Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines
Identifieur interne : 000795 ( Istex/Corpus ); précédent : 000794; suivant : 000796Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines
Auteurs : F. M. Fernandez ; M. E. Conner ; D. C. Hodgins ; A. V. Parwani ; P. R. Nielsen ; S. E. Crawford ; M. K. Estes ; L. J. SaifSource :
- Vaccine [ 0264-410X ] ; 1998.
English descriptors
- Teeft :
- Antibody, Antibody responses, Antibody titers, Bovine, Bovine rotavirus, Calf, Colostrum, Colostrum group, Colostrum pool, Colostrum pools, Colostrum supplements, Control calves, Control colostrum, Control colostrum pool, Control groups, Cows inoculated, Cows vaccinated, Diarrhea, Elisa, Faecal, Faeces, Fernandez, Fewer days, Iggl, Iggl antibodies, Iggl antibody titers, Immune, Inoculated, Inoculation, Intestinal, Isotype, Neutralizing, Newborn calves, Passive immunity, Passive protection, Post challenge, Post inoculation, Recombinant, Rotavirus, Rotavirus diarrhea, Rotavirus vaccines, Saif, Sall, Sall colostrum, Sall rotavirus, Same column, Subunit, Titer, Vaccinated, Vaccinated cows, Vaccine, Viral, Vlps.
Abstract
Abstract: Heterotypic passive immunity to IND (P[5]G6) bovine rotavirus (BRV) was evaluated. Three groups of calves (n = 5 per group) were fed 1% pooled colostrum supplements (birth to 7 days of age) from BRV seropositive cows vaccinated with recombinant SA11(P[2]G3) rotavirus-like particles (VLPs), recombinant SA11 rotavirus core-like particles (CLPs), or inactivated SA11 rotavirus (SA11). Control calves (n = 5 per group) received either pooled colostrum from unvaccinated (BRV field exposure seropositive) control cows, or no colostrum. IgG1 antibody titers to IND BRV for the pooled colostrum were: 1048576 (VLP); 1048576 (CLP); 262144 (SA11); and 16384 (control colostrum). Elevated titers of BRV neutralizing (VN) antibodies were present in VLP colostrum (98 000), and SA11 colostrum (25 000), but not in CLP colostrum (1400), compared to colostrum from nonvaccinates (2081). Calves were orally inoculated with virulent IND BRV at 2 days of age and challenged at post-inoculation day (PID) 21. Calves were monitored daily for diarrhea and faecal BRV shedding through PID 10 and post-challenge day (PCD) 10. After colostrum feeding, the IgG1 antibody titers were highest in serum and faeces of calves fed VLP and CLP colostrum, but VN and IgA antibodies were highest in calves fed VLP colostrum. After BRV inoculation, calves fed colostrum from vaccinated cows had significantly fewer days of BRV-associated diarrhea and BRV shedding than control calves. All calves fed VLP colostrum were protected from diarrhea after BRV inoculation; two calves shed BRV. In the CLP colostrum group, one calf developed BRV-associated diarrhea and all calves shed virus. In the SA11 colostrum group, three calves developed BRV-associated diarrhea and four calves shed virus. BRV-associated diarrhea and shedding occurred in 9 of 10 control calves. Active IgM antibody responses occurred in faeces and/or serum of most calves after BRV inoculation. However, the highest active antibody responses (IgM and IgG1 in serum, and IgM, IgG1 or IgA in faeces) after BRV inoculation were in calves fed control or no colostrum, in association with clinical diarrhea in most of these calves. After challenge at PID 21, BRV-associated diarrhea and shedding were of short duration or absent, in all groups. These results demonstrate the efficacy of colostrum from VLP vaccinated cows to provide heterologous, passive protection against BRV diarrhea and shedding in calves. In comparison, calves fed CLP or SA11 colostrum were only partially protected against BRV diarrhea or shedding.
