Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy
Identifieur interne : 000619 ( Istex/Corpus ); précédent : 000618; suivant : 000620Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy
Auteurs : Patricia Hedenqvist ; Marianne Jensen-Waern ; Sa Fahlman ; Ragnvi Hagman ; Anna EdnerSource :
- Veterinary Anaesthesia and Analgesia [ 1467-2987 ] ; 2015-07.
Abstract
Objective: To compare physiological effects of sufentanil‐midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits. Study design: Prospective, randomized controlled experimental study. Animals: Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg. Methods: Premedication with 0.1 mg kg−1 medetomidine and 5 mg kg−1 carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL−1) and midazolam (0.45 mg mL−1). After endotracheal intubation, anaesthesia was maintained with sufentanil‐midazolam (n = 9) or sevoflurane (n = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by anova. Post‐operatively, 0.05 mg kg−1 buprenorphine was administered once and 5 mg kg−1 carprofen once daily for 2–3 days. Rabbits were examined and weighed daily until one week after surgery. Results: Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg−1 and 0.1 mg kg−1, during induction and 3.9 μg kg−1 hour−1 and 0.8 mg kg−1 hour−1 during surgery, respectively. End‐tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil‐midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre‐surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post‐operatively. Post‐operative problems sometimes resulted from catheterization of the ear artery. Conclusion: Sevoflurane and sufentanil‐midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil‐midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens. Clinical relevance: Anaesthesia with sufentanil‐midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.
Url:
DOI: 10.1111/vaa.12207
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title><author><name sortKey="Hedenqvist, Patricia" sort="Hedenqvist, Patricia" uniqKey="Hedenqvist P" first="Patricia" last="Hedenqvist">Patricia Hedenqvist</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: patricia.hedenqvist@slu.se</mods:affiliation></affiliation></author><author><name sortKey="Jensen Aern, Marianne" sort="Jensen Aern, Marianne" uniqKey="Jensen Aern M" first="Marianne" last="Jensen-Waern">Marianne Jensen-Waern</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Fahlman, Sa" sort="Fahlman, Sa" uniqKey="Fahlman " first=" Sa" last="Fahlman"> Sa Fahlman</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Hagman, Ragnvi" sort="Hagman, Ragnvi" uniqKey="Hagman R" first="Ragnvi" last="Hagman">Ragnvi Hagman</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Edner, Anna" sort="Edner, Anna" uniqKey="Edner A" first="Anna" last="Edner">Anna Edner</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:65AC75EC93306C32B1968635BD4BB3C1F45C745D</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1111/vaa.12207</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-VZGBQKS3-6/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000619</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000619</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title><author><name sortKey="Hedenqvist, Patricia" sort="Hedenqvist, Patricia" uniqKey="Hedenqvist P" first="Patricia" last="Hedenqvist">Patricia Hedenqvist</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: patricia.hedenqvist@slu.se</mods:affiliation></affiliation></author><author><name sortKey="Jensen Aern, Marianne" sort="Jensen Aern, Marianne" uniqKey="Jensen Aern M" first="Marianne" last="Jensen-Waern">Marianne Jensen-Waern</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Fahlman, Sa" sort="Fahlman, Sa" uniqKey="Fahlman " first=" Sa" last="Fahlman"> Sa Fahlman</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Hagman, Ragnvi" sort="Hagman, Ragnvi" uniqKey="Hagman R" first="Ragnvi" last="Hagman">Ragnvi Hagman</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Edner, Anna" sort="Edner, Anna" uniqKey="Edner A" first="Anna" last="Edner">Anna Edner</name><affiliation><mods:affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Anaesthesia and Analgesia</title><title level="j" type="alt">VETERINARY ANAESTHESIA AND ANALGESIA</title><idno type="ISSN">1467-2987</idno><idno type="eISSN">1467-2995</idno><imprint><biblScope unit="vol">42</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="377">377</biblScope><biblScope unit="page" to="385">385</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2015-07">2015-07</date></imprint><idno type="ISSN">1467-2987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1467-2987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: To compare physiological effects of sufentanil‐midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits. Study design: Prospective, randomized controlled experimental study. Animals: Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg. Methods: Premedication with 0.1 mg kg−1 medetomidine and 5 mg kg−1 carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL−1) and midazolam (0.45 mg mL−1). After endotracheal intubation, anaesthesia was maintained with sufentanil‐midazolam (n = 9) or sevoflurane (n = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by anova. Post‐operatively, 0.05 mg kg−1 buprenorphine was administered once and 5 mg kg−1 carprofen once daily for 2–3 days. Rabbits were examined and weighed daily until one week after surgery. Results: Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg−1 and 0.1 mg kg−1, during