Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet
Identifieur interne : 000550 ( Istex/Corpus ); précédent : 000549; suivant : 000551Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet
Auteurs : M. A. Medinsky ; J. A. Popp ; T. E. Hamm ; J. G. DentSource :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1982.
English descriptors
- Teeft :
- Acid deficiencies, American institute, Bieri, Bioserve diet, Blox, Body weights, Chemical pathology, Chlorinated insecticides, Control diet, Diet, Error bars, Female rats, Food consumption, Food efficiency, Growth rates, Hemorrhagic, Hemorrhagic lesions, Hepatic, Hepatic lesions, Hepatic lipidosis, Hepatocytes, Laboratory animals, Lesion, Lipid, Lipid accumulation, Lipidosis, Liver tissue, Male rats, Medinsky, Nutritional studies, Open formula diet, Percentage weight ratios, Periportal, Periportal hepatocytes, Periportal lipidosis, Portal triads, Present formulation, Rat, Weight ratios, Zeigler, Zeigler bros, Zeigler diet.
Abstract
Abstract: The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.
Url:
DOI: 10.1016/0041-008X(82)90107-7
Links to Exploration step
ISTEX:B7582B52F1601CF2186BCCFCBE425D932D0FF833Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title><author><name sortKey="Medinsky, M A" sort="Medinsky, M A" uniqKey="Medinsky M" first="M. A." last="Medinsky">M. A. Medinsky</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author><author><name sortKey="Popp, J A" sort="Popp, J A" uniqKey="Popp J" first="J. A." last="Popp">J. A. Popp</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author><author><name sortKey="Hamm, T E" sort="Hamm, T E" uniqKey="Hamm T" first="T. E." last="Hamm">T. E. Hamm</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author><author><name sortKey="Dent, J G" sort="Dent, J G" uniqKey="Dent J" first="J. G." last="Dent">J. G. Dent</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B7582B52F1601CF2186BCCFCBE425D932D0FF833</idno><date when="1982" year="1982">1982</date><idno type="doi">10.1016/0041-008X(82)90107-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-R1WRQW3R-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000550</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000550</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title><author><name sortKey="Medinsky, M A" sort="Medinsky, M A" uniqKey="Medinsky M" first="M. A." last="Medinsky">M. A. Medinsky</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author><author><name sortKey="Popp, J A" sort="Popp, J A" uniqKey="Popp J" first="J. A." last="Popp">J. A. Popp</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author><author><name sortKey="Hamm, T E" sort="Hamm, T E" uniqKey="Hamm T" first="T. E." last="Hamm">T. E. Hamm</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author><author><name sortKey="Dent, J G" sort="Dent, J G" uniqKey="Dent J" first="J. G." last="Dent">J. G. Dent</name><affiliation><mods:affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982">1982</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="111">111</biblScope><biblScope unit="page" to="120">120</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid deficiencies</term><term>American institute</term><term>Bieri</term><term>Bioserve diet</term><term>Blox</term><term>Body weights</term><term>Chemical pathology</term><term>Chlorinated insecticides</term><term>Control diet</term><term>Diet</term><term>Error bars</term><term>Female rats</term><term>Food consumption</term><term>Food efficiency</term><term>Growth rates</term><term>Hemorrhagic</term><term>Hemorrhagic lesions</term><term>Hepatic</term><term>Hepatic lesions</term><term>Hepatic lipidosis</term><term>Hepatocytes</term><term>Laboratory animals</term><term>Lesion</term><term>Lipid</term><term>Lipid accumulation</term><term>Lipidosis</term><term>Liver tissue</term><term>Male rats</term><term>Medinsky</term><term>Nutritional studies</term><term>Open formula diet</term><term>Percentage weight ratios</term><term>Periportal</term><term>Periportal hepatocytes</term><term>Periportal lipidosis</term><term>Portal triads</term><term>Present formulation</term><term>Rat</term><term>Weight ratios</term><term>Zeigler</term><term>Zeigler bros</term><term>Zeigler diet</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>lipidosis</json:string><json:string>hepatic</json:string><json:string>bieri</json:string><json:string>control diet</json:string><json:string>periportal</json:string><json:string>lipid</json:string><json:string>zeigler</json:string><json:string>blox</json:string><json:string>hemorrhagic</json:string><json:string>hepatocytes</json:string><json:string>periportal lipidosis</json:string><json:string>medinsky</json:string><json:string>male rats</json:string><json:string>hemorrhagic lesions</json:string><json:string>hepatic lipidosis</json:string><json:string>lipid accumulation</json:string><json:string>rat</json:string><json:string>lesion</json:string><json:string>hepatic lesions</json:string><json:string>weight ratios</json:string><json:string>growth rates</json:string><json:string>food efficiency</json:string><json:string>american institute</json:string><json:string>nutritional studies</json:string><json:string>percentage weight ratios</json:string><json:string>food