Url:
DOI: 10.1016/S0264-410X(97)80004-7
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Conner</name><affiliation><mods:affiliation>Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Veterans Administration Medical Center, Houston, TX 77030, USA</mods:affiliation></affiliation></author><author><name sortKey="Hodgins, D C" sort="Hodgins, D C" uniqKey="Hodgins D" first="D. C." last="Hodgins">D. C. Hodgins</name><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation></author><author><name sortKey="Parwani, A V" sort="Parwani, A V" uniqKey="Parwani A" first="A. V." last="Parwani">A. V. 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Crawford</name><affiliation><mods:affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Estes, M K" sort="Estes, M K" uniqKey="Estes M" first="M. K." last="Estes">M. K. Estes</name><affiliation><mods:affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Saif, L J" sort="Saif, L J" uniqKey="Saif L" first="L. J." last="Saif">L. J. Saif</name><affiliation><mods:affiliation>Author to whom all correspondence should be addressed.</mods:affiliation></affiliation><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9ED0BFCD664186A45A56BC6A769D53D5EABB0738</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0264-410X(97)80004-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-734G21G7-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000795</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000795</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</title><author><name sortKey="Fernandez, F M" sort="Fernandez, F M" uniqKey="Fernandez F" first="F. M." last="Fernandez">F. M. Fernandez</name><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Conner, M E" sort="Conner, M E" uniqKey="Conner M" first="M. E." last="Conner">M. E. Conner</name><affiliation><mods:affiliation>Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Veterans Administration Medical Center, Houston, TX 77030, USA</mods:affiliation></affiliation></author><author><name sortKey="Hodgins, D C" sort="Hodgins, D C" uniqKey="Hodgins D" first="D. C." last="Hodgins">D. C. Hodgins</name><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation></author><author><name sortKey="Parwani, A V" sort="Parwani, A V" uniqKey="Parwani A" first="A. V." last="Parwani">A. V. Parwani</name><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation></author><author><name sortKey="Nielsen, P R" sort="Nielsen, P R" uniqKey="Nielsen P" first="P. R." last="Nielsen">P. R. Nielsen</name><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation></author><author><name sortKey="Crawford, S E" sort="Crawford, S E" uniqKey="Crawford S" first="S. E." last="Crawford">S. E. Crawford</name><affiliation><mods:affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Estes, M K" sort="Estes, M K" uniqKey="Estes M" first="M. K." last="Estes">M. K. Estes</name><affiliation><mods:affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Saif, L J" sort="Saif, L J" uniqKey="Saif L" first="L. J." last="Saif">L. J. Saif</name><affiliation><mods:affiliation>Author to whom all correspondence should be addressed.</mods:affiliation></affiliation><affiliation><mods:affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="507">507</biblScope><biblScope unit="page" to="516">516</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term><term>Antibody responses</term><term>Antibody titers</term><term>Bovine</term><term>Bovine rotavirus</term><term>Calf</term><term>Colostrum</term><term>Colostrum group</term><term>Colostrum pool</term><term>Colostrum pools</term><term>Colostrum supplements</term><term>Control calves</term><term>Control colostrum</term><term>Control colostrum pool</term><term>Control groups</term><term>Cows inoculated</term><term>Cows vaccinated</term><term>Diarrhea</term><term>Elisa</term><term>Faecal</term><term>Faeces</term><term>Fernandez</term><term>Fewer days</term><term>Iggl</term><term>Iggl antibodies</term><term>Iggl antibody titers</term><term>Immune</term><term>Inoculated</term><term>Inoculation</term><term>Intestinal</term><term>Isotype</term><term>Neutralizing</term><term>Newborn calves</term><term>Passive immunity</term><term>Passive protection</term><term>Post challenge</term><term>Post inoculation</term><term>Recombinant</term><term>Rotavirus</term><term>Rotavirus diarrhea</term><term>Rotavirus vaccines</term><term>Saif</term><term>Sall</term><term>Sall colostrum</term><term>Sall rotavirus</term><term>Same column</term><term>Subunit</term><term>Titer</term><term>Vaccinated</term><term>Vaccinated cows</term><term>Vaccine</term><term>Viral</term><term>Vlps</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Heterotypic