Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection
Identifieur interne : 000100 ( Istex/Corpus ); précédent : 000099; suivant : 000101Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection
Auteurs : Helmut Wege ; Rihito Watanabe ; Volker Ter MeulenSource :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1984.
English descriptors
- Teeft :
- Allergic encephalomyelitis, Arrow heads, Autoimmune reaction, Blue staining, Brain tissue, Cell infiltrations, Chronic relapsing, Clinical signs, Clinical symptoms, Coronavirus, Demyelinated plaque, Demyelinating, Demyelination, Density gradient, Electron microscopy, Encephalomyelitis, First attack, Fresh demyelinating lesions, Grey matter, Incubation period, Infection, Infectious virus, Intracerebral inoculation, Lesion, Lewis rats, Mouse hepatitis virus, Multiple sclerosis, Mutant, Myelin, Myelin debris, Neutralizing antibodies, Plaque, Rat, Recurrent demyelination, Relapsing, Relapsing demyelination, Remyelinated area, Remyelinated areas, Routine coronavirus, Same level, Schwann cells, Serum dilution, Several weeks, Severe paralysis, Sodium chloride, Spinal, Spinal cord, Viral antigens, Virus, Virus infection, Visna virus, Wege, White matter, Wild type.
Abstract
Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.
Url:
DOI: 10.1016/0165-5728(84)90022-5
Links to Exploration step
ISTEX:ADF4136D1BDD7B9D7C67CD9D035AC24F1EA82F03Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title><author><name sortKey="Wege, Helmut" sort="Wege, Helmut" uniqKey="Wege H" first="Helmut" last="Wege">Helmut Wege</name><affiliation><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Watanabe, Rihito" sort="Watanabe, Rihito" uniqKey="Watanabe R" first="Rihito" last="Watanabe">Rihito Watanabe</name><affiliation><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Ter Meulen, Volker" sort="Ter Meulen, Volker" uniqKey="Ter Meulen V" first="Volker" last="Ter Meulen">Volker Ter Meulen</name><affiliation><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ADF4136D1BDD7B9D7C67CD9D035AC24F1EA82F03</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1016/0165-5728(84)90022-5</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-KH8PFR17-2/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000100</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000100</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title><author><name sortKey="Wege, Helmut" sort="Wege, Helmut" uniqKey="Wege H" first="Helmut" last="Wege">Helmut Wege</name><affiliation><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Watanabe, Rihito" sort="Watanabe, Rihito" uniqKey="Watanabe R" first="Rihito" last="Watanabe">Rihito Watanabe</name><affiliation><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Ter Meulen, Volker" sort="Ter Meulen, Volker" uniqKey="Ter Meulen V" first="Volker" last="Ter Meulen">Volker Ter Meulen</name><affiliation><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="325">325</biblScope><biblScope unit="page" to="336">336</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allergic encephalomyelitis</term><term>Arrow heads</term><term>Autoimmune reaction</term><term>Blue staining</term><term>Brain tissue</term><term>Cell infiltrations</term><term>Chronic relapsing</term><term>Clinical signs</term><term>Clinical symptoms</term><term>Coronavirus</term><term>Demyelinated plaque</term><term>Demyelinating</term><term>Demyelination</term><term>Density gradient</term><term>Electron microscopy</term><term>Encephalomyelitis</term><term>First attack</term><term>Fresh demyelinating lesions</term><term>Grey matter</term><term>Incubation period</term><term>Infection</term><term>Infectious virus</term><term>Intracerebral inoculation</term><term>Lesion</term><term>Lewis rats</term><term>Mouse hepatitis virus</term><term>Multiple sclerosis</term><term>Mutant</term><term>Myelin</term><term>Myelin debris</term><term>Neutralizing antibodies</term><term>Plaque</term><term>Rat</term><term>Recurrent demyelination</term><term>Relapsing</term><term>Relapsing demyelination</term><term>Remyelinated area</term><term>Remyelinated areas</term><term>Routine coronavirus</term><term>Same level</term><term>Schwann cells</term><term>Serum dilution</term><term>Several weeks</term><term>Severe paralysis</term><term>Sodium chloride</term><term>Spinal</term><term>Spinal cord</term><term>Viral antigens</term><term>Virus</term><term>Virus infection</term><term>Visna virus</term><term>Wege</term><term>White matter</term><term>Wild type</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>demyelination</json:string><json:string>relapsing</json:string><json:string>mutant</json:string><json:string>encephalomyelitis</json:string><json:string>spinal</json:string><json:string>spinal cord</json:string><json:string>myelin</json:string><json:string>virus infection</json:string><json:string>demyelinating</json:string><json:string>coronavirus</json:string><json:string>wege</json:string><json:string>first attack</json:string><json:string>same level</json:string><json:string>infectious virus</json:string><json:string>arrow