FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS
Identifieur interne : 000620 ( Istex/Corpus ); précédent : 000619; suivant : 000621FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS
Auteurs : H. J. A. Fleury ; Rachel D. Sheppard ; M. B. Bornstein ; C. S. RaineSource :
- Neuropathology and Applied Neurobiology [ 0305-1846 ] ; 1980-05.
English descriptors
- Teeft :
- Albert einstein college, Animals inoculated, Autoimmune demyelination, Axon, Brain homogenates, Cell processes, Clinical signs, Control animals, Cord, Demyelination, Dorsal root, Electron microscopy, Encephalomyelitis, Endothelial cells, Ependymal, Ependymal cells, Extensive destruction, Extracellular space, Fleury, Giant cell, Giant cell formation, Giant cells, Haematogenous origin, Higher magnification, Impending phagocytosis, Infectious virus, Inoculated, Inoculated intracerebrally, Inoculation, Japanese journal, Kersting pette, Laboratory inuestigation, Lampert, Lesion, Light microscopy, Liver tissue, Macrophage, Mature virions, Mouse, Mouse hepatitis virus, Mouse inoculated, Multinucleated giant cell, Murine virus, Myelin, Myelin degradation, Myelin pathology, Myelinated axons, Myelinated regions, Naked axons, Nerve fibres, Neuron, Oligodendrocyte, Periventricular zones, Powell lampert, Raine, Spinal, Spinal cord, Spinal cord lesions, Stohlman weiner, Suckling mouse brain, Thin sections, Ventricular margin, Ventricular space, Viral assays, Virion, Virus, Virus encephalomyelitis, Virus infection, Virus particles, Virus suspension, Virus titres, Weiner, White matter.
Abstract
Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 Neuropathology and Applied Neurobiology 6,165–179 Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.
Url:
DOI: 10.1111/j.1365-2990.1980.tb00288.x
Links to Exploration step
ISTEX:FD82A30C0DE51362B683294DC926B011C64B1F2DLe document en format XML
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J. A." last="Fleury">H. J. A. Fleury</name><affiliation><mods:affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</mods:affiliation></affiliation></author><author><name sortKey="Sheppard, Rachel D" sort="Sheppard, Rachel D" uniqKey="Sheppard R" first="Rachel D." last="Sheppard">Rachel D. Sheppard</name><affiliation><mods:affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</mods:affiliation></affiliation></author><author><name sortKey="Bornstein, M B" sort="Bornstein, M B" uniqKey="Bornstein M" first="M. B." last="Bornstein">M. B. Bornstein</name><affiliation><mods:affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</mods:affiliation></affiliation></author><author><name sortKey="Raine, C S" sort="Raine, C S" uniqKey="Raine C" first="C. S." last="Raine">C. S. Raine</name><affiliation><mods:affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Neuropathology and Applied Neurobiology</title><title level="j" type="alt">NEUROPATHOLOGY APPLIED NEUROBIOLOGY</title><idno type="ISSN">0305-1846</idno><idno type="eISSN">1365-2990</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="165">165</biblScope><biblScope unit="page" to="179">179</biblScope><biblScope unit="page-count">15</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1980-05">1980-05</date></imprint><idno type="ISSN">0305-1846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albert einstein college</term><term>Animals inoculated</term><term>Autoimmune demyelination</term><term>Axon</term><term>Brain homogenates</term><term>Cell processes</term><term>Clinical signs</term><term>Control animals</term><term>Cord</term><term>Demyelination</term><term>Dorsal root</term><term>Electron microscopy</term><term>Encephalomyelitis</term><term>Endothelial cells</term><term>Ependymal</term><term>Ependymal cells</term><term>Extensive destruction</term><term>Extracellular space</term><term>Fleury</term><term>Giant cell</term><term>Giant cell formation</term><term>Giant cells</term><term>Haematogenous origin</term><term>Higher magnification</term><term>Impending phagocytosis</term><term>Infectious virus</term><term>Inoculated</term><term>Inoculated intracerebrally</term><term>Inoculation</term><term>Japanese journal</term><term>Kersting pette</term><term>Laboratory inuestigation</term><term>Lampert</term><term>Lesion</term><term>Light microscopy</term><term>Liver tissue</term><term>Macrophage</term><term>Mature virions</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Mouse inoculated</term><term>Multinucleated giant cell</term><term>Murine virus</term><term>Myelin</term><term>Myelin degradation</term><term>Myelin pathology</term><term>Myelinated axons</term><term>Myelinated regions</term><term>Naked axons</term><term>Nerve fibres</term><term>Neuron</term><term>Oligodendrocyte</term><term>Periventricular zones</term><term>Powell lampert</term><term>Raine</term><term>Spinal</term><term>Spinal cord</term><term>Spinal cord lesions</term><term>Stohlman weiner</term><term>Suckling mouse brain</term><term>Thin sections</term><term>Ventricular margin</term><term>Ventricular space</term><term>Viral assays</term><term>Virion</term><term>Virus</term><term>Virus encephalomyelitis</term><term>Virus infection</term><term>Virus particles</term><term>Virus suspension</term><term>Virus titres</term><term>Weiner</term><term>White matter</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 Neuropathology and Applied Neurobiology 6,165–179 Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>myelin</json:string><json:string>spinal</json:string><json:string>demyelination</json:string><json:string>encephalomyelitis</json:string><json:string>spinal