutaneous injection of a low dose DB(ah)A (dibenz(ah)anthracene) resulted in cystic keratinizing squamous cell carcinomas in 23 % to 24 % of the rats. High incidences of cystic squamous cell carcinomas in the range of 31.9 % to 76.4 % were observed in rats of Study B1 after a 10-months exposure to tar/pitch condensation aerosol (different B(a)P (benzo(a)pyrene) concentrations) with added carbon black in some groups. After a 20-months exposure period to the same inhalation atmospheres (Study B2) the incidence of squamous cell carcinomas was increased up to 95.8 %. Exposure of rats to various concentrations of unfiltered diesel exhaust (Study C) resulted in incidences of cystic keratinizing epitheliomas ranging from 2.5 % (2.5 mg/m3) to 10.7 % (7.5 mg/m3). Epitheliomas were also observed in 16.2 % of carbon black and 16.0 % of titanium dioxide exposed rats. Only a few cystic keratinizing squamous cell carcinomas occurred. In the intratrachel instillation study (Study D) increased incidences of cystic keratinizing epitheliomas occurred in rats exposed to native diesel exhaust particles (16.7 %), high dose of extracted diesel exhaust particles (14.6 %), extracted printex 90-carbon black particles (18.8 %), and extracted printex 90-carbon black particles + B(a)P (18.8 %). High indicences of cystic keratinizing squamous cell carcinomas were noted in rats that received 15 mg B(a)P (14.6 %) or 30 mg B(a)P (72.7 %) intratracheally. Immunohistochemical labeling of nuclei with PCNA demonstrated proliferative activity in one or two (and focally more than two) peripheral cell layers of cystic keratinizing epitheliomas and in more than three peripheral cell layers of cystic keratinizing squamous cell carcinomas and keratinizing squamous cell carcinomas. The wall of keratinizing cysts showed no or a weak reaction.</abstract><subject lang="en"><genre>Key words</genre><topic>Keratinizing squamous cell lesion, pulmonary</topic><topic>Pulmonary keratinizing squamous cell lesion</topic><topic>Inhalation, different particles</topic><topic>Particles, inhalation</topic><topic>Particles, instillation</topic><topic>Instillation, different particles</topic><topic>Diesel exhaust particles</topic><topic>Coal oven exhaust</topic><topic>Crocidolite instillation</topic><topic>DB (ah) A</topic><topic>dibenz(ah)antracene</topic><topic>B(a)P</topic><topic>benzo(a)pyrene</topic><topic>Carbon black</topic><topic>Gas, irritant</topic><topic>Irritant gas</topic><topic>Tar/pitch condensation aerosol</topic><topic>Titanium dioxide</topic><topic>Aerosol, inhalation</topic><topic>Lung, inhalation, different particles</topic><topic>Lung, keratinizing squamous cell lesion</topic><topic>Proliferative cell nuclear antigen (PCNA)</topic><topic>Squamous metaplasia, lun</topic><topic>Keratinizing cysts, lung</topic><topic>Epithelioma, cystic, keratinizing, lung</topic><topic>Carcinoma, squamous cell, keratinizing, lung</topic></subject><relatedItem type="host"><titleInfo><title>Experimental and Toxicologic Pathology</title></titleInfo><titleInfo type="abbreviated"><title>ETP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued></originInfo><identifier type="ISSN">0940-2993</identifier><identifier type="PII">S0940-2993(97)X8129-1</identifier><part><date>1997</date><detail type="volume"><number>49</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue-pages"><start>409</start><end>512</end></extent><extent unit="pages"><start>433</start><end>446</end></extent></part></relatedItem><identifier type="istex">56FDF44DC07B137BD5A47E528E8B1FDDD16873F3</identifier><identifier type="ark">ark:/67375/6H6-FM7MVC2V-P</identifier><identifier type="DOI">10.1016/S0940-2993(97)80131-5</identifier><identifier type="PII">S0940-2993(97)80131-5</identifier><identifier type="ArticleID">80131</identifier><accessCondition type="use and reproduction" contentType="copyright">©1997 Gustav Fischer Verlag</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Gustav Fischer Verlag, ©1997</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-FM7MVC2V-P/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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