Nuclear Factor-κB: a Key Regulator in Health and Disease of Lungs
Identifieur interne : 000847 ( Istex/Corpus ); précédent : 000846; suivant : 000848Nuclear Factor-κB: a Key Regulator in Health and Disease of Lungs
Auteurs : Sanjay Batra ; Gayathriy Balamayooran ; Malaya K. SahooSource :
- Archivum Immunologiae et Therapiae Experimentalis [ 0004-069X ] ; 2011-10-01.
English descriptors
- KwdEn :
- Cancer, Inflammation, Lung, NF-κB.
Abstract
Abstract: Rel/NF-κB transcription factors play a key role in modulating the response of immunoregulatory genes including cytokines and chemokines, cell adhesion molecules, acute phase proteins, and anti-microbial peptides. Furthermore, an array of genes important for angiogenesis, tumor invasion and metastasis is also regulated by nuclear factor-κB (NF-κB). Close association of NF-κB with inflammation and tumorigenesis makes it an attractive target for basic research as well as for pharmaceutical industries. Studies involving various animal and cellular models have revealed the importance of NF-κB in pathobiology of lung diseases. This review (a) describes structures, activities, and regulation of NF-κB family members; (b) provides information which implicates NF-κB in pathogenesis of pulmonary inflammation and cancer; and (c) discusses information about available synthetic and natural compounds which target NF-κB or specific components of NF-κB signal transduction pathway and which may provide the foundation for development of effective therapy for lung inflammation and bronchogenic carcinomas.
Url:
DOI: 10.1007/s00005-011-0136-z
Links to Exploration step
ISTEX:CF8357DE3433E4A930444CCE2E0FFF619D9BEAD6Le document en format XML
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Furthermore, an array of genes important for angiogenesis, tumor invasion and metastasis is also regulated by nuclear factor-κB (NF-κB). Close association of NF-κB with inflammation and tumorigenesis makes it an attractive target for basic research as well as for pharmaceutical industries. Studies involving various animal and cellular models have revealed the importance of NF-κB in pathobiology of lung diseases. 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Furthermore, an array of genes important for angiogenesis, tumor invasion and metastasis is also regulated by nuclear factor-κB (NF-κB). Close association of NF-κB with inflammation and tumorigenesis makes it an attractive target for basic research as well as for pharmaceutical industries. Studies involving various animal and cellular models have revealed the importance of NF-κB in pathobiology of lung diseases. This review (a) describes structures, activities, and regulation of NF-κB family members; (b) provides information which implicates NF-κB in pathogenesis of pulmonary inflammation and cancer; and (c) discusses information about available synthetic and natural compounds which target NF-κB or specific components of NF-κB signal transduction pathway and which may provide the foundation for development of effective therapy for lung inflammation and bronchogenic carcinomas.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>NF-κB</Keyword><Keyword>Inflammation</Keyword><Keyword>Cancer</Keyword><Keyword>Lung</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Nuclear Factor-κB: a Key Regulator in Health and Disease of Lungs</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Nuclear Factor-κB: a Key Regulator in Health and Disease of Lungs</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Sanjay</namePart><namePart type="family">Batra</namePart><affiliation>Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, 70803, Baton Rouge, LA, USA</affiliation><affiliation>E-mail: sbatra@lsu.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gayathriy</namePart><namePart type="family">Balamayooran</namePart><affiliation>Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, 70803, Baton Rouge, LA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Malaya</namePart><namePart type="given">K.</namePart><namePart type="family">Sahoo</namePart><affiliation>Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, 70803, Baton Rouge, LA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>SP Birkhäuser Verlag Basel</publisher><place><placeTerm type="text">Basel</placeTerm></place><dateCreated encoding="w3cdtf">2011-01-07</dateCreated><dateIssued encoding="w3cdtf">2011-10-01</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Rel/NF-κB transcription factors play a key role in modulating the response of immunoregulatory genes including cytokines and chemokines, cell adhesion molecules, acute phase proteins, and anti-microbial peptides. Furthermore, an array of genes important for angiogenesis, tumor invasion and metastasis is also regulated by nuclear factor-κB (NF-κB). Close association of NF-κB with inflammation and tumorigenesis makes it an attractive target for basic research as well as for pharmaceutical industries. Studies involving various animal and cellular models have revealed the importance of NF-κB in pathobiology of lung diseases. 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