passive immunity to IND (P[5]G6) bovine rotavirus (BRV) was evaluated. Three groups of calves (n = 5 per group) were fed 1% pooled colostrum supplements (birth to 7 days of age) from BRV seropositive cows vaccinated with recombinant SA11(P[2]G3) rotavirus-like particles (VLPs), recombinant SA11 rotavirus core-like particles (CLPs), or inactivated SA11 rotavirus (SA11). Control calves (n = 5 per group) received either pooled colostrum from unvaccinated (BRV field exposure seropositive) control cows, or no colostrum. IgG1 antibody titers to IND BRV for the pooled colostrum were: 1048576 (VLP); 1048576 (CLP); 262144 (SA11); and 16384 (control colostrum). Elevated titers of BRV neutralizing (VN) antibodies were present in VLP colostrum (98 000), and SA11 colostrum (25 000), but not in CLP colostrum (1400), compared to colostrum from nonvaccinates (2081). Calves were orally inoculated with virulent IND BRV at 2 days of age and challenged at post-inoculation day (PID) 21. Calves were monitored daily for diarrhea and faecal BRV shedding through PID 10 and post-challenge day (PCD) 10. After colostrum feeding, the IgG1 antibody titers were highest in serum and faeces of calves fed VLP and CLP colostrum, but VN and IgA antibodies were highest in calves fed VLP colostrum. After BRV inoculation, calves fed colostrum from vaccinated cows had significantly fewer days of BRV-associated diarrhea and BRV shedding than control calves. All calves fed VLP colostrum were protected from diarrhea after BRV inoculation; two calves shed BRV. In the CLP colostrum group, one calf developed BRV-associated diarrhea and all calves shed virus. In the SA11 colostrum group, three calves developed BRV-associated diarrhea and four calves shed virus. BRV-associated diarrhea and shedding occurred in 9 of 10 control calves. Active IgM antibody responses occurred in faeces and/or serum of most calves after BRV inoculation. However, the highest active antibody responses (IgM and IgG1 in serum, and IgM, IgG1 or IgA in faeces) after BRV inoculation were in calves fed control or no colostrum, in association with clinical diarrhea in most of these calves. After challenge at PID 21, BRV-associated diarrhea and shedding were of short duration or absent, in all groups. These results demonstrate the efficacy of colostrum from VLP vaccinated cows to provide heterologous, passive protection against BRV diarrhea and shedding in calves. In comparison, calves fed CLP or SA11 colostrum were only partially protected against BRV diarrhea or shedding.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>colostrum</json:string><json:string>rotavirus</json:string><json:string>iggl</json:string><json:string>faeces</json:string><json:string>vaccine</json:string><json:string>sall</json:string><json:string>vaccinated</json:string><json:string>antibody titers</json:string><json:string>faecal</json:string><json:string>passive immunity</json:string><json:string>recombinant</json:string><json:string>elisa</json:string><json:string>bovine rotavirus</json:string><json:string>fernandez</json:string><json:string>colostrum pools</json:string><json:string>inoculated</json:string><json:string>saif</json:string><json:string>antibody responses</json:string><json:string>control colostrum</json:string><json:string>neutralizing</json:string><json:string>post challenge</json:string><json:string>isotype</json:string><json:string>iggl antibodies</json:string><json:string>intestinal</json:string><json:string>cows vaccinated</json:string><json:string>titer</json:string><json:string>vaccinated cows</json:string><json:string>post inoculation</json:string><json:string>rotavirus vaccines</json:string><json:string>vlps</json:string><json:string>inoculation</json:string><json:string>immune</json:string><json:string>colostrum pool</json:string><json:string>subunit</json:string><json:string>viral</json:string><json:string>colostrum group</json:string><json:string>colostrum supplements</json:string><json:string>passive protection</json:string><json:string>bovine</json:string><json:string>cows inoculated</json:string><json:string>newborn calves</json:string><json:string>same column</json:string><json:string>rotavirus diarrhea</json:string><json:string>control calves</json:string><json:string>control groups</json:string><json:string>calf</json:string><json:string>antibody</json:string><json:string>fewer days</json:string><json:string>sall colostrum</json:string><json:string>sall rotavirus</json:string><json:string>control colostrum pool</json:string><json:string>iggl antibody titers</json:string><json:string>diarrhea</json:string><json:string>antibody