Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea
Identifieur interne : 000682 ( Istex/Corpus ); précédent : 000681; suivant : 000683Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea
Auteurs : M. Kelly ; D. G. Butler ; J. R. HamiltonSource :
- The Journal of Pediatrics [ 0022-3476 ] ; 1972.
English descriptors
- Teeft :
- Acute phase, Adenosine triphosphatase, Alkaline phosphatase, Cholera, Cholera toxin, Clin, Control piglets, Control pigs, Convalescent phase, Deionized water, Dietary lactose, Distal colon, Electrolyte, Enzyme activity, Epithelial cells, Fecal electrolytes, Flame spectrophotometer, Fresh stool, Gastroenteritis, Gesamte virusforsch, Homogenate, Hours post inoculation, Inoculation, Inorganic phosphate, Intestinal, Intestinal mucosa, Intestine, Jejunum, Large intestine, Light microscopy, Litter mates, Male pigs, Minute centrifugation, Mucosal homogenates, Nitric acid, Normal pigs, Original weight, Phosphatase, Pig, Piglet, Proximal, Proximal jejunum, Research institute, Round cell infiltration, Serum determinations, Serum sodium, Sick children, Sigma chemical, Small intestine, Stool determinations, Total volume, Transmissible, Transmissible gastroenteritis, Transmissible gastroenteritis virus, Week post inoculation, Weeks post inoculation.
Abstract
Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.
Url:
DOI: 10.1016/S0022-3476(72)80003-9
Links to Exploration step
ISTEX:8C4B5BD361855A8BB41F11E90E706EDA77198374Le document en format XML
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Butler</name><affiliation><mods:affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hamilton, J R" sort="Hamilton, J R" uniqKey="Hamilton J" first="J. R." last="Hamilton">J. R. 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Kelly</name><affiliation><mods:affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Butler, D G" sort="Butler, D G" uniqKey="Butler D" first="D. G." last="Butler">D. G. Butler</name><affiliation><mods:affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hamilton, J R" sort="Hamilton, J R" uniqKey="Hamilton J" first="J. R." last="Hamilton">J. R. Hamilton</name><affiliation><mods:affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>*Address: Research Institute of the Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Pediatrics</title><title level="j" type="abbrev">YMPD</title><idno type="ISSN">0022-3476</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1972">1972</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="925">925</biblScope><biblScope unit="page" to="931">931</biblScope></imprint><idno type="ISSN">0022-3476</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute phase</term><term>Adenosine triphosphatase</term><term>Alkaline phosphatase</term><term>Cholera</term><term>Cholera toxin</term><term>Clin</term><term>Control piglets</term><term>Control pigs</term><term>Convalescent phase</term><term>Deionized water</term><term>Dietary lactose</term><term>Distal colon</term><term>Electrolyte</term><term>Enzyme activity</term><term>Epithelial cells</term><term>Fecal electrolytes</term><term>Flame spectrophotometer</term><term>Fresh stool</term><term>Gastroenteritis</term><term>Gesamte virusforsch</term><term>Homogenate</term><term>Hours post inoculation</term><term>Inoculation</term><term>Inorganic phosphate</term><term>Intestinal</term><term>Intestinal mucosa</term><term>Intestine</term><term>Jejunum</term><term>Large intestine</term><term>Light microscopy</term><term>Litter mates</term><term>Male pigs</term><term>Minute centrifugation</term><term>Mucosal homogenates</term><term>Nitric acid</term><term>Normal pigs</term><term>Original weight</term><term>Phosphatase</term><term>Pig</term><term>Piglet</term><term>Proximal</term><term>Proximal jejunum</term><term>Research institute</term><term>Round cell infiltration</term><term>Serum determinations</term><term>Serum sodium</term><term>Sick children</term><term>Sigma chemical</term><term>Small intestine</term><term>Stool determinations</term><term>Total volume</term><term>Transmissible</term><term>Transmissible gastroenteritis</term><term>Transmissible gastroenteritis virus</term><term>Week post inoculation</term><term>Weeks post inoculation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>piglet</json:string><json:string>gastroenteritis</json:string><json:string>intestinal</json:string><json:string>control pigs</json:string><json:string>transmissible gastroenteritis</json:string><json:string>proximal jejunum</json:string><json:string>electrolyte</json:string><json:string>transmissible</json:string><json:string>phosphatase</json:string><json:string>clin</json:string><json:string>hours post inoculation</json:string><json:string>litter mates</json:string><json:string>small intestine</json:string><json:string>intestine</json:string><json:string>intestinal mucosa</json:string><json:string>transmissible gastroenteritis virus</json:string><json:string>proximal</json:string><json:string>inoculation</json:string><json:string>cholera</json:string><json:string>enzyme activity</json:string><json:string>weeks post inoculation</json:string><json:string>control piglets</json:string><json:string>alkaline phosphatase</json:string><json:string>serum