Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells
Identifieur interne : 000883 ( Istex/Corpus ); précédent : 000882; suivant : 000884Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells
Auteurs : Sharon A. ToozeSource :
- BBA - Molecular Cell Research [ 0167-4889 ] ; 1998.
English descriptors
- Teeft :
- Acad, Acta, Adaptor, Aggregation, Arvan, Assay, Bbamcr, Biochimica, Biol, Biophysica, Biophysica acta, Carboxypeptidase, Ccvs, Cell biol, Chem, Chromogranin, Clathrin, Constitutive, Constitutive pathway, Constitutive secretory pathway, Constitutive secretory vesicles, Csvs, Cyaan, Cytoplasmic, Cytoplasmic domain, Dynamin, Endocrine, Endocrine cells, Febs lett, Furin, Geel, Geel zwart, Geel zwart tooze biochimica, Golgi, Granule, Granule proteins, Huttner, Immature secretory granules, Isgs, Kinase, Lysosomal, Lysosomal enzymes, Membrane, Membrane proteins, Nascent, Nascent secretory granules, Nascent secretory vesicles, Natl, Neuroendocrine, Neuroendocrine cells, Neurones, Orci, Pathway, Phosphatidylinositol, Phospholipase, Plasma membrane, Proc, Prohormone, Proinsulin, Protein, Protein kinase, Receptor, Secretogranin, Secretory, Secretory granule, Secretory granule formation, Secretory granules, Secretory pathway, Secretory proteins, Secretory vesicle formation, Secretory vesicles, Soluble proteins, Tooze, Tooze biochimica, Vesicle, Vesicle formation, Zwart.
Abstract
Abstract: Secretory granule formation requires selection of soluble and membrane proteins into nascent secretory granules, and exclusion of proteins not required for the function of secretory granules. Both selection and exclusion presumably can occur in the compartment where assembly of the secretory granule begins, the trans most cisternae of the Golgi complex. Current research focused on the initial stages of secretory granule formation includes a search for the ‘signals’ which may mediate active sorting of components into secretory granules, and the role of aggregation of regulated secretory proteins in sorting. In addition, the temporal sequence of the sorting events in the Golgi, and post-Golgi compartments has gained much attention, as summarized by the alternative but not mutually exclusive ‘sorting for entry’ vs. ‘sorting by retention’ models. ‘Sorting for entry’ which encompasses the most popular models requires selection of cargo and membrane and exclusion of non-secretory granule proteins in the TGN prior to secretory granule formation. ‘Sorting by retention’ stipulates that protein selection or exclusion may occur after secretory granule formation: secretory granule specific components are retained during maturation of the granule while non-secretory granule molecules are removed in vesicles which bud from maturing secretory granules. Finally, some progress has been made in the identification of cytosolic components involved in the budding of nascent secretory granules from the TGN. This review will focus on the recent data concerning the events in secretory granule formation which occur, in the trans-Golgi network.
Url:
DOI: 10.1016/S0167-4889(98)00059-7
Links to Exploration step
ISTEX:CD7E828979CBF79FE85EDC6D3DF6057A08EAF989Le document en format XML
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Both selection and exclusion presumably can occur in the compartment where assembly of the secretory granule begins, the trans most cisternae of the Golgi complex. Current research focused on the initial stages of secretory granule formation includes a search for the ‘signals’ which may mediate active sorting of components into secretory granules, and the role of aggregation of regulated secretory proteins in sorting. In addition, the temporal sequence of the sorting events in the Golgi, and post-Golgi compartments has gained much attention, as summarized by the alternative but not mutually exclusive ‘sorting for entry’ vs. ‘sorting by retention’ models. ‘Sorting for entry’ which encompasses the most popular models requires selection of cargo and membrane and exclusion of non-secretory granule proteins in the TGN prior to secretory granule formation. ‘Sorting by retention’ stipulates that protein selection or exclusion may occur after secretory granule formation: secretory granule specific components are retained during maturation of the granule while non-secretory granule molecules are removed in vesicles which bud from maturing secretory granules. Finally, some progress has been made in the identification of cytosolic components involved in the budding of nascent secretory granules from the TGN. This review will focus on the recent data concerning the events in secretory granule formation which occur, in the trans-Golgi network.