titer</json:string><json:string>rotavirus inoculation</json:string><json:string>cumulative faecal scores</json:string><json:string>serum samples</json:string><json:string>faecal samples</json:string><json:string>high titers</json:string><json:string>short duration</json:string><json:string>significant differences</json:string></teeft></keywords><author><json:item><name>F.M. Fernandez</name><affiliations><json:string>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</json:string><json:string>Instituto de Virologia, CICV-INTA, Castelar, Argentina</json:string></affiliations></json:item><json:item><name>M.E. Conner</name><affiliations><json:string>Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA</json:string><json:string>Veterans Administration Medical Center, Houston, TX 77030, USA</json:string></affiliations></json:item><json:item><name>D.C. Hodgins</name><affiliations><json:string>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</json:string></affiliations></json:item><json:item><name>A.V. Parwani</name><affiliations><json:string>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</json:string></affiliations></json:item><json:item><name>P.R. Nielsen</name><affiliations><json:string>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</json:string></affiliations></json:item><json:item><name>S.E. Crawford</name><affiliations><json:string>Instituto de Virologia, CICV-INTA, Castelar, Argentina</json:string></affiliations></json:item><json:item><name>M.K. Estes</name><affiliations><json:string>Instituto de Virologia, CICV-INTA, Castelar, Argentina</json:string></affiliations></json:item><json:item><name>L.J. Saif</name><affiliations><json:string>Author to whom all correspondence should be addressed.</json:string><json:string>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>recombinant rotavirus subunit vaccines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>core-like particles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>virus-like particles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>passive immunity in calves</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bovine rotavirus</value></json:item></subject><arkIstex>ark:/67375/6H6-734G21G7-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Heterotypic passive immunity to IND (P[5]G6) bovine rotavirus (BRV) was evaluated. Three groups of calves (n = 5 per group) were fed 1% pooled colostrum supplements (birth to 7 days of age) from BRV seropositive cows vaccinated with recombinant SA11(P[2]G3) rotavirus-like particles (VLPs), recombinant SA11 rotavirus core-like particles (CLPs), or inactivated SA11 rotavirus (SA11). Control calves (n = 5 per group) received either pooled colostrum from unvaccinated (BRV field exposure seropositive) control cows, or no colostrum. IgG1 antibody titers to IND BRV for the pooled colostrum were: 1048576 (VLP); 1048576 (CLP); 262144 (SA11); and 16384 (control colostrum). Elevated titers of BRV neutralizing (VN) antibodies were present in VLP colostrum (98 000), and SA11 colostrum (25 000), but not in CLP colostrum (1400), compared to colostrum from nonvaccinates (2081). Calves were orally inoculated with virulent IND BRV at 2 days of age and challenged at post-inoculation day (PID) 21. Calves were monitored daily for diarrhea and faecal BRV shedding through PID 10 and post-challenge day (PCD) 10. After colostrum feeding, the IgG1 antibody titers were highest in serum and faeces of calves fed VLP and CLP colostrum, but VN and IgA antibodies were highest in calves fed VLP colostrum. After BRV inoculation, calves fed colostrum from vaccinated cows had significantly fewer days of BRV-associated diarrhea and BRV shedding than control calves. All calves fed VLP colostrum were protected from diarrhea after BRV inoculation; two calves shed BRV. In the CLP colostrum group, one calf developed BRV-associated diarrhea and all calves shed virus. In the SA11 colostrum group, three calves developed BRV-associated diarrhea and four calves shed virus. BRV-associated diarrhea and shedding occurred in 9 of 10 control calves. Active IgM antibody responses occurred in faeces and/or serum of most calves after BRV inoculation. However, the highest active antibody responses (IgM and IgG1 in serum, and IgM, IgG1 or IgA in faeces) after BRV inoculation were in calves fed control or no colostrum, in association with clinical diarrhea in most of these calves. After challenge at PID 21, BRV-associated diarrhea and shedding were of short duration or absent, in all groups. These results demonstrate the efficacy of colostrum from VLP vaccinated cows to provide heterologous, passive protection against BRV diarrhea and shedding in calves. In comparison, calves fed CLP or SA11 colostrum were only partially protected against BRV diarrhea or shedding.