CovidV1, Istex, Corpus, bibRecord, 000535

Rapid viral quasispecies evolution: implications for vaccine and drug strategies

Identifieur interne : 000535 ( Istex/Corpus ); précédent : 000534; suivant : 000536

Rapid viral quasispecies evolution: implications for vaccine and drug strategies

Auteurs : Isabel S. Novella ; Esteban Domingo ; John J. Holland

Source :

Molecular Medicine Today [ 1357-4310 ] ; 1995.

RBID : ISTEX:B2E46C7C36ACAFFD880D038932FC763232DED6DC

English descriptors

Teeft :
- Antiviral, Antiviral agents, Antiviral drugs, Complete shift, Diverse quasispecies populations, Encephalitis, Environmental conditions, Epitope, Error threshold, Genome, Hemorrhagic, Human immunodeficiency virus, Human immunodeficiency virus type, Immune, Immune response, Influenza, Limited number, Measles, Mutant, Mutation, Mutation rates, Original variant, Partial shift, Peptide vaccines, Quasispecies, Rapid evolution, Raven press, Replication, Resistant mutants, Subacute sclerosing panencephalitis, Such mutants, Vaccine, Vaccine design, Vaccine development, Viral, Viral proteins, Viral quasispecies, Virus, Virus infections, Virus quasispecies, Virus vaccines.

Abstract

High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.

Url:

https://api.istex.fr/ark:/67375/6H6-VTCF2J97-Z/fulltext.pdf

DOI: 10.1016/S1357-4310(95)91551-6

Links to Exploration step

ISTEX:B2E46C7C36ACAFFD880D038932FC763232DED6DC

Le document en format XML

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<ce:given-name>J.J.</ce:given-name>
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<sb:title><sb:maintitle>Mutation rates and rapid evolution of RNA viruses</sb:maintitle>
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<sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Morse</ce:surname>
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<sb:title><sb:maintitle>The Evolutionary Biology of Viruses</sb:maintitle>
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<abstract lang="en">High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.</abstract>
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Rapid viral quasispecies evolution: implications for vaccine and drug strategies

Rapid viral quasispecies evolution: implications for vaccine and drug strategies

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