Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Identifieur interne : 000053 ( Istex/Corpus ); précédent : 000052; suivant : 000054Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Auteurs : K. Nagashima ; H. Wege ; R. Meyermann ; V. Ter MeulenSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1979-01-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Allergic encephalomyelitis, Animal model, Astrocytic processes, Axon, Basement membrane, Brain suspension, Chronic relapsing, Clinical signs, Control animals, Corona, Corona virus, Demyelinated areas, Demyelinating, Demyelinating encephalomyelitis, Demyelinating lesions, Demyelinating plaques, Demyelination, Disease process, Electron microscopy, Encephalomyelitis, Federal republic, Glial, Glial cells, Incubation period, Inoculation, Intracerebral inoculation, Late onset, Lesion, Light microscopy, Long incubation period, Lower part, Mononuclear cells, Mouse hepatitis virus, Multiple sclerosis, Murine corona virus, Myelin, Myelin sheaths, Nagashima, Naked axon, Naked axons, Neurological signs, Neuropathol, Optic nerve, Optic tract, Peripheral myelin, Peripheral nerves, Plaque, Present study, Remyelinated areas, Remyelination, Schwann, Schwann cell, Schwann cells, Sclerosis, Sheath, Small cells, Spinal, Spinal cord, Spinal tract, Subacute demyelinating encephalomyelitis, Trigeminal, Trigeminal nerve, Trigeminal nerves, Ultrastructural study, Upper corner, Vesicular disruption, Viral antigen, Virus inoculation, Weanling rats, White matter.
Abstract
Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.
Url:
DOI: 10.1007/BF00702672
Links to Exploration step
ISTEX:893A3708A5B07785EA0E3694B68A9E8274262348Le document en format XML
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From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. 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From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. 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Neuropathologica</JournalTitle><JournalAbbreviatedTitle>Acta Neuropathol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pathology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>45</VolumeIDStart><VolumeIDEnd>45</VolumeIDEnd><VolumeIssueCount>3</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueArticleCount>10</IssueArticleCount><IssueHistory><CoverDate><DateString>1979</DateString><Year>1979</Year><Month>1</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1979</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art5"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00702672</ArticleID><ArticleDOI>10.1007/BF00702672</ArticleDOI><ArticleSequenceNumber>5</ArticleSequenceNumber><ArticleTitle Language="En">Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</ArticleTitle><ArticleSubTitle Language="En">A preliminary report</ArticleSubTitle><ArticleCategory>Original Works</ArticleCategory><ArticleFirstPage>205</ArticleFirstPage><ArticleLastPage>213</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>11</Month><Day>11</Day></RegistrationDate><Received><Year>1978</Year><Month>7</Month><Day>31</Day></Received><Accepted><Year>1978</Year><Month>10</Month><Day>30</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1979</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>45</VolumeIDStart><VolumeIDEnd>45</VolumeIDEnd><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Nagashima</FamilyName></AuthorName><Role>Alexander von Humboldt Stipendiat</Role></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Wege</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff3"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><FamilyName>Meyermann</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><Particle>ter</Particle><FamilyName>Meulen</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Institute for Virology and Immunobiology</OrgDivision><OrgName>University of Würzburg</OrgName><OrgAddress><Street>Versbacher Straße 7</Street><Postcode>D-8700</Postcode><City>Würzburg</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Pathology, Faculty of Medicine</OrgDivision><OrgName>University of Tokyo</OrgName><OrgAddress><Street>7-3-1 Hongo, Bunkyo-ku</Street><Postcode>113</Postcode><City>Tokyo</City><Country>Japan</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Neuropathology</OrgDivision><OrgName>University of Göttingen</OrgName><OrgAddress><Postcode>D-3400</Postcode><City>Göttingen</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined.</Para><Para>Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Corona virus rats</Keyword><Keyword>Late onset demyelination</Keyword><Keyword>Remyelination</Keyword><Keyword>Multiple sclerosis</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>Supported by Deutsche Forschungsgemeinschaft, Schwerpunkt Multiple Sklerose und verwandte Erkrankungen</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</title><subTitle>A preliminary report</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Nagashima</namePart><affiliation>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Alexander von Humboldt Stipendiat</description></name><name type="personal" displayLabel="corresp"><namePart type="given">H.</namePart><namePart type="family">Wege</namePart><affiliation>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Meyermann</namePart><affiliation>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">ter Meulen</namePart><affiliation>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1978-07-31</dateCreated><dateIssued encoding="w3cdtf">1979-01-01</dateIssued><copyrightDate encoding="w3cdtf">1979</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</abstract><note>Original Works</note><subject lang="en"><genre>Key words</genre><topic>Corona virus rats</topic><topic>Late onset demyelination</topic><topic>Remyelination</topic><topic>Multiple sclerosis</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neuropathologica</title></titleInfo><titleInfo type="abbreviated"><title>Acta Neuropathol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1979-01-01</dateIssued><copyrightDate encoding="w3cdtf">1979</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0001-6322</identifier><identifier type="eISSN">1432-0533</identifier><identifier type="JournalID">401</identifier><identifier type="IssueArticleCount">10</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>1979</date><detail type="volume"><number>45</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>205</start><end>213</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1979</recordOrigin></recordInfo></relatedItem><identifier type="istex">893A3708A5B07785EA0E3694B68A9E8274262348</identifier><identifier type="ark">ark:/67375/1BB-1Q58M6WQ-V</identifier><identifier type="DOI">10.1007/BF00702672</identifier><identifier type="ArticleID">BF00702672</identifier><identifier type="ArticleID">Art5</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1979</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1979</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-1Q58M6WQ-V/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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