induction and 3.9 μg kg−1 hour−1 and 0.8 mg kg−1 hour−1 during surgery, respectively. End‐tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil‐midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre‐surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post‐operatively. Post‐operative problems sometimes resulted from catheterization of the ear artery. Conclusion: Sevoflurane and sufentanil‐midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil‐midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens. Clinical relevance: Anaesthesia with sufentanil‐midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>sevo</json:string><json:string>sevoflurane</json:string><json:string>anaesthesia</json:string><json:string>group sevo</json:string><json:string>anaesthetic</json:string><json:string>medetomidine</json:string><json:string>hedenqvist</json:string><json:string>sedation</json:string><json:string>sufentanil</json:string><json:string>midazolam</json:string><json:string>ovariohysterectomy</json:string><json:string>buprenorphine</json:string><json:string>premedicated</json:string><json:string>anesthesia</json:string><json:string>glucose</json:string><json:string>intravenous</json:string><json:string>body weight</json:string><json:string>analgesia</json:string><json:string>himalayan</json:string><json:string>surgical</json:string><json:string>paco2</json:string><json:string>anaesthetist</json:string><json:string>veterinary anaesthetist</json:string><json:string>american college</json:string><json:string>carprofen</json:string><json:string>veterinary anesthesia</json:string><json:string>righting</json:string><json:string>righting reflex</json:string><json:string>sedation preparation</json:string><json:string>himalayan rabbit</json:string><json:string>blood glucose</json:string><json:string>surgical anaesthesia</json:string><json:string>arterial blood pressure</json:string><json:string>surgery surgery hour</json:string><json:string>surgery</json:string><json:string>rabbit</json:string><json:string>agricultural science</json:string><json:string>heart rate</json:string><json:string>measure analysis</json:string><json:string>clinical science</json:string><json:string>mechanical ventilation</json:string><json:string>veterinary medicine</json:string><json:string>medetomidine premedicated rabbit</json:string><json:string>animal science</json:string><json:string>swedish university</json:string><json:string>buprenorphine administration</json:string><json:string>datum</json:string><json:string>arterial carbon dioxide</json:string><json:string>orion pharma animal health</json:string><json:string>endotracheal tube</json:string><json:string>arterial blood gas</json:string><json:string>cardiac complication</json:string><json:string>zealand white rabbit</json:string><json:string>anaesthetic induction</json:string><json:string>prep</json:string><json:string>veterinary</json:string><json:string>lactate</json:string></teeft></keywords><author><json:item><name>Patricia Hedenqvist</name><affiliations><json:string>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</json:string><json:string>E-mail: patricia.hedenqvist@slu.se</json:string></affiliations></json:item><json:item><name>Marianne Jensen‐Waern</name><affiliations><json:string>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</json:string></affiliations></json:item><json:item><name>Åsa Fahlman</name><affiliations><json:string>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</json:string></affiliations></json:item><json:item><name>Ragnvi Hagman</name><affiliations><json:string>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</json:string></affiliations></json:item><json:item><name>Anna Edner</name><affiliations><json:string>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ovariohysterectomy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rabbit anaesthesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sevoflurane</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>total intravenous anaesthesia sufentanil‐midazolam</value></json:item></subject><articleId><json:string>VAA12207</json:string></articleId><arkIstex>ark:/67375/WNG-VZGBQKS3-6</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Objective: To compare physiological effects of sufentanil‐midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits. Study design: Prospective, randomized controlled experimental study. Animals: Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg. Methods: Premedication with 0.1 mg kg−1 medetomidine and 5 mg kg−1 carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL−1) and midazolam (0.45 mg mL−1). After endotracheal intubation, anaesthesia was maintained with sufentanil‐midazolam (n = 9) or sevoflurane (n = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by anova. Post‐operatively, 0.05 mg kg−1 buprenorphine was administered once and 5 mg kg−1 carprofen once daily for 2–3 days. Rabbits were examined and weighed daily until one week after surgery. Results: Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg−1 and 0.1 mg kg−1, during induction and 3.9 μg kg−1 hour−1 and 0.8 mg kg−1 hour−1 during surgery, respectively. End‐tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil‐midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre‐surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post‐operatively. Post‐operative problems sometimes resulted from catheterization of the ear artery. Conclusion: Sevoflurane and sufentanil‐midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil‐midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens. Clinical relevance: Anaesthesia with sufentanil‐midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.