Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
Identifieur interne : 000547 ( Istex/Corpus ); précédent : 000546; suivant : 000548Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
Auteurs : Sandra Kleinau ; Helena Erlandsson ; Rikard Holmdahl ; Lars KlareskogSource :
- Journal of Autoimmunity [ 0896-8411 ] ; 1991.
English descriptors
- Teeft :
- Adjuvant, Ankle joints, Apparent arthritis, Arthritis, Arthritis rheum, Arthritogenicity, Blood samples, Blood smears, Clinical signs, Collagen, Dark agouti, Different times, Heat shock protein, Histological examination, Histopathological examinations, Human proteoglycan, Incomplete adjuvant, Injection, Intradermal injection, Joint space, Kleinau, Lewis rats, Lymph node cells, Marginal erosion, Microtiter plates, Mononuclear cells, Multinucleated giant cells, Mycobacteria, Mycobacteria tuberculosis, Original magnification, Other types, Polymorphonuclear cells, Pristane, Rat, Sandra, Sandra kleinau, Single injection, Specific immunity, Subchondral bone, Synovial subintimal tissue, Vegetable oils.
Abstract
Abstract: An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.
Url:
DOI: 10.1016/0896-8411(91)90050-M
Links to Exploration step
ISTEX:EE39C5EB8E340FC061D60617F9068EEA5F72961ALe document en format XML
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Characterization of the disease and evidence for an immunological involvement</title><author><name sortKey="Kleinau, Sandra" sort="Kleinau, Sandra" uniqKey="Kleinau S" first="Sandra" last="Kleinau">Sandra Kleinau</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Erlandsson, Helena" sort="Erlandsson, Helena" uniqKey="Erlandsson H" first="Helena" last="Erlandsson">Helena Erlandsson</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Holmdahl, Rikard" sort="Holmdahl, Rikard" uniqKey="Holmdahl R" first="Rikard" last="Holmdahl">Rikard Holmdahl</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EE39C5EB8E340FC061D60617F9068EEA5F72961A</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1016/0896-8411(91)90050-M</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-31J1D94N-L/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000547</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000547</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement</title><author><name sortKey="Kleinau, Sandra" sort="Kleinau, Sandra" uniqKey="Kleinau S" first="Sandra" last="Kleinau">Sandra Kleinau</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Erlandsson, Helena" sort="Erlandsson, Helena" uniqKey="Erlandsson H" first="Helena" last="Erlandsson">Helena Erlandsson</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Holmdahl, Rikard" sort="Holmdahl, Rikard" uniqKey="Holmdahl R" first="Rikard" last="Holmdahl">Rikard Holmdahl</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name><affiliation><mods:affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Autoimmunity</title><title level="j" type="abbrev">YJAUT</title><idno type="ISSN">0896-8411</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="871">871</biblScope><biblScope unit="page" to="880">880</biblScope></imprint><idno type="ISSN">0896-8411</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0896-8411</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adjuvant</term><term>Ankle joints</term><term>Apparent arthritis</term><term>Arthritis</term><term>Arthritis rheum</term><term>Arthritogenicity</term><term>Blood samples</term><term>Blood smears</term><term>Clinical signs</term><term>Collagen</term><term>Dark agouti</term><term>Different times</term><term>Heat shock protein</term><term>Histological examination</term><term>Histopathological examinations</term><term>Human proteoglycan</term><term>Incomplete adjuvant</term><term>Injection</term><term>Intradermal injection</term><term>Joint space</term><term>Kleinau</term><term>Lewis rats</term><term>Lymph node cells</term><term>Marginal erosion</term><term>Microtiter plates</term><term>Mononuclear cells</term><term>Multinucleated giant cells</term><term>Mycobacteria</term><term>Mycobacteria tuberculosis</term><term>Original magnification</term><term>Other types</term><term>Polymorphonuclear cells</term><term>Pristane</term><term>Rat</term><term>Sandra</term><term>Sandra kleinau</term><term>Single injection</term><term>Specific immunity</term><term>Subchondral bone</term><term>Synovial subintimal tissue</term><term>Vegetable oils</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. 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Characterization of the disease and evidence for an immunological involvement</title><author xml:id="author-0000"><persName><forename type="first">Sandra</forename><surname>Kleinau</surname></persName><note type="correspondence"><p>Correspondence to: Sandra Kleinau, Department of Medical and Physiological Chemistry, University of Uppsala, Box 575, S-75123 Uppsala, Sweden.