</abstract><qualityIndicators><score>10</score><pdfWordCount>5155</pdfWordCount><pdfCharCount>37469</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>614 x 857 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>390</abstractWordCount><abstractCharCount>2562</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</title><pmid><json:string>9491505</json:string></pmid><pii><json:string>S0264-410X(97)80004-7</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Vaccine</title><language><json:string>unknown</json:string></language><publicationDate>1998</publicationDate><issn><json:string>0264-410X</json:string></issn><pii><json:string>S0264-410X(00)X0054-0</json:string></pii><volume>16</volume><issue>5</issue><pages><first>507</first><last>516</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1998</json:string></date><geogName></geogName><orgName><json:string>Ohio Agricultural Research and Development Center</json:string><json:string>Division of Molecular Virology</json:string><json:string>Veterans Administration Medical Center, Houston</json:string><json:string>The Ohio State University</json:string><json:string>Elsevier Science Ltd.</json:string><json:string>Food Animal Health Research Program and Veterinary Preventive Medicine</json:string><json:string>OARDC</json:string><json:string>USDA NRICGP Competitive grant No. 93-37204-9201</json:string></orgName><orgName_funder><json:string>USDA NRICGP Competitive grant No. 93-37204-9201</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>S.E. Crawford</json:string><json:string>A.V. Parwani</json:string><json:string>ELISA IgGI</json:string><json:string>P.R. Nielsen</json:string><json:string>M.K. Estes</json:string><json:string>F.M. Fernandez</json:string><json:string>M.E. Conner</json:string><json:string>D.C. Hodgins</json:string><json:string>L.J. Saif</json:string><json:string>Madison Avenue</json:string></persName><placeName><json:string>TX</json:string><json:string>Houston</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Ohio Agricultural Research and Development Center, The Ohio State University, 1680</json:string><json:string>F.M. Fernandez et al.</json:string><json:string>[5]</json:string><json:string>Fernandez et al.</json:string><json:string>[2]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-734G21G7-8</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - medicine, research & experimental</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Public Health, Environmental and Occupational Health</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - General 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circulatoire</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S0264-410X(97)80004-7</json:string></doi><id>9ED0BFCD664186A45A56BC6A769D53D5EABB0738</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-734G21G7-8/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-734G21G7-8/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-734G21G7-8/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1998</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Paper</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</title><author xml:id="author-0000"><persName><forename type="first">F.M.</forename><surname>Fernandez</surname></persName><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation><affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</affiliation></author><author xml:id="author-0001"><persName><forename type="first">M.E.</forename><surname>Conner</surname></persName><affiliation>Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA</affiliation><affiliation>Veterans Administration Medical Center, Houston, TX 77030, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">D.C.</forename><surname>Hodgins</surname></persName><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">A.V.</forename><surname>Parwani</surname></persName><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">P.R.</forename><surname>Nielsen</surname></persName><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">S.E.</forename><surname>Crawford</surname></persName><affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</affiliation></author><author xml:id="author-0006"><persName><forename type="first">M.K.</forename><surname>Estes</surname></persName><affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</affiliation></author><author xml:id="author-0007"><persName><forename type="first">L.J.