Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
Identifieur interne : 000270 ( Istex/Corpus ); précédent : 000269; suivant : 000271Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
Auteurs : Huw G. Jenkins ; Hisako IkedaSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1992.
English descriptors
- Teeft :
- Axonal, Axonal transport, Blood vessel, Colliculi, Colliculus, Demyelination, Electron micrograph, Ikeda, Intraocular injection, Intravitreal, Intravitreal injection, Intravitreal injections, Liquid scintillation, Mouse, Mouse vitreous, Multiple sclerosis, Myelin, Myelin destruction, Myelinated axons, Nude mice, Optic, Optic nerve, Optic nerve demyelination, Optic nerve fibres, Optic nerve section, Optic nerve sections, Optic nerves, Retina, Rtnf, Rtnf injection, Sclerosis, Semliki, Semliki forest virus, Semliki forest virus infection, Superior colliculi, Superior colliculus, Tansey, Units rtnf.
Abstract
Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.
Url:
DOI: 10.1016/0022-510X(92)90194-P
Links to Exploration step
ISTEX:1E460BBF817D9AE0F731B027925B861DB71C1248Le document en format XML
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Jenkins</name><affiliation><mods:affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name><affiliation><mods:affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1E460BBF817D9AE0F731B027925B861DB71C1248</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0022-510X(92)90194-P</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000270</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000270</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title><author><name sortKey="Jenkins, Huw G" sort="Jenkins, Huw G" uniqKey="Jenkins H" first="Huw G." last="Jenkins">Huw G. Jenkins</name><affiliation><mods:affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Ikeda, Hisako" sort="Ikeda, Hisako" uniqKey="Ikeda H" first="Hisako" last="Ikeda">Hisako Ikeda</name><affiliation><mods:affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">108</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="99">99</biblScope><biblScope unit="page" to="104">104</biblScope></imprint><idno type="ISSN">0022-510X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Axonal</term><term>Axonal transport</term><term>Blood vessel</term><term>Colliculi</term><term>Colliculus</term><term>Demyelination</term><term>Electron micrograph</term><term>Ikeda</term><term>Intraocular injection</term><term>Intravitreal</term><term>Intravitreal injection</term><term>Intravitreal injections</term><term>Liquid scintillation</term><term>Mouse</term><term>Mouse vitreous</term><term>Multiple sclerosis</term><term>Myelin</term><term>Myelin destruction</term><term>Myelinated axons</term><term>Nude mice</term><term>Optic</term><term>Optic nerve</term><term>Optic nerve demyelination</term><term>Optic nerve fibres</term><term>Optic nerve section</term><term>Optic nerve sections</term><term>Optic nerves</term><term>Retina</term><term>Rtnf</term><term>Rtnf injection</term><term>Sclerosis</term><term>Semliki</term><term>Semliki forest virus</term><term>Semliki forest virus infection</term><term>Superior colliculi</term><term>Superior colliculus</term><term>Tansey</term><term>Units rtnf</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>rtnf</json:string><json:string>optic</json:string><json:string>axonal</json:string><json:string>demyelination</json:string><json:string>axonal transport</json:string><json:string>optic nerves</json:string><json:string>intravitreal</json:string><json:string>ikeda</json:string><json:string>tansey</json:string><json:string>semliki</json:string><json:string>myelin</json:string><json:string>retina</json:string><json:string>superior colliculi</json:string><json:string>colliculi</json:string><json:string>colliculus</json:string><json:string>optic nerve</json:string><json:string>semliki forest virus</json:string><json:string>multiple sclerosis</json:string><json:string>intravitreal injection</json:string><json:string>optic nerve demyelination</json:string><json:string>optic nerve fibres</json:string><json:string>units rtnf</json:string><json:string>blood vessel</json:string><json:string>optic nerve sections</json:string><json:string>sclerosis</json:string><json:string>intraocular injection</json:string><json:string>intravitreal injections</json:string><json:string>liquid scintillation</json:string><json:string>mouse vitreous</json:string><json:string>superior colliculus</json:string><json:string>optic nerve section</json:string><json:string>electron micrograph</json:string><json:string>semliki forest virus infection</json:string><json:string>myelinated axons</json:string><json:string>rtnf injection</json:string><json:string>myelin