sodium</json:string><json:string>adenosine triphosphatase</json:string><json:string>week post inoculation</json:string><json:string>pig</json:string><json:string>homogenate</json:string><json:string>research institute</json:string><json:string>male pigs</json:string><json:string>normal pigs</json:string><json:string>total volume</json:string><json:string>sigma chemical</json:string><json:string>inorganic phosphate</json:string><json:string>sick children</json:string><json:string>mucosal homogenates</json:string><json:string>stool determinations</json:string><json:string>deionized water</json:string><json:string>minute centrifugation</json:string><json:string>nitric acid</json:string><json:string>flame spectrophotometer</json:string><json:string>original weight</json:string><json:string>fresh stool</json:string><json:string>serum determinations</json:string><json:string>cholera toxin</json:string><json:string>acute phase</json:string><json:string>distal colon</json:string><json:string>large intestine</json:string><json:string>convalescent phase</json:string><json:string>fecal electrolytes</json:string><json:string>light microscopy</json:string><json:string>dietary lactose</json:string><json:string>epithelial cells</json:string><json:string>gesamte virusforsch</json:string><json:string>round cell infiltration</json:string><json:string>jejunum</json:string></teeft></keywords><author><json:item><name>M. Kelly B.Sc.</name><affiliations><json:string>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</json:string><json:string>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>D.G. Butler D.V.M., M.Sc.</name><affiliations><json:string>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</json:string><json:string>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>J.R. Hamilton B.Sc., M.D., F.R.C.P. (C)</name><affiliations><json:string>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</json:string><json:string>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</json:string><json:string>*Address: Research Institute of the Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada.</json:string></affiliations></json:item></author><articleId><json:string>72800039</json:string></articleId><arkIstex>ark:/67375/6H6-5PK1J4QN-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.</abstract><qualityIndicators><score>6.71</score><pdfWordCount>3666</pdfWordCount><pdfCharCount>22209</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>504 x 734.28 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>87</abstractWordCount><abstractCharCount>625</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea</title><pmid><json:string>4260289</json:string></pmid><pii><json:string>S0022-3476(72)80003-9</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Clinical laboratory methods and diagnosis</title><language><json:string>unknown</json:string></language><volume>vol. 1</volume><pages><first>165</first></pages><editor><json:item><name>R.B.H. 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V. Mosby Company</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1972</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Supported by grants from the Pathfinder Foundation and the Medical Research Council of Canada.</note><note type="content">Section title: Original article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea</title><author xml:id="author-0000"><persName><forename type="first">M.</forename><surname>Kelly</surname></persName><roleName type="degree">B.Sc.</roleName><affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-0001"><persName><forename type="first">D.G.</forename><surname>Butler</surname></persName><roleName type="degree">D.V.M., M.Sc.</roleName><affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J.R.</forename><surname>Hamilton</surname></persName><roleName type="degree">B.Sc., M.D., F.R.C.P. (C)</roleName><affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</affiliation><affiliation>*Address: Research Institute of the Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada.</affiliation></author><idno type="istex">8C4B5BD361855A8BB41F11E90E706EDA77198374</idno><idno type="ark">ark:/67375/6H6-5PK1J4QN-M</idno><idno type="DOI">10.1016/S0022-3476(72)80003-9</idno><idno type="PII">S0022-3476(72)80003-9</idno><idno type="article-id">72800039</idno></analytic><monogr><title level="j">The Journal of Pediatrics</title><title level="j" type="abbrev">YMPD</title><idno type="pISSN">0022-3476</idno><idno type="PII">S0022-3476(72)X8001-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1972"></date><biblScope unit="volume">80</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="925">925</biblScope><biblScope unit="page" to="931">931</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1972</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.</p></abstract></profileDesc><revisionDesc><change when="1972">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-5PK1J4QN-M/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YMPD</jid><aid>72800039</aid><ce:pii>S0022-3476(72)80003-9</ce:pii><ce:doi>10.1016/S0022-3476(72)80003-9</ce:doi><ce:copyright type="unknown" year="1972">The C. V. Mosby Company</ce:copyright></item-info><head><ce:article-footnote><ce:label>**</ce:label><ce:note-para>Supported by grants from the Pathfinder Foundation and the Medical Research Council of Canada.