CHRONIC ENCEPHALOMYELITIS WITH SPECIFIC INCREASE IN INTRATHECAL MUMPS ANTIBODIES
Identifieur interne : 000536 ( Istex/Corpus ); précédent : 000535; suivant : 000537CHRONIC ENCEPHALOMYELITIS WITH SPECIFIC INCREASE IN INTRATHECAL MUMPS ANTIBODIES
Auteurs : Antti Vaheri ; Ilkka Julkunen ; Marja-Leena KoskiniemiSource :
- The Lancet [ 0140-6736 ] ; 1982.
English descriptors
- Teeft :
- Antibody, Antibody patterns, Antibody production, Antibody ratio, Antibody response, Aqueductal stenosis, Bactericidal activity, Cerebrospinal fluid, Chlamydia group antigen, Chronic encephalomyelitis, Chronic infections, Clin microbiol, Control patients, Enzyme immunoassay, Further deterioration, Fusion protein, Measles, Measles virus, Multiple sclerosis, Mumps, Mumps antibodies, Mumps meningitis, Mumps virus, Mumps virus infection, Mycoplasma pneumoniae, Neuropsychological deficiences, Normal range, Oligoclonal, Outpatient clinic, Panencephalitis, Positive babinski sign, Present case, Protein concentration, Pseudomonas, Respiratory syncytial, Rubella, Sclerosing, Serum mumps, Sick children, Specific increase, Structural proteins, Subacute, Subacute sclerosing panencephalitis, Toxoplasma gondii, Virus.
Abstract
Abstract: Symptoms of severe encephalomyelitis developed in a 31-year-old man in 1967. He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease—chronic mumps virus infection in the central nervous system.
Url:
DOI: 10.1016/S0140-6736(82)90713-9
Links to Exploration step
ISTEX:79E24744BB9DB8750D760A50C64896A62FF66760Le document en format XML
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He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease—chronic mumps virus infection in the central nervous system.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>mumps</json:string><json:string>mumps virus</json:string><json:string>panencephalitis</json:string><json:string>rubella</json:string><json:string>subacute</json:string><json:string>mumps antibodies</json:string><json:string>sclerosing</json:string><json:string>oligoclonal</json:string><json:string>antibody response</json:string><json:string>cerebrospinal fluid</json:string><json:string>normal range</json:string><json:string>multiple sclerosis</json:string><json:string>subacute sclerosing panencephalitis</json:string><json:string>pseudomonas</json:string><json:string>chronic encephalomyelitis</json:string><json:string>control patients</json:string><json:string>measles virus</json:string><json:string>specific increase</json:string><json:string>antibody ratio</json:string><json:string>antibody production</json:string><json:string>measles</json:string><json:string>antibody</json:string><json:string>protein concentration</json:string><json:string>toxoplasma gondii</json:string><json:string>antibody patterns</json:string><json:string>positive babinski sign</json:string><json:string>neuropsychological deficiences</json:string><json:string>serum mumps</json:string><json:string>sick children</json:string><json:string>enzyme immunoassay</json:string><json:string>chronic infections</json:string><json:string>further deterioration</json:string><json:string>fusion protein</json:string><json:string>mumps meningitis</json:string><json:string>aqueductal stenosis</json:string><json:string>mumps virus infection</json:string><json:string>outpatient clinic</json:string><json:string>present case</json:string><json:string>structural proteins</json:string><json:string>bactericidal activity</json:string><json:string>clin microbiol</json:string><json:string>respiratory syncytial</json:string><json:string>chlamydia group antigen</json:string><json:string>mycoplasma pneumoniae</json:string><json:string>virus</json:string></teeft></keywords><author><json:item><name>Antti Vaheri</name><affiliations><json:string>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</json:string></affiliations></json:item><json:item><name>Ilkka Julkunen</name><affiliations><json:string>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</json:string></affiliations></json:item><json:item><name>Marja-Leena Koskiniemi</name><affiliations><json:string>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-SBV3F0H3-1</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Symptoms of severe encephalomyelitis developed in a 31-year-old man in 1967. He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease—chronic mumps virus infection in the central nervous system.