destruction</json:string><json:string>nude mice</json:string><json:string>mouse</json:string></teeft></keywords><author><json:item><name>Huw G. Jenkins</name><affiliations><json:string>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</json:string></affiliations></json:item><json:item><name>Hisako Ikeda</name><affiliations><json:string>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Axonal transport</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cytokine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Demyelination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Optic nerve</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Retina</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Tumour necrosis factor</value></json:item></subject><arkIstex>ark:/67375/6H6-PRPBKB5W-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.</abstract><qualityIndicators><score>6.874</score><pdfWordCount>3338</pdfWordCount><pdfCharCount>21120</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>128</abstractWordCount><abstractCharCount>826</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title><pmid><json:string>1378089</json:string></pmid><pii><json:string>0022-510X(92)90194-P</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of the Neurological Sciences</title><language><json:string>unknown</json:string></language><publicationDate>1992</publicationDate><issn><json:string>0022-510X</json:string></issn><pii><json:string>S0022-510X(00)X0150-5</json:string></pii><volume>108</volume><issue>1</issue><pages><first>99</first><last>104</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1992</json:string></date><geogName><json:string>Semliki</json:string></geogName><orgName><json:string>Vision Research Unit, The Rayne Institute,St</json:string><json:string>Hospital Medical School</json:string><json:string>Baker Ltd.</json:string><json:string>BioRad Microscience Ltd.</json:string><json:string>Rayne Institute, St</json:string><json:string>UMDS</json:string><json:string>National Diagnostics</json:string><json:string>Amersham International</json:string><json:string>Hospital, London</json:string><json:string>Hospital,London</json:string><json:string>Northern Ireland</json:string><json:string>Special Trustees of St</json:string><json:string>Multiple Sclerosis Society of Great Britain</json:string></orgName><orgName_funder><json:string>Northern Ireland</json:string><json:string>Special Trustees of St</json:string><json:string>Multiple Sclerosis Society of Great Britain</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>K.A. Brown</json:string><json:string>U.K.Tel</json:string><json:string>Janet Gladwell</json:string><json:string>H.G. Jenkins</json:string><json:string>Tochimichi Asai</json:string><json:string>Hisako</json:string></persName><placeName></placeName><ref_url></ref_url><ref_bibl><json:string>Brosnan et al.</json:string><json:string>Brosnan et al. 1989</json:string><json:string>Schnapp and Reese 1986</json:string><json:string>Pathak and Webb 1988</json:string><json:string>Aderka et al. 1986</json:string><json:string>Brosnan et al. (1989)</json:string><json:string>Nagashima et al. 1979</json:string><json:string>Tansey et al. 1985</json:string><json:string>Fazakerly and Webb 1987</json:string><json:string>Rao et al. 1981</json:string><json:string>Illavia et al. 1981</json:string><json:string>Jenkins et al. 1988</json:string><json:string>Tansey and Ikeda 1986</json:string><json:string>Nixon 1980</json:string><json:string>Jenkins and Ikeda 1991</json:string><json:string>Atkins et al. 1985</json:string><json:string>Glauert 1975</json:string><json:string>Simmons and Willenborg (1990)</json:string><json:string>Steffen et al. 1988</json:string><json:string>Limb et al. 1989</json:string><json:string>Ikeda and Tansey 1986</json:string><json:string>Simmons and Willenborg 1990</json:string><json:string>Pessoa and Ikeda 1984</json:string><json:string>Wong and Geoddel 1986</json:string><json:string>Bradley and Jaros 1973</json:string><json:string>Tansey and Ikeda 1986b</json:string><json:string>Selmaj and Raine 1988</json:string><json:string>Dawson 1916</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-PRPBKB5W-M</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - clinical neurology</json:string></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - neurologie</json:string></inist></categories><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><doi><json:string>10.1016/0022-510X(92)90194-P</json:string></doi><id>1E460BBF817D9AE0F731B027925B861DB71C1248</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1992</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title><author xml:id="author-0000"><persName><forename type="first">Huw G.