</p></note><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Helena</forename><surname>Erlandsson</surname></persName><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Rikard</forename><surname>Holmdahl</surname></persName><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Lars</forename><surname>Klareskog</surname></persName><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation></author><idno type="istex">EE39C5EB8E340FC061D60617F9068EEA5F72961A</idno><idno type="ark">ark:/67375/6H6-31J1D94N-L</idno><idno type="DOI">10.1016/0896-8411(91)90050-M</idno><idno type="PII">0896-8411(91)90050-M</idno></analytic><monogr><title level="j">Journal of Autoimmunity</title><title level="j" type="abbrev">YJAUT</title><idno type="pISSN">0896-8411</idno><idno type="PII">S0896-8411(00)X0076-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991"></date><biblScope unit="volume">4</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="871">871</biblScope><biblScope unit="page" to="880">880</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1991</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.</p></abstract></profileDesc><revisionDesc><change when="1991">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-31J1D94N-L/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YJAUT</jid><aid>9190050M</aid><ce:pii>0896-8411(91)90050-M</ce:pii><ce:doi>10.1016/0896-8411(91)90050-M</ce:doi><ce:copyright type="unknown" year="1991"></ce:copyright></item-info><head><ce:title>Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement</ce:title><ce:author-group><ce:author><ce:given-name>Sandra</ce:given-name><ce:surname>Kleinau</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>★</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Helena</ce:given-name><ce:surname>Erlandsson</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>★</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Rikard</ce:given-name><ce:surname>Holmdahl</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>★</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Lars</ce:given-name><ce:surname>Klareskog</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>★</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>★</ce:label><ce:textfn>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>†</ce:label><ce:textfn>Department of Clinical Immunology, University Hospital, Uppsala, Sweden</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>‡</ce:label><ce:textfn>Department of Inflammation Research, Kabi-Pharmacia AB, Uppsala, Sweden</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Correspondence to: Sandra Kleinau, Department of Medical and Physiological Chemistry, University of Uppsala, Box 575, S-75123 Uppsala, Sweden.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="2" month="5" year="1991"></ce:date-received><ce:date-accepted day="12" month="6" year="1991"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel<ce:sup>®</ce:sup> A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement</title></titleInfo><name type="personal"><namePart type="given">Sandra</namePart><namePart type="family">Kleinau</namePart><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation><description>Correspondence to: Sandra Kleinau, Department of Medical and Physiological Chemistry, University of Uppsala, Box 575, S-75123 Uppsala, Sweden.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helena</namePart><namePart type="family">Erlandsson</namePart><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rikard</namePart><namePart type="family">Holmdahl</namePart><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Klareskog</namePart><affiliation>Department of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1991</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.</abstract><relatedItem type="host"><titleInfo><title>Journal of Autoimmunity</title></titleInfo><titleInfo type="abbreviated"><title>YJAUT</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1991</dateIssued></originInfo><identifier type="ISSN">0896-8411</identifier><identifier type="PII">S0896-8411(00)X0076-5</identifier><part><date>1991</date><detail type="volume"><number>4</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue-pages"><start>831</start><end>945</end></extent><extent unit="pages"><start>871</start><end>880</end></extent></part></relatedItem><identifier type="istex">EE39C5EB8E340FC061D60617F9068EEA5F72961A</identifier><identifier type="ark">ark:/67375/6H6-31J1D94N-L</identifier><identifier type="DOI">10.1016/0896-8411(91)90050-M</identifier><identifier type="PII">0896-8411(91)90050-M</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-31J1D94N-L/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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