cord</json:string><json:string>lampert</json:string><json:string>oligodendrocyte</json:string><json:string>inoculated</json:string><json:string>virion</json:string><json:string>axon</json:string><json:string>ependymal</json:string><json:string>weiner</json:string><json:string>fleury</json:string><json:string>powell lampert</json:string><json:string>macrophage</json:string><json:string>ependymal cells</json:string><json:string>virus titres</json:string><json:string>white matter</json:string><json:string>giant cell formation</json:string><json:string>lesion</json:string><json:string>mouse hepatitis virus</json:string><json:string>animals inoculated</json:string><json:string>virus encephalomyelitis</json:string><json:string>myelin pathology</json:string><json:string>raine</json:string><json:string>neuron</json:string><json:string>virus infection</json:string><json:string>cell processes</json:string><json:string>virus suspension</json:string><json:string>liver tissue</json:string><json:string>infectious virus</json:string><json:string>extracellular space</json:string><json:string>mature virions</json:string><json:string>naked axons</json:string><json:string>inoculation</json:string><json:string>virus</json:string><json:string>mouse</json:string><json:string>giant cells</json:string><json:string>clinical signs</json:string><json:string>light microscopy</json:string><json:string>thin sections</json:string><json:string>control animals</json:string><json:string>viral assays</json:string><json:string>brain homogenates</json:string><json:string>kersting pette</json:string><json:string>ventricular space</json:string><json:string>periventricular zones</json:string><json:string>myelin degradation</json:string><json:string>myelinated regions</json:string><json:string>nerve fibres</json:string><json:string>haematogenous origin</json:string><json:string>endothelial cells</json:string><json:string>spinal cord lesions</json:string><json:string>virus particles</json:string><json:string>stohlman weiner</json:string><json:string>electron microscopy</json:string><json:string>laboratory inuestigation</json:string><json:string>mouse inoculated</json:string><json:string>inoculated intracerebrally</json:string><json:string>suckling mouse brain</json:string><json:string>impending phagocytosis</json:string><json:string>ventricular margin</json:string><json:string>higher magnification</json:string><json:string>dorsal root</json:string><json:string>albert einstein college</json:string><json:string>multinucleated giant cell</json:string><json:string>giant cell</json:string><json:string>myelinated axons</json:string><json:string>autoimmune demyelination</json:string><json:string>murine virus</json:string><json:string>extensive destruction</json:string><json:string>japanese journal</json:string><json:string>cord</json:string></teeft></keywords><author><json:item><name>H. J. A. FLEURY</name><affiliations><json:string>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</json:string></affiliations></json:item><json:item><name>RACHEL D. SHEPPARD</name><affiliations><json:string>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</json:string></affiliations></json:item><json:item><name>M. B. BORNSTEIN</name><affiliations><json:string>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</json:string></affiliations></json:item><json:item><name>C. S. RAINE</name><affiliations><json:string>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</json:string><json:string>Correspondence address: Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.</json:string></affiliations></json:item></author><articleId><json:string>NAN165</json:string></articleId><arkIstex>ark:/67375/WNG-3J0ZSW8M-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 Neuropathology and Applied Neurobiology 6,165–179 Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.</abstract><qualityIndicators><score>9.12</score><pdfWordCount>4276</pdfWordCount><pdfCharCount>26214</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>15</pdfPageCount><pdfPageSize>486 x 702 pts</pdfPageSize><pdfWordsPerPage>285</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>237</abstractWordCount><abstractCharCount>1676</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS</title><pmid><json:string>6250094</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Neuropathology and Applied Neurobiology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-2990</json:string></doi><issn><json:string>0305-1846</json:string></issn><eissn><json:string>1365-2990</json:string></eissn><publisherId><json:string>NAN</json:string></publisherId><volume>6</volume><issue>3</issue><pages><first>165</first><last>179</last><total>15</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1980</json:string></date><geogName></geogName><orgName><json:string>University of Southern California School of Medicine, Los Angeles</json:string><json:string>Department of Pathology</json:string><json:string>National Multiple Sclerosis Society</json:string><json:string>Blackwell Scientific Publications</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Weiner</json:string><json:string>Howard Finch</json:string><json:string>Leslie P. Wiener</json:string><json:string>A. Feldman</json:string><json:string>Cedric S. Raine</json:string><json:string>Everett Swanson</json:string><json:string>Miriam Pakingan</json:string><json:string>Marianne Van Hooren</json:string><json:string>Dr Lawrence</json:string><json:string>Rachel