</forename><surname>Jenkins</surname></persName><note type="correspondence"><p>Correspondence to: H.G. Jenkins, The Vision Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SE1 7EH, U.K.. Tel: (44)(71) 928-9292, ext. 3407; Fax: (44)(71) 922-8079.</p></note><affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Hisako</forename><surname>Ikeda</surname></persName><affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</affiliation></author><idno type="istex">1E460BBF817D9AE0F731B027925B861DB71C1248</idno><idno type="ark">ark:/67375/6H6-PRPBKB5W-M</idno><idno type="DOI">10.1016/0022-510X(92)90194-P</idno><idno type="PII">0022-510X(92)90194-P</idno></analytic><monogr><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="pISSN">0022-510X</idno><idno type="PII">S0022-510X(00)X0150-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">108</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="99">99</biblScope><biblScope unit="page" to="104">104</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Axonal transport</term></item><item><term>Cytokine</term></item><item><term>Demyelination</term></item><item><term>Optic nerve</term></item><item><term>Retina</term></item><item><term>Tumour necrosis factor</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1991-09-27">Modified</change><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" </istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNS</jid><aid>90194</aid><ce:pii>0022-510X(92)90194-P</ce:pii><ce:doi>10.1016/0022-510X(92)90194-P</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:title>Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</ce:title><ce:author-group><ce:author><ce:given-name>Huw G.</ce:given-name><ce:surname>Jenkins</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Hisako</ce:given-name><ce:surname>Ikeda</ce:surname></ce:author><ce:affiliation><ce:textfn>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Correspondence to: H.G. Jenkins, The Vision Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SE1 7EH, U.K.. Tel: (44)(71) 928-9292, ext. 3407; Fax: (44)(71) 922-8079.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="16" month="4" year="1991"></ce:date-received><ce:date-revised day="27" month="9" year="1991"></ce:date-revised><ce:date-accepted day="4" month="10" year="1991"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para id="SP0005">An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [<ce:sup loc="pre">3</ce:sup>H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Axonal transport</ce:text></ce:keyword><ce:keyword><ce:text>Cytokine</ce:text></ce:keyword><ce:keyword><ce:text>Demyelination</ce:text></ce:keyword><ce:keyword><ce:text>Optic nerve</ce:text></ce:keyword><ce:keyword><ce:text>Retina</ce:text></ce:keyword><ce:keyword><ce:text>Tumour necrosis factor</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve</title></titleInfo><name type="personal"><namePart type="given">Huw G.</namePart><namePart type="family">Jenkins</namePart><affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</affiliation><description>Correspondence to: H.G. Jenkins, The Vision Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SE1 7EH, U.K.. Tel: (44)(71) 928-9292, ext. 3407; Fax: (44)(71) 922-8079.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hisako</namePart><namePart type="family">Ikeda</namePart><affiliation>Vision Research Unit of Sherrington School (UMDS), The Rayne Institute, St. Thomas' Hospital, London, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><dateModified encoding="w3cdtf">1991-09-27</dateModified><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [3H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis.</abstract><subject><genre>Keywords</genre><topic>Axonal transport</topic><topic>Cytokine</topic><topic>Demyelination</topic><topic>Optic nerve</topic><topic>Retina</topic><topic>Tumour necrosis factor</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title></titleInfo><titleInfo type="abbreviated"><title>JNS</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued></originInfo><identifier type="ISSN">0022-510X</identifier><identifier type="PII">S0022-510X(00)X0150-5</identifier><part><date>1992</date><detail type="volume"><number>108</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>119</end></extent><extent unit="pages"><start>99</start><end>104</end></extent></part></relatedItem><identifier type="istex">1E460BBF817D9AE0F731B027925B861DB71C1248</identifier><identifier type="ark">ark:/67375/6H6-PRPBKB5W-M</identifier><identifier type="DOI">10.1016/0022-510X(92)90194-P</identifier><identifier type="PII">0022-510X(92)90194-P</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-PRPBKB5W-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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