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>secretory</json:string><json:string>granule</json:string><json:string>vesicle</json:string><json:string>biol</json:string><json:string>pathway</json:string><json:string>secretory proteins</json:string><json:string>receptor</json:string><json:string>constitutive</json:string><json:string>secretory granules</json:string><json:string>cell biol</json:string><json:string>tooze</json:string><json:string>golgi</json:string><json:string>chem</json:string><json:string>huttner</json:string><json:string>isgs</json:string><json:string>lysosomal</json:string><json:string>lysosomal enzymes</json:string><json:string>secretory 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biochimica</json:string><json:string>constitutive secretory vesicles</json:string><json:string>granule proteins</json:string><json:string>cytoplasmic domain</json:string><json:string>assay</json:string><json:string>membrane</json:string><json:string>nascent secretory granules</json:string><json:string>constitutive secretory pathway</json:string><json:string>constitutive pathway</json:string><json:string>membrane proteins</json:string><json:string>febs lett</json:string><json:string>secretory vesicle formation</json:string><json:string>nascent secretory vesicles</json:string><json:string>protein kinase</json:string><json:string>protein</json:string><json:string>kelly</json:string></teeft></keywords><author><json:item><name>Sharon A Tooze</name><affiliations><json:string>Secretory Pathways Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London, WC2A 3PX, UK</json:string><json:string>E-mail: tooze@icrf.icnet.uk</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Secretion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Regulated secretion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>trans-Golgi network</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Vesicle formation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Immature secretory granule</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TGN, trans-Golgi network</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ISG, immature secretory granule</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MSG, mature secretory granule</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CSV, constitutive secretory vesicle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CCV, clathrin-coated vesicle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CgB, chromogranin B</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SgII, secretogranin II</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hsPG, heparan sulphate proteoglycan</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCs, prohormone converting enzymes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LDCV, large dense core vesicles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DTT, dithiothreitol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ARF, ADP-ribosylation factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>AP-1, adaptor protein-1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PLD, phospholipase D</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GH, growth hormone</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PRL, prolactin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MPR, mannose-6-phosphate receptor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PIP2 (phosphatidylinositol 4,5-bisphosphate)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PITP, phosphatidylinositol transfer protein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PI, phosphatidylinositol</value></json:item></subject><arkIstex>ark:/67375/6H6-7KVDHBS8-K</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Secretory granule formation requires selection of soluble and membrane proteins into nascent secretory granules, and exclusion of proteins not required for the function of secretory granules. Both selection and exclusion presumably can occur in the compartment where assembly of the secretory granule begins, the trans most cisternae of the Golgi complex. Current research focused on the initial stages of secretory granule formation includes a search for the ‘signals’ which may mediate active sorting of components into secretory granules, and the role of aggregation of regulated secretory proteins in sorting. In addition, the temporal sequence of the sorting events in the Golgi, and post-Golgi compartments has gained much attention, as summarized by the alternative but not mutually exclusive ‘sorting for entry’ vs. ‘sorting by retention’ models. ‘Sorting for entry’ which encompasses the most popular models requires selection of cargo and membrane and exclusion of non-secretory granule proteins in the TGN prior to secretory granule formation. ‘Sorting by retention’ stipulates that protein selection or exclusion may occur after secretory granule formation: secretory granule specific components are retained during maturation of the granule while non-secretory granule molecules are removed in vesicles which bud from maturing secretory granules. Finally, some progress has been made in the identification of cytosolic components involved in the budding of nascent secretory granules from the TGN. This review will focus on the recent data concerning the events in secretory granule formation which occur, in the trans-Golgi network.