</forename><surname>Saif</surname></persName><affiliation>Author to whom all correspondence should be addressed.</affiliation><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation></author><idno type="istex">9ED0BFCD664186A45A56BC6A769D53D5EABB0738</idno><idno type="ark">ark:/67375/6H6-734G21G7-8</idno><idno type="DOI">10.1016/S0264-410X(97)80004-7</idno><idno type="PII">S0264-410X(97)80004-7</idno></analytic><monogr><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="pISSN">0264-410X</idno><idno type="PII">S0264-410X(00)X0054-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="507">507</biblScope><biblScope unit="page" to="516">516</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Heterotypic passive immunity to IND (P[5]G6) bovine rotavirus (BRV) was evaluated. Three groups of calves (n = 5 per group) were fed 1% pooled colostrum supplements (birth to 7 days of age) from BRV seropositive cows vaccinated with recombinant SA11(P[2]G3) rotavirus-like particles (VLPs), recombinant SA11 rotavirus core-like particles (CLPs), or inactivated SA11 rotavirus (SA11). Control calves (n = 5 per group) received either pooled colostrum from unvaccinated (BRV field exposure seropositive) control cows, or no colostrum. IgG1 antibody titers to IND BRV for the pooled colostrum were: 1048576 (VLP); 1048576 (CLP); 262144 (SA11); and 16384 (control colostrum). Elevated titers of BRV neutralizing (VN) antibodies were present in VLP colostrum (98 000), and SA11 colostrum (25 000), but not in CLP colostrum (1400), compared to colostrum from nonvaccinates (2081). Calves were orally inoculated with virulent IND BRV at 2 days of age and challenged at post-inoculation day (PID) 21. Calves were monitored daily for diarrhea and faecal BRV shedding through PID 10 and post-challenge day (PCD) 10. After colostrum feeding, the IgG1 antibody titers were highest in serum and faeces of calves fed VLP and CLP colostrum, but VN and IgA antibodies were highest in calves fed VLP colostrum. After BRV inoculation, calves fed colostrum from vaccinated cows had significantly fewer days of BRV-associated diarrhea and BRV shedding than control calves. All calves fed VLP colostrum were protected from diarrhea after BRV inoculation; two calves shed BRV. In the CLP colostrum group, one calf developed BRV-associated diarrhea and all calves shed virus. In the SA11 colostrum group, three calves developed BRV-associated diarrhea and four calves shed virus. BRV-associated diarrhea and shedding occurred in 9 of 10 control calves. Active IgM antibody responses occurred in faeces and/or serum of most calves after BRV inoculation. However, the highest active antibody responses (IgM and IgG1 in serum, and IgM, IgG1 or IgA in faeces) after BRV inoculation were in calves fed control or no colostrum, in association with clinical diarrhea in most of these calves. After challenge at PID 21, BRV-associated diarrhea and shedding were of short duration or absent, in all groups. These results demonstrate the efficacy of colostrum from VLP vaccinated cows to provide heterologous, passive protection against BRV diarrhea and shedding in calves. In comparison, calves fed CLP or SA11 colostrum were only partially protected against BRV diarrhea or shedding.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>recombinant rotavirus subunit vaccines</term></item><item><term>core-like particles</term></item><item><term>virus-like particles</term></item><item><term>passive immunity in calves</term></item><item><term>bovine rotavirus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-08-25">Modified</change><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-734G21G7-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JVAC</jid><aid>97800047</aid><ce:pii>S0264-410X(97)80004-7</ce:pii><ce:doi>10.1016/S0264-410X(97)80004-7</ce:doi><ce:copyright type="unknown" year="1998"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Paper</ce:textfn></ce:dochead><ce:title>Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</ce:title><ce:author-group><ce:author><ce:given-name>F.M.</ce:given-name><ce:surname>Fernandez</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.E.</ce:given-name><ce:surname>Conner</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>‡</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF4"><ce:sup>§</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.C.</ce:given-name><ce:surname>Hodgins</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.V.</ce:given-name><ce:surname>Parwani</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.R.</ce:given-name><ce:surname>Nielsen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.E.