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Original article</ce:textfn></ce:dochead><ce:title>Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea</ce:title><ce:author-group><ce:author><ce:degrees>B.Sc.</ce:degrees><ce:given-name>M.</ce:given-name><ce:surname>Kelly</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>D.V.M., M.Sc.</ce:degrees><ce:given-name>D.G.</ce:given-name><ce:surname>Butler</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:degrees>B.Sc., M.D., F.R.C.P. (C)</ce:degrees><ce:given-name>J.R.</ce:given-name><ce:surname>Hamilton</ce:surname><ce:cross-ref refid="aff1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="fn1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>a</ce:label><ce:textfn>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>b</ce:label><ce:textfn>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</ce:textfn></ce:affiliation><ce:footnote id="fn1"><ce:label>*</ce:label><ce:note-para>Address: Research Institute of the Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada.</ce:note-para></ce:footnote></ce:author-group><ce:abstract id="ab1" class="author" xml:lang="en"><ce:abstract-sec><ce:simple-para>Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.</ce:simple-para></ce:abstract-sec></ce:abstract></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Cramblett</ce:surname><ce:given-name>H.G.</ce:given-name></sb:author><sb:author><ce:surname>Azomi</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Haynes</ce:surname><ce:given-name>R.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The etiology of infectious diarrhea in infancy, with special reference to enteropathogenic E. coli</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. N. Y. Acad. 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I. Immunofluorescence, histopathology and virus production in the smallintestine through the course of infection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch. Gesamte Virus-forsch.</sb:maintitle></sb:title><sb:volume-nr>31</sb:volume-nr></sb:series><sb:date>1970</sb:date></sb:issue><sb:pages><sb:first-page>321</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Transmissible gastroenteritis in piglets:A model of infantile viral diarrhea</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kelly</namePart><namePart type="termsOfAddress">B.Sc.</namePart><affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.G.</namePart><namePart type="family">Butler</namePart><namePart type="termsOfAddress">D.V.M., M.Sc.</namePart><affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.R.</namePart><namePart type="family">Hamilton</namePart><namePart type="termsOfAddress">B.Sc., M.D., F.R.C.P. (C)</namePart><affiliation>Department of Pediatrics, University Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Research Institute of theHospital for Sick Children, Toronto, Ontario, Canada</affiliation><affiliation>*Address: Research Institute of the Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1972</dateIssued><copyrightDate encoding="w3cdtf">1972</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Piglets infected with transmissible gastroenteritis virus, compared to matched-fed littermates, had massive diarrhea characterized by increased quantities and concentrations of sodium, potassium, and chloride. Determinations of Na-K-ATPase in mucosal homogenates from small and large intestine revealed decreased activity of this enzyme in the upper small bowel. Our data indicate that a defect in active sodium transport in this region may be an important factor in the pathogenesis of the diarrhea. Further studies using this model should help to define the mechanisms producing diarrhea in acute infantile gastroenteritis.</abstract><note>Supported by grants from the Pathfinder Foundation and the Medical Research Council of Canada.</note><note type="content">Section title: Original article</note><relatedItem type="host"><titleInfo><title>The Journal of Pediatrics</title></titleInfo><titleInfo type="abbreviated"><title>YMPD</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1972</dateIssued></originInfo><identifier type="ISSN">0022-3476</identifier><identifier type="PII">S0022-3476(72)X8001-X</identifier><part><date>1972</date><detail type="volume"><number>80</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue-pages"><start>909</start><end>1102</end></extent><extent unit="pages"><start>925</start><end>931</end></extent></part></relatedItem><identifier type="istex">8C4B5BD361855A8BB41F11E90E706EDA77198374</identifier><identifier type="ark">ark:/67375/6H6-5PK1J4QN-M</identifier><identifier type="DOI">10.1016/S0022-3476(72)80003-9</identifier><identifier type="PII">S0022-3476(72)80003-9</identifier><identifier type="ArticleID">72800039</identifier><accessCondition type="use and reproduction" contentType="copyright">©1972 The C. V. Mosby Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>The C. V. Mosby Company, ©1972</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-5PK1J4QN-M/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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