consumption</json:string><json:string>periportal hepatocytes</json:string><json:string>zeigler bros</json:string><json:string>zeigler diet</json:string><json:string>diet</json:string><json:string>laboratory animals</json:string><json:string>body weights</json:string><json:string>bioserve diet</json:string><json:string>portal triads</json:string><json:string>acid deficiencies</json:string><json:string>error bars</json:string><json:string>liver tissue</json:string><json:string>chlorinated insecticides</json:string><json:string>female rats</json:string><json:string>present formulation</json:string><json:string>chemical pathology</json:string><json:string>open formula diet</json:string></teeft></keywords><author><json:item><name>M.A. Medinsky</name><affiliations><json:string>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</json:string></affiliations></json:item><json:item><name>J.A. Popp</name><affiliations><json:string>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</json:string></affiliations></json:item><json:item><name>T.E. Hamm</name><affiliations><json:string>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</json:string></affiliations></json:item><json:item><name>J.G. Dent</name><affiliations><json:string>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-R1WRQW3R-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.</abstract><qualityIndicators><score>7.093</score><pdfWordCount>3053</pdfWordCount><pdfCharCount>21057</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>476 x 713 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>170</abstractWordCount><abstractCharCount>1087</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title><pmid><json:string>7064147</json:string></pmid><pii><json:string>0041-008X(82)90107-7</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>A Report of the Committee on Laboratory Animal Diets, Institute of Laboratory Animal Resources, Assembly of Life Sciences, National Research Council</title><language><json:string>unknown</json:string></language></serie><host><title>Toxicology and Applied Pharmacology</title><language><json:string>unknown</json:string></language><publicationDate>1982</publicationDate><issn><json:string>0041-008X</json:string></issn><pii><json:string>S0041-008X(00)X0411-5</json:string></pii><volume>62</volume><issue>1</issue><pages><first>111</first><last>120</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1982</json:string></date><geogName><json:string>Ill</json:string></geogName><orgName><json:string>Academic Press, Inc</json:string><json:string>American Institute of Nutrition</json:string><json:string>National Research Council Committee on Laboratory Animal Diet</json:string><json:string>Institute Development</json:string><json:string>Charles River Breeding Laboratories, Kingston</json:string><json:string>Pitman-Moore, Inc.</json:string><json:string>Bio-Serve, Inc.</json:string><json:string>Committee on Standards for Nutritional Studies</json:string><json:string>AIN</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Animals</json:string><json:string>Wayne Lab</json:string><json:string>Wayne Lab-Blox</json:string><json:string>D. Auman</json:string><json:string>D. Patterson</json:string><json:string>B. Scortichini</json:string><json:string>S. Dennis</json:string></persName><placeName><json:string>HAMM</json:string><json:string>Frencbtown</json:string><json:string>Sendai</json:string><json:string>N.J.</json:string><json:string>Washington Crossing</json:string><json:string>Chicago</json:string><json:string>York</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Sidransky and Baba, 1960</json:string><json:string>Sidransky and Farber, 1958</json:string><json:string>Harper, 1958</json:string><json:string>Nguyen and Woodard, 1980</json:string><json:string>Male 12137</json:string><json:string>Kendall, 1979</json:string><json:string>Plaa, 1980</json:string><json:string>Chu et al., 1980</json:string><json:string>Bieri, 1980</json:string><json:string>Newberne et al., 1978</json:string><json:string>Adamstone and Spector, 1950</json:string><json:string>Takahashi et al., 1980</json:string><json:string>Cousins and Geary, 1966</json:string><json:string>Bieri et al., 1977</json:string><json:string>Roebuck et al., 1979</json:string><json:string>Luna, 1968</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-R1WRQW3R-8</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - toxicology</json:string><json:string>2 - pharmacology & pharmacy</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - toxicology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Toxicology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - tumeurs</json:string></inist></categories><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate><doi><json:string>10.1016/0041-008X(82)90107-7</json:string></doi><id>B7582B52F1601CF2186BCCFCBE425D932D0FF833</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R1WRQW3R-8/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R1WRQW3R-8/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-R1WRQW3R-8/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1982</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title><author xml:id="author-0000"><persName><forename type="first">M.A.