Sheppard</json:string><json:string>Mary Palumbo</json:string><json:string>Steven Stohlman</json:string><json:string>Stohlman</json:string><json:string>Fleury</json:string></persName><placeName><json:string>Nagashima</json:string><json:string>York</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Powell & Lampert, 1975</json:string><json:string>Lampert, Sims & Kniazeff, 1973</json:string><json:string>Weiner, 1973</json:string><json:string>Hirano et al., 1976</json:string><json:string>Goto et al., 1977</json:string><json:string>Raine, 1978</json:string><json:string>Raine, 1976a</json:string><json:string>Raine, 197613</json:string><json:string>Lipton & Dal Canto, 1976</json:string><json:string>Kersting & Pette, 1956</json:string><json:string>Raine, 1977</json:string><json:string>Lampert et al., 1973</json:string><json:string>Raine, 1976</json:string><json:string>Nagashima et al., 1978</json:string><json:string>Bailey et al., 1949</json:string><json:string>Lampert & Carpenter, 1965</json:string><json:string>Fleury et al.</json:string><json:string>Cheever et al. (1949)</json:string><json:string>Stohlman & Weiner, 1978</json:string><json:string>Bornstein & Raine, 1976</json:string><json:string>Krakowka et al., 1973</json:string><json:string>Lucas et al., 1977</json:string><json:string>Hirano, Fujiwara & Matumoto, 1976</json:string><json:string>Raine, 1976b</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-3J0ZSW8M-H</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pathology</json:string><json:string>2 - neurosciences</json:string><json:string>2 - clinical neurology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Physiology (medical)</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Histology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pathology and Forensic Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1980</publicationDate><copyrightDate>1980</copyrightDate><doi><json:string>10.1111/j.1365-2990.1980.tb00288.x</json:string></doi><id>FD82A30C0DE51362B683294DC926B011C64B1F2D</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3J0ZSW8M-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3J0ZSW8M-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-3J0ZSW8M-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1980-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS</title><author xml:id="author-0000"><persName><forename type="first">H. J. A.</forename><surname>FLEURY</surname></persName><affiliation><orgName type="division">Departments of Pathology (Neuropathology)</orgName><orgName type="institution">Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development</orgName><orgName type="institution">Albert Einstein College of Medicine</orgName><address><addrLine>Bronx</addrLine><addrLine>New York 10461, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">RACHEL D.</forename><surname>SHEPPARD</surname></persName><affiliation><orgName type="division">Departments of Pathology (Neuropathology)</orgName><orgName type="institution">Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development</orgName><orgName type="institution">Albert Einstein College of Medicine</orgName><address><addrLine>Bronx</addrLine><addrLine>New York 10461, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">M. B.</forename><surname>BORNSTEIN</surname></persName><affiliation><orgName type="division">Departments of Pathology (Neuropathology)</orgName><orgName type="institution">Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development</orgName><orgName type="institution">Albert Einstein College of Medicine</orgName><address><addrLine>Bronx</addrLine><addrLine>New York 10461, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003" role="corresp"><persName><forename type="first">C. S.</forename><surname>RAINE</surname></persName><affiliation><orgName type="division">Departments of Pathology (Neuropathology)</orgName><orgName type="institution">Neurology and Neuroscience and The Rose F. 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p>Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 <hi rend="italic">Neuropathology and Applied Neurobiology</hi> 6,165–179</p><p>Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis</p><p>Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.</p></abstract><textClass><keywords rend="tocHeading1"><term>Original Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3J0ZSW8M-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2990</doi><issn type="print">0305-1846</issn><issn type="electronic">1365-2990</issn><idGroup><id type="product" value="NAN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="NEUROPATHOLOGY APPLIED NEUROBIOLOGY">Neuropathology and Applied Neurobiology</title></titleGroup></publicationMeta><publicationMeta level="part" position="05003"><doi origin="wiley">10.1111/nan.1980.6.issue-3</doi><numberingGroup><numbering type="journalVolume" number="6">6</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="1980-05">May 1980</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0016500" status="forIssue"><doi origin="wiley">10.1111/j.1365-2990.1980.tb00288.x</doi><idGroup><id type="unit" value="NAN165"></id></idGroup><countGroup><count type="pageTotal" number="15"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><eventGroup><event type="firstOnline" date="2008-06-28"></event><event type="publishedOnlineFinalForm" date="2008-06-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:HeaderRef result:HeaderRef" date="2010-07-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="165">165</numbering><numbering type="pageLast" number="179">179</numbering></numberingGroup><correspondenceTo>Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NAN.NAN165.