</abstract><qualityIndicators><score>9.868</score><pdfWordCount>8877</pdfWordCount><pdfCharCount>55744</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>14</pdfPageCount><pdfPageSize>588 x 794 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>239</abstractWordCount><abstractCharCount>1656</abstractCharCount><keywordCount>25</keywordCount></qualityIndicators><title>Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells</title><pmid><json:string>9714820</json:string></pmid><pii><json:string>S0167-4889(98)00059-7</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>BBA - Molecular Cell Research</title><language><json:string>unknown</json:string></language><publicationDate>1998</publicationDate><issn><json:string>0167-4889</json:string></issn><pii><json:string>S0167-4889(00)X0277-7</json:string></pii><volume>1404</volume><issue>1–2</issue><pages><first>231</first><last>244</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1998</json:string><json:string>5-8-98</json:string></date><geogName></geogName><orgName><json:string>Biochem</json:string><json:string>UK Received</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>L.D. Fricker</json:string><json:string>A. Gedvilaite</json:string><json:string>R. Le Borgne</json:string><json:string>D.U. Rabin</json:string><json:string>Y. Uchiyama</json:string><json:string>J.A. Shapiro</json:string><json:string>D. Grabs</json:string><json:string>S. Natori</json:string><json:string>D. Elahi</json:string><json:string>P.C. Sternweis</json:string><json:string>A. Siddhanta</json:string><json:string>J. Neurosci</json:string><json:string>O. Varlamov</json:string><json:string>W.W. Tam</json:string><json:string>Y.M. Altshuller</json:string><json:string>K. Wirtz</json:string><json:string>A. Perrelet</json:string><json:string>J.D. Baxter</json:string><json:string>T.P. McGee</json:string><json:string>S.M. Hammond</json:string><json:string>R.H. Kehlenbach</json:string><json:string>K. Takei</json:string><json:string>D. Pilkey</json:string><json:string>J. Biol</json:string><json:string>J. Engebrecht</json:string><json:string>P. Simon</json:string><json:string>T. Watanabe</json:string><json:string>M.F. Manolson</json:string><json:string>P. Mayinger</json:string><json:string>S. Wang</json:string><json:string>K.I. Shennan</json:string><json:string>K. Sato</json:string><json:string>M.M. Glombik</json:string><json:string>M. Solimena</json:string><json:string>O. Seksek</json:string><json:string>R.R. McInnes</json:string><json:string>P.L. Fisette</json:string><json:string>T. Terui</json:string><json:string>C.R. Moomaw</json:string><json:string>P.A. Baeuerle</json:string><json:string>M. Adesnik</json:string><json:string>J. Cell</json:string><json:string>S.E. Phillips</json:string><json:string>R.A. Lewis</json:string><json:string>L. Carnell</json:string><json:string>K. Rose</json:string><json:string>P. Pertile</json:string><json:string>P.H. Moore</json:string><json:string>B. Verchere</json:string><json:string>B.G. Kearns</json:string><json:string>M. Grimes</json:string><json:string>J.H. Kim</json:string><json:string>L. Pannell</json:string><json:string>S. Cockcroft</json:string><json:string>E. Normant</json:string><json:string>W.B. Huttner</json:string><json:string>I. Okabe</json:string><json:string>J.R. McIntosh</json:string><json:string>M. Hollinshead</json:string><json:string>B. Burke</json:string><json:string>N. Hajibagheri</json:string><json:string>V. May</json:string><json:string>M.A. McNiven</json:string><json:string>M.D. Fry</json:string><json:string>R. Houghten</json:string><json:string>L.C. Cantley</json:string><json:string>D. Sweeney</json:string><json:string>R. Bauerfeind</json:string><json:string>C. Slaughter</json:string><json:string>S.H. Yoo</json:string><json:string>D. Louvard</json:string><json:string>A. Hille-Rehfeld</json:string><json:string>G.A. Kicska</json:string><json:string>P.S. Furcinitti</json:string><json:string>J.C. Stinchcombe</json:string><json:string>C.S. Chen</json:string><json:string>M. Hermel</json:string><json:string>J.R. Kremer</json:string><json:string>R.H. Scheller</json:string><json:string>J. Salamero</json:string><json:string>P.A. Halban</json:string><json:string>P. Greengard</json:string><json:string>B.J. Paigen</json:string><json:string>I. Gout</json:string><json:string>J.C. Irminger</json:string><json:string>S.D. Fuller</json:string><json:string>P. De