</forename><surname>Medinsky</surname></persName><affiliation>To whom correspondence should be addressed.</affiliation><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">J.A.</forename><surname>Popp</surname></persName><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">T.E.</forename><surname>Hamm</surname></persName><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">J.G.</forename><surname>Dent</surname></persName><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation></author><idno type="istex">B7582B52F1601CF2186BCCFCBE425D932D0FF833</idno><idno type="ark">ark:/67375/6H6-R1WRQW3R-8</idno><idno type="DOI">10.1016/0041-008X(82)90107-7</idno><idno type="PII">0041-008X(82)90107-7</idno></analytic><monogr><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="pISSN">0041-008X</idno><idno type="PII">S0041-008X(00)X0411-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982"></date><biblScope unit="volume">62</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="111">111</biblScope><biblScope unit="page" to="120">120</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1982</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.</p></abstract></profileDesc><revisionDesc><change when="1982">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R1WRQW3R-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YTAAP</jid><aid>82901077</aid><ce:pii>0041-008X(82)90107-7</ce:pii><ce:doi>10.1016/0041-008X(82)90107-7</ce:doi><ce:copyright type="unknown" year="1982"></ce:copyright></item-info><head><ce:title>Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</ce:title><ce:author-group><ce:author><ce:given-name>M.A.</ce:given-name><ce:surname>Medinsky</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.A.</ce:given-name><ce:surname>Popp</ce:surname></ce:author><ce:author><ce:given-name>T.E.</ce:given-name><ce:surname>Hamm</ce:surname></ce:author><ce:author><ce:given-name>J.G.</ce:given-name><ce:surname>Dent</ce:surname></ce:author><ce:affiliation><ce:textfn>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>To whom correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="11" month="5" year="1981"></ce:date-received><ce:date-accepted day="7" month="8" year="1981"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet</title></titleInfo><name type="personal"><namePart type="given">M.A.</namePart><namePart type="family">Medinsky</namePart><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation><description>To whom correspondence should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.A.</namePart><namePart type="family">Popp</namePart><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.E.</namePart><namePart type="family">Hamm</namePart><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.G.</namePart><namePart type="family">Dent</namePart><affiliation>Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park, North Carolina 27709 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The suitability of the AIN-76A diet for Fischer-344 rats was investigated. This diet, proposed by the American Institute of Nutrition for use when a purified diet composed of refined ingredients and added vitamins and minerals is required, was tested in Sprague-Dawley rats. Male weanling Fischer-344 rats were fed three different lots of the AIN-76A diet from two suppliers. Increase in body weights and food consumption were compared to animals fed a cereal-based control diet. Animals were sacrificed at various intervals and tissues were taken for histopathological observation. By 8 weeks moderate to marked periportal lipidosis developed in livers of all rats fed the AIN-76A diet. Liver-body weight ratios over the 8-week period were significantly higher in rats fed AIN-76A diets compared to rats fed the control diet. However, growth rates of rats fed the AIN-76A diet were similar to growth rates of controls. Some rats fed the AIN-76A diet developed severe hemorrhagic lesions. The AIN-76A diet in its present form is not suitable for use with male Fischer-344 rats.</abstract><relatedItem type="host"><titleInfo><title>Toxicology and Applied Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>YTAAP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued></originInfo><identifier type="ISSN">0041-008X</identifier><identifier type="PII">S0041-008X(00)X0411-5</identifier><part><date>1982</date><detail type="volume"><number>62</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>182</end></extent><extent unit="pages"><start>111</start><end>120</end></extent></part></relatedItem><identifier type="istex">B7582B52F1601CF2186BCCFCBE425D932D0FF833</identifier><identifier type="ark">ark:/67375/6H6-R1WRQW3R-8</identifier><identifier type="DOI">10.1016/0041-008X(82)90107-7</identifier><identifier type="PII">0041-008X(82)90107-7</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R1WRQW3R-8/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000550 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000550 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:B7582B52F1601CF2186BCCFCBE425D932D0FF833
|texte= Development of hepatic lesions in male Fischer-344 rats fed AIN-76A purified diet
}}
| This area was generated with Dilib version V0.6.33. |  |