</abstract><qualityIndicators><score>9.665</score><pdfWordCount>4665</pdfWordCount><pdfCharCount>30696</pdfCharCount><pdfVersion>1.6</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>518</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>288</abstractWordCount><abstractCharCount>2391</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title><genre><json:string>article</json:string></genre><host><title>Veterinary Anaesthesia and Analgesia</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1467-2995</json:string></doi><issn><json:string>1467-2987</json:string></issn><eissn><json:string>1467-2995</json:string></eissn><publisherId><json:string>VAA</json:string></publisherId><volume>42</volume><issue>4</issue><pages><first>377</first><last>385</last><total>9</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Paper</value></json:item><json:item><value>Anaesthesia</value></json:item><json:item><value>Research Papers</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-VZGBQKS3-6</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - veterinary sciences</json:string></wos><scienceMetrix><json:string>1 - applied sciences</json:string><json:string>2 - agriculture, fisheries & forestry</json:string><json:string>3 - veterinary sciences</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - General Veterinary</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2015</publicationDate><copyrightDate>2015</copyrightDate><doi><json:string>10.1111/vaa.12207</json:string></doi><id>65AC75EC93306C32B1968635BD4BB3C1F45C745D</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-VZGBQKS3-6/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-VZGBQKS3-6/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-VZGBQKS3-6/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>© 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia</licence></availability><date type="published" when="2015-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Patricia</forename><surname>Hedenqvist</surname></persName><affiliation><orgName type="division">Department of Clinical Sciences</orgName>
<orgName type="division">Faculty of Veterinary Medicine and Animal Science</orgName>
<orgName type="institution">Swedish University of Agricultural Sciences</orgName>
<address><settlement>Uppsala</settlement>
<country key="SE" xml:lang="en">SWEDEN</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Marianne</forename><surname>Jensen‐Waern</surname></persName><affiliation><orgName type="division">Department of Clinical Sciences</orgName>
<orgName type="division">Faculty of Veterinary Medicine and Animal Science</orgName>
<orgName type="institution">Swedish University of Agricultural Sciences</orgName>
<address><settlement>Uppsala</settlement>
<country key="SE" xml:lang="en">SWEDEN</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Åsa</forename><surname>Fahlman</surname></persName><affiliation><orgName type="division">Department of Clinical Sciences</orgName>
<orgName type="division">Faculty of Veterinary Medicine and Animal Science</orgName>
<orgName type="institution">Swedish University of Agricultural Sciences</orgName>
<address><settlement>Uppsala</settlement>
<country key="SE" xml:lang="en">SWEDEN</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Ragnvi</forename><surname>Hagman</surname></persName><affiliation><orgName type="division">Department of Clinical Sciences</orgName>
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<orgName type="division">Faculty of Veterinary Medicine and Animal Science</orgName>
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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main" xml:id="vaa12207-abs-0001"><head>Abstract</head><head>Objective</head><p>To compare physiological effects of sufentanil‐midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits.</p><head>Study design</head><p>Prospective, randomized controlled experimental study.</p><head>Animals</head><p>Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg.</p><head>Methods</head><p>Premedication with 0.1 mg kg<hi rend="superscript">−1</hi> medetomidine and 5 mg kg<hi rend="superscript">−1</hi> carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL<hi rend="superscript">−1</hi>) and midazolam (0.45 mg mL<hi rend="superscript">−1</hi>). After endotracheal intubation, anaesthesia was maintained with sufentanil‐midazolam (<hi rend="italic">n</hi> = 9) or sevoflurane (<hi rend="italic">n</hi> = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by <hi rend="smallCaps">anova</hi>. Post‐operatively, 0.05 mg kg<hi rend="superscript">−1</hi> buprenorphine was administered once and 5 mg kg<hi rend="superscript">−1</hi> carprofen once daily for 2–3 days. Rabbits were examined and weighed daily until one week after surgery.</p><head>Results</head><p>Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg<hi rend="superscript">−1</hi> and 0.1 mg kg<hi rend="superscript">−1</hi>, during induction and 3.9 μg kg<hi rend="superscript">−1</hi> hour<hi rend="superscript">−1</hi> and 0.8 mg kg<hi rend="superscript">−1</hi> hour<hi rend="superscript">−1</hi> during surgery, respectively. End‐tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil‐midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre‐surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post‐operatively. Post‐operative problems sometimes resulted from catheterization of the ear artery.