Camilli</json:string><json:string>J. Michael</json:string><json:string>B.G. Jones</json:string><json:string>J. Humphrey</json:string><json:string>B. Horazdovsky</json:string><json:string>Natori</json:string><json:string>J.D. Vassalli</json:string><json:string>C. David</json:string><json:string>G. Thomas</json:string><json:string>S.M. Jones</json:string><json:string>P. de Camilli</json:string><json:string>S.K. Powell</json:string><json:string>W. Garten</json:string><json:string>I.M. Olivos</json:string><json:string>E. Deignan</json:string><json:string>S. Kagiwada</json:string><json:string>P.W. Majerus</json:string><json:string>L. Caron</json:string><json:string>T.C. Sung</json:string><json:string>M. Liscovitch</json:string><json:string>H.W. Davidson</json:string><json:string>Gerdes</json:string><json:string>H. Xu</json:string><json:string>J. Klumperman</json:string><json:string>G. Gri</json:string><json:string>X. Zhang</json:string><json:string>C. Thiele</json:string><json:string>J.K. Naggert</json:string><json:string>A.J. Morris</json:string><json:string>J.K. de Vries</json:string><json:string>R. Frank</json:string><json:string>W.S. Sossin</json:string><json:string>V. Chalifa</json:string><json:string>P. Rosa</json:string><json:string>K.A. Walsh</json:string><json:string>B.J. Reaves</json:string><json:string>V. Auethavekiat</json:string><json:string>J.M. Fisher</json:string><json:string>H. Baker-Sharp</json:string><json:string>J.C. Hutton</json:string><json:string>H. Damke</json:string><json:string>D.L. Nelson</json:string><json:string>H.C. Palfrey</json:string><json:string>L.C. Bailey</json:string><json:string>G. Snoek</json:string><json:string>E. Chanat</json:string><json:string>J.E. Rothman</json:string><json:string>T.L. Reudelhuber</json:string><json:string>U. Weiss</json:string><json:string>B.G. Talbot</json:string><json:string>C.R. Snell</json:string><json:string>D.D. Sabatini</json:string><json:string>R.L. Nussbaum</json:string><json:string>M.A. Stamnes</json:string><json:string>P. Halban</json:string><json:string>B. Ho</json:string><json:string>C.R. Artalejo</json:string><json:string>J.H. Stack</json:string><json:string>Arvan</json:string><json:string>M.S. Robinson</json:string><json:string>K.E. Howell</json:string><json:string>S.R. Pfe</json:string><json:string>G.H. Jenkins</json:string><json:string>H. Gerdes</json:string><json:string>S.S. Molloy</json:string><json:string>I.E. Ivanov</json:string><json:string>P.S. McPherson</json:string><json:string>C. Wasmeier</json:string><json:string>N. Rondeau</json:string><json:string>L. Orci</json:string><json:string>J. Hum</json:string><json:string>P.J. Peters</json:string><json:string>E.H. Leiter</json:string><json:string>J.J. Hsuan</json:string><json:string>J. Seiler</json:string><json:string>A.S. Dittie</json:string><json:string>K. Ishidoh</json:string><json:string>O. Mundigl</json:string><json:string>B. Shopsin</json:string><json:string>S.A. Rudge</json:string><json:string>V. Colomer</json:string><json:string>M.S. Marks</json:string><json:string>S. Waguri</json:string><json:string>R.J. Carroll</json:string><json:string>P. Arvan</json:string><json:string>M. Ravazzola</json:string><json:string>B. Gumbiner</json:string><json:string>C.D. Austin</json:string><json:string>M. Fenger</json:string><json:string>W.P.M. Geraerts</json:string><json:string>G.M. Thomas</json:string><json:string>S. Spiker</json:string><json:string>A.B. Smit</json:string><json:string>R.G. Anderson</json:string><json:string>H.P. Moore</json:string><json:string>S. Urbe</json:string><json:string>W. Furuya</json:string><json:string>D. Prabakaran</json:string><json:string>A. Stroh</json:string><json:string>K.I. Andreasson</json:string><json:string>N. Sato</json:string><json:string>J. Minnen</json:string><json:string>D.B. Williams</json:string><json:string>M. Mathieu</json:string><json:string>M.J. Rindler</json:string><json:string>O. Attree</json:string><json:string>R.A. Anderson</json:string><json:string>M. Amherdt</json:string><json:string>E. Cunningham</json:string><json:string>M.S. Ladinsky</json:string><json:string>J.R. Henley</json:string><json:string>S. Pleasic-Williams</json:string><json:string>E. van