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication9 July 1979</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="21"></count><count type="linksCrossRef" number="5"></count></countGroup><titleGroup><title type="main">FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>H. 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Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 <i>Neuropathology and Applied Neurobiology</i> 6,165–179</p><p>Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis</p><p>Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS</title></titleInfo><name type="personal"><namePart type="given">H. J. A.</namePart><namePart type="family">FLEURY</namePart><affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RACHEL D.</namePart><namePart type="family">SHEPPARD</namePart><affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. B.</namePart><namePart type="family">BORNSTEIN</namePart><affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">RAINE</namePart><affiliation>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA</affiliation><affiliation>Correspondence address: Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1980-05</dateIssued><edition>Accepted for publication9 July 1979</edition><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">21</extent><extent unit="linksCrossRef">5</extent></physicalDescription><abstract lang="en">Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 Neuropathology and Applied Neurobiology 6,165–179 Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.</abstract><relatedItem type="host"><titleInfo><title>Neuropathology and Applied Neurobiology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0305-1846</identifier><identifier type="eISSN">1365-2990</identifier><identifier type="DOI">10.1111/(ISSN)1365-2990</identifier><identifier type="PublisherID">NAN</identifier><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>165</start><end>179</end><total>15</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. II. Pathology</title></titleInfo><name type="personal"><namePart type="given">O.T.</namePart><namePart type="family">BAILEY</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.M.</namePart><namePart type="family">PAPPENHEIMER</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.S.</namePart><namePart type="family">CHEEVER</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.B.</namePart><namePart type="family">DANIELS</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">BAILEY O.T., PAPPENHEIMER A.M., CHEEVER F.S. & DANIELS J.B. (1949) A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. II. Pathology. Journal of Experimental Medicine 90, 195–212.</note><part><date>1949</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>195</start><end>212</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Experimental Medicine</title></titleInfo><part><date>1949</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>195</start><end>212</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>The initial structural lesion in serum‐induced demyelination in vitro</title></titleInfo><name type="personal"><namePart type="given">M.B.</namePart><namePart type="family">BORNSTEIN</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.S.</namePart><namePart type="family">RAINE</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">BORNSTEIN M.B. & RAINE C.S. (1976) The initial structural lesion in serum‐induced demyelination in vitro. Laboratory Investigation 35, 391–401.</note><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>391</start><end>401</end></extent></part><relatedItem type="host"><titleInfo><title>Laboratory Investigation</title></titleInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>391</start><end>401</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. I. Isolation and biological properties of the virus</title></titleInfo><name type="personal"><namePart type="given">F.S.</namePart><namePart type="family">CHEEVER</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB.</namePart><namePart type="family">DANIELS</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.M.</namePart><namePart type="family">PAPPENHEIMER</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.T.</namePart><namePart type="family">BAILEY</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">CHEEVER F.S., DANIELS JB., PAPPENHEIMER A.M. & BAILEY O.T. (1949) A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. I. Isolation and biological properties of the virus. Journal of Experimental Medicine 90, 181–194.</note><part><date>1949</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>181</start><end>194</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Experimental Medicine</title></titleInfo><part><date>1949</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>181</start><end>194</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>An electron microscope study of the development of a mouse hepatitis virus in tissue culture cells</title></titleInfo><name type="personal"><namePart type="given">J.F.</namePart><namePart type="family">DAVID‐FERREIRA</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.A.</namePart><namePart type="family">MANAKER</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">DAVID‐FERREIRA J.F. & MANAKER, R.A. 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