heads</json:string><json:string>white matter</json:string><json:string>clinical symptoms</json:string><json:string>electron microscopy</json:string><json:string>remyelinated areas</json:string><json:string>clinical signs</json:string><json:string>lewis rats</json:string><json:string>chronic relapsing</json:string><json:string>multiple sclerosis</json:string><json:string>brain tissue</json:string><json:string>serum dilution</json:string><json:string>plaque</json:string><json:string>virus</json:string><json:string>infection</json:string><json:string>fresh demyelinating lesions</json:string><json:string>sodium chloride</json:string><json:string>density gradient</json:string><json:string>allergic encephalomyelitis</json:string><json:string>intracerebral inoculation</json:string><json:string>incubation period</json:string><json:string>autoimmune reaction</json:string><json:string>demyelinated plaque</json:string><json:string>cell infiltrations</json:string><json:string>viral antigens</json:string><json:string>blue staining</json:string><json:string>routine coronavirus</json:string><json:string>wild type</json:string><json:string>mouse hepatitis virus</json:string><json:string>remyelinated area</json:string><json:string>schwann cells</json:string><json:string>several weeks</json:string><json:string>relapsing demyelination</json:string><json:string>myelin debris</json:string><json:string>grey matter</json:string><json:string>visna virus</json:string><json:string>neutralizing antibodies</json:string><json:string>recurrent demyelination</json:string><json:string>severe paralysis</json:string><json:string>lesion</json:string><json:string>rat</json:string></teeft></keywords><author><json:item><name>Helmut Wege</name><affiliations><json:string>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</json:string></affiliations></json:item><json:item><name>Rihito Watanabe</name><affiliations><json:string>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</json:string></affiliations></json:item><json:item><name>Volker ter Meulen</name><affiliations><json:string>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Autoimmune reaction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Corona virus JHM</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Demyelination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Experimental allergic encephalomylitis (EAE)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Persistent infection</value></json:item></subject><arkIstex>ark:/67375/6H6-KH8PFR17-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.</abstract><qualityIndicators><score>8.097</score><pdfWordCount>4309</pdfWordCount><pdfCharCount>24698</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>288 x 432 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>149</abstractWordCount><abstractCharCount>1061</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title><pmid><json:string>6086712</json:string></pmid><pii><json:string>0165-5728(84)90022-5</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Proc. Nat. Acad. Sci. (USA)</title><language><json:string>unknown</json:string></language><volume>75</volume><pages><first>4033</first><last>4036</last></pages></serie><host><title>Journal of Neuroimmunology</title><language><json:string>unknown</json:string></language><publicationDate>1984</publicationDate><issn><json:string>0165-5728</json:string></issn><pii><json:string>S0165-5728(00)X0212-3</json:string></pii><volume>6</volume><issue>5</issue><pages><first>325</first><last>336</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1983</json:string></date><geogName></geogName><orgName><json:string>Dynatech</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl><json:string>Accepted20 December,1983</json:string><json:string>Watanabe et al. 1983</json:string><json:string>Sternberger et aL 1979</json:string><json:string>Haspel et al. 1978</json:string><json:string>Wege et al. 1983</json:string><json:string>Raine et al. 1978</json:string><json:string>McFarlin et al. 1974</json:string><json:string>Vege et al. 1979</json:string><json:string>Lassmann and Wisniewski 1979</json:string><json:string>Received26 August,1983</json:string><json:string>Nagashima et al.</json:string><json:string>Lassmanll and Wisniewski 1979</json:string><json:string>Paine et al. 1978</json:string><json:string>Knobler et aL 1981, 1982</json:string><json:string>Vandevelde et al. 1982</json:string><json:string>Traugott et al. 1982</json:string><json:string>Canto and Lipton 1979</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-KH8PFR17-2</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - neurologie</json:string></inist></categories><publicationDate>1984</publicationDate><copyrightDate>1983</copyrightDate><doi><json:string>10.1016/0165-5728(84)90022-5</json:string></doi><id>ADF4136D1BDD7B9D7C67CD9D035AC24F1EA82F03</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-KH8PFR17-2/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-KH8PFR17-2/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-KH8PFR17-2/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1983</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>This work was supported by the Deutsche Forschungsgemeinschaft and Humboldt-Stiftung.