Donselaar</json:string><json:string>H.F. Kern</json:string><json:string>P. Novick</json:string><json:string>I.M. Olivos-Glander</json:string><json:string>J. Biwersi</json:string><json:string>Howell</json:string><json:string>V. Bankaitis</json:string><json:string>R.G. Kelly</json:string><json:string>A.B. Je</json:string><json:string>Y. Nemoto</json:string><json:string>E.P. Garcia</json:string><json:string>D.L. Quinn</json:string><json:string>M. Zavacki</json:string><json:string>J.S. Bonifacino</json:string><json:string>P. Voorhees</json:string><json:string>C. Irminger</json:string><json:string>M.G. Farquhar</json:string><json:string>W. Dowhan</json:string><json:string>S. Berghofer</json:string><json:string>M. Vey</json:string><json:string>H.A. Brown</json:string><json:string>J.R. Crosby</json:string><json:string>D. Vassalli</json:string><json:string>W. Schafer</json:string><json:string>V.A. Bankaitis</json:string><json:string>T. Ludwig</json:string><json:string>B. Geny</json:string><json:string>C.S. Craik</json:string><json:string>Huttner</json:string><json:string>D. Klenk</json:string><json:string>M. Ohashi</json:string><json:string>P.A. Randazzo</json:string><json:string>A. Leyte</json:string><json:string>P.A. Janne</json:string><json:string>R. Dirkx</json:string><json:string>D. Hersh</json:string><json:string>T.F.J. Martin</json:string><json:string>S.D. Emr</json:string><json:string>G. Grondin</json:string><json:string>E. Kominami</json:string><json:string>J. Tooze</json:string><json:string>J.L. Stow</json:string><json:string>I. Hiles</json:string><json:string>V.I. Slepnev</json:string><json:string>S.W. Pimplikar</json:string><json:string>S. Grinstein</json:string><json:string>P.R. Shepherd</json:string><json:string>Y.G. Chen</json:string><json:string>N.F. Totty</json:string><json:string>C. Chen</json:string><json:string>C.D. Thulin</json:string><json:string>R. Kuliawat</json:string><json:string>O. Truong</json:string></persName><placeName></placeName><ref_url></ref_url><ref_bibl><json:string>[94]</json:string><json:string>[4]</json:string><json:string>[87,88]</json:string><json:string>[89]</json:string><json:string>[102]</json:string><json:string>Arvan et al.</json:string><json:string>[18]</json:string><json:string>[110]</json:string><json:string>[93]</json:string><json:string>[107]</json:string><json:string>[88]</json:string><json:string>[75,76]</json:string><json:string>[39]</json:string><json:string>[14,15]</json:string><json:string>[26,60]</json:string><json:string>[92]</json:string><json:string>[1]</json:string><json:string>[98]</json:string><json:string>[4,18,19]</json:string><json:string>[41,42]</json:string><json:string>[38]</json:string><json:string>[3]</json:string><json:string>[101]</json:string><json:string>[9,10]</json:string><json:string>[97]</json:string><json:string>[26,30]</json:string><json:string>[106]</json:string><json:string>[59]</json:string><json:string>[51,52]</json:string><json:string>[90]</json:string><json:string>[74]</json:string><json:string>[22,31]</json:string><json:string>[47]</json:string><json:string>[108]</json:string><json:string>[100]</json:string><json:string>[95]</json:string><json:string>[77,78]</json:string><json:string>[2]</json:string><json:string>[68]</json:string><json:string>[18,47]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-7KVDHBS8-K</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - cell biology</json:string><json:string>2 - biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - biochemistry & molecular biology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Cell Biology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Molecular Biology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S0167-4889(98)00059-7</json:string></doi><id>CD7E828979CBF79FE85EDC6D3DF6057A08EAF989</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-7KVDHBS8-K/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-7KVDHBS8-K/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-7KVDHBS8-K/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1998 Elsevier Science B.V.</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1998</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Fig. 1: Depicted in a very simple fashion is a scheme of the sorting mechanisms in the secretory pathway of neuroendocrine and endocrine cells proposed by Arvan and colleagues [26] to explain the different models for formation of regulated secretory vesicles from the TGN, i.e. sorting for entry vs. sorting by retention. Also included are other vesicle classes, such as CSVs and constitutive-like secretory vesicles, as well as a pathway for lysosomal enzymes (blue circle) and MPR (black cup-shaped object). The low amount of missorted proteins, such as furin [62], and MPR found in the ISG in the top panel have not been illustrated for simplicity. The regulated secretory proteins are shown as yellow circles, and the constitutive secretory proteins are shown as red circles. For simplicity, all coats and coat proteins have been omitted, as well as any putative interactions of the regulated secretory proteins with the membrane.