</abstract><qualityIndicators><score>7.569</score><pdfWordCount>3241</pdfWordCount><pdfCharCount>21076</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>637 x 910 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>194</abstractWordCount><abstractCharCount>1258</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>CHRONIC ENCEPHALOMYELITIS WITH SPECIFIC INCREASE IN INTRATHECAL MUMPS ANTIBODIES</title><pmid><json:string>6126628</json:string></pmid><pii><json:string>S0140-6736(82)90713-9</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>The Lancet</title><language><json:string>unknown</json:string></language><publicationDate>1982</publicationDate><issn><json:string>0140-6736</json:string></issn><pii><json:string>S0140-6736(00)X6298-8</json:string></pii><volume>320</volume><issue>8300</issue><pages><first>685</first><last>688</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1975</json:string><json:string>1982</json:string><json:string>1967</json:string></date><geogName></geogName><orgName><json:string>Finland Symptoms</json:string><json:string>Emory University</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Roger Anderson</json:string><json:string>Anita Highsmith</json:string></persName><placeName><json:string>Georgia</json:string><json:string>Atlanta</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>March, 1981</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-SBV3F0H3-1</json:string></ark><categories><wos><json:string>1 - 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He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease—chronic mumps virus infection in the central nervous system.</p></abstract></profileDesc><revisionDesc><change when="1982">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-SBV3F0H3-1/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>LANCET</jid><aid>82907139</aid><ce:pii>S0140-6736(82)90713-9</ce:pii><ce:doi>10.1016/S0140-6736(82)90713-9</ce:doi><ce:copyright type="unknown" year="1982"></ce:copyright></item-info><head><ce:title>CHRONIC ENCEPHALOMYELITIS WITH SPECIFIC INCREASE IN INTRATHECAL MUMPS ANTIBODIES</ce:title><ce:author-group><ce:author><ce:given-name>Antti</ce:given-name><ce:surname>Vaheri</ce:surname></ce:author><ce:author><ce:given-name>Ilkka</ce:given-name><ce:surname>Julkunen</ce:surname></ce:author><ce:author><ce:given-name>Marja-Leena</ce:given-name><ce:surname>Koskiniemi</ce:surname><ce:cross-ref refid="ART5-FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</ce:textfn></ce:affiliation><ce:footnote id="ART5-FN1"><ce:label>1</ce:label><ce:note-para>Present address: Department of Paediatrics, University of Helsinki.</ce:note-para></ce:footnote></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Symptoms of severe encephalomyelitis developed in a 31-year-old man in 1967. He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease—chronic mumps virus infection in the central nervous system.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>CHRONIC ENCEPHALOMYELITIS WITH SPECIFIC INCREASE IN INTRATHECAL MUMPS ANTIBODIES</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>CHRONIC ENCEPHALOMYELITIS WITH SPECIFIC INCREASE IN INTRATHECAL MUMPS ANTIBODIES</title></titleInfo><name type="personal"><namePart type="given">Antti</namePart><namePart type="family">Vaheri</namePart><affiliation>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ilkka</namePart><namePart type="family">Julkunen</namePart><affiliation>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marja-Leena</namePart><namePart type="family">Koskiniemi</namePart><affiliation>Departments of Virology and Neurology, University of Helsinki, SF-00290 Helsinki 29, Finland</affiliation><description>Present address: Department of Paediatrics, University of Helsinki.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Symptoms of severe encephalomyelitis developed in a 31-year-old man in 1967. He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease—chronic mumps virus infection in the central nervous system.</abstract><relatedItem type="host"><titleInfo><title>The Lancet</title></titleInfo><titleInfo type="abbreviated"><title>LANCET</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued></originInfo><identifier type="ISSN">0140-6736</identifier><identifier type="PII">S0140-6736(00)X6298-8</identifier><part><date>1982</date><detail type="issue"><title>Originally published as Volume 2, Issue 8300</title></detail><detail type="volume"><number>320</number><caption>vol.</caption></detail><detail type="issue"><number>8300</number><caption>no.</caption></detail><extent unit="issue-pages"><start>675</start><end>726</end></extent><extent unit="pages"><start>685</start><end>688</end></extent></part></relatedItem><identifier type="istex">79E24744BB9DB8750D760A50C64896A62FF66760</identifier><identifier type="ark">ark:/67375/6H6-SBV3F0H3-1</identifier><identifier type="DOI">10.1016/S0140-6736(82)90713-9</identifier><identifier type="PII">S0140-6736(82)90713-9</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-SBV3F0H3-1/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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