</p><head>Conclusion</head><p>Sevoflurane and sufentanil‐midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil‐midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens.</p><head>Clinical relevance</head><p>Anaesthesia with sufentanil‐midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.</p></abstract><textClass><keywords><term xml:id="vaa12207-kwd-0001">ovariohysterectomy</term><term xml:id="vaa12207-kwd-0002">rabbit anaesthesia</term><term xml:id="vaa12207-kwd-0003">sevoflurane</term><term xml:id="vaa12207-kwd-0004">total intravenous anaesthesia sufentanil‐midazolam</term></keywords><keywords rend="articleCategory"><term>Research Paper</term></keywords><keywords rend="tocHeading1"><term>Anaesthesia</term></keywords><keywords rend="tocHeading2"><term>Research Papers</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-VZGBQKS3-6/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="vaa12207" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1467-2995</doi><issn type="print">1467-2987</issn><issn type="electronic">1467-2995</issn><idGroup><id type="product" value="VAA"></id></idGroup><titleGroup><title sort="VETERINARY ANAESTHESIA AND ANALGESIA" type="main">Veterinary Anaesthesia and Analgesia</title><title type="short">Vet Anaesth Analg</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley">10.1111/vaa.2015.42.issue-4</doi><copyright ownership="thirdParty">Copyright © 2015 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia</copyright><numberingGroup><numbering type="journalVolume" number="42">42</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2015-07">July 2015</coverDate></publicationMeta><publicationMeta level="unit" position="50" status="forIssue" type="article"><doi>10.1111/vaa.12207</doi><idGroup><id type="unit" value="VAA12207"></id></idGroup><countGroup><count number="9" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Research Paper</title><title type="tocHeading1">Anaesthesia</title><title type="tocHeading2">Research Papers</title></titleGroup><copyright ownership="thirdParty">© 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia</copyright><eventGroup><event date="2013-12-03" type="manuscriptReceived"></event><event date="2014-05-20" type="manuscriptAccepted"></event><event agent="SPS" date="2014-06-12" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-07-21"></event><event type="firstOnline" date="2014-07-21"></event><event type="publishedOnlineFinalForm" date="2015-06-08"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.7.5 mode:FullText" date="2016-01-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">377</numbering><numbering type="pageLast">385</numbering></numberingGroup><correspondenceTo><b>Correspondence:</b> Patricia Hedenqvist, Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, P.O. Box 7054, SE‐750 07, Uppsala, Sweden. E‐mail: <email>patricia.hedenqvist@slu.se</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:VAA.VAA12207.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Intravenous sufentanil‐midazolam <i>versus</i> sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title><title type="shortAuthors">P Hedenqvist et al.</title></titleGroup><creators><creator affiliationRef="#vaa12207-aff-0001" corresponding="yes" creatorRole="author" xml:id="vaa12207-cr-0001"><personName><givenNames>Patricia</givenNames> <familyName>Hedenqvist</familyName></personName></creator><creator affiliationRef="#vaa12207-aff-0001" creatorRole="author" xml:id="vaa12207-cr-0002"><personName><givenNames>Marianne</givenNames> <familyName>Jensen‐Waern</familyName></personName></creator><creator affiliationRef="#vaa12207-aff-0001" creatorRole="author" xml:id="vaa12207-cr-0003"><personName><givenNames>Åsa</givenNames> <familyName>Fahlman</familyName></personName></creator><creator affiliationRef="#vaa12207-aff-0001" creatorRole="author" xml:id="vaa12207-cr-0004"><personName><givenNames>Ragnvi</givenNames> <familyName>Hagman</familyName></personName></creator><creator affiliationRef="#vaa12207-aff-0001" creatorRole="author" xml:id="vaa12207-cr-0005"><personName><givenNames>Anna</givenNames> <familyName>Edner</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="SE" type="organization" xml:id="vaa12207-aff-0001"><orgDiv>Department of Clinical Sciences</orgDiv> <orgDiv>Faculty of Veterinary Medicine and Animal Science</orgDiv> <orgName>Swedish University of Agricultural Sciences</orgName> <address><city>Uppsala</city> <country>Sweden</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="vaa12207-kwd-0001">ovariohysterectomy</keyword><keyword xml:id="vaa12207-kwd-0002">rabbit anaesthesia</keyword><keyword xml:id="vaa12207-kwd-0003">sevoflurane</keyword><keyword xml:id="vaa12207-kwd-0004">total intravenous anaesthesia sufentanil‐midazolam</keyword></keywordGroup><fundingInfo><fundingAgency>Agria Pet Insurance</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="vaa12207-abs-0001"><title type="main">Abstract</title><section xml:id="vaa12207-sec-0001"><title type="main">Objective</title><p>To compare physiological effects of sufentanil‐midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits.</p></section><section xml:id="vaa12207-sec-0002"><title type="main">Study design</title><p>Prospective, randomized controlled experimental study.</p></section><section xml:id="vaa12207-sec-0003"><title type="main">Animals</title><p>Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg.</p></section><section xml:id="vaa12207-sec-0004"><title type="main">Methods</title><p>Premedication with 0.1 mg kg<sup>−1</sup> medetomidine and 5 mg kg<sup>−1</sup> carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL<sup>−1</sup>) and midazolam (0.45 mg mL<sup>−1</sup>). After endotracheal intubation, anaesthesia was maintained with sufentanil‐midazolam (<i>n</i> = 9) or sevoflurane (<i>n</i> = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by <sc>anova</sc>. Post‐operatively, 0.05 mg kg<sup>−1</sup> buprenorphine was administered once and 5 mg kg<sup>−1</sup> carprofen once daily for 2–3 days. Rabbits were examined and weighed daily until one week after surgery.</p></section><section xml:id="vaa12207-sec-0005"><title type="main">Results</title><p>Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg<sup>−1</sup> and 0.1 mg kg<sup>−1</sup>, during induction and 3.9 μg kg<sup>−1</sup> hour<sup>−1</sup> and 0.8 mg kg<sup>−1</sup> hour<sup>−1</sup> during surgery, respectively. End‐tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil‐midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre‐surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post‐operatively. Post‐operative problems sometimes resulted from catheterization of the ear artery.</p></section><section xml:id="vaa12207-sec-0006"><title type="main">Conclusion</title><p>Sevoflurane and sufentanil‐midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil‐midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens.</p></section><section xml:id="vaa12207-sec-0007"><title type="main">Clinical relevance</title><p>Anaesthesia with sufentanil‐midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Intravenous sufentanil‐midazolam versus sevoflurane anaesthesia in medetomidine pre‐medicated Himalayan rabbits undergoing ovariohysterectomy</title></titleInfo><name type="personal"><namePart type="given">Patricia</namePart><namePart type="family">Hedenqvist</namePart><affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</affiliation><affiliation>E-mail: patricia.hedenqvist@slu.se</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marianne</namePart><namePart type="family">Jensen‐Waern</namePart><affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Åsa</namePart><namePart type="family">Fahlman</namePart><affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ragnvi</namePart><namePart type="family">Hagman</namePart><affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna</namePart><namePart type="family">Edner</namePart><affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-07</dateIssued><dateCreated encoding="w3cdtf">2014-06-12</dateCreated><dateCaptured encoding="w3cdtf">2013-12-03</dateCaptured><dateValid encoding="w3cdtf">2014-05-20</dateValid><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Objective: To compare physiological effects of sufentanil‐midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits. Study design: Prospective, randomized controlled experimental study. Animals: Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg. Methods: Premedication with 0.1 mg kg−1 medetomidine and 5 mg kg−1 carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL−1) and midazolam (0.45 mg mL−1). After endotracheal intubation, anaesthesia was maintained with sufentanil‐midazolam (n = 9) or sevoflurane (n = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by anova. Post‐operatively, 0.05 mg kg−1 buprenorphine was administered once and 5 mg kg−1 carprofen once daily for 2–3 days. Rabbits were examined and weighed daily until one week after surgery. Results: Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg−1 and 0.1 mg kg−1, during induction and 3.9 μg kg−1 hour−1 and 0.8 mg kg−1 hour−1 during surgery, respectively. End‐tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil‐midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre‐surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post‐operatively. Post‐operative problems sometimes resulted from catheterization of the ear artery. Conclusion: Sevoflurane and sufentanil‐midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil‐midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens. Clinical relevance: Anaesthesia with sufentanil‐midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.</abstract><note type="funding">Agria Pet Insurance</note><subject><genre>keywords</genre><topic>ovariohysterectomy</topic><topic>rabbit anaesthesia</topic><topic>sevoflurane</topic><topic>total intravenous anaesthesia sufentanil‐midazolam</topic></subject><relatedItem type="host"><titleInfo><title>Veterinary Anaesthesia and Analgesia</title></titleInfo><titleInfo type="abbreviated"><title>Vet Anaesth Analg</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Paper</topic><topic>Anaesthesia</topic><topic>Research Papers</topic></subject><identifier type="ISSN">1467-2987</identifier><identifier type="eISSN">1467-2995</identifier><identifier type="DOI">10.1111/(ISSN)1467-2995</identifier><identifier type="PublisherID">VAA</identifier><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>377</start><end>385</end><total>9</total></extent></part></relatedItem><relatedItem type="references" displayLabel="vaa12207-cit-0001"><titleInfo><title>Simultaneous BOLD fMRI and local field potential measurements during kainic acid‐induced seizures</title></titleInfo><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Airaksinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Hekmatyar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Jerome</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Airaksinen AM, Hekmatyar SK, Jerome N et al. 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