</ce:given-name><ce:surname>Crawford</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.K.</ce:given-name><ce:surname>Estes</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>L.J.</ce:given-name><ce:surname>Saif</ce:surname><ce:cross-ref refid="COR1"><ce:sup>¶</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>∗</ce:label><ce:textfn>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>†</ce:label><ce:textfn>Instituto de Virologia, CICV-INTA, Castelar, Argentina</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>‡</ce:label><ce:textfn>Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>§</ce:label><ce:textfn>Veterans Administration Medical Center, Houston, TX 77030, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>¶</ce:label><ce:text>Author to whom all correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="9" month="6" year="1997"></ce:date-received><ce:date-revised day="25" month="8" year="1997"></ce:date-revised><ce:date-accepted day="25" month="8" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Heterotypic passive immunity to IND (P[5]G6) bovine rotavirus (BRV) was evaluated. Three groups of calves (<ce:italic>n</ce:italic> = 5 per group) were fed 1% pooled colostrum supplements (birth to 7 days of age) from BRV seropositive cows vaccinated with recombinant SA11(P[2]G3) rotavirus-like particles (VLPs), recombinant SA11 rotavirus core-like particles (CLPs), or inactivated SA11 rotavirus (SA11). Control calves (<ce:italic>n</ce:italic> = 5 per group) received either pooled colostrum from unvaccinated (BRV field exposure seropositive) control cows, or no colostrum. IgG1 antibody titers to IND BRV for the pooled colostrum were: 1048576 (VLP); 1048576 (CLP); 262144 (SA11); and 16384 (control colostrum). Elevated titers of BRV neutralizing (VN) antibodies were present in VLP colostrum (98 000), and SA11 colostrum (25 000), but not in CLP colostrum (1400), compared to colostrum from nonvaccinates (2081). Calves were orally inoculated with virulent IND BRV at 2 days of age and challenged at post-inoculation day (PID) 21. Calves were monitored daily for diarrhea and faecal BRV shedding through PID 10 and post-challenge day (PCD) 10. After colostrum feeding, the IgG1 antibody titers were highest in serum and faeces of calves fed VLP and CLP colostrum, but VN and IgA antibodies were highest in calves fed VLP colostrum. After BRV inoculation, calves fed colostrum from vaccinated cows had significantly fewer days of BRV-associated diarrhea and BRV shedding than control calves. All calves fed VLP colostrum were protected from diarrhea after BRV inoculation; two calves shed BRV. In the CLP colostrum group, one calf developed BRV-associated diarrhea and all calves shed virus. In the SA11 colostrum group, three calves developed BRV-associated diarrhea and four calves shed virus. BRV-associated diarrhea and shedding occurred in 9 of 10 control calves. Active IgM antibody responses occurred in faeces and/or serum of most calves after BRV inoculation. However, the highest active antibody responses (IgM and IgG1 in serum, and IgM, IgG1 or IgA in faeces) after BRV inoculation were in calves fed control or no colostrum, in association with clinical diarrhea in most of these calves. After challenge at PID 21, BRV-associated diarrhea and shedding were of short duration or absent, in all groups. These results demonstrate the efficacy of colostrum from VLP vaccinated cows to provide heterologous, passive protection against BRV diarrhea and shedding in calves. In comparison, calves fed CLP or SA11 colostrum were only partially protected against BRV diarrhea or shedding.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>recombinant rotavirus subunit vaccines</ce:text></ce:keyword><ce:keyword><ce:text>core-like particles</ce:text></ce:keyword><ce:keyword><ce:text>virus-like particles</ce:text></ce:keyword><ce:keyword><ce:text>passive immunity in calves</ce:text></ce:keyword><ce:keyword><ce:text>bovine rotavirus</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines</title></titleInfo><name type="personal"><namePart type="given">F.M.</namePart><namePart type="family">Fernandez</namePart><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation><affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.E.</namePart><namePart type="family">Conner</namePart><affiliation>Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA</affiliation><affiliation>Veterans Administration Medical Center, Houston, TX 77030, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.C.</namePart><namePart type="family">Hodgins</namePart><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.V.