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title><author xml:id="author-0000"><persName><forename type="first">Helmut</forename><surname>Wege</surname></persName><affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Rihito</forename><surname>Watanabe</surname></persName><affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Volker</forename><surname>ter Meulen</surname></persName><affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</affiliation></author><idno type="istex">ADF4136D1BDD7B9D7C67CD9D035AC24F1EA82F03</idno><idno type="ark">ark:/67375/6H6-KH8PFR17-2</idno><idno type="DOI">10.1016/0165-5728(84)90022-5</idno><idno type="PII">0165-5728(84)90022-5</idno></analytic><monogr><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="pISSN">0165-5728</idno><idno type="PII">S0165-5728(00)X0212-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984"></date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="325">325</biblScope><biblScope unit="page" to="336">336</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Autoimmune reaction</term></item><item><term>Corona virus JHM</term></item><item><term>Demyelination</term></item><item><term>Experimental allergic encephalomylitis (EAE)</term></item><item><term>Persistent infection</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1983-12-01">Modified</change><change when="1984">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-KH8PFR17-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" </istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNI</jid><aid>90022</aid><ce:pii>0165-5728(84)90022-5</ce:pii><ce:doi>10.1016/0165-5728(84)90022-5</ce:doi><ce:copyright type="unknown" year="1983"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was supported by the Deutsche Forschungsgemeinschaft and Humboldt-Stiftung.</ce:note-para></ce:article-footnote><ce:title>Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</ce:title><ce:author-group><ce:author><ce:given-name>Helmut</ce:given-name><ce:surname>Wege</ce:surname></ce:author><ce:author><ce:given-name>Rihito</ce:given-name><ce:surname>Watanabe</ce:surname></ce:author><ce:author><ce:given-name>Volker</ce:given-name><ce:surname>ter Meulen</ce:surname></ce:author><ce:affiliation><ce:textfn>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="26" month="8" year="1983"></ce:date-received><ce:date-revised day="1" month="12" year="1983"></ce:date-revised><ce:date-accepted day="20" month="12" year="1983"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para id="SP0005">Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Autoimmune reaction</ce:text></ce:keyword><ce:keyword><ce:text>Corona virus JHM</ce:text></ce:keyword><ce:keyword><ce:text>Demyelination</ce:text></ce:keyword><ce:keyword><ce:text>Experimental allergic encephalomylitis (EAE)</ce:text></ce:keyword><ce:keyword><ce:text>Persistent infection</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection</title></titleInfo><name type="personal"><namePart type="given">Helmut</namePart><namePart type="family">Wege</namePart><affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rihito</namePart><namePart type="family">Watanabe</namePart><affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Volker</namePart><namePart type="family">ter Meulen</namePart><affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1984</dateIssued><dateModified encoding="w3cdtf">1983-12-01</dateModified><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.</abstract><note>This work was supported by the Deutsche Forschungsgemeinschaft and Humboldt-Stiftung.</note><subject><genre>Keywords</genre><topic>Autoimmune reaction</topic><topic>Corona virus JHM</topic><topic>Demyelination</topic><topic>Experimental allergic encephalomylitis (EAE)</topic><topic>Persistent infection</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroimmunology</title></titleInfo><titleInfo type="abbreviated"><title>JNI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1984</dateIssued></originInfo><identifier type="ISSN">0165-5728</identifier><identifier type="PII">S0165-5728(00)X0212-3</identifier><part><date>1984</date><detail type="volume"><number>6</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>303</start><end>371</end></extent><extent unit="pages"><start>325</start><end>336</end></extent></part></relatedItem><identifier type="istex">ADF4136D1BDD7B9D7C67CD9D035AC24F1EA82F03</identifier><identifier type="ark">ark:/67375/6H6-KH8PFR17-2</identifier><identifier type="DOI">10.1016/0165-5728(84)90022-5</identifier><identifier type="PII">0165-5728(84)90022-5</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-KH8PFR17-2/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000100 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000100 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:ADF4136D1BDD7B9D7C67CD9D035AC24F1EA82F03
|texte= Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection
}}
| This area was generated with Dilib version V0.6.33. |  |