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells</title><author xml:id="author-0000"><persName><forename type="first">Sharon A</forename><surname>Tooze</surname></persName><email>tooze@icrf.icnet.uk</email><note type="biography">Fax: +44 (171) 269-3417;</note><affiliation>Fax: +44 (171) 269-3417;</affiliation><affiliation>Secretory Pathways Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London, WC2A 3PX, UK</affiliation></author><idno type="istex">CD7E828979CBF79FE85EDC6D3DF6057A08EAF989</idno><idno type="ark">ark:/67375/6H6-7KVDHBS8-K</idno><idno type="DOI">10.1016/S0167-4889(98)00059-7</idno><idno type="PII">S0167-4889(98)00059-7</idno></analytic><monogr><title level="j">BBA - Molecular Cell Research</title><title level="j" type="abbrev">BBAMCR</title><idno type="pISSN">0167-4889</idno><idno type="PII">S0167-4889(00)X0277-7</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">1404</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="231">231</biblScope><biblScope unit="page" to="244">244</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Secretory granule formation requires selection of soluble and membrane proteins into nascent secretory granules, and exclusion of proteins not required for the function of secretory granules. Both selection and exclusion presumably can occur in the compartment where assembly of the secretory granule begins, the trans most cisternae of the Golgi complex. Current research focused on the initial stages of secretory granule formation includes a search for the ‘signals’ which may mediate active sorting of components into secretory granules, and the role of aggregation of regulated secretory proteins in sorting. In addition, the temporal sequence of the sorting events in the Golgi, and post-Golgi compartments has gained much attention, as summarized by the alternative but not mutually exclusive ‘sorting for entry’ vs. ‘sorting by retention’ models. ‘Sorting for entry’ which encompasses the most popular models requires selection of cargo and membrane and exclusion of non-secretory granule proteins in the TGN prior to secretory granule formation. ‘Sorting by retention’ stipulates that protein selection or exclusion may occur after secretory granule formation: secretory granule specific components are retained during maturation of the granule while non-secretory granule molecules are removed in vesicles which bud from maturing secretory granules. Finally, some progress has been made in the identification of cytosolic components involved in the budding of nascent secretory granules from the TGN. This review will focus on the recent data concerning the events in secretory granule formation which occur, in the trans-Golgi network.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Secretion</term></item><item><term>Regulated secretion</term></item><item><term>trans-Golgi network</term></item><item><term>Vesicle formation</term></item><item><term>Immature secretory granule</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>TGN, trans-Golgi network</term></item><item><term>ISG, immature secretory granule</term></item><item><term>MSG, mature secretory granule</term></item><item><term>CSV, constitutive secretory vesicle</term></item><item><term>CCV, clathrin-coated vesicle</term></item><item><term>CgB, chromogranin B</term></item><item><term>SgII, secretogranin II</term></item><item><term>hsPG, heparan sulphate proteoglycan</term></item><item><term>PCs, prohormone converting enzymes</term></item><item><term>LDCV, large dense core vesicles</term></item><item><term>DTT, dithiothreitol</term></item><item><term>ARF, ADP-ribosylation factor</term></item><item><term>AP-1, adaptor protein-1</term></item><item><term>PLD, phospholipase D</term></item><item><term>GH, growth hormone</term></item><item><term>PRL, prolactin</term></item><item><term>MPR, mannose-6-phosphate receptor</term></item><item><term>PIP2 (phosphatidylinositol 4,5-bisphosphate)</term></item><item><term>PITP, phosphatidylinositol transfer protein</term></item><item><term>PI, phosphatidylinositol</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-7KVDHBS8-K/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>BBAMCR</jid><aid>14334</aid><ce:pii>S0167-4889(98)00059-7</ce:pii><ce:doi>10.1016/S0167-4889(98)00059-7</ce:doi><ce:copyright type="full-transfer" year="1998">Elsevier Science B.V.