</namePart><namePart type="family">Parwani</namePart><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.R.</namePart><namePart type="family">Nielsen</namePart><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.E.</namePart><namePart type="family">Crawford</namePart><affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.K.</namePart><namePart type="family">Estes</namePart><affiliation>Instituto de Virologia, CICV-INTA, Castelar, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.J.</namePart><namePart type="family">Saif</namePart><affiliation>Author to whom all correspondence should be addressed.</affiliation><affiliation>Food Animal Health Research Program and Veterinary Preventive Medicine Department, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><dateModified encoding="w3cdtf">1997-08-25</dateModified><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Heterotypic passive immunity to IND (P[5]G6) bovine rotavirus (BRV) was evaluated. Three groups of calves (n = 5 per group) were fed 1% pooled colostrum supplements (birth to 7 days of age) from BRV seropositive cows vaccinated with recombinant SA11(P[2]G3) rotavirus-like particles (VLPs), recombinant SA11 rotavirus core-like particles (CLPs), or inactivated SA11 rotavirus (SA11). Control calves (n = 5 per group) received either pooled colostrum from unvaccinated (BRV field exposure seropositive) control cows, or no colostrum. IgG1 antibody titers to IND BRV for the pooled colostrum were: 1048576 (VLP); 1048576 (CLP); 262144 (SA11); and 16384 (control colostrum). Elevated titers of BRV neutralizing (VN) antibodies were present in VLP colostrum (98 000), and SA11 colostrum (25 000), but not in CLP colostrum (1400), compared to colostrum from nonvaccinates (2081). Calves were orally inoculated with virulent IND BRV at 2 days of age and challenged at post-inoculation day (PID) 21. Calves were monitored daily for diarrhea and faecal BRV shedding through PID 10 and post-challenge day (PCD) 10. After colostrum feeding, the IgG1 antibody titers were highest in serum and faeces of calves fed VLP and CLP colostrum, but VN and IgA antibodies were highest in calves fed VLP colostrum. After BRV inoculation, calves fed colostrum from vaccinated cows had significantly fewer days of BRV-associated diarrhea and BRV shedding than control calves. All calves fed VLP colostrum were protected from diarrhea after BRV inoculation; two calves shed BRV. In the CLP colostrum group, one calf developed BRV-associated diarrhea and all calves shed virus. In the SA11 colostrum group, three calves developed BRV-associated diarrhea and four calves shed virus. BRV-associated diarrhea and shedding occurred in 9 of 10 control calves. Active IgM antibody responses occurred in faeces and/or serum of most calves after BRV inoculation. However, the highest active antibody responses (IgM and IgG1 in serum, and IgM, IgG1 or IgA in faeces) after BRV inoculation were in calves fed control or no colostrum, in association with clinical diarrhea in most of these calves. After challenge at PID 21, BRV-associated diarrhea and shedding were of short duration or absent, in all groups. These results demonstrate the efficacy of colostrum from VLP vaccinated cows to provide heterologous, passive protection against BRV diarrhea and shedding in calves. In comparison, calves fed CLP or SA11 colostrum were only partially protected against BRV diarrhea or shedding.</abstract><note type="content">Section title: Paper</note><subject><genre>Keywords</genre><topic>recombinant rotavirus subunit vaccines</topic><topic>core-like particles</topic><topic>virus-like particles</topic><topic>passive immunity in calves</topic><topic>bovine rotavirus</topic></subject><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><titleInfo type="abbreviated"><title>JVAC</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued></originInfo><identifier type="ISSN">0264-410X</identifier><identifier type="PII">S0264-410X(00)X0054-0</identifier><part><date>1998</date><detail type="volume"><number>16</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>439</start><end>541</end></extent><extent unit="pages"><start>507</start><end>516</end></extent></part></relatedItem><identifier type="istex">9ED0BFCD664186A45A56BC6A769D53D5EABB0738</identifier><identifier type="ark">ark:/67375/6H6-734G21G7-8</identifier><identifier type="DOI">10.1016/S0264-410X(97)80004-7</identifier><identifier type="PII">S0264-410X(97)80004-7</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-734G21G7-8/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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