</ce:copyright></item-info><head><ce:title>Biogenesis of secretory granules in the <ce:italic>trans</ce:italic>-Golgi network of neuroendocrine and endocrine cells</ce:title><ce:author-group><ce:author><ce:given-name>Sharon A</ce:given-name><ce:surname>Tooze</ce:surname><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>tooze@icrf.icnet.uk</ce:e-address></ce:author><ce:affiliation><ce:textfn>Secretory Pathways Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London, WC2A 3PX, UK</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Fax: +44 (171) 269-3417;</ce:text></ce:correspondence></ce:author-group><ce:date-received day="20" month="11" year="1997"></ce:date-received><ce:date-accepted day="19" month="12" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Secretory granule formation requires selection of soluble and membrane proteins into nascent secretory granules, and exclusion of proteins not required for the function of secretory granules. Both selection and exclusion presumably can occur in the compartment where assembly of the secretory granule begins, the <ce:italic>trans</ce:italic> most cisternae of the Golgi complex. Current research focused on the initial stages of secretory granule formation includes a search for the ‘signals’ which may mediate active sorting of components into secretory granules, and the role of aggregation of regulated secretory proteins in sorting. In addition, the temporal sequence of the sorting events in the Golgi, and post-Golgi compartments has gained much attention, as summarized by the alternative but not mutually exclusive ‘sorting for entry’ vs. ‘sorting by retention’ models. ‘Sorting for entry’ which encompasses the most popular models requires selection of cargo and membrane and exclusion of non-secretory granule proteins in the TGN prior to secretory granule formation. ‘Sorting by retention’ stipulates that protein selection or exclusion may occur after secretory granule formation: secretory granule specific components are retained during maturation of the granule while non-secretory granule molecules are removed in vesicles which bud from maturing secretory granules. Finally, some progress has been made in the identification of cytosolic components involved in the budding of nascent secretory granules from the TGN. This review will focus on the recent data concerning the events in secretory granule formation which occur, in the <ce:italic>trans</ce:italic>-Golgi network.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Secretion</ce:text></ce:keyword><ce:keyword><ce:text>Regulated secretion</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>trans</ce:italic>-Golgi network</ce:text></ce:keyword><ce:keyword><ce:text>Vesicle formation</ce:text></ce:keyword><ce:keyword><ce:text>Immature secretory granule</ce:text></ce:keyword></ce:keywords><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>TGN, <ce:italic>trans</ce:italic>-Golgi network</ce:text></ce:keyword><ce:keyword><ce:text>ISG, immature secretory granule</ce:text></ce:keyword><ce:keyword><ce:text>MSG, mature secretory granule</ce:text></ce:keyword><ce:keyword><ce:text>CSV, constitutive secretory vesicle</ce:text></ce:keyword><ce:keyword><ce:text>CCV, clathrin-coated vesicle</ce:text></ce:keyword><ce:keyword><ce:text>CgB, chromogranin B</ce:text></ce:keyword><ce:keyword><ce:text>SgII, secretogranin II</ce:text></ce:keyword><ce:keyword><ce:text>hsPG, heparan sulphate proteoglycan</ce:text></ce:keyword><ce:keyword><ce:text>PCs, prohormone converting enzymes</ce:text></ce:keyword><ce:keyword><ce:text>LDCV, large dense core vesicles</ce:text></ce:keyword><ce:keyword><ce:text>DTT, dithiothreitol</ce:text></ce:keyword><ce:keyword><ce:text>ARF, ADP-ribosylation factor</ce:text></ce:keyword><ce:keyword><ce:text>AP-1, adaptor protein-1</ce:text></ce:keyword><ce:keyword><ce:text>PLD, phospholipase D</ce:text></ce:keyword><ce:keyword><ce:text>GH, growth hormone</ce:text></ce:keyword><ce:keyword><ce:text>PRL, prolactin</ce:text></ce:keyword><ce:keyword><ce:text>MPR, mannose-6-phosphate receptor</ce:text></ce:keyword><ce:keyword><ce:text>PIP<ce:inf>2</ce:inf> (phosphatidylinositol 4,5-bisphosphate)</ce:text></ce:keyword><ce:keyword><ce:text>PITP, phosphatidylinositol transfer protein</ce:text></ce:keyword><ce:keyword><ce:text>PI, phosphatidylinositol</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Biogenesis of secretory granules in the</title></titleInfo><name type="personal"><namePart type="given">Sharon A</namePart><namePart type="family">Tooze</namePart><affiliation>Secretory Pathways Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London, WC2A 3PX, UK</affiliation><affiliation>E-mail: tooze@icrf.icnet.uk</affiliation><description>Fax: +44 (171) 269-3417;</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Secretory granule formation requires selection of soluble and membrane proteins into nascent secretory granules, and exclusion of proteins not required for the function of secretory granules. Both selection and exclusion presumably can occur in the compartment where assembly of the secretory granule begins, the trans most cisternae of the Golgi complex. Current research focused on the initial stages of secretory granule formation includes a search for the ‘signals’ which may mediate active sorting of components into secretory granules, and the role of aggregation of regulated secretory proteins in sorting. In addition, the temporal sequence of the sorting events in the Golgi, and post-Golgi compartments has gained much attention, as summarized by the alternative but not mutually exclusive ‘sorting for entry’ vs. ‘sorting by retention’ models. ‘Sorting for entry’ which encompasses the most popular models requires selection of cargo and membrane and exclusion of non-secretory granule proteins in the TGN prior to secretory granule formation. ‘Sorting by retention’ stipulates that protein selection or exclusion may occur after secretory granule formation: secretory granule specific components are retained during maturation of the granule while non-secretory granule molecules are removed in vesicles which bud from maturing secretory granules. Finally, some progress has been made in the identification of cytosolic components involved in the budding of nascent secretory granules from the TGN. This review will focus on the recent data concerning the events in secretory granule formation which occur, in the trans-Golgi network.</abstract><note type="content">Fig. 1: Depicted in a very simple fashion is a scheme of the sorting mechanisms in the secretory pathway of neuroendocrine and endocrine cells proposed by Arvan and colleagues [26] to explain the different models for formation of regulated secretory vesicles from the TGN, i.e. sorting for entry vs. sorting by retention. Also included are other vesicle classes, such as CSVs and constitutive-like secretory vesicles, as well as a pathway for lysosomal enzymes (blue circle) and MPR (black cup-shaped object). The low amount of missorted proteins, such as furin [62], and MPR found in the ISG in the top panel have not been illustrated for simplicity. The regulated secretory proteins are shown as yellow circles, and the constitutive secretory proteins are shown as red circles. For simplicity, all coats and coat proteins have been omitted, as well as any putative interactions of the regulated secretory proteins with the membrane.</note><subject><genre>Keywords</genre><topic>Secretion</topic><topic>Regulated secretion</topic><topic>trans-Golgi network</topic><topic>Vesicle formation</topic><topic>Immature secretory granule</topic></subject><subject><genre>Abbreviations</genre><topic>TGN, trans-Golgi network</topic><topic>ISG, immature secretory granule</topic><topic>MSG, mature secretory granule</topic><topic>CSV, constitutive secretory vesicle</topic><topic>CCV, clathrin-coated vesicle</topic><topic>CgB, chromogranin B</topic><topic>SgII, secretogranin II</topic><topic>hsPG, heparan sulphate proteoglycan</topic><topic>PCs, prohormone converting enzymes</topic><topic>LDCV, large dense core vesicles</topic><topic>DTT, dithiothreitol</topic><topic>ARF, ADP-ribosylation factor</topic><topic>AP-1, adaptor protein-1</topic><topic>PLD, phospholipase D</topic><topic>GH, growth hormone</topic><topic>PRL, prolactin</topic><topic>MPR, mannose-6-phosphate receptor</topic><topic>PIP2 (phosphatidylinositol 4,5-bisphosphate)</topic><topic>PITP, phosphatidylinositol transfer protein</topic><topic>PI, phosphatidylinositol</topic></subject><relatedItem type="host"><titleInfo><title>BBA - Molecular Cell Research</title></titleInfo><titleInfo type="abbreviated"><title>BBAMCR</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued></originInfo><identifier type="ISSN">0167-4889</identifier><identifier type="PII">S0167-4889(00)X0277-7</identifier><part><date>1998</date><detail type="volume"><number>1404</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>270</end></extent><extent unit="pages"><start>231</start><end>244</end></extent></part></relatedItem><identifier type="istex">CD7E828979CBF79FE85EDC6D3DF6057A08EAF989</identifier><identifier type="ark">ark:/67375/6H6-7KVDHBS8-K</identifier><identifier type="DOI">10.1016/S0167-4889(98)00059-7</identifier><identifier type="PII">S0167-4889(98)00059-7</identifier><accessCondition type="use and reproduction" contentType="copyright">©1998 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Elsevier Science B.V., ©1998</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-7KVDHBS8-K/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Biogenesis of secretory granules in the trans -Golgi network of neuroendocrine and endocrine cells
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